The Experts below are selected from a list of 5265 Experts worldwide ranked by ideXlab platform
Sahika Inal - One of the best experts on this subject based on the ideXlab platform.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
Christopher M Proctor - One of the best experts on this subject based on the ideXlab platform.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
Joachim Kohn - One of the best experts on this subject based on the ideXlab platform.
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Bioactive agarose carbon-nanotube composites are capable of manipulating Brain-Implant interface
2020Co-Authors: Dan Y Lewitus, Karen L Smith, John Landers, Alexander V Neimark, Joachim KohnAbstract:ABSTRACT: Composite electrodes made of the polysaccharide agarose and carbon nanotubes (A-CNE) have shown potential to be applied as tissue-compatible, micro-electronic devices. In this article, A-CNEs were functionalized using neuro-relevant proteins (laminin and alpha-melanocyte stimulating hormone) and Implanted in Brain tissue for 1 week (acute response) and 4 weeks (chronic response). Qualitative and quantitative analysis of neuronal and immunological responses revealed significant changes in immunological response to Implanted materials depending on the type of biomolecule used. The potential to manipulate tissue response through the use of an anti-inflammatory protein, alpha-melanocyte stimulating hormone, was shown in the reduction of astroglia presence near the Implant site during the glial scar formation. These results suggest that A-CNEs, which are soft, flexible, and easily made bioactive, have the ability to modify Brain tissue response through surface modification as a function of the biomolecule used
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bioactive agarose carbon nanotube composites are capable of manipulating Brain Implant interface
Journal of Applied Polymer Science, 2014Co-Authors: Dan Y Lewitus, Karen L Smith, John Landers, Alexander V Neimark, Joachim KohnAbstract:Composite electrodes made of the polysaccharide agarose and carbon nanotubes (A-CNE) have shown potential to be applied as tissue-compatible, micro-electronic devices. In this article, A-CNEs were functionalized using neuro-relevant proteins (lam- inin and alpha-melanocyte stimulating hormone) and Implanted in Brain tissue for 1 week (acute response) and 4 weeks (chronic response). Qualitative and quantitative analysis of neuronal and immunological responses revealed significant changes in immunologi- cal response to Implanted materials depending on the type of biomolecule used. The potential to manipulate tissue response through the use of an anti-inflammatory protein, alpha-melanocyte stimulating hormone, was shown in the reduction of astroglia presence near the Implant site during the glial scar formation. These results suggest that A-CNEs, which are soft, flexible, and easily made bio- active, have the ability to modify Brain tissue response through surface modification as a function of the biomolecule used. V C 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40297.
Andrea Slezia - One of the best experts on this subject based on the ideXlab platform.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
Ilke Uguz - One of the best experts on this subject based on the ideXlab platform.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.
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an electrocorticography device with an integrated microfluidic ion pump for simultaneous neural recording and electrophoretic drug delivery in vivo
Advanced biosystems, 2019Co-Authors: Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Sahika Inal, Andrea SleziaAbstract:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The challenge of treating neurological disorders has motivated the development of Implantable devices that can deliver treatment when and where it is needed. This study presents a novel Brain Implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the Brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a significant step forward for cortical drug-delivery systems.