The Experts below are selected from a list of 963 Experts worldwide ranked by ideXlab platform
Michael E. Hellberg - One of the best experts on this subject based on the ideXlab platform.
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GPS_PhiST_DeBiasse_et_al_Journal_of_Biogeography
2016Co-Authors: Melissa B. Debiasse, Vincent P. Richards, Mahmood S. Shivji, Michael E. HellbergAbstract:This file contains the sampling site GPS coordinates and PhiST values for Callyspongia vaginalis, Leucothoe ashelyae, Leucothoe kensleyi, and Ophiothrix suensonii required for the Barrier analyses associated with the Journal of Biogeography manuscript "Shared phylogeographical breaks in a Caribbean coral reef sponge and its invertebrate commensals" by Melissa B. DeBiasse, Vincent P. Richards, Mahmood S. Shivji, and Michael E. Hellberg
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Cirhin
2016Co-Authors: Melissa B. Debiasse, Bradley J. Nelson, Michael E. HellbergAbstract:DNA sequences from Callyspongia vaginalis for the Cirhin gene (partial coding sequence
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Cathespsin
2016Co-Authors: Melissa B. Debiasse, Bradley J. Nelson, Michael E. HellbergAbstract:DNA sequences from Callyspongia vaginalis for the Cathepsin gene (partial coding sequence
Melissa B. Debiasse - One of the best experts on this subject based on the ideXlab platform.
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GPS_PhiST_DeBiasse_et_al_Journal_of_Biogeography
2016Co-Authors: Melissa B. Debiasse, Vincent P. Richards, Mahmood S. Shivji, Michael E. HellbergAbstract:This file contains the sampling site GPS coordinates and PhiST values for Callyspongia vaginalis, Leucothoe ashelyae, Leucothoe kensleyi, and Ophiothrix suensonii required for the Barrier analyses associated with the Journal of Biogeography manuscript "Shared phylogeographical breaks in a Caribbean coral reef sponge and its invertebrate commensals" by Melissa B. DeBiasse, Vincent P. Richards, Mahmood S. Shivji, and Michael E. Hellberg
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Cirhin
2016Co-Authors: Melissa B. Debiasse, Bradley J. Nelson, Michael E. HellbergAbstract:DNA sequences from Callyspongia vaginalis for the Cirhin gene (partial coding sequence
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Cathespsin
2016Co-Authors: Melissa B. Debiasse, Bradley J. Nelson, Michael E. HellbergAbstract:DNA sequences from Callyspongia vaginalis for the Cathepsin gene (partial coding sequence
Yonghong Liu - One of the best experts on this subject based on the ideXlab platform.
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Two new alkaloids from marine sponge Callyspongia sp.
Natural Product Research, 2012Co-Authors: Bin Yang, Huaming Tao, Xuefeng Zhou, Xiuping Lin, Yonghong LiuAbstract:Two new alkaloids, callylactam A (1) and callyimine A (4), along with three known ones (2, 3 and 5), were isolated from the marine sponge Callyspongia sp. The structures were determined on the basis of NMR and MS analysis.
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Indole Alkaloids from South China Sea Marine Sponge Callyspongia sp.
Advances in Intelligent and Soft Computing, 2012Co-Authors: Bin Wang, Riming Huang, Yonghong LiuAbstract:Three known indole alkaloids were first isolated from South China Sea marine sponge Callyspongia sp.. Their structures were confirmed by detailed NMR data comparison with those in the literatures.
I Sahidin - One of the best experts on this subject based on the ideXlab platform.
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aktivitas imunomodulator ekstrak etanol spons Callyspongia sp terhadap fagositosis makrofag pada mencit jantan balb c
Journal of Intelligent Information Systems, 2020Co-Authors: Muhammad Y Ilyas, Politeknik Bina Husada Kendari, Asriullah Jabbar, Mentarri Bafadal, Muhammad Hajrul Malaka, Firdayanti Firdayanti, I SahidinAbstract:Sponge Callyspongia sp. has compounds that act as immunomodulatory agents, one of which is flavonoids.Flavonoids have the potential to be immunostimulants by increasing the phagocytic activity of macrophages. This study was experimental with a post test only control group design method. This study used 24 micemalestrain Balb /c with a body weight of 20-30 grams divided into 6 groups. The first group get extracts of sponge Callyspongia sp. 100 mg/kgBW, second group get the extract of sponge Callyspongia sp. 200 mg/kgBW, third group get extracts of sponge Callyspongia sp. 300 mg/kgBW, fourth group get the extract of sponge Callyspongia sp. 400 mg/kgBW, positive control group was given Stimuno® 0,13 mg/kgBW and the negative control group get Na-CMC 0.5%. A test given in orally preparations on the first day until the seven day. On the eighth day of each of the mice are injected bacteria Staphylococcus aureus (SA) by intraperitoneal. The activity of macrophage cells from murine peritoneal fluids sweep by calculating the percentage of macrophages that does phagocytosis of 100 cells are observed. The data obtained were then analyzed by one way Anova statistics and test post hoc Tukey's. As result, the are that ethanol extracts of sponge Callyspongia sp. at doses of 300 mg/kgBW and 400 mg/kgBW have potential as immunomodulator with based on results of statistical tests post hoc Tukey (P > 0.05) showed no meaningful difference against the positive control (Stimuno ®) wich improving the activity of the cells of the macrophage phagocytosis.
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ANTI-INFLAMMATORY ACTIVITY OF MARINE SPONGE Callyspongia SP. AND ITS ACUTE TOXICITY
Asian Journal of Pharmaceutical and Clinical Research, 2019Co-Authors: Adryan Fristiohady, Wahyuni Wahyuni, Fadhliyah Malik, La Ode Muhammad Julian Purnama, Baru Sadarun, I SahidinAbstract:Objective: This study aims to investigate the anti-inflammatory effect of the ethanolic extract of Callyspongia sp. using stabilization of the human red blood cell (HRBC) membrane method and its acute toxicity using brine shrimp lethality test (BSLT) method. Methods: Callyspongia sp. was macerated with 96% ethanol. Extract characterized and screened for the secondary metabolite. Anti-inflammatory activity by stabilization of the HRBC membrane method with a varied dose of 50 ppm; 100 ppm; 200 ppm; 400 ppm; 800 ppm; 1600 ppm; and 3200 ppm. Solutions observed using a photometer to describing stability and ability in preventing membranes hemolytic and statistically analyzed using SPSS. Acute toxicity carried out by the BSLT method and analyzed using Minitab®ver. 17.2.1. Results: The phytochemical screening was indicating that Callyspongia sp. contains flavonoid, alkaloid, and terpenoid. The results of the anti-inflammatory activity test showed that the percentage value of stability and hemolysis of extracts with doses of 50, 100, 200, 400, 800, 1600, and 3200 ppm were 55% and 45%, 63% and 37%, 70% and 30%, 74% and 26%, 80% and 20%, 87% and 13%, and 97% and 3%, respectively. It showed that extract of sponge Callyspongia sp. in all varied dose has activity in stabilizing the HRBC membrane thus can be potential as an anti-inflammatory. The results of acute toxicity assay showed that the value of LC50 was 1281.45 μg/ml and categorized as nontoxic to Artemia salina Leach. Conclusion: Various concentrations of Callyspongia sp. effective as an anti-inflammatory in stabilizing HRBC, and categorized as safe.
Motomasa Kobayashi - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
Tetrahedron Letters, 1998Co-Authors: Nobutoshi Murakami, Weiqi Wang, Masashi Aoki, Yasuhiro Tsutsui, Masanori Sugimoto, Motomasa KobayashiAbstract:Abstract A first total synthesis of callystatin A ( 1 ), a potent cytotoxic polyketide from the marine sponge Callyspongia truncata , has been achieved by use of an E -selective Wittig olefination and asymmetric Evans aldol condensation as the key reactions. Thus, the absolute stereostructure of 1 previously established by us was confirmed.
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Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
Tetrahedron Letters, 1997Co-Authors: Motomasa Kobayashi, Nobutoshi Murakami, Kazuhiro Higuchi, Hisashi Tajima, Shunji AokiAbstract:Abstract Callystatin A (1) has been isolated from the marine sponge, Callyspongia truncata, and the plane structure, including parts of the absolute configurations, is elucidated. Callystatin A (1) is a novel polyketide with a terminal α,β-unsaturated δ-lactone and exhibited potent cytotoxicity against KB cells at IC50 0.01 ng/ml.
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Absolute stereostructure of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata
Tetrahedron Letters, 1997Co-Authors: Nobutoshi Murakami, Weiqi Wang, Masashi Aoki, Yasuhiro Tsutsui, Kazuhiro Higuchi, Shunji Aoki, Motomasa KobayashiAbstract:Abstract The unidentified configurations at C 5 and C 10 in callystatin A ( 1 ), a potent cytotoxic polyketide from the marine sponge Callyspongia truncata , were determined to be R , R by comparing the circular dichroism spectrum of 1 with those of two model compounds 2 and 3 . Compounds 2 and 3 were synthesized by using E -selective Wittig olefination at the C 6 C 7 position as a key reaction.
