The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Rui Zhang - One of the best experts on this subject based on the ideXlab platform.
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association of vitamin d receptor gene polymorphism with the urine Calcium Level in nephrolithiasis patients
Journal of Receptors and Signal Transduction, 2015Co-Authors: Tianbiao Zhou, Zongpei Jiang, Miaofang Huang, Rui ZhangAbstract:AbstractAssociation of vitamin D receptor (VDR) gene polymorphism with the urine Calcium Level in nephrolithiasis patients from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and urine Calcium Level in nephrolithiasis patients using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Four reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with urine Calcium Level in nephrolithiasis patients. In this meta-analysis, VDR BsmI B allele and BB genotype, Fok1 f allele and ff genotype, TaqI, and ApaI gene polymorphism were not associated with urine Calcium Level in nephrolithiasis patients. However, the BsmI bb genotype and Fok1 FF genotype were asso...
R. L. Prince - One of the best experts on this subject based on the ideXlab platform.
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Calcium-Sensing Receptor Gene Polymorphism A986S Does Not Predict Serum Calcium Level, Bone Mineral Density, Calcaneal Ultrasound Indices, or Fracture Rate in a Large Cohort of Elderly Women
Calcified Tissue International, 2004Co-Authors: J. Bollerslev, S. G. Wilson, I. M. Dick, A. Devine, S. S. Dhaliwal, R. L. PrinceAbstract:Postmenopausal osteoporosis is a complex and heterogeneous disease influenced by multiple factors and related to peak bone mass achieved in early adult life, followed by a subsequent continuous bone loss. Genetic variance and polymorphisms have been shown to be of clinical significance for osteoporotic fragility fractures. Previous studies have related variations in the Calcium sensor receptor (CASR) gene to circulating Ca Levels and bone mass in young women and adolescent girls. The aim of this study was to investigate the impact of the A986S polymorphism of the CASR gene on Calcium homeostasis and bone metabolism in elderly women. We studied the distribution of the A986S polymorphism in a large cohort of 1252 ambulatory Australian women in relation to biochemical markers of bone metabolism, bone mass evaluated by quantitative ultrasound measurements (QUS) and DXA of the hip, prevalent and 36-month incident fracture data. No effect of the polymorphism was found on circulating Calcium Level, renal Ca excretion, or biochemical markers of bone turnover. Moreover, A986S was not associated with bone mass or prevalent or incident fractures. Power calculations revealed that a difference in circulating Calcium Levels of 0.05 mmol/l, a difference in DXA bone density of 24 mg, and a 1.6-fold difference in fracture rate could have been detected with a power of 80%. In conclusion, in a large cohort of elderly women the A986S polymorphism of the CASR gene was not found to be significant for Calcium homeostasis or bone mass. It is questioned whether the polymorphism has any clinical significance for postmenopausal osteoporosis.
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clinical investigations Calcium sensing receptor gene polymorphism a986s does not predict serum Calcium Level bone mineral density calcaneal ultrasound indices or fracture rate in a large cohort of elderly women
2004Co-Authors: J. Bollerslev, S. G. Wilson, I. M. Dick, A. Devine, S. S. Dhaliwal, R. L. Prince, Sir CharlesAbstract:Postmenopausal osteoporosis is a complex and heterogeneous disease influenced by multiple factors and related to peak bone mass achieved in early adult life, followed by a subsequent continuous bone loss. Genetic variance and polymorphisms have been shown to be of clinical significance for osteoporotic fragility fractures. Previous studies have related variations in the Calcium sensor receptor (CASR) gene to circulating Ca Levels and bone mass in young women and adolescent girls. The aim of this study was to investigate the impact of the A986S polymorphism of the CASR gene on cal- cium homeostasis and bone metabolism in elderly women. We studied the distribution of the A986S polymorphism in a large cohort of 1252 ambulatory Australian women in relation to biochemical markers of bone metabolism, bone mass evaluated by quantitative ultrasound measurements (QUS) and DXA of the hip, prevalent and 36-month incident fracture data. No effect of the polymorphism was found on circulating Calcium Level, renal Ca excretion, or biochemical markers of bone turnover. Moreover, A986S was not associated with bone mass or prevalent or incident fractures. Power calculations revealed that a difference in circulating Calcium Levels of 0.05 mmol/l, a difference in DXA bone density of 24 mg, and a 1.6-fold difference in fracture rate could have been detected with a power of 80% .I n conclusion, in a large cohort of elderly women the A986S polymorphism of the CASR gene was not found to be significant for Calcium homeostasis or bone mass. It is questioned whether the polymorphism has any clinical significance for postmenopausal osteoporosis.
Mohadeseh Haji Mohamadi - One of the best experts on this subject based on the ideXlab platform.
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Comparison of Salivary Calcium Level in Dentulous and Edentulous Patients.
European journal of dentistry, 2019Co-Authors: Maryam Rabiei, Hamid Neshandar Asli, Mohadeseh Haji MohamadiAbstract:Calcium is an inorganic component of the saliva, which is especially important in oral and dental health. This study sought to compare unstimulated salivary Calcium Level of dentulous and edentulous patients. This case-control study was conducted on 72 participants, including 36 dentulous and 36 edentulous patients. The unstimulated salivary flow rate of patients and the mean salivary Calcium concentration were measured and compared. The data were analyzed using the nonparametric Mann-Whitney U-test. The mean age of participants was 56.3 years. The mean number of teeth was 18.9 in the dentulous group. No significant difference was noted in salivary Calcium Level of dentulous and edentulous patients. The mean salivary Calcium concentration was 0.61 ± 0.3875 mmol/L in dentulous and 0.8025 ± 0.5975 mmol/L in edentulous patients. Salivary Calcium Level had a significant inverse correlation with salivary flow rate (r = -0.370, p = 0.027), and by every 1-unit increase in salivary flow rate, salivary Level of Calcium significantly decreased by 3.85 units. Edentate had averagely higher salivary Calcium Level compared to dentulous. The salivary concentration of Calcium ion is not correlated to the presence or absence of teeth. Salivary flow rate reduces the Calcium concentration. Dental Investigation Society.
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Comparison of Salivary Calcium Level in Dentulous and Edentulous Patients
European Journal of Dentistry, 2019Co-Authors: Maryam Rabiei, Hamid Neshandar Asli, Mohadeseh Haji MohamadiAbstract:Objectives Calcium is an inorganic component of the saliva, which is especially important in oral and dental health. This study sought to compare unstimulated salivary Calcium Level of dentulous and edentulous patients. Materials and Methods This case–control study was conducted on 72 participants, including 36 dentulous and 36 edentulous patients. The unstimulated salivary flow rate of patients and the mean salivary Calcium concentration were measured and compared. The data were analyzed using the nonparametric Mann–Whitney U-test. Results The mean age of participants was 56.3 years. The mean number of teeth was 18.9 in the dentulous group. No significant difference was noted in salivary Calcium Level of dentulous and edentulous patients. The mean salivary Calcium concentration was 0.61 ± 0.3875 mmol/L in dentulous and 0.8025 ± 0.5975 mmol/L in edentulous patients. Salivary Calcium Level had a significant inverse correlation with salivary flow rate (r = –0.370, p = 0.027), and by every 1-unit increase in salivary flow rate, salivary Level of Calcium significantly decreased by 3.85 units. Conclusion Edentate had averagely higher salivary Calcium Level compared to dentulous. The salivary concentration of Calcium ion is not correlated to the presence or absence of teeth. Salivary flow rate reduces the Calcium concentration.
J. Bollerslev - One of the best experts on this subject based on the ideXlab platform.
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Calcium-Sensing Receptor Gene Polymorphism A986S Does Not Predict Serum Calcium Level, Bone Mineral Density, Calcaneal Ultrasound Indices, or Fracture Rate in a Large Cohort of Elderly Women
Calcified Tissue International, 2004Co-Authors: J. Bollerslev, S. G. Wilson, I. M. Dick, A. Devine, S. S. Dhaliwal, R. L. PrinceAbstract:Postmenopausal osteoporosis is a complex and heterogeneous disease influenced by multiple factors and related to peak bone mass achieved in early adult life, followed by a subsequent continuous bone loss. Genetic variance and polymorphisms have been shown to be of clinical significance for osteoporotic fragility fractures. Previous studies have related variations in the Calcium sensor receptor (CASR) gene to circulating Ca Levels and bone mass in young women and adolescent girls. The aim of this study was to investigate the impact of the A986S polymorphism of the CASR gene on Calcium homeostasis and bone metabolism in elderly women. We studied the distribution of the A986S polymorphism in a large cohort of 1252 ambulatory Australian women in relation to biochemical markers of bone metabolism, bone mass evaluated by quantitative ultrasound measurements (QUS) and DXA of the hip, prevalent and 36-month incident fracture data. No effect of the polymorphism was found on circulating Calcium Level, renal Ca excretion, or biochemical markers of bone turnover. Moreover, A986S was not associated with bone mass or prevalent or incident fractures. Power calculations revealed that a difference in circulating Calcium Levels of 0.05 mmol/l, a difference in DXA bone density of 24 mg, and a 1.6-fold difference in fracture rate could have been detected with a power of 80%. In conclusion, in a large cohort of elderly women the A986S polymorphism of the CASR gene was not found to be significant for Calcium homeostasis or bone mass. It is questioned whether the polymorphism has any clinical significance for postmenopausal osteoporosis.
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clinical investigations Calcium sensing receptor gene polymorphism a986s does not predict serum Calcium Level bone mineral density calcaneal ultrasound indices or fracture rate in a large cohort of elderly women
2004Co-Authors: J. Bollerslev, S. G. Wilson, I. M. Dick, A. Devine, S. S. Dhaliwal, R. L. Prince, Sir CharlesAbstract:Postmenopausal osteoporosis is a complex and heterogeneous disease influenced by multiple factors and related to peak bone mass achieved in early adult life, followed by a subsequent continuous bone loss. Genetic variance and polymorphisms have been shown to be of clinical significance for osteoporotic fragility fractures. Previous studies have related variations in the Calcium sensor receptor (CASR) gene to circulating Ca Levels and bone mass in young women and adolescent girls. The aim of this study was to investigate the impact of the A986S polymorphism of the CASR gene on cal- cium homeostasis and bone metabolism in elderly women. We studied the distribution of the A986S polymorphism in a large cohort of 1252 ambulatory Australian women in relation to biochemical markers of bone metabolism, bone mass evaluated by quantitative ultrasound measurements (QUS) and DXA of the hip, prevalent and 36-month incident fracture data. No effect of the polymorphism was found on circulating Calcium Level, renal Ca excretion, or biochemical markers of bone turnover. Moreover, A986S was not associated with bone mass or prevalent or incident fractures. Power calculations revealed that a difference in circulating Calcium Levels of 0.05 mmol/l, a difference in DXA bone density of 24 mg, and a 1.6-fold difference in fracture rate could have been detected with a power of 80% .I n conclusion, in a large cohort of elderly women the A986S polymorphism of the CASR gene was not found to be significant for Calcium homeostasis or bone mass. It is questioned whether the polymorphism has any clinical significance for postmenopausal osteoporosis.
Tianbiao Zhou - One of the best experts on this subject based on the ideXlab platform.
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association of vitamin d receptor gene polymorphism with the urine Calcium Level in nephrolithiasis patients
Journal of Receptors and Signal Transduction, 2015Co-Authors: Tianbiao Zhou, Zongpei Jiang, Miaofang Huang, Rui ZhangAbstract:AbstractAssociation of vitamin D receptor (VDR) gene polymorphism with the urine Calcium Level in nephrolithiasis patients from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and urine Calcium Level in nephrolithiasis patients using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Four reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with urine Calcium Level in nephrolithiasis patients. In this meta-analysis, VDR BsmI B allele and BB genotype, Fok1 f allele and ff genotype, TaqI, and ApaI gene polymorphism were not associated with urine Calcium Level in nephrolithiasis patients. However, the BsmI bb genotype and Fok1 FF genotype were asso...
