The Experts below are selected from a list of 214758 Experts worldwide ranked by ideXlab platform
Carole Fakhry - One of the best experts on this subject based on the ideXlab platform.
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tumor infiltrating lymphocyte quantification stratifies early stage human papillomavirus oropharynx Cancer Prognosis
Laryngoscope, 2020Co-Authors: Farhoud Faraji, Nicholas Fung, Munfarid Zaidi, Christine C Gourin, David W Eisele, Lisa M Rooper, Carole FakhryAbstract:OBJECTIVES/HYPOTHESIS: To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) Cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC). STUDY DESIGN: Retrospective study. METHODS: In this study, TIL density was quantified on hematoxylin and eosin (HE aHR: 0.218; 95% CI: 0.058-0.822). TIL density similarly stratified risk in pathologically staged disease. CONCLUSIONS: In patients with AJCC8 stage I disease, low TIL density was associated with diminished RFS. Our data suggest that assessing TIL density on H&E-stained primary tumor specimens may enhance the prognostic resolution of the AJCC8 staging criteria for HPV-OPC. LEVEL OF EVIDENCE: 4 Laryngoscope, 2019.
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tumor infiltrating lymphocyte quantification stratifies early stage human papillomavirus oropharynx Cancer Prognosis
Laryngoscope, 2020Co-Authors: Farhoud Faraji, Nicholas Fung, Munfarid Zaidi, Christine C Gourin, David W Eisele, Lisa M Rooper, Carole FakhryAbstract:OBJECTIVES/HYPOTHESIS To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) Cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC). STUDY DESIGN Retrospective study. METHODS In this study, TIL density was quantified on hematoxylin and eosin (HE aHR: 0.218; 95% CI: 0.058-0.822). TIL density similarly stratified risk in pathologically staged disease. CONCLUSIONS In patients with AJCC8 stage I disease, low TIL density was associated with diminished RFS. Our data suggest that assessing TIL density on H&E-stained primary tumor specimens may enhance the prognostic resolution of the AJCC8 staging criteria for HPV-OPC. LEVEL OF EVIDENCE 4 Laryngoscope, 130:930-938, 2020.
Farhoud Faraji - One of the best experts on this subject based on the ideXlab platform.
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tumor infiltrating lymphocyte quantification stratifies early stage human papillomavirus oropharynx Cancer Prognosis
Laryngoscope, 2020Co-Authors: Farhoud Faraji, Nicholas Fung, Munfarid Zaidi, Christine C Gourin, David W Eisele, Lisa M Rooper, Carole FakhryAbstract:OBJECTIVES/HYPOTHESIS: To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) Cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC). STUDY DESIGN: Retrospective study. METHODS: In this study, TIL density was quantified on hematoxylin and eosin (HE aHR: 0.218; 95% CI: 0.058-0.822). TIL density similarly stratified risk in pathologically staged disease. CONCLUSIONS: In patients with AJCC8 stage I disease, low TIL density was associated with diminished RFS. Our data suggest that assessing TIL density on H&E-stained primary tumor specimens may enhance the prognostic resolution of the AJCC8 staging criteria for HPV-OPC. LEVEL OF EVIDENCE: 4 Laryngoscope, 2019.
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tumor infiltrating lymphocyte quantification stratifies early stage human papillomavirus oropharynx Cancer Prognosis
Laryngoscope, 2020Co-Authors: Farhoud Faraji, Nicholas Fung, Munfarid Zaidi, Christine C Gourin, David W Eisele, Lisa M Rooper, Carole FakhryAbstract:OBJECTIVES/HYPOTHESIS To evaluate if a simple method for assessing tumor-infiltrating lymphocytes (TIL) in primary tumor specimens improves the prognostic value of the American Joint Committee on Cancer, 8th Edition (AJCC8) Cancer staging system in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC). STUDY DESIGN Retrospective study. METHODS In this study, TIL density was quantified on hematoxylin and eosin (HE aHR: 0.218; 95% CI: 0.058-0.822). TIL density similarly stratified risk in pathologically staged disease. CONCLUSIONS In patients with AJCC8 stage I disease, low TIL density was associated with diminished RFS. Our data suggest that assessing TIL density on H&E-stained primary tumor specimens may enhance the prognostic resolution of the AJCC8 staging criteria for HPV-OPC. LEVEL OF EVIDENCE 4 Laryngoscope, 130:930-938, 2020.
Dominique Trudel - One of the best experts on this subject based on the ideXlab platform.
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visual and automated assessment of matrix metalloproteinase 14 tissue expression for the evaluation of ovarian Cancer Prognosis
Modern Pathology, 2014Co-Authors: Marie Plante, Dominique Trudel, Patrice Desmeules, Stephane Turcotte, Jean Gregoire, Marieclaude Renaud, Michele Orain, Isabelle Bairati, Bernard TetuAbstract:Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian Cancer Prognosis
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human epididymis protein 4 he4 and ovarian Cancer Prognosis
Gynecologic Oncology, 2012Co-Authors: Marie Plante, Dominique Trudel, Bernard Tetu, J Gregoire, M C Renaud, Dimcho Bachvarov, Pierre Douville, Isabelle BairatiAbstract:Abstract Objective A cohort study was conducted to evaluate whether preoperative plasma HE4 levels could predict the occurrence of death (primary endpoint) and progression (secondary endpoint) in women with ovarian Cancer (OC). Methods Between 1998 and 2006, we recruited 136 women newly diagnosed with OC of any FIGO stage at the University Hospital, CHUQ-L'Hotel-Dieu de Quebec, Canada. HE4 was measured using the Abbott's ARCHITECT HE4 assay. Dates of death were obtained by record linkage with the Quebec mortality files. Progression was evaluated using the CA-125 or the RECIST criteria, as recommended by the Gynecology Cancer Intergroup. Adjusted hazard ratios (HR) of death and progression, as well as their 95% confidence intervals (CI), were estimated using the Cox proportional hazard regression model. Results Preoperative levels of HE4 were strongly associated with all OC standard prognostic factors. HE4 levels increased significantly with age (p=0.02), FIGO stage (p Conclusion These results show that preoperative the plasma level of HE4 is a marker of OC aggressiveness and a predictor of death.
Antonio J Berlangataylor - One of the best experts on this subject based on the ideXlab platform.
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neutrophil to lymphocyte ratio and Cancer Prognosis an umbrella review of systematic reviews and meta analyses of observational studies
BMC Medicine, 2020Co-Authors: Meghan A Cupp, Margarita Cariolou, Ioanna Tzoulaki, Dagfinn Aune, Evangelos Evangelou, Antonio J BerlangataylorAbstract:Although neutrophils have been linked to the progression of Cancer, uncertainty exists around their association with Cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lymphocyte ratio (NLR) or tumour-associated neutrophils (TAN) and Cancer Prognosis. We searched MEDLINE, Embase and Cochrane Database of Systematic Reviews from inception to 29 May 2020 for systematic reviews and meta-analyses of observational studies on neutrophil counts (here NLR or TAN) and specific Cancer outcomes related to disease progression or survival. The available evidence was graded as strong, highly suggestive, suggestive, weak or uncertain through the application of pre-set GRADE criteria. A total of 204 meta-analyses from 86 studies investigating the association between either NLR or TAN and Cancer outcomes met the criteria for inclusion. All but one meta-analyses found a hazard ratio (HR) which increased risk (HR > 1). We did not find sufficient meta-analyses to evaluate TAN and Cancer outcomes (N = 9). When assessed for magnitude of effect, significance and bias related to heterogeneity and small study effects, 18 (9%) associations between NLR and outcomes in composite Cancer endpoints (combined analysis), Cancers treated with immunotherapy and some site specific Cancers (urinary, nasopharyngeal, gastric, breast, endometrial, soft tissue sarcoma and hepatocellular Cancers) were supported by strong evidence. In total, 60 (29%) meta-analyses presented strong or highly suggestive evidence. Although the NLR and TAN hold clinical promise in their association with poor Cancer Prognosis, further research is required to provide robust evidence, assess causality and test clinical utility. PROSPERO CRD42017069131 .
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neutrophil counts and Cancer Prognosis an umbrella review of systematic reviews and meta analyses of observational studies
bioRxiv, 2018Co-Authors: Meghan A Cupp, Margarita Cariolou, Ioanna Tzoulaki, Evangelou Evangelos, Antonio J BerlangataylorAbstract:OBJECTIVE: To evaluate the strength and validity of evidence on the association between the neutrophil to lymphocyte ratio (NLR) or tumour-associated neutrophils (TAN) and Cancer Prognosis. DESIGN: Umbrella review of systematic reviews and meta-analyses of observational studies. DATA SOURCES: Medline, EMBASE, Cochrane Database of Systematic Reviews and manual screening of retrieved references. ELIGIBILITY CRITERIA: Systematic reviews or meta-analyses of observational studies evaluating the association between NLR or TAN and specific Cancer outcomes related to disease progression or survival. DATA SYNTHESIS: The available evidence was graded as strong, highly suggestive, suggestive, or weak through the application of pre-set grading criteria. For each included meta-analysis, the grading criteria considered the significance of the random effects estimate, the significance of the largest included study, the number of studies and individuals included, the heterogeneity between included studies, the 95% prediction intervals, presence of small study effects, excess significance and credibility ceilings. RESULTS: 239 meta-analyses investigating the association between NLR or TAN and Cancer outcomes were identified from 57 published studies meeting the eligibility criteria, with 81 meta-analyses from 36 studies meeting the criteria for inclusion. No meta-analyses found a hazard ratio (HR) in the opposite direction of effect (HR<1). When assessed for significance and bias related to heterogeneity and small study effects, only three (4%) associations between NLR and outcomes in gastrointestinal and nasopharyngeal Cancers were supported by strong evidence. CONCLUSION: Despite many publications exploring the association between NLR and Cancer Prognosis, the evidence is limited by significant heterogeneity and small study effects. There is a lack of evidence on the association between TAN and Cancer Prognosis, with all nine associations identified arising from the same study. Further research is required to provide strong evidence for associations between both TAN and NLR and poor Cancer Prognosis.
Sangcheol Lee - One of the best experts on this subject based on the ideXlab platform.
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predictive value of progression related gene classifier in primary non muscle invasive bladder Cancer
Molecular Cancer, 2010Co-Authors: Wunjae Kim, Eunjung Kim, Seonkyu Kim, Yongjune Kim, Pildu Jeong, Minju Kim, Seok Joong Yun, Keon Myung Lee, Sungkwon Moon, Sangcheol LeeAbstract:Background While several molecular markers of bladder Cancer Prognosis have been identified, the limited value of current prognostic markers has created the need for new molecular indicators of bladder Cancer outcomes. The aim of this study was to identify genetic signatures associated with disease Prognosis in bladder Cancer.
