The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Srinivas R Sadda - One of the best experts on this subject based on the ideXlab platform.
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swept source oct angiography imaging of the macular Capillary Network in glaucoma
British Journal of Ophthalmology, 2018Co-Authors: Handan Akil, Srinivas R Sadda, Vikas Chopra, Mayss Alsheikh, Khalil Ghasemi Falavarjani, Alex S Huang, Brian A FrancisAbstract:Purpose To evaluate the macular Capillary Network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects. Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL. Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p 0.05). Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma.
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swept source oct angiography imaging of the foveal avascular zone and macular Capillary Network density in diabetic retinopathy
Investigative Ophthalmology & Visual Science, 2016Co-Authors: Mayss Alsheikh, Handan Akil, Maximilian Pfau, Srinivas R SaddaAbstract:PURPOSE We compared the area of the foveal avascular zone (FAZ) and macular Capillary Network density at different retinal layers using swept-source optical coherence tomography angiography (OCT-A) in normal individuals and patients with diabetic retinopathy (DR). METHODS Images (a 3 × 3 mm cube centered on the fovea) were acquired in 40 eyes of 22 normal individuals and 28 eyes of 18 patients with varying levels of DR using a swept-source OCT-A device (central wavelength 1050 nm; A-scan-rate of 100,000 scans per second). En face images of the retinal vasculature were generated from the superficial and deep retinal layers (SRL/DRL). Quantitative analysis of the vessel density (VD) and FAZ area was performed. Vessel density was assessed as the ratio of the retinal area occupied by vessels. RESULTS Among the DR subjects (mean age, 72 years; 61% male), 35.7% of the eyes had mild, 35.7% moderate, and 7.1% severe nonproliferative DR (NPDR), and 21.4% and proliferative DR (PDR). The mean FAZ area in patients with DR and in normal individuals was 0.518 and 0.339 mm2, respectively, for the SRL (P = 0.003), and 0.615 and 0.358 mm2, respectively, for the DRL (P < 0.001). The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with DR (SRL, P < 0.001; DRL, P = 0.028). CONCLUSIONS Swept-source OCT-A of the microcirculation in eyes of patients with DR can be used to quantitatively demonstrate alterations in the FAZ and VD in the SRL/DRL of the macula compared to normal eyes. Future longitudinal studies may use these metrics to evaluate changes over time or in response to treatment.
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noninvasive visualization and analysis of the human parafoveal Capillary Network using swept source oct optical microangiography
Investigative Ophthalmology & Visual Science, 2015Co-Authors: Laura Kuehlewein, Tudor Tepelus, Lin An, Mary K Durbin, Sowmya Srinivas, Srinivas R SaddaAbstract:PURPOSE. We characterized the foveal avascular zone (FAZ) and the parafoveal Capillary Network in healthy subjects using swept source OCT optical microangiography (OMAG). METHODS. We acquired OMAG images of the macula of 19 eyes (13 healthy individuals) using a prototype swept source laser OCT. En face images of the retinal vasculature were generated for superficial and deep inner retinal layers (SRL/DRL) in regions of interest 250 (ROI-250) and 500 (ROI-500) lm from the FAZ border. RESULTS. The mean area (mm 2 ) of the FAZ was 0.304 6 0.132 for the SRL and 0.486 6 0.162 for the DRL (P < 0.001). Mean vessel density (%) was 67.3 6 6.4 for the SRL and 34.5 6 8.6 for the DRL in the ROI-250 (P < 0.001), and 74.2 6 3.9 for the SRL and 72.3 6 4.9 for the DRL in the ROI-500 (P ¼ 0.160). CONCLUSIONS. Swept source OMAG images of healthy subjects allowed analysis of the FAZ and the density of the parafoveal Capillary Network at different retinal layers.
Austin Roorda - One of the best experts on this subject based on the ideXlab platform.
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disruption of the retinal parafoveal Capillary Network in type 2 diabetes before the onset of diabetic retinopathy
Investigative Ophthalmology & Visual Science, 2011Co-Authors: Kavita P Dhamdhere, Pavan Tiruveedhula, Silvestre Manzanera, Shirin Barez, Marcus A Bearse, Anthony J Adams, Austin RoordaAbstract:Purpose. To establish, using adaptive optics scanning laser ophthalmoscopy (AOSLO), that the retinal parafoveal Capillary Network is altered before the onset of diabetic retinopathy in adult patients with type 2 diabetes.
Fumihiko Kajiya - One of the best experts on this subject based on the ideXlab platform.
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regression of Capillary Network in atrophied soleus muscle induced by hindlimb unweighting
Journal of Applied Physiology, 2005Co-Authors: Hidemi Fujino, Hisaharu Kohzuki, Isao Takeda, Takahiko Kiyooka, Takehiro Miyasaka, Satoshi Mohri, Juichiro Shimizu, Fumihiko KajiyaAbstract:Little is known about the mechanisms responsible for the adaptation and changes in the Capillary Network of hindlimb unweighting (HU)-induced atrophied skeletal muscle, especially the coupling betw...
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Regression of Capillary Network in atrophied soleus muscle induced by hindlimb unweighting
Journal of Applied Physiology, 2004Co-Authors: Hidemi Fujino, Hisaharu Kohzuki, Isao Takeda, Takahiko Kiyooka, Takehiro Miyasaka, Satoshi Mohri, Juichiro Shimizu, Fumihiko KajiyaAbstract:Little is known about the mechanisms responsible for the adaptation and changes in the Capillary Network of hindlimb unweighting (HU)-induced atrophied skeletal muscle, especially the coupling between functional and structural alterations of interCapillary anastomoses and tortuosity of capillaries. We hypothesized that muscle atrophy by HU leads to the apoptotic regression of the capillaries and interCapillary anastomoses with their functional alteration in hemodynamics. To clarify the three-dimensional architecture of the Capillary Network, contrast medium-injected rat soleus muscles were visualized clearly using a confocal laser scanning microscope, and sections were stained by terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) and with anti-von Willebrand factor. In vivo, the red blood cell velocity of soleus muscle capillaries were determined with a pencil-lens intravital microscope brought into direct contact with the soleus surface. After HU, the total muscle mass, myofibril protein mass, and slow-type myosin heavy chain content were significantly lower. The number of capillaries paralleling muscle fiber and red blood cells velocity were higher in atrophied soleus. However, the mean Capillary volume and Capillary luminal diameter were significantly smaller after HU than in the age-matched control group. In addition, we found that the number of anastomoses and the tortuosity were significantly lower and TUNEL-positive endothelial cells were observed in atrophied soleus muscles, especially the anastomoses and/or tortuous capillaries. These results indicate that muscle atrophy by HU generates structural alterations in the Capillary Network, and apoptosis appears to occur in the endothelial cell of the muscle capillaries.
Mayss Alsheikh - One of the best experts on this subject based on the ideXlab platform.
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swept source oct angiography imaging of the macular Capillary Network in glaucoma
British Journal of Ophthalmology, 2018Co-Authors: Handan Akil, Srinivas R Sadda, Vikas Chopra, Mayss Alsheikh, Khalil Ghasemi Falavarjani, Alex S Huang, Brian A FrancisAbstract:Purpose To evaluate the macular Capillary Network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects. Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL. Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p 0.05). Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma.
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swept source oct angiography imaging of the foveal avascular zone and macular Capillary Network density in diabetic retinopathy
Investigative Ophthalmology & Visual Science, 2016Co-Authors: Mayss Alsheikh, Handan Akil, Maximilian Pfau, Srinivas R SaddaAbstract:PURPOSE We compared the area of the foveal avascular zone (FAZ) and macular Capillary Network density at different retinal layers using swept-source optical coherence tomography angiography (OCT-A) in normal individuals and patients with diabetic retinopathy (DR). METHODS Images (a 3 × 3 mm cube centered on the fovea) were acquired in 40 eyes of 22 normal individuals and 28 eyes of 18 patients with varying levels of DR using a swept-source OCT-A device (central wavelength 1050 nm; A-scan-rate of 100,000 scans per second). En face images of the retinal vasculature were generated from the superficial and deep retinal layers (SRL/DRL). Quantitative analysis of the vessel density (VD) and FAZ area was performed. Vessel density was assessed as the ratio of the retinal area occupied by vessels. RESULTS Among the DR subjects (mean age, 72 years; 61% male), 35.7% of the eyes had mild, 35.7% moderate, and 7.1% severe nonproliferative DR (NPDR), and 21.4% and proliferative DR (PDR). The mean FAZ area in patients with DR and in normal individuals was 0.518 and 0.339 mm2, respectively, for the SRL (P = 0.003), and 0.615 and 0.358 mm2, respectively, for the DRL (P < 0.001). The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with DR (SRL, P < 0.001; DRL, P = 0.028). CONCLUSIONS Swept-source OCT-A of the microcirculation in eyes of patients with DR can be used to quantitatively demonstrate alterations in the FAZ and VD in the SRL/DRL of the macula compared to normal eyes. Future longitudinal studies may use these metrics to evaluate changes over time or in response to treatment.
Handan Akil - One of the best experts on this subject based on the ideXlab platform.
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swept source oct angiography imaging of the macular Capillary Network in glaucoma
British Journal of Ophthalmology, 2018Co-Authors: Handan Akil, Srinivas R Sadda, Vikas Chopra, Mayss Alsheikh, Khalil Ghasemi Falavarjani, Alex S Huang, Brian A FrancisAbstract:Purpose To evaluate the macular Capillary Network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects. Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL. Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p 0.05). Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma.
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swept source oct angiography imaging of the foveal avascular zone and macular Capillary Network density in diabetic retinopathy
Investigative Ophthalmology & Visual Science, 2016Co-Authors: Mayss Alsheikh, Handan Akil, Maximilian Pfau, Srinivas R SaddaAbstract:PURPOSE We compared the area of the foveal avascular zone (FAZ) and macular Capillary Network density at different retinal layers using swept-source optical coherence tomography angiography (OCT-A) in normal individuals and patients with diabetic retinopathy (DR). METHODS Images (a 3 × 3 mm cube centered on the fovea) were acquired in 40 eyes of 22 normal individuals and 28 eyes of 18 patients with varying levels of DR using a swept-source OCT-A device (central wavelength 1050 nm; A-scan-rate of 100,000 scans per second). En face images of the retinal vasculature were generated from the superficial and deep retinal layers (SRL/DRL). Quantitative analysis of the vessel density (VD) and FAZ area was performed. Vessel density was assessed as the ratio of the retinal area occupied by vessels. RESULTS Among the DR subjects (mean age, 72 years; 61% male), 35.7% of the eyes had mild, 35.7% moderate, and 7.1% severe nonproliferative DR (NPDR), and 21.4% and proliferative DR (PDR). The mean FAZ area in patients with DR and in normal individuals was 0.518 and 0.339 mm2, respectively, for the SRL (P = 0.003), and 0.615 and 0.358 mm2, respectively, for the DRL (P < 0.001). The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with DR (SRL, P < 0.001; DRL, P = 0.028). CONCLUSIONS Swept-source OCT-A of the microcirculation in eyes of patients with DR can be used to quantitatively demonstrate alterations in the FAZ and VD in the SRL/DRL of the macula compared to normal eyes. Future longitudinal studies may use these metrics to evaluate changes over time or in response to treatment.
