The Experts below are selected from a list of 25773 Experts worldwide ranked by ideXlab platform
Joseph P. Iannotti - One of the best experts on this subject based on the ideXlab platform.
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assessment of the Canine Model of rotator cuff injury and repair
Journal of Shoulder and Elbow Surgery, 2007Co-Authors: Kathleen A Derwin, Andrew R Baker, Michael J Codsi, Joseph P. IannottiAbstract:Animal shoulder Models are used to systematically investigate the factors influencing rotator cuff injury and repair. Each Model has advantages and disadvantages that must be considered in the context of the specific research questions being asked. This study evaluated the utility of the Canine Model for studies of acute, full-thickness rotator cuff tendon injury and repair. We found that time-zero failure load is dependent on the suture type and configuration used for repair. Acute, full-width tendon repairs fail anatomically within the first days after surgery in the Canine Model, regardless of suture type, suture configuration, or postoperative protocol. Robust scar tissue forms in the gap between the failed tendon end and the humerus, which can be visually, mechanically, and histologically misconstrued as tendon if an objective test of repair connectivity is not performed. We conclude that a full-width injury and repair Model in the Canine will provide a rigorous test of whether a new repair strategy or postoperative protocol, such as casting or temporary muscle paralysis, can maintain repair integrity in a high-load environment. Alternatively, a partial-width tendon injury Model allows loads to be shared between the tendon repair and the remaining intact portion of the infraspinatus tendon and prohibits complete tendon retraction. Thus a partial-width injury in the Canine may Model the mechanical environment of many single tendon tears in the human injury condition and warrants further investigation.
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changes in rotator cuff muscle volume fat content and passive mechanics after chronic detachment in a Canine Model
Journal of Bone and Joint Surgery American Volume, 2005Co-Authors: Ori Safran, Kathleen A Derwin, Kimerly A Powell, Joseph P. IannottiAbstract:BackgroundLong-standing tears of the rotator cuff can lead to substantial and perhaps irreversible changes in the affected rotator cuff muscles. We developed a chronic rotator cuff tear in a Canine Model to investigate and quantify the time-related changes in passive mechanics, volume, and fat of th
Neil G. Hockstein - One of the best experts on this subject based on the ideXlab platform.
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transoral robotic surgery tors glottic microsurgery in a Canine Model
Journal of Voice, 2006Co-Authors: Bert W Omalley, Gregory S. Weinstein, Neil G. HocksteinAbstract:Summary Objectives/Hypothesis: We hypothesize that bimanual, three-dimensional robotic surgery will prove valuable for glottic microsurgical procedures. Study Design: To test this hypothesis, we developed and optimized a Canine Model for glottic microsurgery using a commercially available surgical robot. Methods Using a da Vinci Surgical Robot (Intuitive Surgical, Inc., Sunnyvale, CA), glottic microsurgery was performed with a hydrodissection technique in a Canine Model. The experiments were performed on two orotracheal intubated mongrel dogs under general anesthesia in the supine position on a standard operating room table. A videoscope and two, 360-degree rotating, 5- and 8-mm, wrested-end effector instruments were introduced transorally with three robotic arms. The surgeon performed the actual procedures while positioned at a robotic system console that was located across the operating room suite. The procedure was performed in duplicate and was documented with still and video photography. Results: Glottic microsurgery was successfully performed using the da Vinci Surgical Robot, with both 5- and 8-mm instrumentation. The smaller, 5-mm instruments afforded greater visualization of the operative site and increased maneuverability, which resulted in reduced operative time. The robotic system provided excellent visualization as well as controlled and delicate microdissection at the vocal cord level. Conclusions: Robotic laryngeal microsurgery is technically feasible in the Canine Model and warrants consideration for evaluation in controlled human trials.
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Transoral Robotic Surgery: Supraglottic Laryngectomy in a Canine Model
The Laryngoscope, 2005Co-Authors: Gregory S. Weinstein, Bert W. O'malley, Neil G. HocksteinAbstract:Objectives/Hypothesis: To develop a technique for computer enhanced robotic transoral supraglottic partial laryngectomy in the Canine Model. Study Design: Surgical procedure on the larynx in a Canine Model with a commercially available surgical robot. Methods: With use of the da Vinci Surgical Robot (Intuitive Surgical, Inc., Sunnyvale, CA), the supraglottic partial laryngectomy was performed on a mongrel dog that had been orotracheally intubated using general anesthesia. The videoscope and the 8 mm end-effectors of the robotic system were introduced through three ports, transorally. The surgical procedure was performed remotely from the robotic system console. The procedure was documented with still and video photography. Results: Supraglottic partial laryngectomy was successfully performed using the da Vinci Surgical Robot, with 8 mm instrumentation. The robotic system allowed for celerity and accuracy secondary to findings specific to the surgical approach, including excellent hemostasis, superb visualization of the operative field with expeditious identification of laryngeal submucosal soft tissue and skeletal landmarks, and multiplanar transection of tissues. In addition, the use of the robotic system also was found to have technical advantages inherent in robotic surgery, including the use of “wristed” instrumentation, tremor abolition, motion scaling, and three-dimensional vision. Conclusions: The da Vinci Surgical Robot allowed for successful robotic transoral supraglottic partial laryngectomy in the Canine Model.
Kathleen A Derwin - One of the best experts on this subject based on the ideXlab platform.
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assessment of the Canine Model of rotator cuff injury and repair
Journal of Shoulder and Elbow Surgery, 2007Co-Authors: Kathleen A Derwin, Andrew R Baker, Michael J Codsi, Joseph P. IannottiAbstract:Animal shoulder Models are used to systematically investigate the factors influencing rotator cuff injury and repair. Each Model has advantages and disadvantages that must be considered in the context of the specific research questions being asked. This study evaluated the utility of the Canine Model for studies of acute, full-thickness rotator cuff tendon injury and repair. We found that time-zero failure load is dependent on the suture type and configuration used for repair. Acute, full-width tendon repairs fail anatomically within the first days after surgery in the Canine Model, regardless of suture type, suture configuration, or postoperative protocol. Robust scar tissue forms in the gap between the failed tendon end and the humerus, which can be visually, mechanically, and histologically misconstrued as tendon if an objective test of repair connectivity is not performed. We conclude that a full-width injury and repair Model in the Canine will provide a rigorous test of whether a new repair strategy or postoperative protocol, such as casting or temporary muscle paralysis, can maintain repair integrity in a high-load environment. Alternatively, a partial-width tendon injury Model allows loads to be shared between the tendon repair and the remaining intact portion of the infraspinatus tendon and prohibits complete tendon retraction. Thus a partial-width injury in the Canine may Model the mechanical environment of many single tendon tears in the human injury condition and warrants further investigation.
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changes in rotator cuff muscle volume fat content and passive mechanics after chronic detachment in a Canine Model
Journal of Bone and Joint Surgery American Volume, 2005Co-Authors: Ori Safran, Kathleen A Derwin, Kimerly A Powell, Joseph P. IannottiAbstract:BackgroundLong-standing tears of the rotator cuff can lead to substantial and perhaps irreversible changes in the affected rotator cuff muscles. We developed a chronic rotator cuff tear in a Canine Model to investigate and quantify the time-related changes in passive mechanics, volume, and fat of th
Kangyin Chen - One of the best experts on this subject based on the ideXlab platform.
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Protective Effects of Aliskiren on Atrial Ionic ReModeling in a Canine Model of Rapid Atrial Pacing
Cardiovascular drugs and therapy, 2014Co-Authors: Zhiqiang Zhao, Xinghua Wang, Wansong Yang, Lijun Cheng, Yan Chen, Tong Liu, Enzhao Liu, Kangyin ChenAbstract:Purpose Aliskiren inhibits the activation of the renin-angiotensin system. Here, we investigated the effects of aliskiren on chronic atrial iron reModeling in the experimental Canine Model of rapid atrial pacing.
Suli Gao - One of the best experts on this subject based on the ideXlab platform.
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Effect of c-Ski on atrial reModelling in a rapid atrial pacing Canine Model.
Journal of cellular and molecular medicine, 2019Co-Authors: Juan Wang, Min Han, Su‐xia Han, Cuiju Zhi, Suli GaoAbstract:Atrial fibrosis is an important factor in the initiation and maintenance of atrial fibrillation (AF); therefore, understanding the pathogenesis of atrial fibrosis may reveal promising therapeutic targets for AF. In this study, we successfully established a rapid atrial pacing Canine Model and found that the inducibility and duration of AF were significantly reduced by the overexpression of c-Ski, suggesting that this approach may have therapeutic effects. c-Ski was found to be down-regulated in the atrial tissues of the rapid atrial pacing Canine Model. We artificially up-regulated c-Ski expression with a c-Ski-overexpressing adenovirus. Haematoxylin and eosin, Masson's trichrome and picrosirius red staining showed that c-Ski overexpression alleviated atrial fibrosis. Furthermore, we found that the expression levels of collagen III and α-SMA were higher in the groups of dogs subjected to right-atrial pacing, and this increase was attenuated by c-Ski overexpression. In addition, c-Ski overexpression decreased the phosphorylation of smad2, smad3 and p38 MAPK (p38α and p38β) as well as the expression of TGF-β1 in atrial tissues, as shown by a comparison of the right-atrial pacing + c-Ski-overexpression group to the control group with right-atrial pacing only. These results suggest that c-Ski overexpression improves atrial reModelling in a rapid atrial pacing Canine Model by suppressing TGF-β1-Smad signalling and p38 MAPK activation.
