The Experts below are selected from a list of 475875 Experts worldwide ranked by ideXlab platform
Zhen Cheng - One of the best experts on this subject based on the ideXlab platform.
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Optical Image-Guided Cancer Therapy
Current Pharmaceutical Biotechnology, 2014Co-Authors: Lihong Bu, Xiaowei Ma, Baozhong Shen, Yingfeng Tu, Zhen ChengAbstract:Optical molecular imaging holds great promise for image guiding Cancer Therapy. The non-invasive guidance of therapeutic strategies would enable the removal of Cancerous tissue while avoiding side effects and systemic toxicity, preventing damage of healthy tissues and decreasing the risk of postoperative problems. This review article highlights the advantages and disadvantages of the optical imaging techniques that are currently available, including their recent applications in image-guided Cancer Therapy. Three approaches for optical image-guided Cancer Therapy were discussed in this review, namely, bioluminescence imaging (BLI), fluorescence imaging (FI) and Cerenkov luminescence imaging (CLI). BLI is always used in small animal imaging for the in vivo tracking of therapeutic gene expression and cell-based Therapy. To the contrary, FI display high promising for clinical translation. The applications of FI include image-guided surgery, radioTherapy, gene Therapy, drug delivery and sentinel lymph node fluorescence mapping. CLI is a novel radioactive optical hybrid imaging strategy and its use for animal and clinical translation was also discussed. Perspectives on the translation of optical image-guided Cancer Therapy into clinical practice were provided.
Feng Jiang - One of the best experts on this subject based on the ideXlab platform.
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Gut Microbiota Shapes the Efficiency of Cancer Therapy
Frontiers in Microbiology, 2019Co-Authors: Weidong Ma, Qixing Mao, Gaochao Dong, Changhua Yu, Wenjie Xia, Feng JiangAbstract:Summary: The homeostasis of gut microbiome is linked with the balance of host immune system. Increasing evidence showed that Cancer Therapy would perturb the host immune response and result dysbiosis of immune system, which influenced the efficiency of the Therapy. The gut microbes play increasingly significant role in the Cancer Therapy with the deepening of the research, which modulate the drug efficacy, abolish the anti-Cancer effect, and mediate the toxicity. The systems biology provides an opportunity to discover of the important role the gut microbiota playing in almost all aspects of human health. The existed evidence provokes a hypothesis that gut microbiota is closely related to the pharmacological effects of chemical Therapy and novel targeted immunoTherapy. Gut microbiota shapes the efficiency of the drugs through several key mechanisms (metabolism, immunomodulation, translocation, enzymatic degradation, reduction of diversity and ecological variability). Therefore, the gut microbiota emerges as a novel target to enhance the efficacy and reduce the toxicity and adverse effect of Cancer Therapy. In this review, we outlined the role of gut microbiota in modulating Cancer Therapy and the implication in improving the efficacy of chemoTherapy and immunoTherapy in clinical practice. We also summarized the current situation that the limitations to the safety and effectiveness of probiotics in Cancer Therapy in personalized Cancer Therapy.
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Gut Microbiota Shapes the Efficiency of Cancer Therapy.
Frontiers in microbiology, 2019Co-Authors: Qixing Mao, Gaochao Dong, Wenjie Xia, Feng JiangAbstract:Systems biology provides an opportunity to discover the role that gut microbiota play in almost all aspects of human health. Existing evidence supports the hypothesis that gut microbiota is closely related to the pharmacological effects of chemical Therapy and novel targeted immunoTherapy. Gut microbiota shapes the efficiency of drugs through several key mechanisms: metabolism, immunomodulation, translocation, enzymatic degradation, reduction of diversity, and ecological variability. Therefore, gut microbiota have emerged as a novel target to enhance the efficacy and reduce the toxicity and adverse effects of Cancer Therapy. There is growing evidence to show that Cancer Therapy perturbs the host immune response and results in dysbiosis of the immune system, which then influences the efficiency of the Therapy. Studies suggest that gut microbes play a significant role in Cancer Therapy by modulating drug efficacy, abolishing the antiCancer effect, and mediating toxicity. In this review, we outline the role of gut microbiota in modulating Cancer Therapy and the implications for improving the efficacy of chemoTherapy and immunoTherapy in clinical practice. We also summarize the current limitations of the safety and effectiveness of probiotics in Cancer therapies such as personalized Cancer Therapy.
Omid C. Farokhzad - One of the best experts on this subject based on the ideXlab platform.
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Nanoparticle technologies for Cancer Therapy
Handbook of Experimental Pharmacology, 2010Co-Authors: Frank Alexis, Eric M. Pridgen, Robert Langer, Omid C. FarokhzadAbstract:Nanoparticles as drug delivery systems enable unique approaches for Cancer treatment. Over the last two decades, a large number of nanoparticle delivery systems have been developed for Cancer Therapy, including organic and inorganic materials. Many liposomal, polymer-drug conjugates, and micellar formulations are part of the state of the art in the clinics, and an even greater number of nanoparticle platforms are currently in the preclinical stages of development. More recently developed nanoparticles are demonstrating the potential sophistication of these delivery systems by incorporating multifunctional capabilities and targeting strategies in an effort to increase the efficacy of these systems against the most difficult Cancer challenges, including drug resistance and metastatic disease. In this chapter, we will review the available preclinical and clinical nanoparticle technology platforms and their impact for Cancer Therapy.
Ali Shakeri-zadeh - One of the best experts on this subject based on the ideXlab platform.
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Gold nanoparticles in combinatorial Cancer Therapy strategies
Coordination Chemistry Reviews, 2019Co-Authors: Jaber Beik, Maziar Khateri, S. Kamran Kamrava, Siavash Kooranifar, Habib Ghaznavi, Zohreh Khosravi, Ali Shakeri-zadehAbstract:Abstract Cancer is one of the most important health issues, which is the second leading cause of death in the world. Conventional Cancer Therapy methods encounter with serious drawbacks and cannot often provide satisfactory outcomes. It has been demonstrated that the effect of various treatment modalities can be enhanced when combined with nanomaterials. Moreover, a new trend is being emerged in clinical oncology to shift from monoTherapy toward combination Therapy in the presence of useful nanomaterials. This way, the synergistic interactions occur among different treatments, which result in much stronger therapeutic effect than separate use of corresponding monotherapies. Recently, gold nanoparticles (AuNPs) have been widely implemented as one of the leading nanomaterials for combinatorial Cancer Therapy. In this review article, the importance and benefits of AuNPs in the field of combinatorial Cancer Therapy are firstly explained. Then, the applications of AuNPs in the most clinically established Cancer Therapy modalities, including chemoTherapy, radioTherapy and a variety of hyperthermia methods will be described. Recent progresses in the application of AuNPs in dual- and triple-modality Cancer therapies will be reviewed. Also, a brief summary of the role of AuNPs in photodynamic Therapy and gene Therapy will be provided. Finally, the opportunities and challenges of the entry of AuNPs into the clinics for use in Cancer Therapy methods are discussed.
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Gold nanoparticles in combinatorial Cancer Therapy strategies
Coordination Chemistry Reviews, 2019Co-Authors: Jaber Beik, Maziar Khateri, S. Kamran Kamrava, Siavash Kooranifar, Habib Ghaznavi, Zohreh Khosravi, Ali Shakeri-zadehAbstract:Cancer is one of the most important health issues, which is the second leading cause of death in the world. Conventional Cancer Therapy methods encounter with serious drawbacks and cannot often provide satisfactory outcomes. It has been demonstrated that the effect of various treatment modalities can be enhanced when combined with nanomaterials. Moreover, a new trend is being emerged in clinical oncology to shift from monoTherapy toward combination Therapy in the presence of useful nanomaterials. This way, the synergistic interactions occur among different treatments, which result in much stronger therapeutic effect than separate use of corresponding monotherapies. Recently, gold nanoparticles (AuNPs) have been widely implemented as one of the leading nanomaterials for combinatorial Cancer Therapy. In this review article, the importance and benefits of AuNPs in the field of combinatorial Cancer Therapy are firstly explained. Then, the applications of AuNPs in the most clinically established Cancer Therapy modalities, including chemoTherapy, radioTherapy and a variety of hyperthermia methods will be described. Recent progresses in the application of AuNPs in dual- and triple-modality Cancer therapies will be reviewed. Also, a brief summary of the role of AuNPs in photodynamic Therapy and gene Therapy will be provided. Finally, the opportunities and challenges of the entry of AuNPs into the clinics for use in Cancer Therapy methods are discussed. © 2019 Elsevier B.V.
Lihong Bu - One of the best experts on this subject based on the ideXlab platform.
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Optical Image-Guided Cancer Therapy
Current Pharmaceutical Biotechnology, 2014Co-Authors: Lihong Bu, Xiaowei Ma, Baozhong Shen, Yingfeng Tu, Zhen ChengAbstract:Optical molecular imaging holds great promise for image guiding Cancer Therapy. The non-invasive guidance of therapeutic strategies would enable the removal of Cancerous tissue while avoiding side effects and systemic toxicity, preventing damage of healthy tissues and decreasing the risk of postoperative problems. This review article highlights the advantages and disadvantages of the optical imaging techniques that are currently available, including their recent applications in image-guided Cancer Therapy. Three approaches for optical image-guided Cancer Therapy were discussed in this review, namely, bioluminescence imaging (BLI), fluorescence imaging (FI) and Cerenkov luminescence imaging (CLI). BLI is always used in small animal imaging for the in vivo tracking of therapeutic gene expression and cell-based Therapy. To the contrary, FI display high promising for clinical translation. The applications of FI include image-guided surgery, radioTherapy, gene Therapy, drug delivery and sentinel lymph node fluorescence mapping. CLI is a novel radioactive optical hybrid imaging strategy and its use for animal and clinical translation was also discussed. Perspectives on the translation of optical image-guided Cancer Therapy into clinical practice were provided.
