The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Andrei I. Holodny - One of the best experts on this subject based on the ideXlab platform.
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functional translocation of Broca s Area in a low grade left frontal glioma graph theory reveals the novel adaptive network connectivity
Frontiers in Neurology, 2019Co-Authors: Viviane Tabar, Kyung K. Peck, Jian W Dong, Gino Del Ferraro, Nicole Petrovich Brennan, Hernan A Makse, Andrei I. HolodnyAbstract:We describe frontal language reorganization in a 50-60 year-old right-handed patient with a low-grade left frontotemporal insular glioma. Pre-operative fMRI revealed robust activation in the left superior temporal gyrus (Wernicke Area, WA) and in the right inferior frontal gyrus (right anatomical homologue of Broca Area, BA). Intra-operative cortical stimulation of the left inferior frontal gyrus and adjacent cortices elicited no speech deficits, and gross total resection including the expected location of BA resulted in no speech impairment. We employed statistical inference methods to reconstruct the functional brain network and determined how different brain Areas connect with one another. We found that the right homologue of the BA in this patient functionally connected to the same Areas as the left BA in a typical healthy control. As opposed to the functional connection of the left BA in a healthy brain, the right BA did not connect directly with the left WA, but connected indirectly, mediated by the pre-Supplementary Motor Area and the Middle Frontal Gyrus. This case illustrates that pre-surgical fMRI may be used to identify atypical hemispheric language reorganization in the presence of brain tumor and that network theory opens the possibility for future insight into the neural mechanism underlying the language reorganization.
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Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
American Journal of Neuroradiology, 2019Co-Authors: Suril Gohel, M.e. Laino, G. Rajeev-kumar, Viviane Tabar, Mehrnaz Jenabi, Kyung K. Peck, Andrei I. Holodny, Vaios Hatzoglou, Behroze VachhaAbstract:BACKGROUND AND PURPOSE: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca9s Area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between the middle frontal gyrus and Broca Area and that the middle frontal gyrus can serve as a simple and reliable means of measuring language laterality. MATERIALS AND METHODS: Using resting-state fMRI, we compared the middle frontal gyrus with the Broca Area in 51 patients with glial neoplasms for voxel activation, the language laterality index, and the effect of tumor grade on the laterality index. The laterality index derived by resting-state fMRI and task-based fMRI was compared in a subset of 40 patients. RESULTS: Voxel activations in the left middle frontal gyrus and left Broca Area were positively correlated ( r = 0.47, P r = 0.56, P CONCLUSIONS: The middle frontal gyrus is comparable with the Broca Area in its ability to determine hemispheric dominance for language using resting-state fMRI. Our results suggest the addition of resting-state fMRI of the middle frontal gyrus to the list of noninvasive modalities that could be used in patients with gliomas to evaluate hemispheric dominance of language before tumor resection. In patients who cannot participate in traditional task-based fMRI, resting-state fMRI offers a task-free alternate to presurgically map the eloquent cortex.
Argye E. Hillis - One of the best experts on this subject based on the ideXlab platform.
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ischemia in Broca Area is associated with Broca aphasia more reliably in acute than in chronic stroke
Stroke, 2010Co-Authors: Elisa Ochfeld, Melissa Newhart, Cameron Davis, John Molitoris, Richard Leigh, Lauren L. Cloutman, Jennifer T. Crinion, Argye E. HillisAbstract:Background and Purpose—We aimed to determine if ischemia involving Broca Area predicts Broca aphasia more reliably in acute or chronic stroke. Methods—We included consecutive right-hand-dominant patients with left hemisphere ischemic stroke ( 6 months after stroke for chronic stroke). MRI scans were analyzed for ischemic lesions or hypoperfusion in Broca Area (Brodmann Areas 44 and 45). Patients were scored on the Western Aphasia Battery to classify aphasia syndromes; χ2 tests were used to identify significant associations. Results—The presence of infarct involving any part of Broca Area and the presence of Broca or global aphasia was much stronger in acute (χ2=38.1; df1; P<0.0001) than in chronic stroke (χ2=0.54; df1; P=0.46; not significant). The association between infarct or hypoperfusion covering all of Broca Area and the presence of Broca or global aphasia was much stronger in acute (χ2=35.8; df1; P<0.0001) than in chronic stroke (χ2=1.2; df1; p=0.27; not sig...
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Ischemia in Broca Area Is Associated With Broca Aphasia More Reliably in Acute Than in Chronic Stroke
Stroke, 2009Co-Authors: Elisa Ochfeld, Melissa Newhart, Cameron Davis, John Molitoris, Richard Leigh, Lauren L. Cloutman, Jennifer T. Crinion, Argye E. HillisAbstract:Background and Purpose—We aimed to determine if ischemia involving Broca Area predicts Broca aphasia more reliably in acute or chronic stroke. Methods—We included consecutive right-hand-dominant patients with left hemisphere ischemic stroke ( 6 months after stroke for chronic stroke). MRI scans were analyzed for ischemic lesions or hypoperfusion in Broca Area (Brodmann Areas 44 and 45). Patients were scored on the Western Aphasia Battery to classify aphasia syndromes; χ2 tests were used to identify significant associations. Results—The presence of infarct involving any part of Broca Area and the presence of Broca or global aphasia was much stronger in acute (χ2=38.1; df1; P
Behroze Vachha - One of the best experts on this subject based on the ideXlab platform.
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Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
American Journal of Neuroradiology, 2019Co-Authors: Suril Gohel, M.e. Laino, G. Rajeev-kumar, Viviane Tabar, Mehrnaz Jenabi, Kyung K. Peck, Andrei I. Holodny, Vaios Hatzoglou, Behroze VachhaAbstract:BACKGROUND AND PURPOSE: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca9s Area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between the middle frontal gyrus and Broca Area and that the middle frontal gyrus can serve as a simple and reliable means of measuring language laterality. MATERIALS AND METHODS: Using resting-state fMRI, we compared the middle frontal gyrus with the Broca Area in 51 patients with glial neoplasms for voxel activation, the language laterality index, and the effect of tumor grade on the laterality index. The laterality index derived by resting-state fMRI and task-based fMRI was compared in a subset of 40 patients. RESULTS: Voxel activations in the left middle frontal gyrus and left Broca Area were positively correlated ( r = 0.47, P r = 0.56, P CONCLUSIONS: The middle frontal gyrus is comparable with the Broca Area in its ability to determine hemispheric dominance for language using resting-state fMRI. Our results suggest the addition of resting-state fMRI of the middle frontal gyrus to the list of noninvasive modalities that could be used in patients with gliomas to evaluate hemispheric dominance of language before tumor resection. In patients who cannot participate in traditional task-based fMRI, resting-state fMRI offers a task-free alternate to presurgically map the eloquent cortex.
Viviane Tabar - One of the best experts on this subject based on the ideXlab platform.
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functional translocation of Broca s Area in a low grade left frontal glioma graph theory reveals the novel adaptive network connectivity
Frontiers in Neurology, 2019Co-Authors: Viviane Tabar, Kyung K. Peck, Jian W Dong, Gino Del Ferraro, Nicole Petrovich Brennan, Hernan A Makse, Andrei I. HolodnyAbstract:We describe frontal language reorganization in a 50-60 year-old right-handed patient with a low-grade left frontotemporal insular glioma. Pre-operative fMRI revealed robust activation in the left superior temporal gyrus (Wernicke Area, WA) and in the right inferior frontal gyrus (right anatomical homologue of Broca Area, BA). Intra-operative cortical stimulation of the left inferior frontal gyrus and adjacent cortices elicited no speech deficits, and gross total resection including the expected location of BA resulted in no speech impairment. We employed statistical inference methods to reconstruct the functional brain network and determined how different brain Areas connect with one another. We found that the right homologue of the BA in this patient functionally connected to the same Areas as the left BA in a typical healthy control. As opposed to the functional connection of the left BA in a healthy brain, the right BA did not connect directly with the left WA, but connected indirectly, mediated by the pre-Supplementary Motor Area and the Middle Frontal Gyrus. This case illustrates that pre-surgical fMRI may be used to identify atypical hemispheric language reorganization in the presence of brain tumor and that network theory opens the possibility for future insight into the neural mechanism underlying the language reorganization.
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Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
American Journal of Neuroradiology, 2019Co-Authors: Suril Gohel, M.e. Laino, G. Rajeev-kumar, Viviane Tabar, Mehrnaz Jenabi, Kyung K. Peck, Andrei I. Holodny, Vaios Hatzoglou, Behroze VachhaAbstract:BACKGROUND AND PURPOSE: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca9s Area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between the middle frontal gyrus and Broca Area and that the middle frontal gyrus can serve as a simple and reliable means of measuring language laterality. MATERIALS AND METHODS: Using resting-state fMRI, we compared the middle frontal gyrus with the Broca Area in 51 patients with glial neoplasms for voxel activation, the language laterality index, and the effect of tumor grade on the laterality index. The laterality index derived by resting-state fMRI and task-based fMRI was compared in a subset of 40 patients. RESULTS: Voxel activations in the left middle frontal gyrus and left Broca Area were positively correlated ( r = 0.47, P r = 0.56, P CONCLUSIONS: The middle frontal gyrus is comparable with the Broca Area in its ability to determine hemispheric dominance for language using resting-state fMRI. Our results suggest the addition of resting-state fMRI of the middle frontal gyrus to the list of noninvasive modalities that could be used in patients with gliomas to evaluate hemispheric dominance of language before tumor resection. In patients who cannot participate in traditional task-based fMRI, resting-state fMRI offers a task-free alternate to presurgically map the eloquent cortex.
Kyung K. Peck - One of the best experts on this subject based on the ideXlab platform.
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functional translocation of Broca s Area in a low grade left frontal glioma graph theory reveals the novel adaptive network connectivity
Frontiers in Neurology, 2019Co-Authors: Viviane Tabar, Kyung K. Peck, Jian W Dong, Gino Del Ferraro, Nicole Petrovich Brennan, Hernan A Makse, Andrei I. HolodnyAbstract:We describe frontal language reorganization in a 50-60 year-old right-handed patient with a low-grade left frontotemporal insular glioma. Pre-operative fMRI revealed robust activation in the left superior temporal gyrus (Wernicke Area, WA) and in the right inferior frontal gyrus (right anatomical homologue of Broca Area, BA). Intra-operative cortical stimulation of the left inferior frontal gyrus and adjacent cortices elicited no speech deficits, and gross total resection including the expected location of BA resulted in no speech impairment. We employed statistical inference methods to reconstruct the functional brain network and determined how different brain Areas connect with one another. We found that the right homologue of the BA in this patient functionally connected to the same Areas as the left BA in a typical healthy control. As opposed to the functional connection of the left BA in a healthy brain, the right BA did not connect directly with the left WA, but connected indirectly, mediated by the pre-Supplementary Motor Area and the Middle Frontal Gyrus. This case illustrates that pre-surgical fMRI may be used to identify atypical hemispheric language reorganization in the presence of brain tumor and that network theory opens the possibility for future insight into the neural mechanism underlying the language reorganization.
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Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
American Journal of Neuroradiology, 2019Co-Authors: Suril Gohel, M.e. Laino, G. Rajeev-kumar, Viviane Tabar, Mehrnaz Jenabi, Kyung K. Peck, Andrei I. Holodny, Vaios Hatzoglou, Behroze VachhaAbstract:BACKGROUND AND PURPOSE: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca9s Area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between the middle frontal gyrus and Broca Area and that the middle frontal gyrus can serve as a simple and reliable means of measuring language laterality. MATERIALS AND METHODS: Using resting-state fMRI, we compared the middle frontal gyrus with the Broca Area in 51 patients with glial neoplasms for voxel activation, the language laterality index, and the effect of tumor grade on the laterality index. The laterality index derived by resting-state fMRI and task-based fMRI was compared in a subset of 40 patients. RESULTS: Voxel activations in the left middle frontal gyrus and left Broca Area were positively correlated ( r = 0.47, P r = 0.56, P CONCLUSIONS: The middle frontal gyrus is comparable with the Broca Area in its ability to determine hemispheric dominance for language using resting-state fMRI. Our results suggest the addition of resting-state fMRI of the middle frontal gyrus to the list of noninvasive modalities that could be used in patients with gliomas to evaluate hemispheric dominance of language before tumor resection. In patients who cannot participate in traditional task-based fMRI, resting-state fMRI offers a task-free alternate to presurgically map the eloquent cortex.
