The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform
M. A. Norton - One of the best experts on this subject based on the ideXlab platform.
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The dual role of Carbenicillin in shoot regeneration and somatic embryogenesis of horseradish (Armoracia rusticana) in vitro
Plant Cell Tissue and Organ Culture (PCTOC), 2010Co-Authors: A. M. Shehata, W. Wannarat, R. M. Skirvin, M. A. NortonAbstract:Carbenicillin, a well-known antibiotic, has been reported to have growth regulator-like activity in vitro for some plant species. In the present paper we add horseradish ( Armoracia rusticana) to the list of plants exhibiting such responses. This project began as an effort to eliminate latent bacterial contamination among established in vitro horseradish plants. Carbenicillin (100 mg L^−1) added to regeneration medium eliminated all visible bacterial contaminants. Unexpectedly, Carbenicillin-grown explants regenerated adventitious shoots faster (14 days) than those on control medium (21 days). In addition eight of 11 horseradish cultivars grown on Carbenicillin produced more adventitious shoots per explant than control. At much higher levels (2,000 mg L^−1) Carbenicillin was found to retard somatic embryogenic callus induction. Based on these observations we suggest that Carbenicillin at moderate levels enhances shoot development in horseradish. The mode of action of Carbenicillin’s growth regulator-like activity needs to be investigated.
Isiah M. Warner - One of the best experts on this subject based on the ideXlab platform.
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octenidine Carbenicillin gumbos as potential treatment for oropharyngeal gonorrhoea
Journal of Antimicrobial Chemotherapy, 2020Co-Authors: Kelsey M. Lopez, Jeffrey A Hobden, Isiah M. WarnerAbstract:Background Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and Carbenicillin) was evaluated as a potential treatment for gonorrhoea. Octenidine/Carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and Carbenicillin, respectively. Methods Antibacterial activities for octenidine dihydrochloride, disodium Carbenicillin, octenidine/Carbenicillin and stoichiometrically equivalent 1:1 octenidine dihydrochloride to disodium Carbenicillin were assessed using the Kirby-Bauer disc diffusion assay for N. gonorrhoeae (ATCC 49226) and three clinical isolates. Predictive permeability using the Parallel Artificial Membrane Permeability Assay and cytotoxicity against HeLa cells was also evaluated. Results Additive in vitro antibacterial activities against N. gonorrhoeae were observed in this study, which suggests octenidine/Carbenicillin could be a useful agent in reducing N. gonorrhoeae transmission and minimizing gonorrhoea infections. Octenidine/Carbenicillin also exhibited bioequivalence to azithromycin and doxycycline, two currently prescribed antibiotics. Likewise, octenidine/Carbenicillin had improved predicted permeability compared with octenidine dihydrochloride. Conclusions Antimicrobial GUMBOS synthesized in this study could be used as an adjunctive treatment approach to current drug therapies for oropharyngeal gonorrhoea infection control and prevention.
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Octenidine/Carbenicillin GUMBOS as potential treatment for oropharyngeal gonorrhoea
The Journal of antimicrobial chemotherapy, 2020Co-Authors: Kelsey M. Lopez, Jeffrey A Hobden, Isiah M. WarnerAbstract:Background Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and Carbenicillin) was evaluated as a potential treatment for gonorrhoea. Octenidine/Carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and Carbenicillin, respectively. Methods Antibacterial activities for octenidine dihydrochloride, disodium Carbenicillin, octenidine/Carbenicillin and stoichiometrically equivalent 1:1 octenidine dihydrochloride to disodium Carbenicillin were assessed using the Kirby-Bauer disc diffusion assay for N. gonorrhoeae (ATCC 49226) and three clinical isolates. Predictive permeability using the Parallel Artificial Membrane Permeability Assay and cytotoxicity against HeLa cells was also evaluated. Results Additive in vitro antibacterial activities against N. gonorrhoeae were observed in this study, which suggests octenidine/Carbenicillin could be a useful agent in reducing N. gonorrhoeae transmission and minimizing gonorrhoea infections. Octenidine/Carbenicillin also exhibited bioequivalence to azithromycin and doxycycline, two currently prescribed antibiotics. Likewise, octenidine/Carbenicillin had improved predicted permeability compared with octenidine dihydrochloride. Conclusions Antimicrobial GUMBOS synthesized in this study could be used as an adjunctive treatment approach to current drug therapies for oropharyngeal gonorrhoea infection control and prevention.
A. M. Shehata - One of the best experts on this subject based on the ideXlab platform.
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The dual role of Carbenicillin in shoot regeneration and somatic embryogenesis of horseradish (Armoracia rusticana) in vitro
Plant Cell Tissue and Organ Culture (PCTOC), 2010Co-Authors: A. M. Shehata, W. Wannarat, R. M. Skirvin, M. A. NortonAbstract:Carbenicillin, a well-known antibiotic, has been reported to have growth regulator-like activity in vitro for some plant species. In the present paper we add horseradish ( Armoracia rusticana) to the list of plants exhibiting such responses. This project began as an effort to eliminate latent bacterial contamination among established in vitro horseradish plants. Carbenicillin (100 mg L^−1) added to regeneration medium eliminated all visible bacterial contaminants. Unexpectedly, Carbenicillin-grown explants regenerated adventitious shoots faster (14 days) than those on control medium (21 days). In addition eight of 11 horseradish cultivars grown on Carbenicillin produced more adventitious shoots per explant than control. At much higher levels (2,000 mg L^−1) Carbenicillin was found to retard somatic embryogenic callus induction. Based on these observations we suggest that Carbenicillin at moderate levels enhances shoot development in horseradish. The mode of action of Carbenicillin’s growth regulator-like activity needs to be investigated.
Kelsey M. Lopez - One of the best experts on this subject based on the ideXlab platform.
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octenidine Carbenicillin gumbos as potential treatment for oropharyngeal gonorrhoea
Journal of Antimicrobial Chemotherapy, 2020Co-Authors: Kelsey M. Lopez, Jeffrey A Hobden, Isiah M. WarnerAbstract:Background Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and Carbenicillin) was evaluated as a potential treatment for gonorrhoea. Octenidine/Carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and Carbenicillin, respectively. Methods Antibacterial activities for octenidine dihydrochloride, disodium Carbenicillin, octenidine/Carbenicillin and stoichiometrically equivalent 1:1 octenidine dihydrochloride to disodium Carbenicillin were assessed using the Kirby-Bauer disc diffusion assay for N. gonorrhoeae (ATCC 49226) and three clinical isolates. Predictive permeability using the Parallel Artificial Membrane Permeability Assay and cytotoxicity against HeLa cells was also evaluated. Results Additive in vitro antibacterial activities against N. gonorrhoeae were observed in this study, which suggests octenidine/Carbenicillin could be a useful agent in reducing N. gonorrhoeae transmission and minimizing gonorrhoea infections. Octenidine/Carbenicillin also exhibited bioequivalence to azithromycin and doxycycline, two currently prescribed antibiotics. Likewise, octenidine/Carbenicillin had improved predicted permeability compared with octenidine dihydrochloride. Conclusions Antimicrobial GUMBOS synthesized in this study could be used as an adjunctive treatment approach to current drug therapies for oropharyngeal gonorrhoea infection control and prevention.
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Octenidine/Carbenicillin GUMBOS as potential treatment for oropharyngeal gonorrhoea
The Journal of antimicrobial chemotherapy, 2020Co-Authors: Kelsey M. Lopez, Jeffrey A Hobden, Isiah M. WarnerAbstract:Background Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and Carbenicillin) was evaluated as a potential treatment for gonorrhoea. Octenidine/Carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and Carbenicillin, respectively. Methods Antibacterial activities for octenidine dihydrochloride, disodium Carbenicillin, octenidine/Carbenicillin and stoichiometrically equivalent 1:1 octenidine dihydrochloride to disodium Carbenicillin were assessed using the Kirby-Bauer disc diffusion assay for N. gonorrhoeae (ATCC 49226) and three clinical isolates. Predictive permeability using the Parallel Artificial Membrane Permeability Assay and cytotoxicity against HeLa cells was also evaluated. Results Additive in vitro antibacterial activities against N. gonorrhoeae were observed in this study, which suggests octenidine/Carbenicillin could be a useful agent in reducing N. gonorrhoeae transmission and minimizing gonorrhoea infections. Octenidine/Carbenicillin also exhibited bioequivalence to azithromycin and doxycycline, two currently prescribed antibiotics. Likewise, octenidine/Carbenicillin had improved predicted permeability compared with octenidine dihydrochloride. Conclusions Antimicrobial GUMBOS synthesized in this study could be used as an adjunctive treatment approach to current drug therapies for oropharyngeal gonorrhoea infection control and prevention.
R. M. Skirvin - One of the best experts on this subject based on the ideXlab platform.
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The dual role of Carbenicillin in shoot regeneration and somatic embryogenesis of horseradish (Armoracia rusticana) in vitro
Plant Cell Tissue and Organ Culture (PCTOC), 2010Co-Authors: A. M. Shehata, W. Wannarat, R. M. Skirvin, M. A. NortonAbstract:Carbenicillin, a well-known antibiotic, has been reported to have growth regulator-like activity in vitro for some plant species. In the present paper we add horseradish ( Armoracia rusticana) to the list of plants exhibiting such responses. This project began as an effort to eliminate latent bacterial contamination among established in vitro horseradish plants. Carbenicillin (100 mg L^−1) added to regeneration medium eliminated all visible bacterial contaminants. Unexpectedly, Carbenicillin-grown explants regenerated adventitious shoots faster (14 days) than those on control medium (21 days). In addition eight of 11 horseradish cultivars grown on Carbenicillin produced more adventitious shoots per explant than control. At much higher levels (2,000 mg L^−1) Carbenicillin was found to retard somatic embryogenic callus induction. Based on these observations we suggest that Carbenicillin at moderate levels enhances shoot development in horseradish. The mode of action of Carbenicillin’s growth regulator-like activity needs to be investigated.