The Experts below are selected from a list of 6621 Experts worldwide ranked by ideXlab platform
Donald P Cain - One of the best experts on this subject based on the ideXlab platform.
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repeated mild lateral fluid percussion Brain injury in the rat causes cumulative long term behavioral impairments neuroinflammation and cortical loss in an animal model of repeated Concussion
Journal of Neurotrauma, 2012Co-Authors: Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald P CainAbstract:There is growing evidence that repeated Brain Concussion can result in cumulative and long-term behavioral symptoms, neuropathological changes, and neurodegeneration. Little is known about the factors and mechanisms that contribute to these effects. The current study addresses the need to investigate and better understand the effects of repeated Concussion through the development of an animal model. Male Long-Evans rats received 1, 3, or 5 mild lateral fluid percussion injuries or sham injuries spaced 5 days apart. After the final injury, rats received either a short (24 h) or long (8 weeks) post-injury recovery period, followed by a detailed behavioral analysis consisting of tests for rodent anxiety-like behavior, cognition, social behavior, sensorimotor function, and depression-like behavior. Brains were examined immunohistochemically to assess neuroinflammation and cortical damage. Rats given 1, 3, or 5 mild percussion injuries displayed significant short-term cognitive impairments. Rats given repeated mild percussion injuries displayed significantly worse short- and long-term cognitive impairments. Rats given 5 mild percussion injuries also displayed increased anxiety- and depression-like behaviors. Neuropathological analysis revealed short-term neuroinflammation in 3-injury rats, and both short- and long-term neuroinflammation in 5-injury rats. There was also evidence that repeated injuries induced short- and long-term cortical damage. These cumulative and long-term changes are consistent with findings in human patients suffering repeated Brain Concussion, provide support for the use of repeated mild lateral fluid percussion injuries to study repeated Concussion in the rat, and suggest that neuroinflammation may be important for understanding the cumulative and chronic effects of repeated Concussion.
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a single mild fluid percussion injury induces short term behavioral and neuropathological changes in the long evans rat support for an animal model of Concussion
Behavioural Brain Research, 2011Co-Authors: Sandy R Shultz, Derrick F Macfabe, Kelly A Foley, Roy Taylor, Donald P CainAbstract:Abstract Brain Concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant Brain damage. The current study addresses the need to better understand the effects of a mild lateral fluid percussion injury on rat behavior and neuropathology in an animal model of Concussion. Male Long–Evans rats received either a single mild fluid percussion injury or a sham-injury, and either a short (24 h) or long (4 weeks) post-injury recovery period. After recovery, rats underwent a detailed behavioral analysis consisting of tests for rodent anxiety, cognition, social behavior, sensorimotor function, and depression-like behavior. After testing all rats were sacrificed and Brains were examined immunohistochemically with markers for microglia/macrophage activation, reactive astrocytosis, and axonal injury. Injured rats (mean injury force: 1.20 ± .03 atm) displayed significant short-term cognitive impairments in the water maze and significantly more anxiolytic-like behavior in the elevated-plus maze compared to sham controls. Neuropathological analysis of the Brains of injured rats showed an acute increase in reactive astrogliosis and activated microglia in cortex and evidence of axonal injury in the corpus callosum. There were no significant long-term effects on any behavioral or neuropathological measure 4 weeks after injury. These short-term behavioral and neuropathological changes are consistent with findings in human patients suffering a Brain Concussion, and provide further evidence for the use of a single mild lateral fluid percussion injury to study Concussion in the rat.
Sandy R Shultz - One of the best experts on this subject based on the ideXlab platform.
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repeated mild lateral fluid percussion Brain injury in the rat causes cumulative long term behavioral impairments neuroinflammation and cortical loss in an animal model of repeated Concussion
Journal of Neurotrauma, 2012Co-Authors: Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald P CainAbstract:There is growing evidence that repeated Brain Concussion can result in cumulative and long-term behavioral symptoms, neuropathological changes, and neurodegeneration. Little is known about the factors and mechanisms that contribute to these effects. The current study addresses the need to investigate and better understand the effects of repeated Concussion through the development of an animal model. Male Long-Evans rats received 1, 3, or 5 mild lateral fluid percussion injuries or sham injuries spaced 5 days apart. After the final injury, rats received either a short (24 h) or long (8 weeks) post-injury recovery period, followed by a detailed behavioral analysis consisting of tests for rodent anxiety-like behavior, cognition, social behavior, sensorimotor function, and depression-like behavior. Brains were examined immunohistochemically to assess neuroinflammation and cortical damage. Rats given 1, 3, or 5 mild percussion injuries displayed significant short-term cognitive impairments. Rats given repeated mild percussion injuries displayed significantly worse short- and long-term cognitive impairments. Rats given 5 mild percussion injuries also displayed increased anxiety- and depression-like behaviors. Neuropathological analysis revealed short-term neuroinflammation in 3-injury rats, and both short- and long-term neuroinflammation in 5-injury rats. There was also evidence that repeated injuries induced short- and long-term cortical damage. These cumulative and long-term changes are consistent with findings in human patients suffering repeated Brain Concussion, provide support for the use of repeated mild lateral fluid percussion injuries to study repeated Concussion in the rat, and suggest that neuroinflammation may be important for understanding the cumulative and chronic effects of repeated Concussion.
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a single mild fluid percussion injury induces short term behavioral and neuropathological changes in the long evans rat support for an animal model of Concussion
Behavioural Brain Research, 2011Co-Authors: Sandy R Shultz, Derrick F Macfabe, Kelly A Foley, Roy Taylor, Donald P CainAbstract:Abstract Brain Concussion is a serious public health concern and is associated with short-term cognitive impairments and behavioral disturbances that typically occur in the absence of significant Brain damage. The current study addresses the need to better understand the effects of a mild lateral fluid percussion injury on rat behavior and neuropathology in an animal model of Concussion. Male Long–Evans rats received either a single mild fluid percussion injury or a sham-injury, and either a short (24 h) or long (4 weeks) post-injury recovery period. After recovery, rats underwent a detailed behavioral analysis consisting of tests for rodent anxiety, cognition, social behavior, sensorimotor function, and depression-like behavior. After testing all rats were sacrificed and Brains were examined immunohistochemically with markers for microglia/macrophage activation, reactive astrocytosis, and axonal injury. Injured rats (mean injury force: 1.20 ± .03 atm) displayed significant short-term cognitive impairments in the water maze and significantly more anxiolytic-like behavior in the elevated-plus maze compared to sham controls. Neuropathological analysis of the Brains of injured rats showed an acute increase in reactive astrogliosis and activated microglia in cortex and evidence of axonal injury in the corpus callosum. There were no significant long-term effects on any behavioral or neuropathological measure 4 weeks after injury. These short-term behavioral and neuropathological changes are consistent with findings in human patients suffering a Brain Concussion, and provide further evidence for the use of a single mild lateral fluid percussion injury to study Concussion in the rat.
Arthur Brown - One of the best experts on this subject based on the ideXlab platform.
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repeated mild lateral fluid percussion Brain injury in the rat causes cumulative long term behavioral impairments neuroinflammation and cortical loss in an animal model of repeated Concussion
Journal of Neurotrauma, 2012Co-Authors: Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald P CainAbstract:There is growing evidence that repeated Brain Concussion can result in cumulative and long-term behavioral symptoms, neuropathological changes, and neurodegeneration. Little is known about the factors and mechanisms that contribute to these effects. The current study addresses the need to investigate and better understand the effects of repeated Concussion through the development of an animal model. Male Long-Evans rats received 1, 3, or 5 mild lateral fluid percussion injuries or sham injuries spaced 5 days apart. After the final injury, rats received either a short (24 h) or long (8 weeks) post-injury recovery period, followed by a detailed behavioral analysis consisting of tests for rodent anxiety-like behavior, cognition, social behavior, sensorimotor function, and depression-like behavior. Brains were examined immunohistochemically to assess neuroinflammation and cortical damage. Rats given 1, 3, or 5 mild percussion injuries displayed significant short-term cognitive impairments. Rats given repeated mild percussion injuries displayed significantly worse short- and long-term cognitive impairments. Rats given 5 mild percussion injuries also displayed increased anxiety- and depression-like behaviors. Neuropathological analysis revealed short-term neuroinflammation in 3-injury rats, and both short- and long-term neuroinflammation in 5-injury rats. There was also evidence that repeated injuries induced short- and long-term cortical damage. These cumulative and long-term changes are consistent with findings in human patients suffering repeated Brain Concussion, provide support for the use of repeated mild lateral fluid percussion injuries to study repeated Concussion in the rat, and suggest that neuroinflammation may be important for understanding the cumulative and chronic effects of repeated Concussion.
Charlotte Chiu - One of the best experts on this subject based on the ideXlab platform.
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repeated mild lateral fluid percussion Brain injury in the rat causes cumulative long term behavioral impairments neuroinflammation and cortical loss in an animal model of repeated Concussion
Journal of Neurotrauma, 2012Co-Authors: Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald P CainAbstract:There is growing evidence that repeated Brain Concussion can result in cumulative and long-term behavioral symptoms, neuropathological changes, and neurodegeneration. Little is known about the factors and mechanisms that contribute to these effects. The current study addresses the need to investigate and better understand the effects of repeated Concussion through the development of an animal model. Male Long-Evans rats received 1, 3, or 5 mild lateral fluid percussion injuries or sham injuries spaced 5 days apart. After the final injury, rats received either a short (24 h) or long (8 weeks) post-injury recovery period, followed by a detailed behavioral analysis consisting of tests for rodent anxiety-like behavior, cognition, social behavior, sensorimotor function, and depression-like behavior. Brains were examined immunohistochemically to assess neuroinflammation and cortical damage. Rats given 1, 3, or 5 mild percussion injuries displayed significant short-term cognitive impairments. Rats given repeated mild percussion injuries displayed significantly worse short- and long-term cognitive impairments. Rats given 5 mild percussion injuries also displayed increased anxiety- and depression-like behaviors. Neuropathological analysis revealed short-term neuroinflammation in 3-injury rats, and both short- and long-term neuroinflammation in 5-injury rats. There was also evidence that repeated injuries induced short- and long-term cortical damage. These cumulative and long-term changes are consistent with findings in human patients suffering repeated Brain Concussion, provide support for the use of repeated mild lateral fluid percussion injuries to study repeated Concussion in the rat, and suggest that neuroinflammation may be important for understanding the cumulative and chronic effects of repeated Concussion.
Vanessa Omana - One of the best experts on this subject based on the ideXlab platform.
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repeated mild lateral fluid percussion Brain injury in the rat causes cumulative long term behavioral impairments neuroinflammation and cortical loss in an animal model of repeated Concussion
Journal of Neurotrauma, 2012Co-Authors: Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald P CainAbstract:There is growing evidence that repeated Brain Concussion can result in cumulative and long-term behavioral symptoms, neuropathological changes, and neurodegeneration. Little is known about the factors and mechanisms that contribute to these effects. The current study addresses the need to investigate and better understand the effects of repeated Concussion through the development of an animal model. Male Long-Evans rats received 1, 3, or 5 mild lateral fluid percussion injuries or sham injuries spaced 5 days apart. After the final injury, rats received either a short (24 h) or long (8 weeks) post-injury recovery period, followed by a detailed behavioral analysis consisting of tests for rodent anxiety-like behavior, cognition, social behavior, sensorimotor function, and depression-like behavior. Brains were examined immunohistochemically to assess neuroinflammation and cortical damage. Rats given 1, 3, or 5 mild percussion injuries displayed significant short-term cognitive impairments. Rats given repeated mild percussion injuries displayed significantly worse short- and long-term cognitive impairments. Rats given 5 mild percussion injuries also displayed increased anxiety- and depression-like behaviors. Neuropathological analysis revealed short-term neuroinflammation in 3-injury rats, and both short- and long-term neuroinflammation in 5-injury rats. There was also evidence that repeated injuries induced short- and long-term cortical damage. These cumulative and long-term changes are consistent with findings in human patients suffering repeated Brain Concussion, provide support for the use of repeated mild lateral fluid percussion injuries to study repeated Concussion in the rat, and suggest that neuroinflammation may be important for understanding the cumulative and chronic effects of repeated Concussion.