The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
P.-o. Grände - One of the best experts on this subject based on the ideXlab platform.
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In vivo effects of tumor necrosis factor-alpha on Capillary Permeability and vascular tone in a skeletal muscle.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: John Jahr, P.-o. GrändeAbstract:Background. The present study aims at analysing short-term effects of TNFα on Capillary Permeability, on transCapillary fluid fluxes, and on vascular tone in a whole organ cat skeletal muscle in vivo preparation. Methods. The denervated muscle was isolated from the body but with intact vascular supply. The experimental setup allowed continuous recording of vascular tone, of hydrostatic Capillary pressure and tissue volume variations. The Capillary filtration coefficient (CFC), which represents the net effect for transCapillary fluid exchange of Capillary Permeability and number of open capillaries, was calculated before and during intra-arterial TNF infusion. Results. We found that TNF had a minor effect on vascular tone in terms of a small vasodilation, and that no effect on hydrostatic Capillary pressure could be recorded. CFC increased by 64% during the TNF infusion and this increase must be attributed to an increase in Capillary Permeability rather than an increase in the number of capillaries available for fluid exchange since the TNF effect on vascular tone is small. This was also supported by TNF-induced transCapillary filtration. Conclusions. TNF is a potent drug for increasing Capillary Permeability causing transCapillary filtration in vivo. Its release, e.g. during sepsis, may therefore contribute to the Capillary leakage often seen in this clinical situation.
Anthony Arellano-kruse - One of the best experts on this subject based on the ideXlab platform.
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The lung Permeability index: A feasible measurement of pulmonary Capillary Permeability
Respiratory Medicine, 2010Co-Authors: Armando J. Huaringa, Manuel H. Haro, Francisco J Leyva, Armand B. Glassman, Anthony Arellano-kruseAbstract:Summary Background We performed this study to determine the pulmonary Capillary Permeability (PCP) measuring radiolabeled human serum albumin leakage into the lung. The objective was to use PCP to differentiate between cardiogenic and non-cardiogenic pulmonary edema etiologies. Methods We conducted this study in 10 patients admitted to the intensive care unit who had recently developed bilateral pulmonary infiltrates and required hemodynamic monitoring. In these patients we determined the association among the lung Permeability index, cardiac output, pulmonary Capillary wedge pressure, myocardial performance index, and the protein content of the bronchoalveolar lavage as expressed by bronchoalveolar lavage (BAL) total protein and BAL-to-serum protein ratio. Twenty mCi of technetium-labeled albumin was injected and measure in the heart and the lung at 10 and 180 min post-injection. Lung and heart uptake ratios as well as the lung Permeability index were calculated. Results We found a good correlation between the lung Permeability index and both the myocardial performance index (cardiac output/pulmonary Capillary wedge pressure) and the total protein content of the bronchoalveolar lavage fluid. Conclusion The lung Permeability index is a feasible, noninvasive estimation of the pulmonary Capillary Permeability.
John Jahr - One of the best experts on this subject based on the ideXlab platform.
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In vivo effects of tumor necrosis factor-alpha on Capillary Permeability and vascular tone in a skeletal muscle.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: John Jahr, P.-o. GrändeAbstract:Background. The present study aims at analysing short-term effects of TNFα on Capillary Permeability, on transCapillary fluid fluxes, and on vascular tone in a whole organ cat skeletal muscle in vivo preparation. Methods. The denervated muscle was isolated from the body but with intact vascular supply. The experimental setup allowed continuous recording of vascular tone, of hydrostatic Capillary pressure and tissue volume variations. The Capillary filtration coefficient (CFC), which represents the net effect for transCapillary fluid exchange of Capillary Permeability and number of open capillaries, was calculated before and during intra-arterial TNF infusion. Results. We found that TNF had a minor effect on vascular tone in terms of a small vasodilation, and that no effect on hydrostatic Capillary pressure could be recorded. CFC increased by 64% during the TNF infusion and this increase must be attributed to an increase in Capillary Permeability rather than an increase in the number of capillaries available for fluid exchange since the TNF effect on vascular tone is small. This was also supported by TNF-induced transCapillary filtration. Conclusions. TNF is a potent drug for increasing Capillary Permeability causing transCapillary filtration in vivo. Its release, e.g. during sepsis, may therefore contribute to the Capillary leakage often seen in this clinical situation.
Armando J. Huaringa - One of the best experts on this subject based on the ideXlab platform.
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The lung Permeability index: A feasible measurement of pulmonary Capillary Permeability
Respiratory Medicine, 2010Co-Authors: Armando J. Huaringa, Manuel H. Haro, Francisco J Leyva, Armand B. Glassman, Anthony Arellano-kruseAbstract:Summary Background We performed this study to determine the pulmonary Capillary Permeability (PCP) measuring radiolabeled human serum albumin leakage into the lung. The objective was to use PCP to differentiate between cardiogenic and non-cardiogenic pulmonary edema etiologies. Methods We conducted this study in 10 patients admitted to the intensive care unit who had recently developed bilateral pulmonary infiltrates and required hemodynamic monitoring. In these patients we determined the association among the lung Permeability index, cardiac output, pulmonary Capillary wedge pressure, myocardial performance index, and the protein content of the bronchoalveolar lavage as expressed by bronchoalveolar lavage (BAL) total protein and BAL-to-serum protein ratio. Twenty mCi of technetium-labeled albumin was injected and measure in the heart and the lung at 10 and 180 min post-injection. Lung and heart uptake ratios as well as the lung Permeability index were calculated. Results We found a good correlation between the lung Permeability index and both the myocardial performance index (cardiac output/pulmonary Capillary wedge pressure) and the total protein content of the bronchoalveolar lavage fluid. Conclusion The lung Permeability index is a feasible, noninvasive estimation of the pulmonary Capillary Permeability.
Yukichi Yonemasu - One of the best experts on this subject based on the ideXlab platform.
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Sequential change of Capillary Permeability in the rat brain after surgical removal of an experimental brain tumor
Journal of Neuro-Oncology, 1993Co-Authors: Akira Hodozuka, Kazuhiro Sako, Yukichi YonemasuAbstract:Experimental brain tumors were excised from rats for sequential observation of changes in local Capillary Permeability during the postsurgical period. Experimental brain tumor-bearing rats were prepared by stereotaxic transplantation of cultured tumor cells and the resultant tumor was delineated by administration of a dye. Following excision of the stained tumor by craniotomy, sequential changes in local Capillary Permeability were quantitatively followed-up by autoradiography, using^14C-amino-isobutyric acid as a tracer. Capillary Permeability was enhanced following surgery, reaching a maximum both in the extent and degree on the third day. After undergoing a gradual reduction, it showed a marked increase for the second time in a very small area on the 10th postoperative day. A recurrence of the tumor was responsible for this late but marked increase. For a control group, the caudate nucleus was excised from normal rats, followed by observation of the sequential changes in the local Capillary Permeability. Due to surgical procedure, Capillary Permeability reached a maximum both in the extent and degree on the 5th postoperative day (slightly later than in the tumor group). This change in Capillary Permeability was less pronounced than in the tumor group. The difference in the conditions of surgery — tumor excision and partial excision of a normal brain tissue — appeared to explain this difference. The results of this study indicated that it is more desirable to give water-soluble antineoplastic agents early during the postoperative period for chemotherapy of a malignant brain tumor after surgery.
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Sequential change of Capillary Permeability in the rat brain after surgical removal of an experimental brain tumor
Journal of neuro-oncology, 1993Co-Authors: Akira Hodozuka, Kazuhiro Sako, Yukichi YonemasuAbstract:Experimental brain tumors were excised from rats for sequential observation of changes in local Capillary Permeability during the postsurgical period. Experimental brain tumor-bearing rats were prepared by stereotaxic transplantation of cultured tumor cells and the resultant tumor was delineated by administration of a dye. Following excision of the stained tumor by craniotomy, sequential changes in local Capillary Permeability were quantitatively followed-up by autoradiography, using14C-amino-isobutyric acid as a tracer. Capillary Permeability was enhanced following surgery, reaching a maximum both in the extent and degree on the third day. After undergoing a gradual reduction, it showed a marked increase for the second time in a very small area on the 10th postoperative day. A recurrence of the tumor was responsible for this late but marked increase. For a control group, the caudate nucleus was excised from normal rats, followed by observation of the sequential changes in the local Capillary Permeability. Due to surgical procedure, Capillary Permeability reached a maximum both in the extent and degree on the 5th postoperative day (slightly later than in the tumor group). This change in Capillary Permeability was less pronounced than in the tumor group. The difference in the conditions of surgery — tumor excision and partial excision of a normal brain tissue — appeared to explain this difference. The results of this study indicated that it is more desirable to give water-soluble antineoplastic agents early during the postoperative period for chemotherapy of a malignant brain tumor after surgery.
