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Luc Defebvre - One of the best experts on this subject based on the ideXlab platform.
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a specific clinical pattern of Camptocormia in parkinson s disease
Journal of Neurology Neurosurgery and Psychiatry, 2006Co-Authors: A.-c. Lepoutre, David Devos, V. Pardessus, Claude-alain Maurage, D. Ferriby, J.-f. Hurtevent, A Cotten, Alain Destée, A Blancharddauphin, Luc DefebvreAbstract:Background: Camptocormia, characterised by extreme forward flexion of the thoracolumbar spine and severe stooping in the supine position, seems to be prevalent in Parkinson’s disease. Objective: The aim of this study was to identify features of parkinsonian Camptocormia and to describe the main clinical characteristics of patients with Parkinson’s disease who develop the condition. Methods: An extensive range of clinical, biochemical and imaging data were gathered for 23 patients with Parkinson’s disease with Camptocormia, notably including magnetic resonance imaging (MRI) of the brain and spine, electromyographic recordings of the paravertebral muscles and muscle biopsies. Results: Camptocormia occurred in severe Parkinson’s disease with axial predominance, motor fluctuations and dysautonomic symptoms. The condition was often associated with spondyloarthritic changes and pain. MRI showed paraspinal muscle signal abnormalities in five patients and fatty involution in seven patients. The seven patients had motor unit reductions on the spinal erector electromyogram. The MRI results for the girdle muscles were normal. Cranial MRI showed signal abnormalities for the basal ganglia in three patients. Discussion: Various mechanisms may contribute to the development of parkinsonian Camptocormia: dopaminergic depletion in Parkinson’s disease induces functional changes in the organisation of the corticospinal and reticulospinal tracts, where dysfunction could contribute to axial rigidity. Furthermore, rigidity of the spinal flexion muscles could lead to under-use of the spinal extension muscles, which become progressively atrophic. Rigidity may also induce spinal deformations, leading to a neurogenic syndrome via compression of the spinal nerves. Conclusion: The screening and early management of Camptocormia in Parkinson’s disease is likely to be important for preventing axial disorders and spinal deformations.
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A specific clinical pattern of Camptocormia in Parkinson’s disease
Journal of neurology neurosurgery and psychiatry, 2006Co-Authors: A.-c. Lepoutre, David Devos, A. Blanchard-dauphin, V. Pardessus, Claude-alain Maurage, D. Ferriby, J.-f. Hurtevent, A Cotten, Alain Destée, Luc DefebvreAbstract:Background: Camptocormia, characterised by extreme forward flexion of the thoracolumbar spine and severe stooping in the supine position, seems to be prevalent in Parkinson’s disease. Objective: The aim of this study was to identify features of parkinsonian Camptocormia and to describe the main clinical characteristics of patients with Parkinson’s disease who develop the condition. Methods: An extensive range of clinical, biochemical and imaging data were gathered for 23 patients with Parkinson’s disease with Camptocormia, notably including magnetic resonance imaging (MRI) of the brain and spine, electromyographic recordings of the paravertebral muscles and muscle biopsies. Results: Camptocormia occurred in severe Parkinson’s disease with axial predominance, motor fluctuations and dysautonomic symptoms. The condition was often associated with spondyloarthritic changes and pain. MRI showed paraspinal muscle signal abnormalities in five patients and fatty involution in seven patients. The seven patients had motor unit reductions on the spinal erector electromyogram. The MRI results for the girdle muscles were normal. Cranial MRI showed signal abnormalities for the basal ganglia in three patients. Discussion: Various mechanisms may contribute to the development of parkinsonian Camptocormia: dopaminergic depletion in Parkinson’s disease induces functional changes in the organisation of the corticospinal and reticulospinal tracts, where dysfunction could contribute to axial rigidity. Furthermore, rigidity of the spinal flexion muscles could lead to under-use of the spinal extension muscles, which become progressively atrophic. Rigidity may also induce spinal deformations, leading to a neurogenic syndrome via compression of the spinal nerves. Conclusion: The screening and early management of Camptocormia in Parkinson’s disease is likely to be important for preventing axial disorders and spinal deformations.
A.-c. Lepoutre - One of the best experts on this subject based on the ideXlab platform.
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a specific clinical pattern of Camptocormia in parkinson s disease
Journal of Neurology Neurosurgery and Psychiatry, 2006Co-Authors: A.-c. Lepoutre, David Devos, V. Pardessus, Claude-alain Maurage, D. Ferriby, J.-f. Hurtevent, A Cotten, Alain Destée, A Blancharddauphin, Luc DefebvreAbstract:Background: Camptocormia, characterised by extreme forward flexion of the thoracolumbar spine and severe stooping in the supine position, seems to be prevalent in Parkinson’s disease. Objective: The aim of this study was to identify features of parkinsonian Camptocormia and to describe the main clinical characteristics of patients with Parkinson’s disease who develop the condition. Methods: An extensive range of clinical, biochemical and imaging data were gathered for 23 patients with Parkinson’s disease with Camptocormia, notably including magnetic resonance imaging (MRI) of the brain and spine, electromyographic recordings of the paravertebral muscles and muscle biopsies. Results: Camptocormia occurred in severe Parkinson’s disease with axial predominance, motor fluctuations and dysautonomic symptoms. The condition was often associated with spondyloarthritic changes and pain. MRI showed paraspinal muscle signal abnormalities in five patients and fatty involution in seven patients. The seven patients had motor unit reductions on the spinal erector electromyogram. The MRI results for the girdle muscles were normal. Cranial MRI showed signal abnormalities for the basal ganglia in three patients. Discussion: Various mechanisms may contribute to the development of parkinsonian Camptocormia: dopaminergic depletion in Parkinson’s disease induces functional changes in the organisation of the corticospinal and reticulospinal tracts, where dysfunction could contribute to axial rigidity. Furthermore, rigidity of the spinal flexion muscles could lead to under-use of the spinal extension muscles, which become progressively atrophic. Rigidity may also induce spinal deformations, leading to a neurogenic syndrome via compression of the spinal nerves. Conclusion: The screening and early management of Camptocormia in Parkinson’s disease is likely to be important for preventing axial disorders and spinal deformations.
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A specific clinical pattern of Camptocormia in Parkinson’s disease
Journal of neurology neurosurgery and psychiatry, 2006Co-Authors: A.-c. Lepoutre, David Devos, A. Blanchard-dauphin, V. Pardessus, Claude-alain Maurage, D. Ferriby, J.-f. Hurtevent, A Cotten, Alain Destée, Luc DefebvreAbstract:Background: Camptocormia, characterised by extreme forward flexion of the thoracolumbar spine and severe stooping in the supine position, seems to be prevalent in Parkinson’s disease. Objective: The aim of this study was to identify features of parkinsonian Camptocormia and to describe the main clinical characteristics of patients with Parkinson’s disease who develop the condition. Methods: An extensive range of clinical, biochemical and imaging data were gathered for 23 patients with Parkinson’s disease with Camptocormia, notably including magnetic resonance imaging (MRI) of the brain and spine, electromyographic recordings of the paravertebral muscles and muscle biopsies. Results: Camptocormia occurred in severe Parkinson’s disease with axial predominance, motor fluctuations and dysautonomic symptoms. The condition was often associated with spondyloarthritic changes and pain. MRI showed paraspinal muscle signal abnormalities in five patients and fatty involution in seven patients. The seven patients had motor unit reductions on the spinal erector electromyogram. The MRI results for the girdle muscles were normal. Cranial MRI showed signal abnormalities for the basal ganglia in three patients. Discussion: Various mechanisms may contribute to the development of parkinsonian Camptocormia: dopaminergic depletion in Parkinson’s disease induces functional changes in the organisation of the corticospinal and reticulospinal tracts, where dysfunction could contribute to axial rigidity. Furthermore, rigidity of the spinal flexion muscles could lead to under-use of the spinal extension muscles, which become progressively atrophic. Rigidity may also induce spinal deformations, leading to a neurogenic syndrome via compression of the spinal nerves. Conclusion: The screening and early management of Camptocormia in Parkinson’s disease is likely to be important for preventing axial disorders and spinal deformations.
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A specific clinical pattern of Camptocormia in Parkinson's disease. Commentary
Journal of Neurology Neurosurgery and Psychiatry, 2006Co-Authors: R. Djaldetti, E. Melamed, A.-c. Lepoutre, David Devos, A. Blanchard-dauphin, V. Pardessus, Claude-alain Maurage, D. Ferriby, J.-f. Hurtevent, A. GottenAbstract:Background: Camptocormia, characterised by extreme forward flexion of the thoracolumbar spine and severe stooping in the supine position, seems to be prevalent in Parkinson's disease. Objective: The aim of this study was to identify features of parkinsonian Camptocormia and to describe the main clinical characteristics of patients with Parkinson's disease who develop the condition. Methods: An extensive range of clinical, biochemical and imaging data were gathered for 23 patients with Parkinson's disease with Camptocormia, notably including magnetic resonance imaging (MRI) of the brain and spine, electromyographic recordings of the paravertebral muscles and muscle biopsies. Results: Camptocormia occurred in severe Parkinson's disease with axial predominance, motor fluctuations and dysautonomic symptoms. The condition was often associated with spondyloarthritic changes and pain. MRI showed paraspinal muscle signal abnormalities in five patients and fatty involution in seven patients. The seven patients had motor unit reductions on the spinal erector electromyogram. The MRI results for the girdle muscles were normal. Cranial MRI showed signal abnormalities for the basal ganglia in three patients. Discussion: Various mechanisms may contribute to the development of parkinsonian Camptocormia: dopaminergic depletion in Parkinson's disease induces functional changes in the organisation of the corticospinal and reticulospinal tracts, where dysfunction could contribute to axial rigidity. Furthermore, rigidity of the spinal flexion muscles could lead to under-use of the spinal extension muscles, which become progressively atrophic. Rigidity may also induce spinal deformations, leading to a neurogenic syndrome via compression of the spinal nerves. Conclusion: The screening and early management of Camptocormia in Parkinson's disease is likely to be important for preventing axial disorders and spinal deformations.
Shunya Nakane - One of the best experts on this subject based on the ideXlab platform.
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The Cross-Sectional Area of Paraspinal Muscles Predicts the Efficacy of Deep Drain Stimulation for Camptocormia.
Journal of Parkinson's disease, 2017Co-Authors: Waka Sakai, Shunya Nakane, Eiichirou Urasaki, Keisuke Toyoda, Eisaku Sadakata, Akiko Nagaishi, Takayasu Fukudome, Yuzo Yamakawa, Hidenori MatsuoAbstract:Background Camptocormia, a disturbance of posture, is a well-described clinical feature of PD and other parkinsonian syndromes. Previous reports have shown that DBS of the subthalamic nucleus (STN) or globus pallidus internus is effective in treating Camptocormia. However, the efficacy of DBS for Camptocormia varies. Objective To determine a clinical marker for selecting an appropriate therapy for Camptocormia, a disabling manifestation of Parkinson's disease (PD) that has a variable response to systemic and local therapies. Methods We obtained pre-operative lumbar magnetic resonance imaging of 14 consecutive PD patients with Camptocormia who underwent subthalamic nucleus deep brain stimulation (STN-DBS) in this retrospective-designed study. Lumbar MRI was performed three to six months prior to the operation. We measured the cross-sectional area (CSA) and width of each participant's paraspinal muscles. Results Four (28.6%) patients were effective (EF), five (35.7%) were partially effective (PE), and five (35.7%) were non-effective (NE) to STN-DBS. The lumbar paraspinal CSA and width were significantly larger in the EF group than in the PE and NE groups. Conclusions The CSA of paraspinal muscles and erector spinae width can be good predictive markers for improving Camptocormia in patients with PD after deep brain stimulation.
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The characteristics of Camptocormia in patients with Parkinson's disease: A large cross-sectional multicenter study in Japan.
Journal of the neurological sciences, 2015Co-Authors: Shunya Nakane, Masaru Yoshioka, Nobuhito Oda, Takashi Tani, Keiji Chida, Mikiya Suzuki, Itaru Funakawa, Akira Inukai, Kazuko Hasegawa, Kenji KurodaAbstract:The goal of the present study was to clarify the clinical characteristics and laboratory results of parkinsonian symptoms among patients with and without Camptocormia. Seventy-eight Parkinson's disease (PD) patients with Camptocormia and 78 PD patients without Camptocormia underwent a neurological examination, a blood test, and spinal magnetic resonance imaging (MRI). PD with Camptocormia group and PD with non-Camptocormia group were matched on age, age at PD onset, and sex. Camptocormia group had significantly higher prevalence of compression fractures, more severe parkinsonian symptoms, and a greater incidence of dementia than those without Camptocormia. Serum creatine kinase levels in Camptocormia group significantly elevated compared with non-Camptocormia group. There were higher prevalence of abnormal findings in spine MRI including compression fractures and paravertebral muscle changes in Camptocormia group compared with non-Camptocormia group. Camptocormia is associated with a greater prevalence of compression fractures and associated with greater UPDRS part II, part III score, axial score, and lower MMSE in this cross-sectional study. Thus, it can be concluded that Camptocormia in PD is predominantly myopathic. Copyright © 2015 Elsevier B.V. All rights reserved.
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The characteristics of Camptocormia in patients with Parkinson's disease: A large cross-sectional multicenter study in Japan.
Journal of the Neurological Sciences, 2015Co-Authors: Shunya Nakane, Masaru Yoshioka, Nobuhito Oda, Takashi Tani, Keiji Chida, Mikiya Suzuki, Itaru Funakawa, Akira Inukai, Kazuko Hasegawa, Kenji KurodaAbstract:Abstract Purpose The goal of the present study was to clarify the clinical characteristics and laboratory results of parkinsonian symptoms among patients with and without Camptocormia. Methods Seventy-eight Parkinson's disease (PD) patients with Camptocormia and 78 PD patients without Camptocormia underwent a neurological examination, a blood test, and spinal magnetic resonance imaging (MRI). PD with Camptocormia group and PD with non-Camptocormia group were matched on age, age at PD onset, and sex. Principal results Camptocormia group had significantly higher prevalence of compression fractures, more severe parkinsonian symptoms, and a greater incidence of dementia than those without Camptocormia. Serum creatine kinase levels in Camptocormia group significantly elevated compared with non-Camptocormia group. There were higher prevalence of abnormal findings in spine MRI including compression fractures and paravertebral muscle changes in Camptocormia group compared with non-Camptocormia group. Major conclusions Camptocormia is associated with a greater prevalence of compression fractures and associated with greater UPDRS part II, part III score, axial score, and lower MMSE in this cross-sectional study. Thus, it can be concluded that Camptocormia in PD is predominantly myopathic.
Hulagu Kaptan - One of the best experts on this subject based on the ideXlab platform.
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Camptocormia and deep brain stimulation: The interesting overlapping etiologies and the therapeutic role of subthalamic nucleus-deep brain stimulation in Parkinson disease with Camptocormia.
Surgical neurology international, 2016Co-Authors: Hakan Ekmekci, Hulagu KaptanAbstract:Camptocormia is known as "bent spine syndrome" and defined as a forward hyperflexion. The most common etiologic factor is related with the movement disorders, mainly in Parkinson's disease (PD). We present the case of a 51-year-old woman who has been followed with PD for the last 10 years, and also under the therapy for PD. An unappreciated correlation low back pain with Camptocormia developed. She underwent deep brain stimulation (DBS) in the subthalamic nucleus bilaterally and improved her bending posture. The relationship between the DBS and Camptocormia is discussed in this unique condition.
Hui-fang Shang - One of the best experts on this subject based on the ideXlab platform.
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Predictors of Camptocormia in patients with Parkinson's disease: A prospective study from southwest China.
Parkinsonism & related disorders, 2018Co-Authors: Hui Liu, Wei Song, Bi Zhao, Bei Cao, Yongping Chen, Qianqian Wei, Yanbing Hou, Xiaoqin Yuan, Hui-fang ShangAbstract:Abstract Background Camptocormia is becoming increasingly recognized as a prominent phenomenon in Parkinson's disease (PD). Objective This study aims to investigate the clinical predictors of future Camptocormia in a cohort of PD patients. Methods A total of 263 PD patients without Camptocormia were prospectively monitored for approximately 3 years. The end-point was the occurrence of Camptocormia. Results Overall, Camptocormia was observed in 23 patients (8.7%) during the study period. The following variables including the proportion of males; age; disease duration; total levodopa equivalent daily dosage; Unified PD Rating Scale (UPDRS) III score; Hoehn and Yahr stage; the percentages of festination, freezing of gait and falls; and the subscores (e.g., “problems having sex”) and frequencies (e.g., “forget to do things”) of the Non-Motor Symptoms Scale were significantly higher in patients with Camptocormia compared to those variables in patients without Camptocormia ( P P P = 0.001), a higher UPDRS III score (OR = 1.099, P = 0.001), a higher sexual dysfunction score (OR = 1.033, P = 0.038) and a lower orientation score (OR = 0.392, P = 0.018). Conclusions Camptocormia may emerge as PD progresses. Male patients and those with sexual dysfunction or disorientation are likely to present with Camptocormia in the future.
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Characteristics of non-motor symptoms in patients with Parkinson's disease exhibiting Camptocormia
Gait & posture, 2014Co-Authors: Xiaoyan Guo, Wei Song, Bi Zhao, Bei Cao, Qianqian Wei, Na Shao, Hui-fang ShangAbstract:Abstract Objective This study aims to investigate the differences in the prevalence and severity of NMS between patients with Parkinson's disease (PD) who manifest Camptocormia and those who do not manifest Camptocormia. Methods A total of 50 PD patients with Camptocormia and 50 gender and disease duration 1:1 matched patients with PD but without Camptocormia were included in this case–control study. The severity of motor symptoms was assessed with the Unified PD Rating Scale (UPDRS) part III and Hoehn and Yahr (H&Y) staging. The prevalence and severity of NMS were assessed with non-motor symptom scale (NMSS). Results Patients with PD exhibiting Camptocormia showed significantly higher scores in UPDRS part III and H&Y staging than those who do not exhibit Camptocormia ( P P P Conclusions PD patients manifesting Camptocormia are likely subjected to NMS than patients without Camptocormia, especially autonomic and miscellaneous symptoms. These patients also suffered from more severe neuropsychiatric symptoms and sleep disorders.
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Camptocormia in Chinese patients with Parkinson's disease.
Journal of the neurological sciences, 2013Co-Authors: Wei Song, Xiaoyan Guo, Ke Chen, Rui Huang, Bi Zhao, Bei Cao, Yongping Chen, Hui-fang ShangAbstract:To investigate the frequency and clinical characteristics of Camptocormia in Chinese PD patients, we included 705 patients with PD and studied the clinical features and prevalence of Camptocormia. Forty-six (6.5%) patients presented with Camptocormia at the time of evaluation. The mean disease duration of PD patients with Camptocormia was significantly longer than that without Camptocormia (P < 0.01). After adjusted for age and disease duration, compared with patients without Camptocormia, PD patients with Camptocormia presented with higher score of UPDRS part III (P < 0.01), higher H&Y stage (P < 0.01), higher score of Non-Motor Symptoms Scale (P < 0.01) and lower score of Mini-Mental Status Examination (P < 0.01). Binary logistic regression models indicated that Camptocormia is associated with higher H&Y stage and UPDRS part III score. Camptocormia is not rare (6.5%) with the disease progression of PD in Chinese PD population and is associated with more advanced PD.