The Experts below are selected from a list of 1425 Experts worldwide ranked by ideXlab platform
Ali Akbar Moghadamnia - One of the best experts on this subject based on the ideXlab platform.
-
Cadmium toxicity and treatment: An update
Caspian Journal of Internal Medicine, 2017Co-Authors: Mehrdad Rafati Rahimzadeh, Sohrab Kazemi, Ali Akbar MoghadamniaAbstract:Cadmium Poisoning has been reported from many parts of the world. It is one of the global health problems that affect many organs and in some cases it can cause deaths annually. Long-term exposure to Cadmium through air, water, soil, and food leads to cancer and organ system toxicity such as skeletal, urinary, reproductive, cardiovascular, central and peripheral nervous, and respiratory systems. Cadmium levels can be measured in the blood, urine, hair, nail and saliva samples. Patients with Cadmium toxicity need gastrointestinal tract irrigation, supportive care, and chemical decontamination traditional-based chelation therapy with appropriate new chelating agents and nanoparticle-based antidotes. Furthermore it has been likewise recommended to determine the level of food contamination and suspicious areas, consider public education and awareness programs for the exposed people to prevent Cadmium Poisoning.
Xiaodong Liu - One of the best experts on this subject based on the ideXlab platform.
-
Effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein in liver and kidney of rats
Biological trace element research, 2012Co-Authors: Ding Zhang, Jianfeng Gao, Kerong Zhang, Xiaodong LiuAbstract:An experiment was conducted to invest effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein gene expression and protein synthesis in liver and kidney in rats. Forty rats, 6 weeks old, were randomly allocated into two groups. A group was given CdCl(2) (1 mg/KgCd(2+)) by intraperitoneal injection once a day. The other group was treated with normal saline in the same way. Liver and kidney were collected for analysis at the end of the third week. Results showed that Cd exposure increased Cd (P
-
effects of chronic Cadmium Poisoning on zn cu fe ca and metallothionein in liver and kidney of rats
Biological Trace Element Research, 2012Co-Authors: Ding Zhang, Jianfeng Gao, Kerong Zhang, Xiaodong LiuAbstract:An experiment was conducted to invest effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein gene expression and protein synthesis in liver and kidney in rats. Forty rats, 6 weeks old, were randomly allocated into two groups. A group was given CdCl(2) (1 mg/KgCd(2+)) by intraperitoneal injection once a day. The other group was treated with normal saline in the same way. Liver and kidney were collected for analysis at the end of the third week. Results showed that Cd exposure increased Cd (P<0.01) and Zn (P<0.01) content both in liver and kidney. Fe and Ca concentration had a considerable increase in kidney (P<0.01), while both had different degree reduction in liver. Discrepancies between MT mRNA and protein were observed in liver and kidney. In liver, both MT mRNA and protein had a significant increase (P<0.01), while in kidney, only MT gene increase was checked. Meanwhile, the expression levels of MT-1 mRNA and MT-2 mRNA were distinct between liver and kidney. The present study indicated that changes in tissue Cd and Zn levels tended to reflect MT mRNA expression, but bear no clear relationship with MT protein. There did not have a strict dose-dependent relationship among Cd content, MT gene expression, and MT protein synthesis. What is more, changes of Zn, Fe, Cu, and Ca had a certain interaction with both MT mRNA and protein.
Larissa Di Santi Teixeira - One of the best experts on this subject based on the ideXlab platform.
-
Study of the influence of the ph of water in the initiation of digestive tract injury in Cadmium Poisoning in rats
Toxicology reports, 2015Co-Authors: Gisele Alborghetti Nai, Mozart Alves Gonçalves Filho, Mariani Paulino Soriano Estrella, Larissa Di Santi TeixeiraAbstract:Abstract Cancer has genetic and environmental causes, one of which is the ingestion of heavy metals such as Cadmium. Objective To evaluate the lesions caused by Cadmium Poisoning in the digestive tract and the possible effect of the drinking water pH in the initiation of these lesions. Methods 90 male Wistar rats were used, divided into six groups (n = 15): A – received 400 mg/l Cadmium chloride (CdCl2) in drinking water at a neutral pH of 7.0; B – received CdCl2 (400 mg/l) in drinking water at an acidic pH of 5.0; C – received CdCl2 (400 mg/l) in drinking water at a basic pH of 8.0; D – received water at an acidic pH of 5.0; E – received water at a basic pH of 8.0; and F – received water at a neutral pH of 7.0. Animals were euthanized after 6 months. Samples of the esophagus, stomach, small intestine and large intestine of each rat were removed for microscopic analysis. Results There were no microscopic changes in either the esophagus or small and large intestines. Only Cadmium-exposed animals showed mild dysplasia of the gastric mucosa (p = 0.012), regardless of the pH (p > 0.05). Conclusion Cadmium exposure led to the formation of dysplastic lesions in the gastric glandular epithelium, regardless of the water pH.
Mehrdad Rafati Rahimzadeh - One of the best experts on this subject based on the ideXlab platform.
-
Cadmium toxicity and treatment: An update
Caspian Journal of Internal Medicine, 2017Co-Authors: Mehrdad Rafati Rahimzadeh, Sohrab Kazemi, Ali Akbar MoghadamniaAbstract:Cadmium Poisoning has been reported from many parts of the world. It is one of the global health problems that affect many organs and in some cases it can cause deaths annually. Long-term exposure to Cadmium through air, water, soil, and food leads to cancer and organ system toxicity such as skeletal, urinary, reproductive, cardiovascular, central and peripheral nervous, and respiratory systems. Cadmium levels can be measured in the blood, urine, hair, nail and saliva samples. Patients with Cadmium toxicity need gastrointestinal tract irrigation, supportive care, and chemical decontamination traditional-based chelation therapy with appropriate new chelating agents and nanoparticle-based antidotes. Furthermore it has been likewise recommended to determine the level of food contamination and suspicious areas, consider public education and awareness programs for the exposed people to prevent Cadmium Poisoning.
Ding Zhang - One of the best experts on this subject based on the ideXlab platform.
-
Effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein in liver and kidney of rats
Biological trace element research, 2012Co-Authors: Ding Zhang, Jianfeng Gao, Kerong Zhang, Xiaodong LiuAbstract:An experiment was conducted to invest effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein gene expression and protein synthesis in liver and kidney in rats. Forty rats, 6 weeks old, were randomly allocated into two groups. A group was given CdCl(2) (1 mg/KgCd(2+)) by intraperitoneal injection once a day. The other group was treated with normal saline in the same way. Liver and kidney were collected for analysis at the end of the third week. Results showed that Cd exposure increased Cd (P
-
effects of chronic Cadmium Poisoning on zn cu fe ca and metallothionein in liver and kidney of rats
Biological Trace Element Research, 2012Co-Authors: Ding Zhang, Jianfeng Gao, Kerong Zhang, Xiaodong LiuAbstract:An experiment was conducted to invest effects of chronic Cadmium Poisoning on Zn, Cu, Fe, Ca, and metallothionein gene expression and protein synthesis in liver and kidney in rats. Forty rats, 6 weeks old, were randomly allocated into two groups. A group was given CdCl(2) (1 mg/KgCd(2+)) by intraperitoneal injection once a day. The other group was treated with normal saline in the same way. Liver and kidney were collected for analysis at the end of the third week. Results showed that Cd exposure increased Cd (P<0.01) and Zn (P<0.01) content both in liver and kidney. Fe and Ca concentration had a considerable increase in kidney (P<0.01), while both had different degree reduction in liver. Discrepancies between MT mRNA and protein were observed in liver and kidney. In liver, both MT mRNA and protein had a significant increase (P<0.01), while in kidney, only MT gene increase was checked. Meanwhile, the expression levels of MT-1 mRNA and MT-2 mRNA were distinct between liver and kidney. The present study indicated that changes in tissue Cd and Zn levels tended to reflect MT mRNA expression, but bear no clear relationship with MT protein. There did not have a strict dose-dependent relationship among Cd content, MT gene expression, and MT protein synthesis. What is more, changes of Zn, Fe, Cu, and Ca had a certain interaction with both MT mRNA and protein.
