Brain Cortex

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

A S Verkman - One of the best experts on this subject based on the ideXlab platform.

Prashant Padmawar - One of the best experts on this subject based on the ideXlab platform.

Liu Xing-bo - One of the best experts on this subject based on the ideXlab platform.

  • Studies of the Therapy of Melatonin on Rat Brain Cortex Oxidated Trauma after Following Traumatic Brain Injury
    Journal of Jinzhou Medical College, 2020
    Co-Authors: Liu Xing-bo
    Abstract:

    Objective To study the therapy of melatonin on rat Brain Cortex oxidated trauma after following traumatic Brain injury and the relation of quantity and effect. Methods Seventy-two Sprague-Dawley rats were put into experiment and divided into six groups of 12 rats each.Traumatic Brain injury has been developed through Feeney's method.MT and VC was given intraperitoneal(i.p.) after being injuried 5 minutes and determined the activities of GSH-Px and CAT and the content of MDA in rat Brain Cortex after 2 hours following TBI.The ultrastructure in Brain Cortex was also been examined. Results The activeties of of GSH-Px and CAT reduced in rat Brain Cortex following traumatic Brain injury,but content of MDA rose.MT early treatment can partly reverse thses changes,and the more much MT was used,the more obviously effect on reducing the Brain edema can be observed. Conclusions Melatonin was found to resist Brain Cortex oxidated trauma and be neuroprotective in instances of traumatic Brain injury,its probable mechanism is related to protect the activities of GSH-Px and CAT.Thus,melatonin may be a valuable therapeutic agent in the treatment of TBI.

  • Studies of Protective Effect of Melatonin on Rat Brain Cortex Following Traumatic Brain Injury
    Journal of Jinzhou Medical College, 2020
    Co-Authors: Liu Xing-bo
    Abstract:

    Objective To observe the protective effect of melatonin on the rat Cortex following traumatic Brain injury. Methods Ninety Sprague-Dawley rats were put into experiment and divided into five groups of 18 rats each.Traumatic Braininjury has been developed through Feeney's method.MT was given intraperitoneal(i.p.) before being injuried 30 minutes and mensurated the activities of GPx and SOD and the content of MDA in rat Brain Cortex after 60 minitues following TBI.The ultrastructure in Brain Cortex was also been examined. Results The activities of GPx and SOD reduced in rat Brain Cortex following traumatic Brain injury, but content of MDA rose.MT pretreatment can partly reverse these changes and reduced the Brain edema.The effect of melatonin was also confirmed histopathologically. Conclusions Melatonin was found to be neuroprotective in instances of traumatic Brain injury, its probable mechanism is related to protect the activities of GPx and SOD.Thus, melatonin may be a valuable therapeutic agent in the treatment of TBI.

Geoffrey T Manley - One of the best experts on this subject based on the ideXlab platform.

Orin Bloch - One of the best experts on this subject based on the ideXlab platform.