The Experts below are selected from a list of 24930 Experts worldwide ranked by ideXlab platform
K. Takeshita - One of the best experts on this subject based on the ideXlab platform.
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Clinicopathologic features of gastric Cancer infiltrating the lower esophagus
World journal of surgery, 1994Co-Authors: K. Takeshita, Habu H, Naoya Saito, M. Sunagawa, Toshihisa Ashikawa, Masao Tani, Michio Maruyama, Mitsuo EndoAbstract:A total of 211 patients with gastric Cancer in the upper third of the stomach were clinicopathologically evaluated. Of the 211 patients, 82 had esophageal Infiltration and 129 did not. These two groups were compared. The study on patients who had undergone resection and radioisotope (99mTc-phytate) uptake testing revealed that it was important to dissect the lymph nodes (predominantly nodes 7,9,11, and 16) during surgery in the patients with gastric Cancer plus esophageal Infiltration. When Cancer Infiltration of the esophagus exceeds 1 cm, the preferred surgical procedure is lower esophagectomy and total gastrectomy with abdominal and intrathoracic lymphadenectomy via the left thoracoabdominal approach. When residual Cancer is suggested in the more proximal esophageal stump due to intramural metastasis from vascular invasion, rapid pathologic diagnosis should be made by frozen sections during surgery and then subtotal esophagectomy by blunt removal of the esophagus proximally from the aortic arch using a left thoracotomy considered.
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Endoscopic evaluation of gastric Cancer infiltrating the lower esophagus
Surgical Endoscopy, 1992Co-Authors: K. Takeshita, M. Sunagawa, H. Habu, N. Saito, T. Honda, M. Iida, S. Watanuki, M. EndoAbstract:Endoscopic and histopathological findings were compared in 74 patients with gastric Cancer infiltrating the lower esophagus who had undergone gastrectomy to evaluate mode of esophageal Infiltration. There were no early Cancers. Cancer Infiltration modes were histopathologically broken down into three types: superficial, whole layer, and deep layer. Endoscopic findings were broken down into five types for proximal Infiltration. Endoseopy used for histological evaluation frequently revealed the protruded type to be whole layer and had a highly accurate diagnosis rate (94%); it revealed the histology of the other four types to be primarily superficial. Extent of Cancer invasion was underestimated in giant-rugae tumors (40%), as endoseopy could barely detect the small nest of esophageal Infiltrations. Lugol staining was useful in preventing underestimation. For flat Cancer, which is poorly demarcated and is often accompanied by vascular invasion, preoperative evaluation is very difficult, requiring preoperative examination of a frozen section taken from the proximal edge of resected specimen.
Mitsumasa Nishi - One of the best experts on this subject based on the ideXlab platform.
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How extensive should lymph node dissection be for Cancer of the thoracic esophagus
The Journal of thoracic and cardiovascular surgery, 1994Co-Authors: Toshiki Matsubara, Mamoru Ueda, Osamu Yanagida, Toshifusa Nakajima, Mitsumasa NishiAbstract:From 1985 to 1992, 171 patients with Cancer of the thoracic esophagus underwent esophagectomy with systematic dissection of regional lymph nodes including cervical nodes. The hospital mortality rate was 5.3 %. The dissected nodes were classified into four groups: the deep cervical (C), upper mediastinal and cervical paratracheal (U), middle and lower mediastinal (L), and upper perigastric (G) groups. The U group mainly consisted of nodes beside the recurrent laryngeal nerves. The phase of Cancer Infiltration of lymph nodes was evaluated by the total number and the distribution of involved nodes. Of cases with nodal involvement, only 37% were in the late phase, in which more than seven nodes or in which the U, L, and G groups were all involved. Of cases in the earliest phase in which only one node was involved, 93% had either the U or G group involved. The C group of nodes was infrequently involved until the late phase. Cancer had metastasized to the U and G groups across a considerable anatomic distance even in earlier phases. Outcomes of the cases with nodal involvement not in the late phase were satisfactory; the cumulative survival was 60% at 3 years and 54% at 5 years. Systematic nodal dissection would benefit even cases with nodal involvement, unless the disease is in the late phase. Nodes beside the recurrent nerves and upper perigastric nodes should be dissected with higher priority, though they are located anatomically distant.
Zhu Yan - One of the best experts on this subject based on the ideXlab platform.
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Ezrin mRNA expression in cervical Cancer and its significance
Journal of Modern Oncology, 2010Co-Authors: Zhu YanAbstract:Objective:To study the expression of ezrin in cervical Cancer tissues and its adjacent normal tissues and its relationship to clinical parameters.Methods:Fifty cervical Cancer tissue samples and adjacent normal tissues were collected method to detect mRNA level of ezrin by RT-PCR.Results:The expression of ezrin was up-regulated in cervical cell carcinoma tissue as compared with adjacent normal tissue(P0.01).Ezrin mRNA expression was not associated with histopathologic grade,the depth of Cancer Infiltration and lymph node metastasis(P0.05).Conclusion:ezrin mayrplay important role in cervical Cancer development,but the relation between ezrin mRNA and cervical Cancer has not been known.
Laura Cortesi - One of the best experts on this subject based on the ideXlab platform.
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Combined Hormonal Contraceptive Use and Risk of Breast Cancer in a Population of Women With a Family History.
Clinical breast cancer, 2017Co-Authors: Giovanni Grandi, Angela Toss, Angelo Cagnacci, Luigi Marcheselli, Silvia Pavesi, Fabio Facchinetti, Stefano Cascinu, Laura CortesiAbstract:Abstract Background We estimated the association between combined hormonal contraceptive (CHC) use and breast Cancer (BC) incidence in a well-selected population of women at familial risk of BC at the Modena Family Cancer Clinic. Materials and Methods We performed a retrospective cohort study by reviewing the data from 2527 women (4.5% BRCA mutation carriers, 72.2% high risk, and 23.3% intermediate risk using the Modena criteria and the Tyrer-Cuzick model). Results We did not find any specific feature of breast Cancer (Infiltration, hormone receptor and HER2 status, onset before age 35 years, multiple diagnoses) in the CHC users (P > .05). Only 2.0% of women used a preparation with ≥ 50 μg of ethinylestradiol (EE). The use of CHCs was not associated with an increased risk of breast Cancer (cumulative hazard: never used, 0.17; CHC users, 0.20; P = .998), regardless of the duration of use (cumulative hazard: never used, 0.17, used 10 years, 0.25; P = .414). This was confirmed for the different risk groups when interacted in a Cox proportional hazard regression model. The EE dose did not influence the risk of BC (cumulative hazard, 2.37; 95% confidence interval, 0.53-10.1; never used, 0.18; EE Conclusions CHC use does not increase the risk of BC in a population of women with a family history, encouraging CHC use in this group of women.
M. Endo - One of the best experts on this subject based on the ideXlab platform.
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Endoscopic evaluation of gastric Cancer infiltrating the lower esophagus
Surgical Endoscopy, 1992Co-Authors: K. Takeshita, M. Sunagawa, H. Habu, N. Saito, T. Honda, M. Iida, S. Watanuki, M. EndoAbstract:Endoscopic and histopathological findings were compared in 74 patients with gastric Cancer infiltrating the lower esophagus who had undergone gastrectomy to evaluate mode of esophageal Infiltration. There were no early Cancers. Cancer Infiltration modes were histopathologically broken down into three types: superficial, whole layer, and deep layer. Endoscopic findings were broken down into five types for proximal Infiltration. Endoseopy used for histological evaluation frequently revealed the protruded type to be whole layer and had a highly accurate diagnosis rate (94%); it revealed the histology of the other four types to be primarily superficial. Extent of Cancer invasion was underestimated in giant-rugae tumors (40%), as endoseopy could barely detect the small nest of esophageal Infiltrations. Lugol staining was useful in preventing underestimation. For flat Cancer, which is poorly demarcated and is often accompanied by vascular invasion, preoperative evaluation is very difficult, requiring preoperative examination of a frozen section taken from the proximal edge of resected specimen.
