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Carlos E Rodriguezmartinez - One of the best experts on this subject based on the ideXlab platform.
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validation of a spanish version of the sleep related Breathing Disorder scale of the pediatric sleep questionnaire in children living in a high altitude city
Pediatric Pulmonology, 2020Co-Authors: Maria Camila Villalobosaguirre, Sonia M Restrepogualteros, Alberto Penavalenzuela, Monica P Sossabriceno, Carlos E RodriguezmartinezAbstract:OBJECTIVES We aimed to validate a Spanish version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ) in children living in a high-altitude Colombian city. METHODS In a prospective cohort validation study, patients aged between 2 and 17 years who attended the Ear, Nose, and Throat pediatric department of our institution for symptoms related to sleep-related Breathing Disorders had a baseline visit at enrollment, a second visit the day scheduled for the surgical intervention, and a follow-up visit at least 3 months after the surgical intervention. In these three visits, we gathered the necessary data for assessing the criterion validity, construct validity, test-retest reliability, internal consistency, and sensitivity to change of the Spanish version of the SRBD-PSQ. RESULTS In total, 121 patients were included in the analyses. The exploratory factor analysis (generalized least squares method, varimax rotation) yielded a four-factor structure, explaining 65.93% of the cumulative variance. The intraclass correlation coefficient (ICC) of the measurements was 0.887 (95% CI: 0.809-0.934), and the Lin concordance correlation coefficient was 0.882 (95% CI, 0.821-0.943). SRBD-PSQ scores at baseline were significantly higher than those obtained after adenotonsillectomy surgery (median [IQR] 11.0 [9.0- 14.0] vs. 4.00 [1.50-7.0]; p < 0.0001). Cronbach's α was 0.7055 for the questionnaire as a whole. CONCLUSIONS The Spanish version of the SRBD-PSQ has acceptable construct validity, excellent test-retest reliability and sensitivity to change, and adequate internal consistency-reliability when used in pediatric patients living at high altitude with symptoms related to sleep-related Breathing Disorders.
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validation of a spanish version of the sleep related Breathing Disorder scale of the pediatric sleep questionnaire in children living in a high altitude city
Authorea Preprints, 2020Co-Authors: Maria Camila Villalobosaguirre, Sonia M Restrepogualteros, Alberto Penavalenzuela, Monica P Sossabriceno, Carlos E RodriguezmartinezAbstract:Objectives. We aimed to validate a Spanish version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ) in children living in a high-altitude Colombian city. Methods. In a prospective cohort validation study, patients aged between 2 and 18 years who attended the Ear, Nose, and Throat pediatric department of our institution for symptoms related to sleep-related Breathing Disorders had a baseline visit at enrollment, a second visit the day scheduled for the surgical intervention, and a follow-up visit at least three months after the surgical intervention. In these three visits, we gathered the necessary data for assessing the criterion validity, construct validity, test–retest reliability, internal consistency, and sensitivity to change of the Spanish version of the SRBD-PSQ. Results. In total, 121 patients were included in the analyses. The exploratory factor analysis (generalized least squares method, varimax rotation) yielded a four-factor structure, explaining 65.93% of the cumulative variance. The intraclass correlation coefficient (ICC) of the measurements was 0.887 (95% CI: 0.809–0.934), and the Lin concordance correlation coefficient was 0.882 (95% CI, 0.821-0.943). SRBD-PSQ scores at baseline were significantly higher than those obtained after adeno-tonsillectomy surgery (median [IQR] 11.0 [9.0- 14.0] vs. 4.00 [1.50- 7.0]; p<0.0001). Cronbach’s α was 0.7055 for the questionnaire as a whole. Conclusions. The Spanish version of the SRBD-PSQ has acceptable construct validity, excellent test-retest reliability and sensitivity to change, and adequate internal consistency-reliability when used in pediatric patients living at high altitude with symptoms related to sleep-related Breathing Disorders.
Alberto Staffieri - One of the best experts on this subject based on the ideXlab platform.
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sleep related adductor laryngeal dystonia causing sleep apnea a sleep related Breathing Disorder diagnosed with sleep endoscopy and treated with botulinum toxin
Laryngoscope, 2013Co-Authors: Rosario Marcheseragona, Andrea Vianello, Domenico A Restivo, Giovanni Pittoni, Marco Lionello, Alessandro Martini, Daniele Manfredini, Bhik Kotecha, Alberto StaffieriAbstract:Objectives/Hypothesis Obstructive sleep apnea syndrome (OSAS) is a chronic condition, characterized by recurrent episodes of upper airway collapse during sleep, which affects up to 5% of adults in the Western population. The muscle tone of the human body ordinarily relaxes during sleep, thus causing airway obstruction and leading to sleep apnea. We report a case of a 68-years old male in which dystonic closure of the larynx during sleep caused OSAS. The sleep endoscopy was crucial in establishing the diagnosis of laryngeal dystonia. A botulinum toxin injection in the vocal cord improved the OSAS. These findings define a novel sleep-related Breathing Disorder.
J R Stradling - One of the best experts on this subject based on the ideXlab platform.
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effect of cpap therapy on endothelial function in obstructive sleep apnoea a systematic review and meta analysis
Respirology, 2015Co-Authors: Esther I Schwarz, J R Stradling, Milo A Puhan, Christian Schlatzer, Malcolm KohlerAbstract:Obstructive sleep apnoea (OSA) is a prevalent sleep-related Breathing Disorder associated with adverse cardiovascular outcome. Endothelial dysfunction is one of the proposed mechanistic links between OSA and the increased cardiovascular risk. Treatment with continuous positive airway pressure (CPAP) may reverse this detrimental pathophysiological consequence of OSA. Most studies on the effect of CPAP on endothelial function in OSA are limited by their low sample size. The objective of this systematic review was to assess the effect CPAP therapy on endothelial function in patients with OSA. We conducted a systematic review and meta-analysis searching literature databases up to August 2013 for randomized controlled trials (RCTs) on the effect of CPAP on endothelial function in OSA, assessed by flow-mediated dilatation (FMD) and other validated techniques. The primary outcome for the meta-analysis (DerSimonian/Laird random-effects method) was the treatment effect on FMD. Eight RCTs comparing the effects of therapeutic CPAP versus subtherapeutic CPAP (or no intervention) on endothelial function involving 245 OSA patients were included in the systematic review. The studies are consistent in effect direction, showing an improvement of endothelial function by CPAP. Four RCTs involving 150 patients could be used for the meta-analysis. Compared to the control group, CPAP therapy (range 2-24 weeks) significantly increased absolute % FMD by 3.87% (95% confidence interval: 1.93-5.80, P < 0.001). In patients with OSA, CPAP therapy improves endothelial function significantly and to a clinically important extent.
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sleep Disordered Breathing effects of adenotonsillectomy on behaviour and psychological functioning
European Journal of Pediatrics, 1996Co-Authors: N J Ali, D J Pitson, J R StradlingAbstract:Children on the adenotonsillectomy waiting list aged 6 years or more were screened by questionnaire and overnight sleep monitoring to identify 12 with a moderate sleep and Breathing Disorder (SBD) group. They were matched by age and sex with 11 children who had a similar history of snoring and sleep disturbance but without an obvious sleep and Breathing problem when monitored (snorer group) and also with a group of ten children most of whom were refered for an unrelated surgical procedure (control group). All children were studied before and 3–6 months after surgery. Pre-operatively the SBD and snorer groups both had significantly more restless sleep than the control group. The SBD group also had significantly more (>4%) dips in oxygen saturation than the other two groups. After surgery there were no longer any significant differences between the three groups. After adenotonsillectomy the SBD group showed a significant reduction in aggression, inattention and hyperactivity on the parent Conners scale, and an improvement in vigilance on the Continuous Performance Test. The snorer group also improved showing less hyperactive behaviour than pre-operatively and better vigilance. The control groups's behaviour and performance did not change significantly. There were no significant changes in the performance of the Matching Familiar Figures Test in any of the groups.
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snoring sleep disturbance and behaviour in 4 5 year olds
Archives of Disease in Childhood, 1993Co-Authors: N J Ali, D J Pitson, J R StradlingAbstract:Parents of 996 children aged 4-5 years identified consecutively from the Oxford health visitor register were asked to complete a questionnaire about Breathing Disorders during sleep. A total of 782 (78.5%) was returned. Ninety five (12.1%) children were reported to snore on most nights. Habitual snoring was significantly associated with daytime sleepiness, restless sleep, and hyperactivity. The questionnaire responses were used to select two subgroups, one at high risk of a sleep and Breathing Disorder and a control group. These children (132 in total) were monitored at home with overnight video recording and oximetry, and had formal behavioural assessment using the Conners scale. Seven (7/66) children from the high risk group and none from the control group had obvious sleep disturbance consequent on snoring and upper airway obstruction. Thus our estimate of the prevalence of sleep and Breathing Disorders in this age group is 7/996 or 0.7%. The high risk group had significantly higher nocturnal movement, oxygen saturation dip rates, and overnight pulse rates than the controls. Maternal but not paternal smoking was associated with the high risk group. Parents and teachers thought those in the high risk group were more hyperactive and inattentive than the controls, but only their parents thought them more aggressive. Significant sleep and Breathing Disorders occur in about 0.7% of 4-5 year olds. Children whose parents report snoring and sleep disturbance have objective evidence of sleep disruption and show more behaviour problems than controls.
Anawin Sanguankeo - One of the best experts on this subject based on the ideXlab platform.
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severity of Breathing Disorder during sleep is not correlated with idiopathic pulmonary fibrosis a systematic review and meta analysis
QJM: An International Journal of Medicine, 2016Co-Authors: Sikarin Upala, Anawin SanguankeoAbstract:Dear Editor, We read an article written by Lee et al .1 with interest. The authors found that gas exchange and oxygenation during sleep in patients with idiopathic pulmonary fibrosis (IPF) is worse than during exercise. The authors also mentioned that the findings from their study were consistent with other reports that IPF may associate with sleep Disorder. However, there is still controversy regarding association between sleep-Disordered Breathing (SDB) and IPF. We completed a systematic review and meta-analysis of …
J H Peter - One of the best experts on this subject based on the ideXlab platform.
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the heart rate response to exercise is blunted in patients with sleep related Breathing Disorder
The Cardiology, 2004Co-Authors: Ludger Grote, Jan Hedner, J H PeterAbstract:Background: This study addressed the hypothesis that cardiovascular reactivity during graded bicycle exercise is influenced by a coexisting sleep-related Breathing Disorder (SRBD).
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mean blood pressure pulse pressure and grade of hypertension in untreated hypertensive patients with sleep related Breathing Disorder
Journal of Hypertension, 2001Co-Authors: Ludger Grote, Jan Hedner, J H PeterAbstract:Objective To test the hypothesis that sleep-related Breathing Disorder (SRBD) is associated with increasing severity of cardiovascular risk markers. Design A cross-sectional study of sleep laboratory patients. Setting University Hospital Sleep Disorders Centre. Patients We studied 591 patients referred for a sleep study, all of them without a history of systemic hypertension. Interventions Clinical interview, two unattended sleep studies, and assessment of office blood pressure, cholesterol concentration, alcohol and nicotine consumption and daytime blood gases. Main outcome measure Post-hoc analysis of different cardiovascular risk markers: mean blood pressure, pulse pressure, and the type and grade of systemic hypertension. Results Patients were classified as normotensive (blood pressure < 140/90 mmHg, n = 228) or hypertensive (blood pressure ≥ 140/90 mmHg, n = 363) according to office blood pressure measurements. Mixed (systolic and diastolic) hypertension was the most common type of hypertension (n = 182), followed by isolated diastolic hypertension (n = 101), borderline isolated systolic hypertension (n = 70), and isolated systolic hypertension (n = 10). The frequency of mixed hypertension increased with SRBD activity (P< 0.05) and respiratory disturbance index (RDI; the number of Breathing Disorders per hour of estimated sleep time) was increased in those with mixed hypertension compared with those with normotension (24.8 compared with 15.7; t test: P< 0.01). In hypertensive patients classified as having grades 1 -3 of hypertension (n = 265, 80 and 18, respectively), there was a progressive increase in RDI (18.9, 27.2 and 30.3, respectively, P < 0.01). Mean blood pressure increased significantly with RDI. Pulse pressure increased significantly with age (P < 0.001), but was unrelated to the degree of SRBD. Conclusion We conclude that mean blood pressure and the severity of hypertension, but not pulse pressure, increase with the severity of the SRBD.
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sleep related Breathing Disorder is an independent risk factor for uncontrolled hypertension
Journal of Hypertension, 2000Co-Authors: Ludger Grote, Jan Hedner, J H PeterAbstract:OBJECTIVE To test the hypothesis that sleep-related Breathing Disorder (SRBD) is associated with poor blood pressure control in hypertensive patients independent from confounding factors such as age, body mass index, alcohol, smoking and daytime blood gases. DESIGN AND METHODS This cross-sectional study of a sleep laboratory cohort was carried out at the University Hospital Sleep Disorders Centre, Marburg. The study comprised 599 patients referred for a sleep study, all of them with a documented history of systemic hypertension and/or previously initiated antihypertensive therapy. Data were obtained from a clinical interview, two unattended sleep studies and assessment of clinic blood pressure, cholesterol level, alcohol and nicotine consumption and daytime blood gases. The main outcome measure was a post hoc analysis of predictors for poor blood pressure control. RESULTS Respiratory disturbance index (RDI) was significantly higher in patients with uncontrolled hypertension (blood pressure > or = 160 and/or 95 mmHg, n = 463) than in those with controlled hypertension (n = 136) (34.0 +/- 26.8 versus 27.0 +/- 23.5, P < 0.01). The relative proportion of patients with uncontrolled hypertension increased significantly as SRBD activity increased (chi2, P< 0.05). Body mass index was the only independent predictor (P = 0.006) of uncontrolled hypertension in the whole study sample. However, in the subset of patients aged < or = 50 years, RDI (P= 0.006) and age (P = 0.016) were the only independent predictors. The probability of uncontrolled hypertension increased by approximately 2% (B = 0.019, P= 0.006) for each RDI unit. CONCLUSION SRBD should be considered, in addition to traditional confounders, as a risk factor for poor blood pressure control in younger hypertensive patients (< or = 50 years of age).
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sleep related Breathing Disorder is an independent risk factor for systemic hypertension
American Journal of Respiratory and Critical Care Medicine, 1999Co-Authors: Ludger Grote, Thomas Penzel, T Ploch, J Heitmann, Lennart Knaack, J H PeterAbstract:The exact influence of sleep-related Breathing Disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The protocol includes clinical interview, physical examination, office blood pressure measurement, cholesterol, and blood gas analysis. Unattended home monitoring of nocturnal Breathing was performed for assessment of SRBD activity (respiratory disturbance index [RDI]). RDI was independently and linearly associated with systolic blood pressure (unstandardized coefficient [B] 5 0.07 6 0.03, p 5 0.03), diastolic blood pressure (B 5 0.07 6 0.02, p 5 0 , 0.001), and heart rate (B 5 0.10 6 0.02, p , 0.001) at rest. The relative risk for hypertension (blood pressure > 160/95 mm Hg) increased with SRBD severity (odds ratio [OR], 4.15 for RDI > 40 versus , 5 [95% CI, 2.7 to 6.5]). This relative risk was also elevated in younger ( 40 versus , 5). These cross-sectional clinical data suggest a relationship between SRBD severity and systolic blood pressure, diastolic blood pressure, and heart rate after control for confounders such as body mass index (BMI), age, alcohol/nicotine consumption, cholesterol level, and daytime P O2 and P CO2 . SRBD is an independent risk factor for systemic hypertension with an increased likelihood in subjects < 50 yr of age. Grote L, Ploch T, Heitmann J, Knaack L, Penzel T, Peter JH. Sleep-related Breathing Disorder is an independent risk factor for systemic hypertension. AM J RESPIR CRIT CARE MED 1999;160:1875‐1882.