The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform
Evan Prince Sabina - One of the best experts on this subject based on the ideXlab platform.
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Pre-treatment with Beta Carotene Gives Protection Against Nephrotoxicity Induced by Bromobenzene via Modulation of Antioxidant System, Pro-inflammatory Cytokines and Pro-apoptotic Factors
Applied Biochemistry and Biotechnology, 2019Co-Authors: Priya Josson Akkara, Evan Prince SabinaAbstract:Bromobenzene is an environmental toxin which causes hepatotoxicity, and the secondary metabolites on biotransformation cause nephrotoxicity. The objective of this study was to assess the alleviation of the nephrotoxic effect of bromobenzene by beta carotene in female Wistar albino rats. Beta carotene (10 mg/kg b.w.p.o.) was delivered orally to the rats for 9 days before bromobenzene (10 mM/kg b.w.p.o.) was intragastrically intubated. Kidney markers, antioxidant status and lipid peroxidation were evaluated. In addition, the levels of TNF-α, IL-6 and IL-1β were measured in serum and in kidney tissue homogenate using ELISA. Caspase, COX-2 and NF-κB were measured with the help of Western blotting. Histopathological analysis of the kidney was done for the control and experimental rats. Bromobenzene induction caused elevation in levels of creatinine, urea, uric acid, cytokines and lipid per oxidation along with deterioration in histological observations and antioxidant status. Pre-treatment with beta carotene significantly (* p
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Pre-treatment with Beta Carotene Gives Protection Against Nephrotoxicity Induced by Bromobenzene via Modulation of Antioxidant System, Pro-inflammatory Cytokines and Pro-apoptotic Factors
Applied Biochemistry and Biotechnology, 2019Co-Authors: Priya Josson Akkara, Evan Prince SabinaAbstract:Bromobenzene is an environmental toxin which causes hepatotoxicity, and the secondary metabolites on biotransformation cause nephrotoxicity. The objective of this study was to assess the alleviation of the nephrotoxic effect of bromobenzene by beta carotene in female Wistar albino rats. Beta carotene (10 mg/kg b.w.p.o.) was delivered orally to the rats for 9 days before bromobenzene (10 mM/kg b.w.p.o.) was intragastrically intubated. Kidney markers, antioxidant status and lipid peroxidation were evaluated. In addition, the levels of TNF-α, IL-6 and IL-1β were measured in serum and in kidney tissue homogenate using ELISA. Caspase, COX-2 and NF-κB were measured with the help of Western blotting. Histopathological analysis of the kidney was done for the control and experimental rats. Bromobenzene induction caused elevation in levels of creatinine, urea, uric acid, cytokines and lipid per oxidation along with deterioration in histological observations and antioxidant status. Pre-treatment with beta carotene significantly (* p
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Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation
Cell Biology and Toxicology, 2016Co-Authors: Mahima Vedi, Evan Prince SabinaAbstract:Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress. The present study aimed to evaluate the possible protective role of withaferin A against bromobenzene-induced liver and kidney damage in mice. Withaferin A (10 mg/kg) was administered orally to the mice for 8 days before intragastric intubation of bromobenzene (10 mmol/kg). As results of this experiment, the levels of liver and kidney functional markers, lipid peroxidation, and cytokines (TNF-α and IL-1β) presented an increase and there was a decrease in anti-oxidant activity in the bromobenzene-treated group of mice. Pre-treatment with withaferin A not only significantly decreased the levels of liver and kidney functional markers and cytokines but also reduced oxidative stress, as evidenced by improved anti-oxidant status. In addition, the mitochondrial dysfunction shown through the decrease in the activities of mitochondrial enzymes and imbalance in the Bax/Bcl-2 expression in the livers and kidneys of bromobenzene-treated mice was effectively prevented by pre-administration of withaferin A. These results validated our conviction that bromobenzene caused liver and kidney damage via mitochondrial pathway and withaferin A provided significant protection against it. Thus, withaferin A may have possible usage in clinical liver and kidney diseases in which oxidative stress and mitochondrial dysfunction may be existent.
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Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress
Toxicology reports, 2014Co-Authors: Mahima Vedi, Mahaboobkhan Rasool, Evan Prince SabinaAbstract:The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the levels of mitochondrial enzymes and antioxidant activity. Pre-treatment with W. somnifera significantly decreased the levels of liver marker enzymes, TNF-α, IL-1β, VEGF and ameliorated histopathological manifestations in bromobenzene-treated rats. The molecular docking analysis predicted that the pro-inflammatory mediator NF-κB showed significant interaction with selected various active components of W. somnifera (withaferin A, withanolide D and withanolide E). This study demonstrates a good protective effect of W. somnifera against bromobenzene-induced oxidative stress.
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BROMOBENZENE: A HEPATOTOXIN
International Journal of Drug Development and Research, 2013Co-Authors: Mahima Vedi, Evan Prince Sabina, Mahaboobkhan RasoolAbstract:Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver, kidney and lungs. In the following review, mechanisms and various genes involved in the bromobenzene induced hepatotoxicity have been discussed. Also, the toxicokinetics, involving absorption, metabolism and elimination of bromobenzene from the body have been reviewed in this article. Various herbal extracts and chemicals have been found to exhibit protective effect against bromobenzene induced liver injury proving their potential in use as hepatoprotective agents.
Zoltán Hell - One of the best experts on this subject based on the ideXlab platform.
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Study of the Structure-Activity Relationship in a Heterogeneous Copper-Palladium Catalysed Suzuki-Miyaura Coupling
Catalysis Letters, 2015Co-Authors: Anna Fodor, Laurence Pirault-roy, Agnes Magyar, Zoltán HellAbstract:Copper-palladium bimetallic catalyst supported on 4 molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki-Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho-substituted iodo- or Bromobenzenes gave lower yield independently from the substituent. But most m- and p-substituted iodo- and Bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised.
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Study of the Structure–Activity Relationship in a Heterogeneous Copper–Palladium Catalysed Suzuki–Miyaura Coupling
Catalysis Letters, 2015Co-Authors: Anna Fodor, Laurence Pirault-roy, Agnes Magyar, Dóra Barczikai, Zoltán HellAbstract:Copper–palladium bimetallic catalyst supported on 4 Å molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki–Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho -substituted iodo- or Bromobenzenes gave lower yield independently from the substituent. But most m - and p -substituted iodo- and Bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised. Graphical Abstract
Henri Doucet - One of the best experts on this subject based on the ideXlab platform.
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Palladium-catalysed direct heteroarylation of Bromobenzenes bearing SO2R substituents at C2 or C4
RSC Advances, 2015Co-Authors: Charles Beromeo Bheeter, Rongwei Jin, Jitendra K. Bera, Henri DoucetAbstract:Palladium-catalysed direct arylation of 4- or 2-Bromobenzenesulfonic acid derivatives in the presence of a variety of heteroaromatics was found to proceed using 0.1-0.5 mol% palladium acetate as the catalyst. However, both the nature and position of the SO2R substituent on such Bromobenzenes has an influence on the reaction rates and yields. The presence of SO2Et or SO2NEt2 at the C2 or C4 position of bromobenzene is tolerated. Good results were also obtained from bromobenzene substituted at C4 by SO2NHPh or SO2OPh. On the other hand, the reactions of Bromobenzenes bearing either SO2N(Me)CH2Ph or SO2OAr at C2 led in some cases to intramolecular reactions instead of the desired intermolecular couplings. Some reactions were performed in cyclopentyl methyl ether, which can be considered as a green solvent.
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Palladium-catalysed direct heteroarylation of Bromobenzenes bearing SO2R substituents at C2 or C4
RSC Advances, 2015Co-Authors: Charles Beromeo Bheeter, Rongwei Jin, Jitendra K. Bera, Henri DoucetAbstract:Palladium-catalysed direct arylation of 4- or 2-Bromobenzenesulfonic acid derivatives in the presence of a variety of heteroaromatics was found to proceed using 0.1-0.5 mol% palladium acetate as the catalyst. However, both the nature and position of the SO2R substituent on such Bromobenzenes has an influence on the reaction rates and yields. The presence of SO2Et or SO2NEt2 at the C2 or C4 position of bromobenzene is tolerated. Good results were also obtained from bromobenzene substituted at C4 by SO2NHPh or SO2OPh. On the other hand, the reactions of Bromobenzenes bearing either SO2N(Me)CH2Ph or SO2OAr at C2 led in some cases to intramolecular reactions instead of the desired intermolecular couplings. Some reactions were performed in cyclopentyl methyl ether, which can be considered as a green solvent.
Anna Fodor - One of the best experts on this subject based on the ideXlab platform.
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Study of the Structure-Activity Relationship in a Heterogeneous Copper-Palladium Catalysed Suzuki-Miyaura Coupling
Catalysis Letters, 2015Co-Authors: Anna Fodor, Laurence Pirault-roy, Agnes Magyar, Zoltán HellAbstract:Copper-palladium bimetallic catalyst supported on 4 molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki-Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho-substituted iodo- or Bromobenzenes gave lower yield independently from the substituent. But most m- and p-substituted iodo- and Bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised.
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Study of the Structure–Activity Relationship in a Heterogeneous Copper–Palladium Catalysed Suzuki–Miyaura Coupling
Catalysis Letters, 2015Co-Authors: Anna Fodor, Laurence Pirault-roy, Agnes Magyar, Dóra Barczikai, Zoltán HellAbstract:Copper–palladium bimetallic catalyst supported on 4 Å molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki–Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho -substituted iodo- or Bromobenzenes gave lower yield independently from the substituent. But most m - and p -substituted iodo- and Bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised. Graphical Abstract
Janusz Serwatowski - One of the best experts on this subject based on the ideXlab platform.
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Bromine as the ortho-directing group in the aromatic metalation/silylation of substituted Bromobenzenes.
Journal of Organic Chemistry, 2003Co-Authors: Sergiusz Luliński, Janusz SerwatowskiAbstract:The one-pot metalation/disilylation of selected Bromobenzenes bearing electron-withdrawing substituents p-, m-, o-XC6H4Br (X = F, Cl, I, CN, CF3) using 2 equiv of lithium diisopropylamide (LDA) and 2 equiv of chlorotrimethylsilane (TMSCl) was investigated. The best results of disilylation were obtained for para-substituted Bromobenzenes, but the regioselectivity of the reaction is strongly influenced by the ortho-directing power of the substituent. On the contrary, the disilylation of meta-substituted Bromobenzenes was not efficient or even failed in some cases and hence monosilylated derivatives were isolated as major or sole products. Diverse reactivity was observed for ortho-substituted Bromobenzenes, e.g., 2-bromobenzonitrile and 2-bromochlorobenzene, were converted into corresponding disilylated derivatives in a high and moderate yield, respectively, whereas 1-bromo-2-(trifluoromethyl)benzene underwent only monosilylation.
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bromine as the ortho directing group in the aromatic metalation silylation of substituted Bromobenzenes
Journal of Organic Chemistry, 2003Co-Authors: Sergiusz Lulinski, Janusz SerwatowskiAbstract:The one-pot metalation/disilylation of selected Bromobenzenes bearing electron-withdrawing substituents p-, m-, o-XC6H4Br (X = F, Cl, I, CN, CF3) using 2 equiv of lithium diisopropylamide (LDA) and 2 equiv of chlorotrimethylsilane (TMSCl) was investigated. The best results of disilylation were obtained for para-substituted Bromobenzenes, but the regioselectivity of the reaction is strongly influenced by the ortho-directing power of the substituent. On the contrary, the disilylation of meta-substituted Bromobenzenes was not efficient or even failed in some cases and hence monosilylated derivatives were isolated as major or sole products. Diverse reactivity was observed for ortho-substituted Bromobenzenes, e.g., 2-bromobenzonitrile and 2-bromochlorobenzene, were converted into corresponding disilylated derivatives in a high and moderate yield, respectively, whereas 1-bromo-2-(trifluoromethyl)benzene underwent only monosilylation.
