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Breast Cell Line

The Experts below are selected from a list of 6009 Experts worldwide ranked by ideXlab platform

Sami G Abdelhamide – 1st expert on this subject based on the ideXlab platform

  • design synthesis and biological evaluation of novel quinazoLine derivatives as potential antitumor agents molecular docking study
    European Journal of Medicinal Chemistry, 2010
    Co-Authors: Adel S Elazab, Mohamed A Alomar, Alaa A M Abdelaziz, Naglaa I Abdelaziz, Magda A A Elsayed, Abdulaziz M Aleisa, Mohamed M Sayedahmed, Sami G Abdelhamide

    Abstract:

    Abstract Novel derivatives of quinazoLine (1–27) have been synthesized and tested for their antitumor activity against three tumor Cell Lines among these Cell Lines the human Breast carcinoma Cell Line (MCF-7) in which EGFR is highly expressed. All tested compounds showed potent and selective activity against Breast cancer (MCF-7) with IC50 range of 3.35–6.81 μg/ml. With regarding broad-spectrum activity compounds 5, 9, 15, 18 and 20 exploited potent antitumor against human liver Cell Line (HEPG2), human Breast Cell Line (MCF-7) and human cervix Cell Line (HELA) with IC50 range of 3.35–5.59 μg/ml. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors.

Céline Galés – 2nd expert on this subject based on the ideXlab platform

  • Dosage-dependent regulation of Cell proliferation and adhesion through dual β2-adrenergic receptor/cAMP signals.
    FASEB Journal, 2014
    Co-Authors: Ariana Bruzzone, Aude Saulière, Frédéric Finana, Jean-michel Sénard, Isabel Lüthy, Céline Galés

    Abstract:

    The role of β-adrenergic receptors (β-ARs) remains controversial in normal and tumor Breast. Herein we explore the cAMP signaling involved in β-AR-dependent control of proliferation and adhesion of nontumor human Breast Cell Line MCF-10A. Low concentrations of a β-agonist, isoproterenol (ISO), promote Cell adhesion (87.5% Cells remaining adherent to the plastic dishes following specific detachment vs. 35.0% in control, P

Edward J. Delikatny – 3rd expert on this subject based on the ideXlab platform

  • Induction of magnetic resonance-visible lipid in a transformed human Breast Cell Line by tetraphenylphosphonium chloride.
    International Journal of Cancer, 1997
    Co-Authors: Sandrine K. Roman, Rebecca L. Hancock, Thomas M. Jeitner, Darryl C. Rideout, Wendy A. Cooper, Edward J. Delikatny

    Abstract:

    Proton magnetic resonance spectroscopy (1H MRS) and DNA flow cytometry were used to monitor the effects of the cationic lipophilic phosphonium salt and potential antineoplastic agent tetraphenylphosphonium chloride (TPP) on the transformed human Breast Cell Line HBL-100. TPP treatment for 48 hr was cytostatic at low concentrations and cytotoxic at higher concentrations with an IC50 of 55 μM as measured by Trypan blue exclusion. At micromolar concentrations, TPP caused a significant increase in the methylene MR signal arising from mobile lipid as measured by the ratio of the lipid CH2 peak height to either the CH3 peak height (internal referencing) or the peak height for p-aminobenzoic acid (PABA) as an external reference in a co-axial capillary within the sample. Over the same concentration range, TPP caused a slowing of passage through S phase as demonstrated by a significant depletion of Cells in G2/M phase with a concurrent but non-significant increase in Cells in S. Time-dependent increases in MR-visible lipid were observed with 2 μM TPP treatment, and the removal of TPP from the culture medium caused no significant reduction in mobile lipid. Two-dimensional 1H|Cv1H COSY spectra of TPP-treated HBL-100 Cells revealed concentration-dependent increases in cross-peak volume ratios arising from lipid acyl chains relative to both internal (lysine, polyamines) and external (PABA) standards. Increases in choLine and glycerophosphochoLine cross-peak volume ratios were observed, indicating that the catabolism or rearrangement of phospholipids may be responsible for the observed MR-visible lipid increases. Int. J. Cancer 73:570–579, 1997. © 1997 Wiley-Liss, Inc.

  • Tetraphenylphosphonium chloride induced mr-visible lipid accumulation in a malignant human Breast Cell Line
    International Journal of Cancer, 1996
    Co-Authors: Edward J. Delikatny, Sandrine K. Roman, Rebecca L. Hancock, Thomas M. Jeitner, Catherine M. Lander, Darryl C. Rideout, Carolyn E. Mountford

    Abstract:

    The effect of the cationic lipophilic phosphonium salt tetraphenylphosphonium chloride (TPP) on a human malignant Breast Cell Line, DU4475, was monitored with proton nuclear magnetic resonance ( 1 H MRS). TPP caused a dose- and time-dependent increase in resonances arising from MR-visible lipid as measured by the CH 2 /CH 3 ratio in the 1-dimensional 1 H MR spectrum. Two-dimensional MRS identified increases in the glycerophosphochoLine/lysine cross-peak ratio and corresponding decreases in the phosphochoLine/lysine ratio in a dose-dependent fashion in TPP-treated Cells. Lipid metabolic changes are discussed in the light of other MR experiments, and the data indicate that accumulation of MR-visible lipids may arise from the rearrangement of phospholipids accompanying mitochondrial destruction or from the catabolism of phospholipids associated with early events in the cytotoxic process.