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Calcium Alginate

The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform

Subhas C Kundu – 1st expert on this subject based on the ideXlab platform

  • Calcium Alginate beads embedded in silk fibroin as 3d dual drug releasing scaffolds
    Biomaterials, 2009
    Co-Authors: Biman B. Mandal, Subhas C Kundu

    Abstract:

    Abstract 3D scaffolds based on embedding drug loaded Calcium Alginate beads within silk fibroin protein were fabricated for investigating controlled dual drug release. The 3D matrices were evaluated for in vitro release using two different molecular weight model compounds, bovine serum albumin (66 kDa) and FITC–Inulin (3.9 kDa). The model compound release profiles revealed dependence on molecular weight of encapsulated model drugs for sustained release. Further, silk fibroin protein blended Calcium Alginate beads resulted in prolonged drug release without initial bursts for 35 days as compared to Calcium Alginate beads without silk fibroin as control. The release kinetics were further tested as a function of wt% silk content for scaffold fabrication suggesting their possible role in restricting initial burst and leading to sustainable release of compounds for prolong time. Silk coatings on Calcium Alginate beads provided mechanically stable shells as well as a diffusion barrier to the encapsulated protein drugs thus controlling their release. Scanning electron microscopic observations were carried out to assess cellular viability and biocompatibility of bead embedded-silk 3D scaffolds using fibroblast cells. The results highlight the versatile and tunable properties of Calcium Alginate embedded fibroin 3D scaffolds making them exciting candidate for the controlled release of a wide spectrum of bioactive molecules from a single delivery vehicle.

  • Calcium Alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds
    Biomaterials, 2009
    Co-Authors: Biman B. Mandal, Subhas C Kundu

    Abstract:

    3D scaffolds based on embedding drug loaded Calcium Alginate beads within silk fibroin protein were fabricated for investigating controlled dual drug release. The 3D matrices were evaluated for in vitro release using two different molecular weight model compounds, bovine serum albumin (66 kDa) and FITC-Inulin (3.9 kDa). The model compound release profiles revealed dependence on molecular weight of encapsulated model drugs for sustained release. Further, silk fibroin protein blended Calcium Alginate beads resulted in prolonged drug release without initial bursts for 35 days as compared to Calcium Alginate beads without silk fibroin as control. The release kinetics were further tested as a function of wt% silk content for scaffold fabrication suggesting their possible role in restricting initial burst and leading to sustainable release of compounds for prolong time. Silk coatings on Calcium Alginate beads provided mechanically stable shells as well as a diffusion barrier to the encapsulated protein drugs thus controlling their release. Scanning electron microscopic observations were carried out to assess cellular viability and biocompatibility of bead embedded-silk 3D scaffolds using fibroblast cells. The results highlight the versatile and tunable properties of Calcium Alginate embedded fibroin 3D scaffolds making them exciting candidate for the controlled release of a wide spectrum of bioactive molecules from a single delivery vehicle. © 2009 Elsevier Ltd. All rights reserved.

Biman B. Mandal – 2nd expert on this subject based on the ideXlab platform

  • Calcium Alginate beads embedded in silk fibroin as 3d dual drug releasing scaffolds
    Biomaterials, 2009
    Co-Authors: Biman B. Mandal, Subhas C Kundu

    Abstract:

    Abstract 3D scaffolds based on embedding drug loaded Calcium Alginate beads within silk fibroin protein were fabricated for investigating controlled dual drug release. The 3D matrices were evaluated for in vitro release using two different molecular weight model compounds, bovine serum albumin (66 kDa) and FITC–Inulin (3.9 kDa). The model compound release profiles revealed dependence on molecular weight of encapsulated model drugs for sustained release. Further, silk fibroin protein blended Calcium Alginate beads resulted in prolonged drug release without initial bursts for 35 days as compared to Calcium Alginate beads without silk fibroin as control. The release kinetics were further tested as a function of wt% silk content for scaffold fabrication suggesting their possible role in restricting initial burst and leading to sustainable release of compounds for prolong time. Silk coatings on Calcium Alginate beads provided mechanically stable shells as well as a diffusion barrier to the encapsulated protein drugs thus controlling their release. Scanning electron microscopic observations were carried out to assess cellular viability and biocompatibility of bead embedded-silk 3D scaffolds using fibroblast cells. The results highlight the versatile and tunable properties of Calcium Alginate embedded fibroin 3D scaffolds making them exciting candidate for the controlled release of a wide spectrum of bioactive molecules from a single delivery vehicle.

  • Calcium Alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds
    Biomaterials, 2009
    Co-Authors: Biman B. Mandal, Subhas C Kundu

    Abstract:

    3D scaffolds based on embedding drug loaded Calcium Alginate beads within silk fibroin protein were fabricated for investigating controlled dual drug release. The 3D matrices were evaluated for in vitro release using two different molecular weight model compounds, bovine serum albumin (66 kDa) and FITC-Inulin (3.9 kDa). The model compound release profiles revealed dependence on molecular weight of encapsulated model drugs for sustained release. Further, silk fibroin protein blended Calcium Alginate beads resulted in prolonged drug release without initial bursts for 35 days as compared to Calcium Alginate beads without silk fibroin as control. The release kinetics were further tested as a function of wt% silk content for scaffold fabrication suggesting their possible role in restricting initial burst and leading to sustainable release of compounds for prolong time. Silk coatings on Calcium Alginate beads provided mechanically stable shells as well as a diffusion barrier to the encapsulated protein drugs thus controlling their release. Scanning electron microscopic observations were carried out to assess cellular viability and biocompatibility of bead embedded-silk 3D scaffolds using fibroblast cells. The results highlight the versatile and tunable properties of Calcium Alginate embedded fibroin 3D scaffolds making them exciting candidate for the controlled release of a wide spectrum of bioactive molecules from a single delivery vehicle. © 2009 Elsevier Ltd. All rights reserved.

Yanhui Li – 3rd expert on this subject based on the ideXlab platform

  • filtration and adsorption properties of porous Calcium Alginate membrane for methylene blue removal from water
    Chemical Engineering Journal, 2017
    Co-Authors: Qi Li, Yanhui Li, Qiuju Du, Dechang Wang, Cuiping Wang, Hongliang Li

    Abstract:

    Abstract Porous sodium Alginate membrane was first prepared by vacuum freeze-dry method, then, sodium ions were substituted by Calcium ions through cross-linking reaction to obtain the porous Calcium Alginate membrane via natural drying. The filtration and the adsorption properties of methylene blue on the porous Calcium Alginate membrane were studied through investigating the experimental parameters such as the pH, contact time, temperature and dosage. The data of the adsorption equilibrium were described by the Langmuir and Freundlich isotherms. The pseudo-first order, pseudo-second order, and intra-particle diffusion equation were used to evaluate the kinetic data. Thermodynamic analysis indicated that the adsorption of methylene blue on to the porous Calcium Alginate membrane was an exothermic reaction.

  • methylene blue adsorption on graphene oxide Calcium Alginate composites
    Carbohydrate Polymers, 2013
    Co-Authors: Yanhui Li, Qiuju Du, Yonghao Wang, Shaoling Wu, Zonghua Wang

    Abstract:

    Abstract Graphene oxide has been used as an adsorbent in wastewater treatment. However, the dispersibility in aqueous solution and the biotoxicity to human cells of graphene oxide limits its practical application in environmental protection. In this research, a novel environmental friendly adsorbent, Calcium Alginate immobilized graphene oxide composites was prepared. The effects of pH, contact time, temperature and dosage on the adsorption properties of methylene blue onto Calcium Alginate immobilized graphene oxide composites were investigated. The equilibrium adsorption data were described by the Langmuir and Freundlich isotherms. The maximum adsorption capacity obtained from Langmuir isotherm equation was 181.81 mg/g. The pseudo-first order, pseudo-second order, and intraparticle diffusion equation were used to evaluate the kinetic data. Thermodynamic analysis of equilibriums indicated that the adsorption reaction of methylene blue onto Calcium Alginate immobilized graphene oxide composites was exothermic and spontaneous in nature.

  • Methylene blue adsorption on graphene oxide/Calcium Alginate composites
    Carbohydrate Polymers, 2013
    Co-Authors: Yanhui Li, Qiuju Du, Yonghao Wang, Shaoling Wu, Zonghua Wang

    Abstract:

    Abstract Graphene oxide has been used as an adsorbent in wastewater treatment. However, the dispersibility in aqueous solution and the biotoxicity to human cells of graphene oxide limits its practical application in environmental protection. In this research, a novel environmental friendly adsorbent, Calcium Alginate immobilized graphene oxide composites was prepared. The effects of pH, contact time, temperature and dosage on the adsorption properties of methylene blue onto Calcium Alginate immobilized graphene oxide composites were investigated. The equilibrium adsorption data were described by the Langmuir and Freundlich isotherms. The maximum adsorption capacity obtained from Langmuir isotherm equation was 181.81 mg/g. The pseudo-first order, pseudo-second order, and intraparticle diffusion equation were used to evaluate the kinetic data. Thermodynamic analysis of equilibriums indicated that the adsorption reaction of methylene blue onto Calcium Alginate immobilized graphene oxide composites was exothermic and spontaneous in nature.