The Experts below are selected from a list of 3582 Experts worldwide ranked by ideXlab platform
J A Bruijn - One of the best experts on this subject based on the ideXlab platform.
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Surgical/pathologic-stage migration confounds comparisons of gastric Cancer Survival Rates between Japan and Western countries.
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
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surgical pathologic stage migration confounds comparisons of gastric Cancer Survival Rates between japan and western countries
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
A M G Bunt - One of the best experts on this subject based on the ideXlab platform.
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Surgical/pathologic-stage migration confounds comparisons of gastric Cancer Survival Rates between Japan and Western countries.
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
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surgical pathologic stage migration confounds comparisons of gastric Cancer Survival Rates between japan and western countries
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
Vernon M. Chinchilli - One of the best experts on this subject based on the ideXlab platform.
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Regional, racial, gender, and tumor biology disparities in breast Cancer Survival Rates in Africa: A systematic review and meta-analysis.
PLOS ONE, 2019Co-Authors: Paddy Ssentongo, Joseph A. Lewcun, Xavier Candela, Anna E. Ssentongo, Eustina G. Kwon, Djibril Ba, John S. Oh, Forster Amponsah-manu, Alicia C. Mcdonald, Vernon M. ChinchilliAbstract:BACKGROUND: The Survival Rates from breast Cancer in Africa are poor and yet the incidence Rates are on the rise. In this study, we hypothesized that, in Africa, a continent with great disparities in socio-economic status, race, tumor biology, and cultural characteristics, the Survival Rates from breast Cancer vary greatly based on region, tumor biology (hormone receptor), gender, and race. We aimed to conduct the first comprehensive systematic review and meta-analysis on region, gender, tumor-biology and race-specific 5-year breast Cancer Survival Rates in Africa and compared them to 20-year Survival trends in the United States. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library to identify studies on breast Cancer Survival in African published before October 17, 2018. Pooled 5-year Survival Rates of breast Cancer were estimated by random-effects models. We explored sources of heterogeneity through subgroup meta-analyses and meta-regression. Results were reported as absolute difference (AD) in percentages. We compared the Survival Rates of breast Cancer in Africa and the United States. FINDINGS: There were 54 studies included, consisting of 18,970 breast Cancer cases. There was substantial heterogeneity in the Survival Rates (mean 52.9%, range 7-91%, I2 = 99.1%; p for heterogeneity
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regional racial gender and tumor biology disparities in breast Cancer Survival Rates in africa a systematic review and meta analysis
PLOS ONE, 2019Co-Authors: Paddy Ssentongo, Joseph A. Lewcun, Xavier Candela, Anna E. Ssentongo, Eustina G. Kwon, Djibril Ba, John S. Oh, Alicia C. Mcdonald, Forster Amponsahmanu, Vernon M. ChinchilliAbstract:BACKGROUND: The Survival Rates from breast Cancer in Africa are poor and yet the incidence Rates are on the rise. In this study, we hypothesized that, in Africa, a continent with great disparities in socio-economic status, race, tumor biology, and cultural characteristics, the Survival Rates from breast Cancer vary greatly based on region, tumor biology (hormone receptor), gender, and race. We aimed to conduct the first comprehensive systematic review and meta-analysis on region, gender, tumor-biology and race-specific 5-year breast Cancer Survival Rates in Africa and compared them to 20-year Survival trends in the United States. METHODS: We searched MEDLINE, EMBASE, and Cochrane Library to identify studies on breast Cancer Survival in African published before October 17, 2018. Pooled 5-year Survival Rates of breast Cancer were estimated by random-effects models. We explored sources of heterogeneity through subgroup meta-analyses and meta-regression. Results were reported as absolute difference (AD) in percentages. We compared the Survival Rates of breast Cancer in Africa and the United States. FINDINGS: There were 54 studies included, consisting of 18,970 breast Cancer cases. There was substantial heterogeneity in the Survival Rates (mean 52.9%, range 7-91%, I2 = 99.1%; p for heterogeneity <0.0001). Meta-regression analyses suggested that age and gender-adjusted 5-year Survival Rates were lower in sub-Saharan Africa compared to north Africa (AD: -25.4%; 95% CI: -34.9 - -15.82%), and in predominantly black populations compared to predominantly non-black populations (AD: -25.9%; 95% CI: 35.40 - -16.43%). Survival Rates were 10 percentage points higher in the female population compared to male, but the difference was not significant. Progesterone and estrogen receptor-positive breast Cancer subtypes were positively associated with Survival (r = 0.39, p = 0.08 and r = 0.24, p = 0.29 respectively), but triple-negative breast Cancer was negatively associated with Survival. Survival Rates are increasing over time more in non-black Africans (55% in 2000 versus 65% in 2018) compared to black Africans (33% in 2000 versus 40% in 2018); but, the Survival Rates for Africans are still significantly lower when compared to black (76% in 2015) and white (90% in 2015) populations in the United States. CONCLUSION: Regional, sub-regional, gender, and racial disparities exist, influencing the Survival Rates of breast Cancer in Africa. Therefore, region and race-specific public health interventions coupled with prospective genetic studies are urgently needed to improve breast Cancer Survival in this region.
Chunming Chang - One of the best experts on this subject based on the ideXlab platform.
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the combined effect of individual and neighborhood socioeconomic status on Cancer Survival Rates
PLOS ONE, 2012Co-Authors: Chunming Chang, Yuchieh Su, Kuangyung Huang, Souhsin Chien, Yuhan Chang, Weicheng LianAbstract:Background This population-based study investigated the relationship between individual and neighborhood socioeconomic status (SES) and mortality Rates for major Cancers in Taiwan.
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multivariate analyses to assess the effects of surgeon and hospital volume on Cancer Survival Rates a nationwide population based study in taiwan
PLOS ONE, 2012Co-Authors: Chunming Chang, Yuchieh Su, Kuangyung Huang, Weizhen Yang, Tingchang Chen, Pesus ChouAbstract:Background Positive results between caseloads and outcomes have been validated in several procedures and Cancer treatments. However, there is limited information available on the combined effects of surgeon and hospital caseloads. We used nationwide population-based data to explore the association between surgeon and hospital caseloads and Survival Rates for major Cancers. Methodology A total of 11677 patients with incident Cancer diagnosed in 2002 were identified from the Taiwan National Health Insurance Research Database. Survival analysis, the Cox proportional hazards model, and propensity scores were used to assess the relationship between 5-year Survival Rates and different caseload combinations. Results Based on the Cox proportional hazard model, Cancer patients treated by low-volume surgeons in low-volume hospitals had poorer Survival Rates, and hazard ratios ranged from 1.3 in head and neck Cancer to 1.8 in lung Cancer after adjusting for patients’ demographic variables, co-morbidities, and treatment modality. When analyzed using the propensity scores, the adjusted 5-year Survival Rates were poorer for patients treated by low-volume surgeons in low-volume hospitals, compared to those treated by high-volume surgeons in high-volume hospitals (P<0.005). Conclusions After adjusting for differences in the case mix, Cancer patients treated by low-volume surgeons in low-volume hospitals had poorer 5-year Survival Rates. Payers may implement quality care improvement in low-volume surgeons.
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Multivariate analyses to assess the effects of surgeon and hospital volume on Cancer Survival Rates: a nationwide population-based study in Taiwan.
PLOS ONE, 2012Co-Authors: Chunming Chang, Yuchieh Su, Kuangyung Huang, Weizhen Yang, Tingchang Chen, Pesus ChouAbstract:Background Positive results between caseloads and outcomes have been validated in several procedures and Cancer treatments. However, there is limited information available on the combined effects of surgeon and hospital caseloads. We used nationwide population-based data to explore the association between surgeon and hospital caseloads and Survival Rates for major Cancers. Methodology A total of 11677 patients with incident Cancer diagnosed in 2002 were identified from the Taiwan National Health Insurance Research Database. Survival analysis, the Cox proportional hazards model, and propensity scores were used to assess the relationship between 5-year Survival Rates and different caseload combinations. Results Based on the Cox proportional hazard model, Cancer patients treated by low-volume surgeons in low-volume hospitals had poorer Survival Rates, and hazard ratios ranged from 1.3 in head and neck Cancer to 1.8 in lung Cancer after adjusting for patients’ demographic variables, co-morbidities, and treatment modality. When analyzed using the propensity scores, the adjusted 5-year Survival Rates were poorer for patients treated by low-volume surgeons in low-volume hospitals, compared to those treated by high-volume surgeons in high-volume hospitals (P
J Hermans - One of the best experts on this subject based on the ideXlab platform.
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Surgical/pathologic-stage migration confounds comparisons of gastric Cancer Survival Rates between Japan and Western countries.
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
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surgical pathologic stage migration confounds comparisons of gastric Cancer Survival Rates between japan and western countries
Journal of Clinical Oncology, 1995Co-Authors: A M G Bunt, J Hermans, V T H B M Smit, C J H Van De Velde, Gert Jan Fleuren, J A BruijnAbstract:PURPOSEPossible causes underlying the substantial differences in gastric Cancer Survival Rates observed between Japan and the West were examined in a randomized trial comparing the Western R1 resection with limited lymphadenectomy and the Japanese R2 resection with extended lymphadenectomy.PATIENTS AND METHODSThe effect of four factors associated with lymphadenectomy on microscopic tumor-node-metastasis (TNM) staging, and on stage-specific Survival Rates was assessed in 473 curatively resected patients.RESULTSAfter application of extended lymphadenectomy, additional information on N status was available, only in R2 resections with up-staging to N2 status in 30% of patients. The calculated effect of this stage migration on known 5-year Survival Rates was as follows: an increase of 1% in TNM stage Ia, 2% in Ib, 7% in II, 15% in IIIa, and 15% in IIIb. A further increase in Survival was observed by stage migration to N3 or N4 status, due to selective extension of lymphadenectomy to clinically overt metastases...
