The Experts below are selected from a list of 951 Experts worldwide ranked by ideXlab platform
Geoffrey K. Isbister - One of the best experts on this subject based on the ideXlab platform.
-
2 methyl 4 chlorophenoxyacetic acid mcpa and Bromoxynil herbicide ingestion
Clinical Toxicology, 2018Co-Authors: Angela L. Chiew, Colin B. Page, Ahmed Mostafa, Michael S. Roberts, David J Clancy, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. D...
-
2-Methyl-4-chlorophenoxyacetic acid (MCPA) and Bromoxynil herbicide ingestion
2017Co-Authors: Angela L. Chiew, Colin B. Page, David Clancy, Ahmed Mostafa, Michael S. Roberts, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. Case details: Case 1: A 50-year-old female presented 18 h post-ingestion of 200 mL of Bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced. She deteriorated, becoming hypotensive, hyperthermic (39.5 °C) and hypercapnic (80 mmHg). She was cooled, paralysed, received CVVHDF for 2d and was extubated on day 4 making a full recovery. Case 2: A 60-year-old male presented 6 h post-ingestion of an unknown amount of Bromoxynil (200 g/L) and MCPA (200 g/L). On arrival, he was tachycardic and tachypneic (pCO2 25 mmHg). At 8h post-ingestion he became hyperthermic, hypercapnic and acidotic (pH 7.15), and was intubated, paralysed, cooled and received CVVHDF for 36 h. He was extubated after 42 h and made a full recovery. Bromoxynil and MCPA serum and effluent concentrations were measured. Peak MCPA serum concentrations were 161 µg/ml and 259 µg/ml and peak Bromoxynil concentrations were 119 µg/ml and 155 µg/ml in case 1 and 2, respectively. The estimated clearance of both herbicides by CVVHDF was low (
-
2-methyl-4-chlorophenoxyacetic acid and Bromoxynil herbicide death.
'Informa UK Limited', 2015Co-Authors: Buckley, Nicholas A., Downes M., Geoffrey K. IsbisterAbstract:CASE REPORT: We report a fatal case of a 37 year old gentleman who ingested a MCPA/Bromoxynil co-formulation herbicide. Although clinically well on initial examination, our patient declined dramatically over his 18 h admission with increasing CO2 production, hyperthermia and metabolic derangement to eventually die from cardiac asystole 20 h post ingestion. Two hours after ingestion the MCPA concentration was 83.9 μg/mL and Bromoxynil concentration was 137 μg/mL. DISCUSSION: The patients' mechanism of death appeared to be uncoupling of oxidative phosphorylation, excess CO2 production and hyperthermia. There is limited knowledge on the acute toxicity of these herbicides, in particular Bromoxynil, and this case highlights the relentless progression of severe toxicity in humans.The collaboration was supported by an NHMRC Program Grant (1055176). Geoff Isbister is supported by an NHMRC Senior Research Fellowship ID 1061041 and Mike Roberts is supported by an NHMRC Senior Principal Research Fellowship ID 1002611
Angela L. Chiew - One of the best experts on this subject based on the ideXlab platform.
-
2 methyl 4 chlorophenoxyacetic acid mcpa and Bromoxynil herbicide ingestion
Clinical Toxicology, 2018Co-Authors: Angela L. Chiew, Colin B. Page, Ahmed Mostafa, Michael S. Roberts, David J Clancy, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. D...
-
2-Methyl-4-chlorophenoxyacetic acid (MCPA) and Bromoxynil herbicide ingestion
2017Co-Authors: Angela L. Chiew, Colin B. Page, David Clancy, Ahmed Mostafa, Michael S. Roberts, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. Case details: Case 1: A 50-year-old female presented 18 h post-ingestion of 200 mL of Bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced. She deteriorated, becoming hypotensive, hyperthermic (39.5 °C) and hypercapnic (80 mmHg). She was cooled, paralysed, received CVVHDF for 2d and was extubated on day 4 making a full recovery. Case 2: A 60-year-old male presented 6 h post-ingestion of an unknown amount of Bromoxynil (200 g/L) and MCPA (200 g/L). On arrival, he was tachycardic and tachypneic (pCO2 25 mmHg). At 8h post-ingestion he became hyperthermic, hypercapnic and acidotic (pH 7.15), and was intubated, paralysed, cooled and received CVVHDF for 36 h. He was extubated after 42 h and made a full recovery. Bromoxynil and MCPA serum and effluent concentrations were measured. Peak MCPA serum concentrations were 161 µg/ml and 259 µg/ml and peak Bromoxynil concentrations were 119 µg/ml and 155 µg/ml in case 1 and 2, respectively. The estimated clearance of both herbicides by CVVHDF was low (
Gerald K Sims - One of the best experts on this subject based on the ideXlab platform.
-
dehalogenation of the herbicides Bromoxynil 3 5 dibromo 4 hydroxybenzonitrile and ioxynil 3 5 diiodino 4 hydroxybenzonitrile by desulfitobacterium chlororespirans
Applied and Environmental Microbiology, 2005Co-Authors: Alison M Cupples, Gerald K SimsAbstract:Desulfitobacterium chlororespirans has been shown to grow by coupling the oxidation of lactate to the metabolic reductive dehalogenation of ortho chlorines on polysubstituted phenols. Here, we examine the ability of D. chlororespirans to debrominate and deiodinate the polysubstituted herbicides Bromoxynil (3,5-dibromo-4-hydroxybenzonitrile), ioxynil (3,5-diiodo-4-hydroxybenzonitrile), and the Bromoxynil metabolite 3,5-dibromo-4-hydroxybenzoate (DBHB). Stoichiometric debromination of Bromoxynil to 4-cyanophenol and DBHB to 4-hydroxybenzoate occurred. Further, Bromoxynil (35 to 75 μM) and DBHB (250 to 260 μM) were used as electron acceptors for growth. Doubling times for growth (means ± standard deviations for triplicate cultures) on Bromoxynil (18.4 ± 5.2 h) and DBHB (11.9 ± 1.4 h), determined by rate of [14C]lactate uptake into biomass, were similar to those previously reported for this microorganism during growth on pyruvate (15.4 h). In contrast, ioxynil was not deiodinated when added alone or when added with Bromoxynil; however, ioxynil dehalogenation, with stoichiometric conversion to 4-cyanophenol, was observed when the culture was amended with 3-chloro-4-hydroxybenzoate (a previously reported electron acceptor). To our knowledge, this is the first direct report of deiodination by a bacterium in the Desulfitobacterium genus and the first report of an anaerobic pure culture with the ability to transform Bromoxynil or ioxynil. This research provides valuable insights into the substrate range of D. chlororespirans.
Ahmed Mostafa - One of the best experts on this subject based on the ideXlab platform.
-
2 methyl 4 chlorophenoxyacetic acid mcpa and Bromoxynil herbicide ingestion
Clinical Toxicology, 2018Co-Authors: Angela L. Chiew, Colin B. Page, Ahmed Mostafa, Michael S. Roberts, David J Clancy, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. D...
-
2-Methyl-4-chlorophenoxyacetic acid (MCPA) and Bromoxynil herbicide ingestion
2017Co-Authors: Angela L. Chiew, Colin B. Page, David Clancy, Ahmed Mostafa, Michael S. Roberts, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. Case details: Case 1: A 50-year-old female presented 18 h post-ingestion of 200 mL of Bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced. She deteriorated, becoming hypotensive, hyperthermic (39.5 °C) and hypercapnic (80 mmHg). She was cooled, paralysed, received CVVHDF for 2d and was extubated on day 4 making a full recovery. Case 2: A 60-year-old male presented 6 h post-ingestion of an unknown amount of Bromoxynil (200 g/L) and MCPA (200 g/L). On arrival, he was tachycardic and tachypneic (pCO2 25 mmHg). At 8h post-ingestion he became hyperthermic, hypercapnic and acidotic (pH 7.15), and was intubated, paralysed, cooled and received CVVHDF for 36 h. He was extubated after 42 h and made a full recovery. Bromoxynil and MCPA serum and effluent concentrations were measured. Peak MCPA serum concentrations were 161 µg/ml and 259 µg/ml and peak Bromoxynil concentrations were 119 µg/ml and 155 µg/ml in case 1 and 2, respectively. The estimated clearance of both herbicides by CVVHDF was low (
Colin B. Page - One of the best experts on this subject based on the ideXlab platform.
-
2 methyl 4 chlorophenoxyacetic acid mcpa and Bromoxynil herbicide ingestion
Clinical Toxicology, 2018Co-Authors: Angela L. Chiew, Colin B. Page, Ahmed Mostafa, Michael S. Roberts, David J Clancy, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. D...
-
2-Methyl-4-chlorophenoxyacetic acid (MCPA) and Bromoxynil herbicide ingestion
2017Co-Authors: Angela L. Chiew, Colin B. Page, David Clancy, Ahmed Mostafa, Michael S. Roberts, Geoffrey K. IsbisterAbstract:Context: Ingestion of Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. Case details: Case 1: A 50-year-old female presented 18 h post-ingestion of 200 mL of Bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced. She deteriorated, becoming hypotensive, hyperthermic (39.5 °C) and hypercapnic (80 mmHg). She was cooled, paralysed, received CVVHDF for 2d and was extubated on day 4 making a full recovery. Case 2: A 60-year-old male presented 6 h post-ingestion of an unknown amount of Bromoxynil (200 g/L) and MCPA (200 g/L). On arrival, he was tachycardic and tachypneic (pCO2 25 mmHg). At 8h post-ingestion he became hyperthermic, hypercapnic and acidotic (pH 7.15), and was intubated, paralysed, cooled and received CVVHDF for 36 h. He was extubated after 42 h and made a full recovery. Bromoxynil and MCPA serum and effluent concentrations were measured. Peak MCPA serum concentrations were 161 µg/ml and 259 µg/ml and peak Bromoxynil concentrations were 119 µg/ml and 155 µg/ml in case 1 and 2, respectively. The estimated clearance of both herbicides by CVVHDF was low (
