The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform

Thomas Dresbach - One of the best experts on this subject based on the ideXlab platform.

  • The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types
    Frontiers in neuroanatomy, 2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general synaptic vesicle marker synaptophysin in sixteen Brain Areas. We find that mover is particularly abundant in the septal nuclei, ventral pallidum, amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e. between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas.

  • Image_1_The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.PDF
    2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle (SV) protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general SV marker synaptophysin in 16 Brain Areas. We find that mover is particularly abundant in the septal nuclei (SNu), ventral pallidum (VPa), amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e., between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas.

  • The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types
    Frontiers Media S.A., 2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle (SV) protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general SV marker synaptophysin in 16 Brain Areas. We find that mover is particularly abundant in the septal nuclei (SNu), ventral pallidum (VPa), amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e., between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas

Raymond J Dolan - One of the best experts on this subject based on the ideXlab platform.

  • functional mapping of Brain Areas implicated in auditory verbal memory function
    Brain, 1993
    Co-Authors: P M Grasby, C D Frith, K J Friston, C J Bench, Richard S J Frackowiak, Raymond J Dolan
    Abstract:

    Position emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during two auditory—verbal memory tasks: a subspan and supraspan task. The difference in rCBF between tasks was used to identify Brain Areas/systems involved in auditory—verbal long-term memory. Increases in rCBF were observed in the left and right prefrontal cortex, precuneus and the retrosplenial area of the cingulate gyrus. Decreases in blood flow were centred in the superior temporal gyrus bilaterally. Separate comparisons were also made between each span task and a resting state. Brain regions showing increases in rCBF in these comparisons included the thalamus, left anterior cingulate, right parahippocampal gyrus, cerebellum and the superior temporal gyrus. The Brain Areas identified in these comparisons define a number of the neuroanatomical components of a distributed system for signal processing and storage relevant to auditory—verbal memory function.

  • Functional mapping of Brain Areas implicated in auditory—verbal memory function
    Brain, 1993
    Co-Authors: P M Grasby, C D Frith, K J Friston, C J Bench, Richard S J Frackowiak, Raymond J Dolan
    Abstract:

    Position emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during two auditory—verbal memory tasks: a subspan and supraspan task. The difference in rCBF between tasks was used to identify Brain Areas/systems involved in auditory—verbal long-term memory. Increases in rCBF were observed in the left and right prefrontal cortex, precuneus and the retrosplenial area of the cingulate gyrus. Decreases in blood flow were centred in the superior temporal gyrus bilaterally. Separate comparisons were also made between each span task and a resting state. Brain regions showing increases in rCBF in these comparisons included the thalamus, left anterior cingulate, right parahippocampal gyrus, cerebellum and the superior temporal gyrus. The Brain Areas identified in these comparisons define a number of the neuroanatomical components of a distributed system for signal processing and storage relevant to auditory—verbal memory function.

Rebecca Wallrafen - One of the best experts on this subject based on the ideXlab platform.

  • The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types
    Frontiers in neuroanatomy, 2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general synaptic vesicle marker synaptophysin in sixteen Brain Areas. We find that mover is particularly abundant in the septal nuclei, ventral pallidum, amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e. between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas.

  • Image_1_The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types.PDF
    2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle (SV) protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general SV marker synaptophysin in 16 Brain Areas. We find that mover is particularly abundant in the septal nuclei (SNu), ventral pallidum (VPa), amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e., between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas.

  • The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types
    Frontiers Media S.A., 2018
    Co-Authors: Rebecca Wallrafen, Thomas Dresbach
    Abstract:

    The assembly and function of presynaptic nerve terminals relies on evolutionarily conserved proteins. A small number of presynaptic proteins occurs only in vertebrates. These proteins may add specialized functions to certain synapses, thus increasing synaptic heterogeneity. Here, we show that the vertebrate-specific synaptic vesicle (SV) protein mover is differentially distributed in the foreBrain and cerebellum of the adult mouse. Using a quantitative immunofluorescence approach, we compare the expression of mover to the expression of the general SV marker synaptophysin in 16 Brain Areas. We find that mover is particularly abundant in the septal nuclei (SNu), ventral pallidum (VPa), amygdala and hippocampus. Within the hippocampus, mover is predominantly associated with excitatory synapses. Its levels are low in layers that receive afferent input from the entorhinal cortex, and high in layers harboring intra-hippocampal circuits. In contrast, mover levels are high in all nuclei of the amygdala, and mover is associated with inhibitory synapses in the medioposterior amygdala. Our data reveal a striking heterogeneity in the abundance of mover on three levels, i.e., between Brain Areas, within individual Brain Areas and between synapse types. This distribution suggests a role for mover in providing specialization to subsets of synapses, thereby contributing to the functional diversity of Brain Areas

P M Grasby - One of the best experts on this subject based on the ideXlab platform.

  • functional mapping of Brain Areas implicated in auditory verbal memory function
    Brain, 1993
    Co-Authors: P M Grasby, C D Frith, K J Friston, C J Bench, Richard S J Frackowiak, Raymond J Dolan
    Abstract:

    Position emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during two auditory—verbal memory tasks: a subspan and supraspan task. The difference in rCBF between tasks was used to identify Brain Areas/systems involved in auditory—verbal long-term memory. Increases in rCBF were observed in the left and right prefrontal cortex, precuneus and the retrosplenial area of the cingulate gyrus. Decreases in blood flow were centred in the superior temporal gyrus bilaterally. Separate comparisons were also made between each span task and a resting state. Brain regions showing increases in rCBF in these comparisons included the thalamus, left anterior cingulate, right parahippocampal gyrus, cerebellum and the superior temporal gyrus. The Brain Areas identified in these comparisons define a number of the neuroanatomical components of a distributed system for signal processing and storage relevant to auditory—verbal memory function.

  • Functional mapping of Brain Areas implicated in auditory—verbal memory function
    Brain, 1993
    Co-Authors: P M Grasby, C D Frith, K J Friston, C J Bench, Richard S J Frackowiak, Raymond J Dolan
    Abstract:

    Position emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during two auditory—verbal memory tasks: a subspan and supraspan task. The difference in rCBF between tasks was used to identify Brain Areas/systems involved in auditory—verbal long-term memory. Increases in rCBF were observed in the left and right prefrontal cortex, precuneus and the retrosplenial area of the cingulate gyrus. Decreases in blood flow were centred in the superior temporal gyrus bilaterally. Separate comparisons were also made between each span task and a resting state. Brain regions showing increases in rCBF in these comparisons included the thalamus, left anterior cingulate, right parahippocampal gyrus, cerebellum and the superior temporal gyrus. The Brain Areas identified in these comparisons define a number of the neuroanatomical components of a distributed system for signal processing and storage relevant to auditory—verbal memory function.

H. -j. Wagner - One of the best experts on this subject based on the ideXlab platform.