The Experts below are selected from a list of 201 Experts worldwide ranked by ideXlab platform
P. Pfister - One of the best experts on this subject based on the ideXlab platform.
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Candida Meningitis/Course, Prognosis and Mortality before and after Introduction of the New Antimycotics. Die Candida Meningitis: Verlauf, Prognose und Letalität vor und nach Einführung der neuen Antimycotica
Mykosen, 2009Co-Authors: S. Buchs, P. PfisterAbstract:Summary: Screening of all the cases of Candida Meningitis accessible to the authors from the literature of the last 40 years has shown that amphotericin B and 5-fluorocytosin have lowered the mortality rate by 7 1/2 times compared with the period before 1958. The combination of amphotericin B and 5-fluorocytosin is significantly more effective than amphotericin B alone and seems to bring the mortality rate down to almost nil. The number of cures without residual mental handicap has however only doubled. Of the survivors, almost one-third still suffer long-term damage as a result of this disease, a proportion similar to that recorded in the pre-antimycotic era. Zusammenfassung: Die Sichtung samtlicher den Verfassern zuganglichen Candida-Meningitiden der Literatur der letzten 40 Jahre hat gezeigt, das Amphotericin B und 5-Fluorocytosin die Sterblichkeit, verglichen mit der Zeit vor 1958, um das 7 1/2-fache gesenkt haben. Die Kombination von Amphotericin B und 5-Fluoro-cytosin ist bedeutend wirksamer als die Applikation von Amphotericin B allein und scheint die Letalitat sogar gegen Null zu verschieben. Die Heilungen ohne Defekt sind aber nur um das Doppelte angestiegen. Von den uberlebenden tragt auch weiterhin fast ein Drittel Spatschaden davon, ahnlich wie in der vor-antimycotischen Aera.
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Candida Meningitis course prognosis and mortality before and after introduction of the new antimycotics die Candida Meningitis verlauf prognose und letalitat vor und nach einfuhrung der neuen antimycotica
Mycoses, 2009Co-Authors: S. Buchs, P. PfisterAbstract:Summary: Screening of all the cases of Candida Meningitis accessible to the authors from the literature of the last 40 years has shown that amphotericin B and 5-fluorocytosin have lowered the mortality rate by 7 1/2 times compared with the period before 1958. The combination of amphotericin B and 5-fluorocytosin is significantly more effective than amphotericin B alone and seems to bring the mortality rate down to almost nil. The number of cures without residual mental handicap has however only doubled. Of the survivors, almost one-third still suffer long-term damage as a result of this disease, a proportion similar to that recorded in the pre-antimycotic era. Zusammenfassung: Die Sichtung samtlicher den Verfassern zuganglichen Candida-Meningitiden der Literatur der letzten 40 Jahre hat gezeigt, das Amphotericin B und 5-Fluorocytosin die Sterblichkeit, verglichen mit der Zeit vor 1958, um das 7 1/2-fache gesenkt haben. Die Kombination von Amphotericin B und 5-Fluoro-cytosin ist bedeutend wirksamer als die Applikation von Amphotericin B allein und scheint die Letalitat sogar gegen Null zu verschieben. Die Heilungen ohne Defekt sind aber nur um das Doppelte angestiegen. Von den uberlebenden tragt auch weiterhin fast ein Drittel Spatschaden davon, ahnlich wie in der vor-antimycotischen Aera.
H J Lee - One of the best experts on this subject based on the ideXlab platform.
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201 Clinical Features and Radiologic Findings in Neonatal Candida Meningitis: A 8-Year Experience
Pediatric Research, 2005Co-Authors: C S Kim, S L Lee, H J LeeAbstract:Background: Candida species are becoming one of the most common pathogens associated with nosocomial infection in the neonatal intensive care units (NICU). This study was undertaken to investigate clinical features and radiologic findings of Meningitis complicating Candida sepsis in the neonates. Methods: Eighty-seven neonates with Candida sepsis were enrolled who were admitted in the NICU of Dongsan Medical Center, Keimyung University from Jan. 1997 to Dec. 2004. Retrospective analysis of the medical records and radiologic images performed. Results: The commom species of Candida sepsis were C. albicans (62%), C. parapsilosis (27%) and others such as C. guilliermondi(7%), C. glabrata (2%) and C. tropicalis (2%), and CNS involvement developed in 13(15%) of the 87 patients. Almost all the causative organism was C. albicans (92%) and the other was C. parapsilosis (8%) in 13 cases with Meningitis. Findings of CSF study at the early stage of infection were variable: pleocytosis showed in 10(77%), elevated protein and Candidal isolation in 7(54%) respectively, and hypoglycorrhachia was inconsistent. Between the two groups of patients who had Candida sepsis (group 1: with Meningitis, group 2: without Meningitis), demographic characteristics were similar distribution, but fever or seizure at onset of infection was more common in group 1 (P
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201 Clinical Features and Radiologic Findings in Neonatal Candida Meningitis: A 8-Year Experience
Pediatric Research, 2005Co-Authors: C S Kim, S L Lee, H J LeeAbstract:Background: Candida species are becoming one of the most common pathogens associated with nosocomial infection in the neonatal intensive care units (NICU). This study was undertaken to investigate clinical features and radiologic findings of Meningitis complicating Candida sepsis in the neonates.
D K Benjamin - One of the best experts on this subject based on the ideXlab platform.
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Neonatal Candida Meningitis: significance of cerebrospinal fluid parameters and blood cultures
Journal of Perinatology, 2007Co-Authors: M Cohen-wolkowiez, P B Smith, B Mangum, W J Steinbach, B D Alexander, C M Cotten, R H Clark, T J Walsh, D K BenjaminAbstract:Objective: The purpose of this study was to examine the frequency of normal cerebrospinal fluid (CSF) parameters in Candida Meningitis and the proportion of candidemia associated with Candida Meningitis. Study design: We evaluated the initial lumbar puncture results from infants discharged from 150 Neonatal Intensive Care Units between 1997 and 2004. Candida Meningitis was diagnosed by a positive CSF culture or positive Gram stain for yeast. We calculated two-tailed P -values using non-parametric testing, Mann–Whitney, Kruskal–Wallis or Fisher's exact tests where appropriate. Results: Twenty infants had culture-positive Candida Meningitis. Normal CSF parameters were found in 43% (3/7) of the infants with Candida Meningitis and only 37% (7/19) of them had positive blood cultures for Candida . Conclusion: Normal CSF parameters do not exclude the diagnosis of neonatal Candida Meningitis. The majority of infants in this cohort with Candida Meningitis did not have evidence of candidemia at the time of diagnosis.
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Neonatal Candida Meningitis: significance of cerebrospinal fluid parameters and blood cultures
Journal of perinatology : official journal of the California Perinatal Association, 2006Co-Authors: M Cohen-wolkowiez, P B Smith, B Mangum, W J Steinbach, B D Alexander, C M Cotten, R H Clark, T J Walsh, D K BenjaminAbstract:Neonatal Candida Meningitis: significance of cerebrospinal fluid parameters and blood cultures
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Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months.
Pediatrics, 2006Co-Authors: D K Benjamin, Barbara J. Stoll, Avory A. Fanaroff, Scott A. Mcdonald, Rosemary D. Higgins, Shahnaz Duara, Kenneth Poole, R. Laptook, Ronald N. GoldbergAbstract:BACKGROUND. Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported. METHODS. Data were collected prospectively for neonates born at 1 day after initiation of antifungal therapy), compared with infants whose catheters were removed or replaced promptly. CONCLUSIONS. Blood cultures were negative for approximately one half of the infants with Candida Meningitis. Persistent candidiasis was common. Delayed catheter removal was associated with increased death and NDI rates.
S. Buchs - One of the best experts on this subject based on the ideXlab platform.
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Candida Meningitis/Course, Prognosis and Mortality before and after Introduction of the New Antimycotics. Die Candida Meningitis: Verlauf, Prognose und Letalität vor und nach Einführung der neuen Antimycotica
Mykosen, 2009Co-Authors: S. Buchs, P. PfisterAbstract:Summary: Screening of all the cases of Candida Meningitis accessible to the authors from the literature of the last 40 years has shown that amphotericin B and 5-fluorocytosin have lowered the mortality rate by 7 1/2 times compared with the period before 1958. The combination of amphotericin B and 5-fluorocytosin is significantly more effective than amphotericin B alone and seems to bring the mortality rate down to almost nil. The number of cures without residual mental handicap has however only doubled. Of the survivors, almost one-third still suffer long-term damage as a result of this disease, a proportion similar to that recorded in the pre-antimycotic era. Zusammenfassung: Die Sichtung samtlicher den Verfassern zuganglichen Candida-Meningitiden der Literatur der letzten 40 Jahre hat gezeigt, das Amphotericin B und 5-Fluorocytosin die Sterblichkeit, verglichen mit der Zeit vor 1958, um das 7 1/2-fache gesenkt haben. Die Kombination von Amphotericin B und 5-Fluoro-cytosin ist bedeutend wirksamer als die Applikation von Amphotericin B allein und scheint die Letalitat sogar gegen Null zu verschieben. Die Heilungen ohne Defekt sind aber nur um das Doppelte angestiegen. Von den uberlebenden tragt auch weiterhin fast ein Drittel Spatschaden davon, ahnlich wie in der vor-antimycotischen Aera.
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Candida Meningitis course prognosis and mortality before and after introduction of the new antimycotics die Candida Meningitis verlauf prognose und letalitat vor und nach einfuhrung der neuen antimycotica
Mycoses, 2009Co-Authors: S. Buchs, P. PfisterAbstract:Summary: Screening of all the cases of Candida Meningitis accessible to the authors from the literature of the last 40 years has shown that amphotericin B and 5-fluorocytosin have lowered the mortality rate by 7 1/2 times compared with the period before 1958. The combination of amphotericin B and 5-fluorocytosin is significantly more effective than amphotericin B alone and seems to bring the mortality rate down to almost nil. The number of cures without residual mental handicap has however only doubled. Of the survivors, almost one-third still suffer long-term damage as a result of this disease, a proportion similar to that recorded in the pre-antimycotic era. Zusammenfassung: Die Sichtung samtlicher den Verfassern zuganglichen Candida-Meningitiden der Literatur der letzten 40 Jahre hat gezeigt, das Amphotericin B und 5-Fluorocytosin die Sterblichkeit, verglichen mit der Zeit vor 1958, um das 7 1/2-fache gesenkt haben. Die Kombination von Amphotericin B und 5-Fluoro-cytosin ist bedeutend wirksamer als die Applikation von Amphotericin B allein und scheint die Letalitat sogar gegen Null zu verschieben. Die Heilungen ohne Defekt sind aber nur um das Doppelte angestiegen. Von den uberlebenden tragt auch weiterhin fast ein Drittel Spatschaden davon, ahnlich wie in der vor-antimycotischen Aera.
Renya Zhan - One of the best experts on this subject based on the ideXlab platform.
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Candida Meningitis in neurosurgical patients: a single-institute study of nine cases over 7 years.
Epidemiology and infection, 2020Co-Authors: Mantao Chen, Chongchao Chen, Qing Yang, Renya ZhanAbstract:Candida Meningitis in neurosurgical patients is relatively unusual but is associated with a high mortality rate. We present our experience with this infection and discuss the clinical characteristics, treatment options and outcomes. We retrospectively reviewed neurosurgical patients with multiple positive cerebrospinal fluid (CSF) culture results in our hospital from January 2013 to December 2019. Nine patients were available for review according to our inclusion and exclusion criteria. Four species of Candida were isolated from the CSF samples and Candida albicans accounted for half of all infections. Eight infections were associated with ventricle peritoneal shunt, lumbar cistern peritoneal shunt or external ventricular drain. All of these foreign intracranial materials were removed or changed and all the patients received antifungal treatment, including fluconazole and/or voriconazole. It is associated with severe long-term outcomes in survivors and a mortality rate that reaches 11.1%. Prior treatments with broad-spectrum and high-grade antibiotics and anaemia are possible risk factors for Candida Meningitis. We advise that foreign intracranial material should be removed or changed as early as possible and the timing of re-shunt operation can be 1 month after control of Candida Meningitis has been achieved, with several negative CSF culture results.
