The Experts below are selected from a list of 195 Experts worldwide ranked by ideXlab platform
Anne Greenough - One of the best experts on this subject based on the ideXlab platform.
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G11 Lung function, transfusion, pulmonary Capillary Blood volume and sickle cell disease
Archives of Disease in Childhood, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Aims Sickle cell disease is the most common inherited disorder in African and Caribbean populations. Restrictive lung function abnormalities become increasingly common in older patients and indeed are characteristic of sickle chronic lung disease. Young children with SCD, however, frequently have obstructive lung function abnormalities. It is not clear whether the obstructive abnormalities are due to asthma or the elevated pulmonary Capillary Blood volume seen in SCD children because of their chronic anaemia. Such data are essential to determine the most effective preventative strategies. Hence, our aim was to investigate whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and this was associated with increased airways obstruction. Methods Measurements of respiratory system resistance and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6–18.5) years. The respiratory system resistance was measured using impulse oscillometry and a frequency of 5 Hz (Rrs5) and was used to assess small airway function. Lung function results were expressed as the percent predicted for height. Pulmonary Capillary Blood volume was measured using the single breath-hold method for gas transfer for carbon monoxide (DLCO) and nitric oxide (DLNO). Pulmonary membrane diffusing capacity (DMCO) and pulmonary Capillary Blood volume (PCBV) were then determined using the Roughton-Forster model. Results Post transfusion, the median Rrs5 increased from 127.4 to 141.3% predicted for height (p Conclusion Significant increases in pulmonary Capillary Blood volume and respiratory system resistance occurred immediately following Blood transfusion in children with SCD. Furthermore, the increase in respiratory system resistance significantly correlated with the increase in pulmonary Capillary Blood volume. These results provide evidence of a potential interaction between the increased pulmonary Capillary Blood volume and pulmonary function abnormalities seen in SCD children.
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lung function transfusion pulmonary Capillary Blood volume and sickle cell disease
Respiratory Physiology & Neurobiology, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Lung function abnormalities occur in children with sickle cell disease (SCD) and may be associated with elevated pulmonary Blood volume. To investigate that association, we determined whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and increased respiratory system resistance (Rrs5). Measurements of Rrs5 and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6-18.5) years. Diffusing capacity for carbon monoxide and nitric oxide were assessed to calculate the PCBV. Post transfusion, the median Rrs5 had increased from 127.4 to 141.3% predicted (p<0.0001) and pulmonary Capillary Blood volume from 39.7 to 64.1 ml/m2 (p<0.0001); forced expiratory volume in one second (p=0.0056) and vital capacity (p=0.0008) decreased. The increase in Rrs5 correlated with the increase in PCBV (r=0.50, p=0.0493). Increased pulmonary Capillary Blood volume may at least partially explain the lung function abnormalities in SCD children.
Gerwin J. Puppels - One of the best experts on this subject based on the ideXlab platform.
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Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow in the acute respiratory distress syndrome.
Critical Care Medicine, 2000Co-Authors: Karan J.k. Kanhai, Henk Strijdhorst, Jan C. Pompe, Wim P.j. Holland, Gerwin J. PuppelsAbstract:OBJECTIVE: Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. DESIGN: Experimental animal study. SETTING: University center for animal experiments. INTERVENTIONS: In 12 mechanically ventilated pigs, the nonshunted pulmonary Capillary Blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure. MEASUREMENTS AND MAIN RESULTS: Nonshunted pulmonary Capillary Blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r2 varied between .58 and .94; p < .01). The trend in the development of nonshunted pulmonary Capillary Blood flow as measured with AART was in agreement with the trend detected by cardiac output corrected for venous admixture in 92% of all events. CONCLUSIONS: We conclude that AART can be used to monitor changes in nonshunted pulmonary Capillary Blood flow in cases of acute respiratory distress syndrome noninvasively and continuously.
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Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow in the acute respiratory distress syndrome.
Critical care medicine, 2000Co-Authors: Karan J.k. Kanhai, Henk Strijdhorst, Jan C. Pompe, Wim P.j. Holland, Eveline G. J. Ong, Gerwin J. PuppelsAbstract:Objective: Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. Design: Experimental animal study Setting: University center for animal experiments Interventions: In 12 mechanically ventilated pigs, the nonshunted pulmonary Capillary Blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure. Measurements and Main Results: Nonshunted pulmonary Capillary Blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r2 varied between .58 and .94; p
Alan Lunt - One of the best experts on this subject based on the ideXlab platform.
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G11 Lung function, transfusion, pulmonary Capillary Blood volume and sickle cell disease
Archives of Disease in Childhood, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Aims Sickle cell disease is the most common inherited disorder in African and Caribbean populations. Restrictive lung function abnormalities become increasingly common in older patients and indeed are characteristic of sickle chronic lung disease. Young children with SCD, however, frequently have obstructive lung function abnormalities. It is not clear whether the obstructive abnormalities are due to asthma or the elevated pulmonary Capillary Blood volume seen in SCD children because of their chronic anaemia. Such data are essential to determine the most effective preventative strategies. Hence, our aim was to investigate whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and this was associated with increased airways obstruction. Methods Measurements of respiratory system resistance and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6–18.5) years. The respiratory system resistance was measured using impulse oscillometry and a frequency of 5 Hz (Rrs5) and was used to assess small airway function. Lung function results were expressed as the percent predicted for height. Pulmonary Capillary Blood volume was measured using the single breath-hold method for gas transfer for carbon monoxide (DLCO) and nitric oxide (DLNO). Pulmonary membrane diffusing capacity (DMCO) and pulmonary Capillary Blood volume (PCBV) were then determined using the Roughton-Forster model. Results Post transfusion, the median Rrs5 increased from 127.4 to 141.3% predicted for height (p Conclusion Significant increases in pulmonary Capillary Blood volume and respiratory system resistance occurred immediately following Blood transfusion in children with SCD. Furthermore, the increase in respiratory system resistance significantly correlated with the increase in pulmonary Capillary Blood volume. These results provide evidence of a potential interaction between the increased pulmonary Capillary Blood volume and pulmonary function abnormalities seen in SCD children.
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lung function transfusion pulmonary Capillary Blood volume and sickle cell disease
Respiratory Physiology & Neurobiology, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Lung function abnormalities occur in children with sickle cell disease (SCD) and may be associated with elevated pulmonary Blood volume. To investigate that association, we determined whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and increased respiratory system resistance (Rrs5). Measurements of Rrs5 and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6-18.5) years. Diffusing capacity for carbon monoxide and nitric oxide were assessed to calculate the PCBV. Post transfusion, the median Rrs5 had increased from 127.4 to 141.3% predicted (p<0.0001) and pulmonary Capillary Blood volume from 39.7 to 64.1 ml/m2 (p<0.0001); forced expiratory volume in one second (p=0.0056) and vital capacity (p=0.0008) decreased. The increase in Rrs5 correlated with the increase in PCBV (r=0.50, p=0.0493). Increased pulmonary Capillary Blood volume may at least partially explain the lung function abnormalities in SCD children.
Karan J.k. Kanhai - One of the best experts on this subject based on the ideXlab platform.
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Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow in the acute respiratory distress syndrome.
Critical Care Medicine, 2000Co-Authors: Karan J.k. Kanhai, Henk Strijdhorst, Jan C. Pompe, Wim P.j. Holland, Gerwin J. PuppelsAbstract:OBJECTIVE: Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. DESIGN: Experimental animal study. SETTING: University center for animal experiments. INTERVENTIONS: In 12 mechanically ventilated pigs, the nonshunted pulmonary Capillary Blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure. MEASUREMENTS AND MAIN RESULTS: Nonshunted pulmonary Capillary Blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r2 varied between .58 and .94; p < .01). The trend in the development of nonshunted pulmonary Capillary Blood flow as measured with AART was in agreement with the trend detected by cardiac output corrected for venous admixture in 92% of all events. CONCLUSIONS: We conclude that AART can be used to monitor changes in nonshunted pulmonary Capillary Blood flow in cases of acute respiratory distress syndrome noninvasively and continuously.
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Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow in the acute respiratory distress syndrome.
Critical care medicine, 2000Co-Authors: Karan J.k. Kanhai, Henk Strijdhorst, Jan C. Pompe, Wim P.j. Holland, Eveline G. J. Ong, Gerwin J. PuppelsAbstract:Objective: Noninvasive monitoring of nonshunted pulmonary Capillary Blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome. Design: Experimental animal study Setting: University center for animal experiments Interventions: In 12 mechanically ventilated pigs, the nonshunted pulmonary Capillary Blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure. Measurements and Main Results: Nonshunted pulmonary Capillary Blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r2 varied between .58 and .94; p
Emily Mcghee - One of the best experts on this subject based on the ideXlab platform.
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G11 Lung function, transfusion, pulmonary Capillary Blood volume and sickle cell disease
Archives of Disease in Childhood, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Aims Sickle cell disease is the most common inherited disorder in African and Caribbean populations. Restrictive lung function abnormalities become increasingly common in older patients and indeed are characteristic of sickle chronic lung disease. Young children with SCD, however, frequently have obstructive lung function abnormalities. It is not clear whether the obstructive abnormalities are due to asthma or the elevated pulmonary Capillary Blood volume seen in SCD children because of their chronic anaemia. Such data are essential to determine the most effective preventative strategies. Hence, our aim was to investigate whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and this was associated with increased airways obstruction. Methods Measurements of respiratory system resistance and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6–18.5) years. The respiratory system resistance was measured using impulse oscillometry and a frequency of 5 Hz (Rrs5) and was used to assess small airway function. Lung function results were expressed as the percent predicted for height. Pulmonary Capillary Blood volume was measured using the single breath-hold method for gas transfer for carbon monoxide (DLCO) and nitric oxide (DLNO). Pulmonary membrane diffusing capacity (DMCO) and pulmonary Capillary Blood volume (PCBV) were then determined using the Roughton-Forster model. Results Post transfusion, the median Rrs5 increased from 127.4 to 141.3% predicted for height (p Conclusion Significant increases in pulmonary Capillary Blood volume and respiratory system resistance occurred immediately following Blood transfusion in children with SCD. Furthermore, the increase in respiratory system resistance significantly correlated with the increase in pulmonary Capillary Blood volume. These results provide evidence of a potential interaction between the increased pulmonary Capillary Blood volume and pulmonary function abnormalities seen in SCD children.
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lung function transfusion pulmonary Capillary Blood volume and sickle cell disease
Respiratory Physiology & Neurobiology, 2016Co-Authors: Alan Lunt, Emily Mcghee, Polly Robinson, Sue Height, David C Rees, Anne GreenoughAbstract:Lung function abnormalities occur in children with sickle cell disease (SCD) and may be associated with elevated pulmonary Blood volume. To investigate that association, we determined whether Blood transfusion in SCD children acutely increased pulmonary Capillary Blood volume (PCBV) and increased respiratory system resistance (Rrs5). Measurements of Rrs5 and spirometry were made before and after Blood transfusion in 18 children, median age 14.2 (6.6-18.5) years. Diffusing capacity for carbon monoxide and nitric oxide were assessed to calculate the PCBV. Post transfusion, the median Rrs5 had increased from 127.4 to 141.3% predicted (p<0.0001) and pulmonary Capillary Blood volume from 39.7 to 64.1 ml/m2 (p<0.0001); forced expiratory volume in one second (p=0.0056) and vital capacity (p=0.0008) decreased. The increase in Rrs5 correlated with the increase in PCBV (r=0.50, p=0.0493). Increased pulmonary Capillary Blood volume may at least partially explain the lung function abnormalities in SCD children.
