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T P Sastry - One of the best experts on this subject based on the ideXlab platform.
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Collagen Scaffold Incorporated with Macrotyloma uniflorum Plant Extracts as a–Burn/Wound Dressing Material, in Vitro and in Vivo Evaluation
2014Co-Authors: Thangavelu Muthukumar, T P SastryAbstract:Collagen is the most abundantly available connective tissue protein, which is being used as a biomaterial for various biomedical applications. Presently, fish wastes are disposed improperly which is causing serious environmental pollution resulting in offensive odour. Fish scales are promising source of Type I collagen. Medicinal plants have been used since time immemorial for treatment of various ailments of skin and dermatological disorders especially cuts, wounds, and Burns. Developing biomaterials from the natural sources which are having wound healing properties within the search of a common man is the need of hour, particularly in developing and third world countries. With these objectives in view we have developed a wound Dressing material containing fish scale collagen (FSC) incorporated with Macrotyloma uniflorum plant extract (PE). The wound Dressing composite was characterized for its physiochemical properties using conventional methods. SEM image revealed that the composite has fibrous and porous surface which helps in transportation of oxygen as well as absorbing wound fluids. The biomaterial has shown 95% biocompatibility with required mechanical strength and has exhibited antimicrobial properties. This biomaterial has been used as a wound Dressing material in experimental wounds of rats. The healing pattern was evaluated by macroscopic observations, panimetric studies, biochemical, histopathological observations. The results showed faster healing pattern in the wounds treated with CSPE compared to the other composites used in this study and untreated control. These experiments clearly suggest that CSPE can be used as wound/Burn Dressing materials
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fish scale collagen sponge incorporated with macrotyloma uniflorum plant extract as a possible wound Burn Dressing material
Colloids and Surfaces B: Biointerfaces, 2014Co-Authors: Thangavelu Muthukumar, P Prabu, Kausik Ghosh, T P SastryAbstract:Application of plant extracts for the Burn/wound treatment is followed over the decades as a common practice and it is an important aspect in clinical management. In this study porous collagen sponges (CS) were prepared using fish scales and were incorporated with mupirocin (CSM) and extracts of Macrotyloma uniflorum (CSPE) separately to impart antimicrobial activity to the sponges. The results showed that the addition of plant extract increased the tensile strength of CSPE and stability against collagenase enzyme. FTIR studies have shown the incorporation of plant extract in CSPE, SEM studies have revealed the porous nature of the sponges and XRD patterns have shown the retention of collagen triple helical structure even after the addition of plant extract. CSPE and CSM have exhibited antimicrobial properties. The sponges prepared were analysed for their in vitro biocompatibility studies using fibroblasts and keratinocyte cell lines and the results have shown their biocompatible nature. Based on the results obtained, CS, CSM and CSPE may be tried as a Burn/wound Dressing materials, initially, in small animals in vivo.
Thangavelu Muthukumar - One of the best experts on this subject based on the ideXlab platform.
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Collagen Scaffold Incorporated with Macrotyloma uniflorum Plant Extracts as a–Burn/Wound Dressing Material, in Vitro and in Vivo Evaluation
2014Co-Authors: Thangavelu Muthukumar, T P SastryAbstract:Collagen is the most abundantly available connective tissue protein, which is being used as a biomaterial for various biomedical applications. Presently, fish wastes are disposed improperly which is causing serious environmental pollution resulting in offensive odour. Fish scales are promising source of Type I collagen. Medicinal plants have been used since time immemorial for treatment of various ailments of skin and dermatological disorders especially cuts, wounds, and Burns. Developing biomaterials from the natural sources which are having wound healing properties within the search of a common man is the need of hour, particularly in developing and third world countries. With these objectives in view we have developed a wound Dressing material containing fish scale collagen (FSC) incorporated with Macrotyloma uniflorum plant extract (PE). The wound Dressing composite was characterized for its physiochemical properties using conventional methods. SEM image revealed that the composite has fibrous and porous surface which helps in transportation of oxygen as well as absorbing wound fluids. The biomaterial has shown 95% biocompatibility with required mechanical strength and has exhibited antimicrobial properties. This biomaterial has been used as a wound Dressing material in experimental wounds of rats. The healing pattern was evaluated by macroscopic observations, panimetric studies, biochemical, histopathological observations. The results showed faster healing pattern in the wounds treated with CSPE compared to the other composites used in this study and untreated control. These experiments clearly suggest that CSPE can be used as wound/Burn Dressing materials
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fish scale collagen sponge incorporated with macrotyloma uniflorum plant extract as a possible wound Burn Dressing material
Colloids and Surfaces B: Biointerfaces, 2014Co-Authors: Thangavelu Muthukumar, P Prabu, Kausik Ghosh, T P SastryAbstract:Application of plant extracts for the Burn/wound treatment is followed over the decades as a common practice and it is an important aspect in clinical management. In this study porous collagen sponges (CS) were prepared using fish scales and were incorporated with mupirocin (CSM) and extracts of Macrotyloma uniflorum (CSPE) separately to impart antimicrobial activity to the sponges. The results showed that the addition of plant extract increased the tensile strength of CSPE and stability against collagenase enzyme. FTIR studies have shown the incorporation of plant extract in CSPE, SEM studies have revealed the porous nature of the sponges and XRD patterns have shown the retention of collagen triple helical structure even after the addition of plant extract. CSPE and CSM have exhibited antimicrobial properties. The sponges prepared were analysed for their in vitro biocompatibility studies using fibroblasts and keratinocyte cell lines and the results have shown their biocompatible nature. Based on the results obtained, CS, CSM and CSPE may be tried as a Burn/wound Dressing materials, initially, in small animals in vivo.
Kenardy Justin - One of the best experts on this subject based on the ideXlab platform.
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Parent and clinician communication during paediatric Burn wound care: a qualitative study
'Elsevier BV', 2020Co-Authors: Brown, Erin A, Egberts Marthe, Wardhani Rachmania, De Young Alexandra, Kimble Roy, Griffin Bronwyn, Storey Kristen, Kenardy JustinAbstract:To thematically describe parent-clinician communication during a child's first Burn Dressing change following emergency department presentation.An observational study of parent-clinician communication during the first Burn Dressing change at a tertiary children's hospital. Verbal communication between those present at the Dressing change for 87 families, was audio recorded. The recordings were transcribed verbatim and transcripts were analysed within NVivo11 qualitative data analysis software using qualitative content analysis.Three themes, underpinned by parent-clinician rapport-building, were identified. Firstly, knowledge sharing was demonstrated: Clinicians frequently informed the parent about the state of the child's wound, what the procedure will involve, and need for future treatment. Comparatively, parents informed the clinician about their child's temperament and coping since the accident. Secondly, child procedural distress management was discussed: Clinicians and parents had expectations about the likelihood of procedural distress, which was also related to communication about how to prevent and interpret procedural distress (i.e., pain/fear). Finally, parents communicated to clinicians about their own distress, worry and uncertainty, from the accident and wound care. Parents also communicated guilt and blame in relation to injury responsibility.This study provides a description of parent-clinician communication during paediatric Burn wound care.The results can assist healthcare professionals to be prepared for a range of conversations with parents during potentially distressing paediatric medical procedures
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Parent and clinician communication during paediatric Burn wound care: A qualitative study
'Elsevier BV', 2020Co-Authors: Brown, Erin A, Egberts Marthe, Wardhani Rachmania, De Young Alexandra, Kimble Roy, Griffin Bronwyn, Storey Kristen, Kenardy JustinAbstract:Purpose: To thematically describe parent-clinician communication during a child's first Burn Dressing change following emergency department presentation. Design and methods: An observational study of parent-clinician communication during the first Burn Dressing change at a tertiary children's hospital. Verbal communication between those present at the Dressing change for 87 families, was audio recorded. The recordings were transcribed verbatim and transcripts were analysed within NVivo11 qualitative data analysis software using qualitative content analysis. Findings: Three themes, underpinned by parent-clinician rapport-building, were identified. Firstly, knowledge sharing was demonstrated: Clinicians frequently informed the parent about the state of the child's wound, what the procedure will involve, and need for future treatment. Comparatively, parents informed the clinician about their child's temperament and coping since the accident. Secondly, child procedural distress management was discussed: Clinicians and parents had expectations about the likelihood of procedural distress, which was also related to communication about how to prevent and interpret procedural distress (i.e., pain/fear). Finally, parents communicated to clinicians about their own distress, worry and uncertainty, from the accident and wound care. Parents also communicated guilt and blame in relation to injury responsibility. Conclusions: This study provides a description of parent-clinician communication during paediatric Burn wound care. Practical implications: The results can assist healthcare professionals to be prepared for a range of conversations with parents during potentially distressing paediatric medical procedures
Daidi Fan - One of the best experts on this subject based on the ideXlab platform.
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Optimization of human-like collagen composite polysaccharide hydrogel Dressing preparation using response surface for Burn repair.
Carbohydrate polymers, 2020Co-Authors: Huan Lei, Chenhui Zhu, Daidi FanAbstract:Collagen and polysaccharide materials have great advantages for Burn wound healing and skin regeneration. The purpose of this study was to develop a promising Burn Dressing. Mixing hyaluronic acid (HA), carboxylated chitosan (CCS) and human-like collagen (HLC) to simulate extracellular matrix (ECM), and glutamine transaminase (TG) was used as a crosslinker. The mechanical properties and pore size of the hydrogel were optimized by response surface methodology. The results showed that the tensile elastic modulus of the hydrogel was 480.43 ± 15.82 kPa, the tensile strain was 55.23 ± 2.43 %, and the pore size was 90.43 ± 5.57 μm. This study constructed a skin Burn model and demonstrated that the hydrogel Dressing could effectively prevent bacteria infection and confirmed that the hydrogel Dressing was more beneficial for promoting Burn wound healing than a commercial film (DUO DERM). Therefore, the HLC/HA/CCS hydrogel can be considered a promising Burn wound Dressing.
Brown, Erin A - One of the best experts on this subject based on the ideXlab platform.
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Parent and clinician communication during paediatric Burn wound care: a qualitative study
'Elsevier BV', 2020Co-Authors: Brown, Erin A, Egberts Marthe, Wardhani Rachmania, De Young Alexandra, Kimble Roy, Griffin Bronwyn, Storey Kristen, Kenardy JustinAbstract:To thematically describe parent-clinician communication during a child's first Burn Dressing change following emergency department presentation.An observational study of parent-clinician communication during the first Burn Dressing change at a tertiary children's hospital. Verbal communication between those present at the Dressing change for 87 families, was audio recorded. The recordings were transcribed verbatim and transcripts were analysed within NVivo11 qualitative data analysis software using qualitative content analysis.Three themes, underpinned by parent-clinician rapport-building, were identified. Firstly, knowledge sharing was demonstrated: Clinicians frequently informed the parent about the state of the child's wound, what the procedure will involve, and need for future treatment. Comparatively, parents informed the clinician about their child's temperament and coping since the accident. Secondly, child procedural distress management was discussed: Clinicians and parents had expectations about the likelihood of procedural distress, which was also related to communication about how to prevent and interpret procedural distress (i.e., pain/fear). Finally, parents communicated to clinicians about their own distress, worry and uncertainty, from the accident and wound care. Parents also communicated guilt and blame in relation to injury responsibility.This study provides a description of parent-clinician communication during paediatric Burn wound care.The results can assist healthcare professionals to be prepared for a range of conversations with parents during potentially distressing paediatric medical procedures
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Parent and clinician communication during paediatric Burn wound care: A qualitative study
'Elsevier BV', 2020Co-Authors: Brown, Erin A, Egberts Marthe, Wardhani Rachmania, De Young Alexandra, Kimble Roy, Griffin Bronwyn, Storey Kristen, Kenardy JustinAbstract:Purpose: To thematically describe parent-clinician communication during a child's first Burn Dressing change following emergency department presentation. Design and methods: An observational study of parent-clinician communication during the first Burn Dressing change at a tertiary children's hospital. Verbal communication between those present at the Dressing change for 87 families, was audio recorded. The recordings were transcribed verbatim and transcripts were analysed within NVivo11 qualitative data analysis software using qualitative content analysis. Findings: Three themes, underpinned by parent-clinician rapport-building, were identified. Firstly, knowledge sharing was demonstrated: Clinicians frequently informed the parent about the state of the child's wound, what the procedure will involve, and need for future treatment. Comparatively, parents informed the clinician about their child's temperament and coping since the accident. Secondly, child procedural distress management was discussed: Clinicians and parents had expectations about the likelihood of procedural distress, which was also related to communication about how to prevent and interpret procedural distress (i.e., pain/fear). Finally, parents communicated to clinicians about their own distress, worry and uncertainty, from the accident and wound care. Parents also communicated guilt and blame in relation to injury responsibility. Conclusions: This study provides a description of parent-clinician communication during paediatric Burn wound care. Practical implications: The results can assist healthcare professionals to be prepared for a range of conversations with parents during potentially distressing paediatric medical procedures
