The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Meizuo Zhong - One of the best experts on this subject based on the ideXlab platform.
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problems to affect long term survival for breast Cancer patients an observational study of subsequent lung Bronchus malignancies
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
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Problems to affect long-term survival for breast Cancer patients: An observational study of subsequent lung/Bronchus malignancies.
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
James R. Hébert - One of the best experts on this subject based on the ideXlab platform.
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Regional variation in lung and Bronchus Cancer survival in the US using mortality-to-incidence ratios.
Spatial and spatio-temporal epidemiology, 2018Co-Authors: Cassie L. Odahowski, James R. Hébert, Jan M. EberthAbstract:Abstract Despite major achievements aimed at reducing smoking over the last 50 years in the U.S., lung Cancer remains the leading cause of Cancer death. This study used mortality-to-incidence rate ratios (MIR) calculated from 2008 to 2012 National Cancer Institute data to highlight state-level variations in relative lung and Bronchus Cancer survival. In an ad hoc sensitivity analysis, we calculated a correlation between our state-level MIRs and five-year 1-survival rates for states reporting incident lung and Bronchus Cancer cases (2004–2008) to the Surveillance, Epidemiology, and End Results (SEER) Program database. Differences were observed in state lung and Bronchus Cancer MIRs, with the highest MIR values (poor relative survival) in southern states and the lowest MIRs primarily in northeastern states. In our sensitivity analysis, state-level MIRs were highly correlated with 1-survival rates. Examining regional variation in survival using MIRs can be a useful tool for identifying areas of health disparities and conducting surveillance activities.
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Mindfulness-based stress reduction teachers, practice characteristics, Cancer incidence, and health: a nationwide ecological description
BMC complementary and alternative medicine, 2015Co-Authors: Sara Wagner Robb, Kelsey M Benson, Lauren Middleton, Christine Meyers, James R. HébertAbstract:Studies have demonstrated the potential of the Mindfulness-Based Stress Reduction (MBSR) program to improve the condition of individuals with health outcomes such as hypertension, diabetes, and chronic pain; improve psychological well-being; reduce stress levels; and increase survival among Cancer patients. To date, only one study has focused on the effect of long-term meditation on stress, showing a positive protective relationship. However, the relationship between meditation and Cancer incidence remains unexplored. The objective of this study was to describe the state-level relationship between MBSR instructors and their practices and county-level health outcomes, including Cancer incidence, in the United States. This ecologic study was performed using geospatial mapping and descriptive epidemiology of statewide MBSR characteristics and overall health, mental health state rankings, and age-adjusted Cancer incidence rates. Weak to moderate state-level correlations between meditation characteristics and colorectal and cervical Cancer incidence were detected, with states with more meditation (e.g., more MBSR teachers per population) correlated with a decreased Cancer incidence. A negative correlation was detected between lung & Bronchus Cancer and years teaching MBSR only. Moderate positive correlations were detected between Hodgkin’s Lymphoma and female breast Cancer in relation to all meditation characteristics. Statistically significant correlations with moderate coefficients were detected for overall health ranks and all meditation characteristics, most strongly for total number of years teaching MBSR and total number of years of general meditation practice. Our analyses might suggest that a relationship exists between the total number of MBSR teachers per state and the total number of years of general meditation practice per state, and colorectal and cervical Cancer incidence. Positive correlations were observed with overall health rankings. Despite this study’s limitations, its findings could serve to generate hypotheses and to inform and motivate a new focus on meditation and stress reduction in relation to Cancer incidence, with specific relevance to colorectal and cervical Cancer.
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Mindfulness-based stress reduction teachers, practice characteristics, Cancer incidence, and health: a nationwide ecological description
BMC Complementary and Alternative Medicine, 2015Co-Authors: Sara Wagner Robb, Lauren Middleton, Christine Meyers, Kelsey Benson, James R. HébertAbstract:Background Studies have demonstrated the potential of the Mindfulness-Based Stress Reduction (MBSR) program to improve the condition of individuals with health outcomes such as hypertension, diabetes, and chronic pain; improve psychological well-being; reduce stress levels; and increase survival among Cancer patients. To date, only one study has focused on the effect of long-term meditation on stress, showing a positive protective relationship. However, the relationship between meditation and Cancer incidence remains unexplored. The objective of this study was to describe the state-level relationship between MBSR instructors and their practices and county-level health outcomes, including Cancer incidence, in the United States. Methods This ecologic study was performed using geospatial mapping and descriptive epidemiology of statewide MBSR characteristics and overall health, mental health state rankings, and age-adjusted Cancer incidence rates. Results Weak to moderate state-level correlations between meditation characteristics and colorectal and cervical Cancer incidence were detected, with states with more meditation (e.g., more MBSR teachers per population) correlated with a decreased Cancer incidence. A negative correlation was detected between lung & Bronchus Cancer and years teaching MBSR only. Moderate positive correlations were detected between Hodgkin’s Lymphoma and female breast Cancer in relation to all meditation characteristics. Statistically significant correlations with moderate coefficients were detected for overall health ranks and all meditation characteristics, most strongly for total number of years teaching MBSR and total number of years of general meditation practice. Conclusions Our analyses might suggest that a relationship exists between the total number of MBSR teachers per state and the total number of years of general meditation practice per state, and colorectal and cervical Cancer incidence. Positive correlations were observed with overall health rankings. Despite this study’s limitations, its findings could serve to generate hypotheses and to inform and motivate a new focus on meditation and stress reduction in relation to Cancer incidence, with specific relevance to colorectal and cervical Cancer.
Jieqiong Liu - One of the best experts on this subject based on the ideXlab platform.
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Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016.
JAMA network open, 2020Co-Authors: Weiye Deng, Jieqiong Liu, Yifan Wang, Xiangyu Liu, Liang Wang, Zhaogang Yang, Mingming Yang, Chad Tang, Nina N. SanfordAbstract:Importance To date, the risk of developing second primary Cancers (SPCs) after the first primary melanoma has not been studied in the era of immune checkpoint inhibitors (ICIs). Objective To assess differences in the risk of SPCs in patients with primary melanoma before (2005-2010) and after (2011-2016) the introduction and approval of ICIs. Design, Setting, and Participants Population-based cohort study using the Surveillance, Epidemiology, and End Results database from January 2005 to December 2016 of patients diagnosed with metastatic melanoma. Data were analyzed from January 4 to June 30, 2020. Exposures Receipt of immunotherapy or other antiCancer agents. Main Outcomes and Measures The primary outcome was the development of second primary Cancers in patients with melanoma. Standardized incidence ratios (SIRs) were calculated for the development of SPCs before and after the introduction of ICIs. Results Among 5016 patients with diagnosed metastatic melanoma, 2888 (58%) were younger than 65 years at the time of diagnosis, and 3441 (69%) were male. From 2005 to 2010, SIRs were 3.24 (95% CI, 0.08-18.04) for small intestine Cancer, 1.93 (95% CI, 1.14-3.05) for lung and Bronchus Cancer, 2.77 (95% CI, 1.02-6.03) for kidney Cancer, and 7.29 (95% CI, 2.93-15.02) for myeloma. From 2011 to 2016, SIRs were 9.23 (95% CI, 1.12-33.35) for small intestine Cancer, 1.54 (95% CI, 0.71-2.93) for lung and Bronchus Cancer, 2.66 (95% CI, 0.73-6.82) for kidney Cancer, and 5.90 (95% CI, 1.61-15.10) for myeloma. The overall risk of developing SPCs in individuals who survived the first primary melanoma was 65% higher (SIR, 1.65; 95% CI, 1.35-2.00) in the pre-ICIs period and 98% higher (SIR, 1.98; 95% CI, 1.57-2.45) in the post-ICIs period than the overall Cancer incidence rate in the general population. Conclusions and Relevance In this study, an increase in the overall risk of second primary Cancers after melanoma after the introduction of immune checkpoint inhibitors was observed. The pattern of SPCs has been altered in the era of systemic therapy. Close monitoring and screening for SPCs may be warranted in patients with metastatic melanoma.
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problems to affect long term survival for breast Cancer patients an observational study of subsequent lung Bronchus malignancies
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
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Problems to affect long-term survival for breast Cancer patients: An observational study of subsequent lung/Bronchus malignancies.
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
Kevin Watjou - One of the best experts on this subject based on the ideXlab platform.
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Extensions to Multivariate Space Time Mixture Modeling of Small Area Cancer Data
International Journal of Environmental Research and Public Health, 2017Co-Authors: Rachel Carroll, Christel Faes, Russell S. Kirby, Mehreteab Aregay, Andrew B Lawson, Kevin WatjouAbstract:Oral cavity and pharynx Cancer, even when considered together, is a fairly rare disease. Implementation of multivariate modeling with lung and Bronchus Cancer, as well as melanoma Cancer of the skin, could lead to better inference for oral cavity and pharynx Cancer. The multivariate structure of these models is accomplished via the use of shared random effects, as well as other multivariate prior distributions. The results in this paper indicate that care should be taken when executing these types of models, and that multivariate mixture models may not always be the ideal option, depending on the data of interest.
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Space-time variation of respiratory Cancers in South Carolina: a flexible multivariate mixture modeling approach to risk estimation.
Annals of epidemiology, 2016Co-Authors: Rachel Carroll, Christel Faes, Russell S. Kirby, Mehreteab Aregay, Andrew B Lawson, Kevin WatjouAbstract:Abstract Purpose Many types of Cancer have an underlying spatiotemporal distribution. Spatiotemporal mixture modeling can offer a flexible approach to risk estimation via the inclusion of latent variables. Methods In this article, we examine the application and benefits of using four different spatiotemporal mixture modeling methods in the modeling of Cancer of the lung and Bronchus as well as “other” respiratory Cancer incidences in the state of South Carolina. Results Of the methods tested, no single method outperforms the other methods; which method is best depends on the Cancer under consideration. The lung and Bronchus Cancer incidence outcome is best described by the univariate modeling formulation, whereas the “other” respiratory Cancer incidence outcome is best described by the multivariate modeling formulation. Conclusions Spatiotemporal multivariate mixture methods can aid in the modeling of Cancers with small and sparse incidences when including information from a related, more common type of Cancer.
Yuhua Feng - One of the best experts on this subject based on the ideXlab platform.
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problems to affect long term survival for breast Cancer patients an observational study of subsequent lung Bronchus malignancies
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
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Problems to affect long-term survival for breast Cancer patients: An observational study of subsequent lung/Bronchus malignancies.
Medicine, 2018Co-Authors: Jieqiong Liu, Yuhua Feng, Shan Zeng, Meizuo ZhongAbstract:The overall survival of breast Cancer (BC) patients increased significantly for decades; however, their long-term survival was seriously impaired by subsequent malignancies. This study aimed to investigate the risk factors of subsequent lung / Bronchus primary malignancies among BC survivors.A total of 535,941 BC female survivors diagnosed were identified by using SEERStat database in 1973 to 2014. Among them, 9398 had subsequent lung/Bronchus malignancies. Clinico-pathological risk factors were evaluated for the development of subsequent lung/Bronchus Cancer. The main measures were the incidence and risk factors of subsequent lung/Bronchus primaries. Logistic regression analysis and survival analysis were performed.Overall, among 535,941 BC survivors, 73,394 (13.69%) patients with subsequent primaries were identified from 1973 to 2014. The overall medium second tumor-free time was 72 months. Estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, human epidermal growth factor receptor-2 (HER2)-positive, radiotherapy, and surgery treatment were protective factors against overall subsequent malignancies, whereas HER2/hormone receptor (HR) subtype triple negative, increasing tumor size, low differentiation grade, and high TNM stage were risk factors associated with overall subsequent malignancies. Surgical implantation reconstruction was risk factor for lung/Bronchus Cancer. Even though BC patients had a favorite 5-year survival, their long-term survival was affected by subsequent malignancies, especially for lung/Bronchus Cancer with high mortality.Nearly 13% BC survivors suffered from subsequent malignancies. Increased risk was related to HER2/HR triple negative and advanced TNM stages. Radiotherapy and surgery were protective factors. Our findings may inform the subsequent Cancer counseling of female BC survivors.
