The Experts below are selected from a list of 16707 Experts worldwide ranked by ideXlab platform
I Hemmila - One of the best experts on this subject based on the ideXlab platform.
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expression of the tumour associated Antigen CA 242 in transitional cell bladder tumours a comparison with CA 50
European Journal of Cancer, 1993Co-Authors: P Lipponen, M Eskelinen, I HemmilaAbstract:The tissue expression of CArbohydrate Antigen CA-242 was analysed in formalin-fixed biopsy specimens from 147 transitional cell bladder tumours. The staining was related to established prognostic factors and survival during a mean follow-up of over 12 years and the staining results were also compared to expression of CA-50 Antigen. Forty-one percent (60/147) of the tumours were negative for CA-242 and 59% (87/147) were positive. Normal bladder mucosa was positive for CA-242 and the umbrella cells in particular showed intense positive staining. In tumours, the umbrella cells were usually positive (when present) and in tumour tissue, positive cells appeared either as individual positive cells or in groups. None of the tumours was entirely positive for CA-242. The tissue expression of CA-242 could not be signifiCAntly related to TNM classifiCAtion, papillary status, WHO grade or quantitative variables (DNA ploidy, S phase fraction, mitotic frequency, nuclear factors). The tissue expression of CA-242 was signifiCAntly weaker than the expression of CA-50. The expression of CA-242 was related to favourable prognosis in survival analysis (P = 0.04). The results show that the expression of the novel tumour marker Antigen CA-242 as determined in paraffin-embedded material is a weak prognostic factor as compared with established prognostic factors in transitional cell bladder tumours.
P Lipponen - One of the best experts on this subject based on the ideXlab platform.
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expression of the tumour associated Antigen CA 242 in transitional cell bladder tumours a comparison with CA 50
European Journal of Cancer, 1993Co-Authors: P Lipponen, M Eskelinen, I HemmilaAbstract:The tissue expression of CArbohydrate Antigen CA-242 was analysed in formalin-fixed biopsy specimens from 147 transitional cell bladder tumours. The staining was related to established prognostic factors and survival during a mean follow-up of over 12 years and the staining results were also compared to expression of CA-50 Antigen. Forty-one percent (60/147) of the tumours were negative for CA-242 and 59% (87/147) were positive. Normal bladder mucosa was positive for CA-242 and the umbrella cells in particular showed intense positive staining. In tumours, the umbrella cells were usually positive (when present) and in tumour tissue, positive cells appeared either as individual positive cells or in groups. None of the tumours was entirely positive for CA-242. The tissue expression of CA-242 could not be signifiCAntly related to TNM classifiCAtion, papillary status, WHO grade or quantitative variables (DNA ploidy, S phase fraction, mitotic frequency, nuclear factors). The tissue expression of CA-242 was signifiCAntly weaker than the expression of CA-50. The expression of CA-242 was related to favourable prognosis in survival analysis (P = 0.04). The results show that the expression of the novel tumour marker Antigen CA-242 as determined in paraffin-embedded material is a weak prognostic factor as compared with established prognostic factors in transitional cell bladder tumours.
M Eskelinen - One of the best experts on this subject based on the ideXlab platform.
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expression of the tumour associated Antigen CA 242 in transitional cell bladder tumours a comparison with CA 50
European Journal of Cancer, 1993Co-Authors: P Lipponen, M Eskelinen, I HemmilaAbstract:The tissue expression of CArbohydrate Antigen CA-242 was analysed in formalin-fixed biopsy specimens from 147 transitional cell bladder tumours. The staining was related to established prognostic factors and survival during a mean follow-up of over 12 years and the staining results were also compared to expression of CA-50 Antigen. Forty-one percent (60/147) of the tumours were negative for CA-242 and 59% (87/147) were positive. Normal bladder mucosa was positive for CA-242 and the umbrella cells in particular showed intense positive staining. In tumours, the umbrella cells were usually positive (when present) and in tumour tissue, positive cells appeared either as individual positive cells or in groups. None of the tumours was entirely positive for CA-242. The tissue expression of CA-242 could not be signifiCAntly related to TNM classifiCAtion, papillary status, WHO grade or quantitative variables (DNA ploidy, S phase fraction, mitotic frequency, nuclear factors). The tissue expression of CA-242 was signifiCAntly weaker than the expression of CA-50. The expression of CA-242 was related to favourable prognosis in survival analysis (P = 0.04). The results show that the expression of the novel tumour marker Antigen CA-242 as determined in paraffin-embedded material is a weak prognostic factor as compared with established prognostic factors in transitional cell bladder tumours.
Sture Larsson - One of the best experts on this subject based on the ideXlab platform.
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cliniCAl usefulness of serum assays of neuron specific enolase CArcinoembryonic Antigen and CA 50 Antigen in the diagnosis of lung CAncer
European Journal of Cancer, 1993Co-Authors: Bengt Bergman, Fredthomas Brezicka, Carlpeter Engstrom, Sture LarssonAbstract:Abstract Serum concentrations of neuron-specific enolase (NSE), CArcinoembryonic Antigen (CEA) and CA-50 Antigen were determined in 168 consecutive patients with lung CAncer. All three markers were signifiCAntly elevated compared with levels in 102 patients with non-malignant chest diseases. NSE and CEA varied signifiCAntly across histologiCAl lung CAncer types, with most highly elevated serum levels in small cell lung CAncer and adenoCArcinomas, respectively. The overall diagnostic accuracy was 0.66 for NSE, 0.74 for CEA, and 0.62 for CA-50, implying that CEA best discriminated between lung CAncer and benign chest diseases, while CA-50 was less efficient as a diagnostic marker. In multivariate analysis of the three markers combined, a positive predictive value of 95% for lung CAncer could be achieved with a diagnostic sensitivity of 57%, with a cut-off level defined as 0.037 · NSE + 0.052 · CEA + 0.011 · CA-50 > 1. In 22% of the CAncer patients, the time from admission to histologiCAl or cytologiCAl lung CAncer diagnosis exceeded 1 month. In 52% of these patients, the initial weighted tumour marker index was > 1, strongly implying the CAncer diagnosis. The study lends support to the potential use of combined analysis of NSE, CEA and CA-50 as a complementary tool in the diagnosis of lung CAncer.
Bengt Bergman - One of the best experts on this subject based on the ideXlab platform.
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cliniCAl usefulness of serum assays of neuron specific enolase CArcinoembryonic Antigen and CA 50 Antigen in the diagnosis of lung CAncer
European Journal of Cancer, 1993Co-Authors: Bengt Bergman, Fredthomas Brezicka, Carlpeter Engstrom, Sture LarssonAbstract:Abstract Serum concentrations of neuron-specific enolase (NSE), CArcinoembryonic Antigen (CEA) and CA-50 Antigen were determined in 168 consecutive patients with lung CAncer. All three markers were signifiCAntly elevated compared with levels in 102 patients with non-malignant chest diseases. NSE and CEA varied signifiCAntly across histologiCAl lung CAncer types, with most highly elevated serum levels in small cell lung CAncer and adenoCArcinomas, respectively. The overall diagnostic accuracy was 0.66 for NSE, 0.74 for CEA, and 0.62 for CA-50, implying that CEA best discriminated between lung CAncer and benign chest diseases, while CA-50 was less efficient as a diagnostic marker. In multivariate analysis of the three markers combined, a positive predictive value of 95% for lung CAncer could be achieved with a diagnostic sensitivity of 57%, with a cut-off level defined as 0.037 · NSE + 0.052 · CEA + 0.011 · CA-50 > 1. In 22% of the CAncer patients, the time from admission to histologiCAl or cytologiCAl lung CAncer diagnosis exceeded 1 month. In 52% of these patients, the initial weighted tumour marker index was > 1, strongly implying the CAncer diagnosis. The study lends support to the potential use of combined analysis of NSE, CEA and CA-50 as a complementary tool in the diagnosis of lung CAncer.