The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform

Kathleen T Anderson - One of the best experts on this subject based on the ideXlab platform.

  • Breath Alcohol Analyzer mistakes methanol poisoning for Alcohol intoxication
    Annals of Emergency Medicine, 2010
    Co-Authors: Martin E Caravati, Kathleen T Anderson
    Abstract:

    Breath Alcohol Analyzers are used to detect ethanol in motorists and others suspected of public intoxication. One concern is their ability to detect interfering substances that may falsely increase the ethanol reading. A 47-year-old-man was found in a public park, acting intoxicated. A Breath Analyzer test (Intoxilyzer 5000EN) measured 0.288 g/210 L Breath ethanol, without an interferent noted. In the emergency department, the patient admitted to drinking HEET Gas-Line antifreeze, which contains 99% methanol. Two to three hours after ingestion, serum and urine toxicology screen results were negative for ethanol and multiple other substances. His serum methanol concentration was 589 mg/dL, serum osmolality 503 mOsm/kg, osmolar gap 193 mOsm/kg, and anion gap 17 mmol/L. The patient was treated with intravenous ethanol, fomepizole, and hemodialysis without complication. This is a unique clinical case of a Breath Alcohol Analyzer reporting methanol as ethanol. Intoxilyzer devices have been shown to indicate some substances (acetone) as interferents in humans but not methanol. Increased serum concentrations of methanol can be reported as ethanol by a commonly used Breath Alcohol Analyzer, which can result in a delayed diagnosis or misdiagnosis and subsequent methanol toxicity if antidotal treatment is not administered in a timely manner.

Martin E Caravati - One of the best experts on this subject based on the ideXlab platform.

  • Breath Alcohol Analyzer mistakes methanol poisoning for Alcohol intoxication
    Annals of Emergency Medicine, 2010
    Co-Authors: Martin E Caravati, Kathleen T Anderson
    Abstract:

    Breath Alcohol Analyzers are used to detect ethanol in motorists and others suspected of public intoxication. One concern is their ability to detect interfering substances that may falsely increase the ethanol reading. A 47-year-old-man was found in a public park, acting intoxicated. A Breath Analyzer test (Intoxilyzer 5000EN) measured 0.288 g/210 L Breath ethanol, without an interferent noted. In the emergency department, the patient admitted to drinking HEET Gas-Line antifreeze, which contains 99% methanol. Two to three hours after ingestion, serum and urine toxicology screen results were negative for ethanol and multiple other substances. His serum methanol concentration was 589 mg/dL, serum osmolality 503 mOsm/kg, osmolar gap 193 mOsm/kg, and anion gap 17 mmol/L. The patient was treated with intravenous ethanol, fomepizole, and hemodialysis without complication. This is a unique clinical case of a Breath Alcohol Analyzer reporting methanol as ethanol. Intoxilyzer devices have been shown to indicate some substances (acetone) as interferents in humans but not methanol. Increased serum concentrations of methanol can be reported as ethanol by a commonly used Breath Alcohol Analyzer, which can result in a delayed diagnosis or misdiagnosis and subsequent methanol toxicity if antidotal treatment is not administered in a timely manner.

Lindberg Lars - One of the best experts on this subject based on the ideXlab platform.

  • Breath Alcohol analysis incorporating standardization to water vapour is as precise as blood Alcohol analysis.
    'Elsevier BV', 2012
    Co-Authors: Grubb David, Rasmussen B, Linnet K, Olsson S G, Lindberg Lars
    Abstract:

    A novel Breath-Alcohol Analyzer based on the standardization of the Breath Alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular Breath Analyzer with arterial blood Alcohol concentrations (ABAC), the most relevant quantitative measure of brain Alcohol exposure. The precision of analysis of Alcohol in arterial blood and Breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6gAlcohol/kg bodyweight via an orogastric tube. Duplicate Breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the Alcohol metabolism with particular emphasis on the absorption phase. The precision of the Breath Analyzer was similar to the determination of blood Alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=0.43). The ABAC/BrAC ratio stabilized 30min post-dosing (2089±99; mean±SD). Before this the BrAC tended to underestimate the coexisting ABAC. In conclusion, Breath Alcohol analysis utilizing standardization of Alcohol to water vapour was as precise as blood Alcohol analysis, the present "gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30min onwards after the intake of Alcohol

Grubb David - One of the best experts on this subject based on the ideXlab platform.

  • Breath Alcohol analysis incorporating standardization to water vapour is as precise as blood Alcohol analysis.
    'Elsevier BV', 2012
    Co-Authors: Grubb David, Rasmussen B, Linnet K, Olsson S G, Lindberg Lars
    Abstract:

    A novel Breath-Alcohol Analyzer based on the standardization of the Breath Alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular Breath Analyzer with arterial blood Alcohol concentrations (ABAC), the most relevant quantitative measure of brain Alcohol exposure. The precision of analysis of Alcohol in arterial blood and Breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6gAlcohol/kg bodyweight via an orogastric tube. Duplicate Breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the Alcohol metabolism with particular emphasis on the absorption phase. The precision of the Breath Analyzer was similar to the determination of blood Alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=0.43). The ABAC/BrAC ratio stabilized 30min post-dosing (2089±99; mean±SD). Before this the BrAC tended to underestimate the coexisting ABAC. In conclusion, Breath Alcohol analysis utilizing standardization of Alcohol to water vapour was as precise as blood Alcohol analysis, the present "gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30min onwards after the intake of Alcohol

Olsson S G - One of the best experts on this subject based on the ideXlab platform.

  • Breath Alcohol analysis incorporating standardization to water vapour is as precise as blood Alcohol analysis.
    'Elsevier BV', 2012
    Co-Authors: Grubb David, Rasmussen B, Linnet K, Olsson S G, Lindberg Lars
    Abstract:

    A novel Breath-Alcohol Analyzer based on the standardization of the Breath Alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular Breath Analyzer with arterial blood Alcohol concentrations (ABAC), the most relevant quantitative measure of brain Alcohol exposure. The precision of analysis of Alcohol in arterial blood and Breath were determined as well as the agreement between ABAC and BrAC over time post-dosing. Twelve healthy volunteers were administered 0.6gAlcohol/kg bodyweight via an orogastric tube. Duplicate Breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the Alcohol metabolism with particular emphasis on the absorption phase. The precision of the Breath Analyzer was similar to the determination of blood Alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=0.43). The ABAC/BrAC ratio stabilized 30min post-dosing (2089±99; mean±SD). Before this the BrAC tended to underestimate the coexisting ABAC. In conclusion, Breath Alcohol analysis utilizing standardization of Alcohol to water vapour was as precise as blood Alcohol analysis, the present "gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30min onwards after the intake of Alcohol