The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Antonio Rosas - One of the best experts on this subject based on the ideXlab platform.
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Primary visual cortex in neandertals as revealed from the occipital remains from the El Sidrón site, with emphasis on the new SD‐2300 specimen
Journal of anatomy, 2018Co-Authors: Antonio García-tabernero, Angel Peña-melián, Antonio RosasAbstract:The comparative analysis of the endocranial surface of the El Sidron new occipital fragment SD-2300 shows meaningful differences in the configuration of the occipital pole region between neandertals and anatomically modern humans (AMH). The particular asymmetries found in neandertals in the venous sinus drainage and the petalial patterns are recognizable in this new specimen as well. In addition, the supra- and infracalcarine fossae of the occipital pole region appear to deviate obliquely from the mid-line when compared with sapiens. Due to the excellent preservation conditions of SD-2300, the main sulci and gyri of the occipital pole Area have been identified, this degree of detail being uncommon in a fossil specimen; in general, the gyrification pattern is similar to AMH, but with some notable differences. Particularly interesting is the description of the lunate and the calcarine sulci. The lunate sulcus is located close to the occipital pole, in a similar posterior position to in other Homo species. Regarding the calcarine sulcus, there are significant differences in the primary visual cortex, with the V1 Area, or Brodmann Area 17, being larger in Homo neanderthalensis than in Homo sapiens. This may lead to greater visual acuity in neandertals than in sapiens.
Miguel Angel Navarro - One of the best experts on this subject based on the ideXlab platform.
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Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT2A receptors in Brodmann Areas and brain hemispheres
Psychiatry Research-neuroimaging, 2002Co-Authors: Pilar Rosel, Belén Arranz, Mikel Urretavizcaya, Miguel Oros, Luis San, Julio Vallejo, Miguel Angel NavarroAbstract:Abstract The aim of the present study was to determine the distribution of the presynaptic 5-HT reuptake complex and the 5-HT 2A receptors through Brodmann Areas from two control subjects, together with the possible existence of laterality between both brain hemispheres. A left laterality was observed in the postsynaptic 5-HT 2A binding sites, with significantly higher B max values in the left frontal and cingulate cortex. In frontal cortex , [ 3 H]imipramine and [ 3 H]paroxetine binding showed the highest B max values in Areas 25, 10 and 11. In cingulate cortex , the highest [ 3 H]imipramine and [ 3 H]paroxetine B max values were noted in Brodmann Area 33 followed by Area 24, while postsynaptic 5-HT 2A receptors were mainly distributed through Brodmann Areas 23 and 29. In temporal cortex , the highest [ 3 H]imipramine and [ 3 H]paroxetine B max was noted in Brodmann Areas 28 and 34, followed by Areas 35 and 38. All Brodmann Areas from parietal cortex (1, 2, 3, 4, 5, 6, 7, 39, 40 and 43) showed similar presynaptic and postsynaptic binding values. In occipital cortex no differences were observed with regard to the brain hemisphere or to the Brodmann Area (17, 18 and 19). These results suggest the need to carefully define the brain hemisphere and the Brodmann Areas studied, as well to avoid comparisons between studies including different Brodmann Areas or brain hemispheres.
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Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT(2A) receptors in Brodmann Areas and brain hemispheres.
Psychiatry research, 2002Co-Authors: Pilar Rosel, Belén Arranz, Mikel Urretavizcaya, Miguel Oros, Luis San, Julio Vallejo, Miguel Angel NavarroAbstract:The aim of the present study was to determine the distribution of the presynaptic 5-HT reuptake complex and the 5-HT(2A) receptors through Brodmann Areas from two control subjects, together with the possible existence of laterality between both brain hemispheres. A left laterality was observed in the postsynaptic 5-HT(2A) binding sites, with significantly higher B(max) values in the left frontal and cingulate cortex. In frontal cortex, [3H]imipramine and [3H]paroxetine binding showed the highest B(max) values in Areas 25, 10 and 11. In cingulate cortex, the highest [3H]imipramine and [3H]paroxetine B(max) values were noted in Brodmann Area 33 followed by Area 24, while postsynaptic 5-HT(2A) receptors were mainly distributed through Brodmann Areas 23 and 29. In temporal cortex, the highest [3H]imipramine and [3H]paroxetine B(max) was noted in Brodmann Areas 28 and 34, followed by Areas 35 and 38. All Brodmann Areas from parietal cortex (1, 2, 3, 4, 5, 6, 7, 39, 40 and 43) showed similar presynaptic and postsynaptic binding values. In occipital cortex no differences were observed with regard to the brain hemisphere or to the Brodmann Area (17, 18 and 19). These results suggest the need to carefully define the brain hemisphere and the Brodmann Areas studied, as well to avoid comparisons between studies including different Brodmann Areas or brain hemispheres.
Dennis W. Dickson - One of the best experts on this subject based on the ideXlab platform.
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Original Article Perivascular Neuritic Dystrophy Associated with Cerebral Amyloid Angiopathy in Alzheimer's Disease
2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic
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Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
International journal of clinical and experimental pathology, 2008Co-Authors: Kenichi Oshima, Hirotake Uchikado, Dennis W. DicksonAbstract:Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann Area 18) and a primary cortex (Brodmann Area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Aβ score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Aβ scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy.
Antonio García-tabernero - One of the best experts on this subject based on the ideXlab platform.
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Primary visual cortex in neandertals as revealed from the occipital remains from the El Sidrón site, with emphasis on the new SD‐2300 specimen
Journal of anatomy, 2018Co-Authors: Antonio García-tabernero, Angel Peña-melián, Antonio RosasAbstract:The comparative analysis of the endocranial surface of the El Sidron new occipital fragment SD-2300 shows meaningful differences in the configuration of the occipital pole region between neandertals and anatomically modern humans (AMH). The particular asymmetries found in neandertals in the venous sinus drainage and the petalial patterns are recognizable in this new specimen as well. In addition, the supra- and infracalcarine fossae of the occipital pole region appear to deviate obliquely from the mid-line when compared with sapiens. Due to the excellent preservation conditions of SD-2300, the main sulci and gyri of the occipital pole Area have been identified, this degree of detail being uncommon in a fossil specimen; in general, the gyrification pattern is similar to AMH, but with some notable differences. Particularly interesting is the description of the lunate and the calcarine sulci. The lunate sulcus is located close to the occipital pole, in a similar posterior position to in other Homo species. Regarding the calcarine sulcus, there are significant differences in the primary visual cortex, with the V1 Area, or Brodmann Area 17, being larger in Homo neanderthalensis than in Homo sapiens. This may lead to greater visual acuity in neandertals than in sapiens.
Pilar Rosel - One of the best experts on this subject based on the ideXlab platform.
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Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT2A receptors in Brodmann Areas and brain hemispheres
Psychiatry Research-neuroimaging, 2002Co-Authors: Pilar Rosel, Belén Arranz, Mikel Urretavizcaya, Miguel Oros, Luis San, Julio Vallejo, Miguel Angel NavarroAbstract:Abstract The aim of the present study was to determine the distribution of the presynaptic 5-HT reuptake complex and the 5-HT 2A receptors through Brodmann Areas from two control subjects, together with the possible existence of laterality between both brain hemispheres. A left laterality was observed in the postsynaptic 5-HT 2A binding sites, with significantly higher B max values in the left frontal and cingulate cortex. In frontal cortex , [ 3 H]imipramine and [ 3 H]paroxetine binding showed the highest B max values in Areas 25, 10 and 11. In cingulate cortex , the highest [ 3 H]imipramine and [ 3 H]paroxetine B max values were noted in Brodmann Area 33 followed by Area 24, while postsynaptic 5-HT 2A receptors were mainly distributed through Brodmann Areas 23 and 29. In temporal cortex , the highest [ 3 H]imipramine and [ 3 H]paroxetine B max was noted in Brodmann Areas 28 and 34, followed by Areas 35 and 38. All Brodmann Areas from parietal cortex (1, 2, 3, 4, 5, 6, 7, 39, 40 and 43) showed similar presynaptic and postsynaptic binding values. In occipital cortex no differences were observed with regard to the brain hemisphere or to the Brodmann Area (17, 18 and 19). These results suggest the need to carefully define the brain hemisphere and the Brodmann Areas studied, as well to avoid comparisons between studies including different Brodmann Areas or brain hemispheres.
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Different distributions of the 5-HT reuptake complex and the postsynaptic 5-HT(2A) receptors in Brodmann Areas and brain hemispheres.
Psychiatry research, 2002Co-Authors: Pilar Rosel, Belén Arranz, Mikel Urretavizcaya, Miguel Oros, Luis San, Julio Vallejo, Miguel Angel NavarroAbstract:The aim of the present study was to determine the distribution of the presynaptic 5-HT reuptake complex and the 5-HT(2A) receptors through Brodmann Areas from two control subjects, together with the possible existence of laterality between both brain hemispheres. A left laterality was observed in the postsynaptic 5-HT(2A) binding sites, with significantly higher B(max) values in the left frontal and cingulate cortex. In frontal cortex, [3H]imipramine and [3H]paroxetine binding showed the highest B(max) values in Areas 25, 10 and 11. In cingulate cortex, the highest [3H]imipramine and [3H]paroxetine B(max) values were noted in Brodmann Area 33 followed by Area 24, while postsynaptic 5-HT(2A) receptors were mainly distributed through Brodmann Areas 23 and 29. In temporal cortex, the highest [3H]imipramine and [3H]paroxetine B(max) was noted in Brodmann Areas 28 and 34, followed by Areas 35 and 38. All Brodmann Areas from parietal cortex (1, 2, 3, 4, 5, 6, 7, 39, 40 and 43) showed similar presynaptic and postsynaptic binding values. In occipital cortex no differences were observed with regard to the brain hemisphere or to the Brodmann Area (17, 18 and 19). These results suggest the need to carefully define the brain hemisphere and the Brodmann Areas studied, as well to avoid comparisons between studies including different Brodmann Areas or brain hemispheres.
