The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
P Demoly - One of the best experts on this subject based on the ideXlab platform.
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negative Predictive Value of skin tests to neuromuscular blocking agents
Allergy, 2012Co-Authors: L F Ramirez, Ana Margarida Pereira, A M Chiriac, Marie Caroline Bonnetboyer, P DemolyAbstract:To cite this article: Ramirez LF, Pereira A, Chiriac AM, Bonnet-Boyer M-C, Demoly P. Negative Predictive Value of skin tests to neuromuscular blocking agents. Allergy 2012; 67: 439–441. Abstract Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is widely recognized, the lack of information about their negative Predictive Value represents an important issue in the management of patients who require a new procedure with NMBA injection. We present a series of 49 patients with confirmed allergy to NMBAs, six of whom required a subsequent surgery with neuromuscular blockade. Negative skin tests allowed the selection of an alternative NMBA, which was well tolerated in all 6 cases. We found an excellent negative Predictive Value of skin tests in our series but larger studies are required to properly address this question.
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determining the negative Predictive Value of provocation tests with beta lactams
Allergy, 2010Co-Authors: P Demoly, Antonino Romano, Carmen Botelho, L Bousquetrouanet, Francesco Gaeta, Rui Silva, G Rumi, Rodrigues J Cernadas, P J BousquetAbstract:To cite this article: Demoly P, Romano A, Botelho C, Bousquet-Rouanet L, Gaeta F, Silva R, Rumi G, Rodrigues Cernadas J, Bousquet PJ. Determining the negative Predictive Value of provocation tests with beta-lactams. Allergy 2010; 65: 327–332. Abstract Background: The beta-lactam allergic work-up is mostly standardized. However, the negative Predictive Value of drug provocation tests is not yet well established. Method: A historical-prospective multicentre cohort study was conducted in four centres (one in France, one in Portugal, two in Italy) to assess the negative Predictive Value of provocation tests with beta-lactams in patients initially tested for a suspicion of drug allergy/hypersensitivity. Patients were contacted at least 6 months after the work-up, between 2003 and 2007. A new allergic work-up was proposed to reacting patients. Results: Among the 457 patients included, 365 (79.9%) were followed up (159 [79.1%] from France, 153 [82.7%] from Italy and 53 [74.6%] from Portugal). Only 118 (25.8%) were re-exposed to the negatively tested beta-lactam. Nine (7.6%) reported a non-immediate (occurring more than 1 h after drug administration) reaction: five urticaria, three exanthema and one undefined cutaneous reaction. None were severe. Only four accepted a re-challenge, negative in two cases and positive in the two others. The negative Predictive Value was 94.1% (89.8–98.3) (111 out of 118 patients). Conclusion: Although the negative Predictive Value of drug provocation tests may not be 100%, none of the false negative patients experienced a life-threatening reaction. This should reassure doctors who might hesitate to prescribe beta-lactams, even in patients with negative allergic work-ups.
P J Bousquet - One of the best experts on this subject based on the ideXlab platform.
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determining the negative Predictive Value of provocation tests with beta lactams
Allergy, 2010Co-Authors: P Demoly, Antonino Romano, Carmen Botelho, L Bousquetrouanet, Francesco Gaeta, Rui Silva, G Rumi, Rodrigues J Cernadas, P J BousquetAbstract:To cite this article: Demoly P, Romano A, Botelho C, Bousquet-Rouanet L, Gaeta F, Silva R, Rumi G, Rodrigues Cernadas J, Bousquet PJ. Determining the negative Predictive Value of provocation tests with beta-lactams. Allergy 2010; 65: 327–332. Abstract Background: The beta-lactam allergic work-up is mostly standardized. However, the negative Predictive Value of drug provocation tests is not yet well established. Method: A historical-prospective multicentre cohort study was conducted in four centres (one in France, one in Portugal, two in Italy) to assess the negative Predictive Value of provocation tests with beta-lactams in patients initially tested for a suspicion of drug allergy/hypersensitivity. Patients were contacted at least 6 months after the work-up, between 2003 and 2007. A new allergic work-up was proposed to reacting patients. Results: Among the 457 patients included, 365 (79.9%) were followed up (159 [79.1%] from France, 153 [82.7%] from Italy and 53 [74.6%] from Portugal). Only 118 (25.8%) were re-exposed to the negatively tested beta-lactam. Nine (7.6%) reported a non-immediate (occurring more than 1 h after drug administration) reaction: five urticaria, three exanthema and one undefined cutaneous reaction. None were severe. Only four accepted a re-challenge, negative in two cases and positive in the two others. The negative Predictive Value was 94.1% (89.8–98.3) (111 out of 118 patients). Conclusion: Although the negative Predictive Value of drug provocation tests may not be 100%, none of the false negative patients experienced a life-threatening reaction. This should reassure doctors who might hesitate to prescribe beta-lactams, even in patients with negative allergic work-ups.
L F Ramirez - One of the best experts on this subject based on the ideXlab platform.
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negative Predictive Value of skin tests to neuromuscular blocking agents
Allergy, 2012Co-Authors: L F Ramirez, Ana Margarida Pereira, A M Chiriac, Marie Caroline Bonnetboyer, P DemolyAbstract:To cite this article: Ramirez LF, Pereira A, Chiriac AM, Bonnet-Boyer M-C, Demoly P. Negative Predictive Value of skin tests to neuromuscular blocking agents. Allergy 2012; 67: 439–441. Abstract Allergy to neuromuscular blocking agents (NMBAs) is the most important caue of perioperative anaphylaxis in France. The diagnosis relies on a careful clinical history, the search of serum IgE antibodies, and the realization of skin tests. Although the skin tests are the most important tool and their sensitivity is widely recognized, the lack of information about their negative Predictive Value represents an important issue in the management of patients who require a new procedure with NMBA injection. We present a series of 49 patients with confirmed allergy to NMBAs, six of whom required a subsequent surgery with neuromuscular blockade. Negative skin tests allowed the selection of an alternative NMBA, which was well tolerated in all 6 cases. We found an excellent negative Predictive Value of skin tests in our series but larger studies are required to properly address this question.
Willi Suter - One of the best experts on this subject based on the ideXlab platform.
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Predictive Value of in vitro safety studies.
Current opinion in chemical biology, 2006Co-Authors: Willi SuterAbstract:The Predictive Value of in vitro safety studies is discussed for three important areas of pharmaceutical safety evaluations. In genetic toxicology, currently assays are sensitive for the prediction of cancer, but their overall Predictive Value is strongly diminished because of their low specificity. In the area of safety pharmacology blockage of hERG channel in vitro has recently been introduced to predict cardiac repolarization delay (QT interval prolongation) in patients. There is a plethora of in vitro methods to predict and characterize liver toxicity. However, little data is available that demonstrate a reliable prediction for hepatotoxicity in vivo over a wide range of chemical structures. In all three areas, further improvements are needed. ‘Omics’ technologies and new cell lines derived from stem cells are expected to strongly contribute to establish new and more Predictive in vitro assays.
Patrick S Romano - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the Predictive Value of icd 9 cm coded administrative data for venous thromboembolism in the united states
Thrombosis Research, 2010Co-Authors: Richard H White, Martina Garcia, Banafsheh Sadeghi, Daniel J Tancredi, Patricia A Zrelak, Joanne Cuny, Pradeep Sama, Harriet M Gammon, Stephen Schmaltz, Patrick S RomanoAbstract:article study. Analysis was stratified by position of the code in the principal versus a secondary position. Results: Among 1096 cases that had a thromboembolism code in the principal position the positive Predictive Value for any acute venous thrombosis was 95% (95%CI:93-97), whereas among 2360 cases that had a throm- boembolism code in a secondary position the Predictive Value was lower, 75% (95%CI:71-80). The corre- sponding positive Predictive Values for lower extremity deep-vein thrombosis or pulmonary embolism were 91% (95%CI:86-95) and 50% (95%CI:41-58), respectively. More highly defined codes had higher Predictive Value. Among codes in a secondary position that were false positive, 22% (95%CI:16-27) had chronic/prior venous thrombosis, 15% (95%CI:10-19) had an upper extremity thrombosis, 6% (95%CI:4-8) had a superficial vein thrombosis, and 7% (95%CI:4-13) had no mention of any thrombosis. Conclusions: ICD-9-CM codes for venous thromboembolism had high Predictive Value when present in the principal position, and lower Predictive Value when in a secondary position. New thromboembolism codes that were added in 2009 that specify chronic thrombosis, upper extremity thrombosis and superficial venous thrombosis should reduce the frequency of false-positive thromboembolism codes.
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positive Predictive Value of the ahrq accidental puncture or laceration patient safety indicator
Annals of Surgery, 2009Co-Authors: Garth H Utter, Banafsheh Sadeghi, Daniel J Tancredi, Patricia A Zrelak, Ruth Baron, Jeffrey J Geppert, Patrick S RomanoAbstract:Objective:Patient Safety Indicator (PSI) 15, or “Accidental Puncture or Laceration” (APL), of the US Agency for Healthcare Research and Quality was recently endorsed as a consensus standard for quality of care by the National Quality Forum. We sought to determine the positive Predictive Value (PPV)