The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Josep Esteve-romero - One of the best experts on this subject based on the ideXlab platform.
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Quantitation of antihistamines in pharmaceutical preparations by liquid chromatography with a micellar mobile phase of sodium dodecyl sulfate and pentanol
Journal of AOAC International, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, Josep Esteve-romero, María Celia García-alvarez-coqueAbstract:A reversed-phase liquid chromatographic procedure with a micellar mobile phase of sodium dodecyl sulfate (SDS), containing a small amount of pentanol, was developed for the control of 7 antihistamines of diverse action in pharmaceutical preparations (tablets, capsules, powders, solutions, and syrups): azatadine, Carbinoxamine, cyclizine, cyproheptadine, diphenhydramine, doxylamine, and tripelennamine. The retention times of the drugs were
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Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
The Analyst, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, María Celia García-alvarez-coque, Ma. Elisa Capella-peiró, Josep Esteve-romeroAbstract:The chromatographic behaviour of binary and ternary mixtures of several phenethylamines (phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, Carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, tripolidine, azatadine and phenyltoloxamine), found in cough–cold pharmaceutical preparations, was studied using C8, C18 and cyano columns, micellar mobile phases of sodium dodecyl sulfate (SDS) and pentanol and UV detection. Using a C8 column and mobile phases of 0.05 mol l−1 SDS–6% v/v pentanol or 0.15 mol l−1 SDS–2% v/v pentanol at pH 7, more than 30 different phenethylamine–antihistamine combinations can be resolved in
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Spectrophotometric Determination of the Antihistamines, Carbinoxamine Maleate and Doxylamine Succinate, in an N-Cetylpyridinium Chloride Micellar Medium
Analytical Letters, 1996Co-Authors: Li Monferrer-pons, Josep Esteve-romero, Guillermo Ramis-ramos, M.c. García-alvarez-coqueAbstract:Abstract The pyridine antihistamines Carbinoxamine maleate and doxylamine succinate were derivatized by hydrolysis with cyanogen bromide and coupling with aniline to form a polymethine dye, and determined by colorimetry. In a micellar cationic medium of N-cetylpyridinium chloride (NCPC), the reaction times were reduced and the sensitivities improved. In 0.1 M NCPC the apparent molar absorptivities of the derivatives were 5,900 and 3,500 M−1 cm−1, and the limits of detection (as 3s) were 8.6x10−7 M and 1.7x106 M, for Carbinoxamine and doxylamine, respectively. The sensitivity was enhanced in a three- to six-fold factor with respect to a non-micellar medium. The reproducibility was 0.8% for 1.6x10−4 M Carbinoxamine, and 1.8% for 1.3x10−4 M doxylamine. The procedure was applied to the evaluation of the drugs in pharmaceutical preparations.
Mayte Gil-agustí - One of the best experts on this subject based on the ideXlab platform.
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Quantitation of antihistamines in pharmaceutical preparations by liquid chromatography with a micellar mobile phase of sodium dodecyl sulfate and pentanol
Journal of AOAC International, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, Josep Esteve-romero, María Celia García-alvarez-coqueAbstract:A reversed-phase liquid chromatographic procedure with a micellar mobile phase of sodium dodecyl sulfate (SDS), containing a small amount of pentanol, was developed for the control of 7 antihistamines of diverse action in pharmaceutical preparations (tablets, capsules, powders, solutions, and syrups): azatadine, Carbinoxamine, cyclizine, cyproheptadine, diphenhydramine, doxylamine, and tripelennamine. The retention times of the drugs were
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Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
The Analyst, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, María Celia García-alvarez-coque, Ma. Elisa Capella-peiró, Josep Esteve-romeroAbstract:The chromatographic behaviour of binary and ternary mixtures of several phenethylamines (phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, Carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, tripolidine, azatadine and phenyltoloxamine), found in cough–cold pharmaceutical preparations, was studied using C8, C18 and cyano columns, micellar mobile phases of sodium dodecyl sulfate (SDS) and pentanol and UV detection. Using a C8 column and mobile phases of 0.05 mol l−1 SDS–6% v/v pentanol or 0.15 mol l−1 SDS–2% v/v pentanol at pH 7, more than 30 different phenethylamine–antihistamine combinations can be resolved in
María Celia García-alvarez-coque - One of the best experts on this subject based on the ideXlab platform.
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Quantitation of antihistamines in pharmaceutical preparations by liquid chromatography with a micellar mobile phase of sodium dodecyl sulfate and pentanol
Journal of AOAC International, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, Josep Esteve-romero, María Celia García-alvarez-coqueAbstract:A reversed-phase liquid chromatographic procedure with a micellar mobile phase of sodium dodecyl sulfate (SDS), containing a small amount of pentanol, was developed for the control of 7 antihistamines of diverse action in pharmaceutical preparations (tablets, capsules, powders, solutions, and syrups): azatadine, Carbinoxamine, cyclizine, cyproheptadine, diphenhydramine, doxylamine, and tripelennamine. The retention times of the drugs were
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Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
The Analyst, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, María Celia García-alvarez-coque, Ma. Elisa Capella-peiró, Josep Esteve-romeroAbstract:The chromatographic behaviour of binary and ternary mixtures of several phenethylamines (phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, Carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, tripolidine, azatadine and phenyltoloxamine), found in cough–cold pharmaceutical preparations, was studied using C8, C18 and cyano columns, micellar mobile phases of sodium dodecyl sulfate (SDS) and pentanol and UV detection. Using a C8 column and mobile phases of 0.05 mol l−1 SDS–6% v/v pentanol or 0.15 mol l−1 SDS–2% v/v pentanol at pH 7, more than 30 different phenethylamine–antihistamine combinations can be resolved in
Ran Liu - One of the best experts on this subject based on the ideXlab platform.
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Development and full validation of a liquid chromatography-tandem mass spectrometry method for determination of Carbinoxamine in beagle plasma and its application to a pharmacokinetic study.
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2018Co-Authors: Jie Xiao, Jing Liu, Ran LiuAbstract:Abstract Carbinoxamine maleate is an antihistamine drug with mild sedation effects, which is used to treat seasonal and perennial allergic rhinitis clinically. In order to optimize drug therapy, reduce drug accumulation, lessen the frequency of adverse effects and facilitate clinical research, a high performance liquid chromatography tandem mass spectrometry assay was firstly established and fully validated for the quantitative admeasurements of Carbinoxamine. After extraction with ethyl acetate, the chromatographic separation was implemented on a C18 column (Hypersil GOLD, 100 mm × 2.1 mm, 3.0 μm) using gradient elution with water (containing 0.1% formic acid) and methanol at the flow rate of 0.4 mL/min. The analytes were measured under multiple reactions monitoring (MRM) mode with m/z 291.2 → 202.1 for Carbinoxamine and m/z 285.0 → 193.2 for diazepam (IS) using electrospray ionization source (ESI) in the positive ion mode. A satisfactory linearity was obtained over the wide extent of 0.1–100.0 ng/mL (r > 0.99). Inter- and intra-day precision and accuracy of the assay were favorably accorded with the currently recognized limits (
Li Monferrer-pons - One of the best experts on this subject based on the ideXlab platform.
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Quantitation of antihistamines in pharmaceutical preparations by liquid chromatography with a micellar mobile phase of sodium dodecyl sulfate and pentanol
Journal of AOAC International, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, Josep Esteve-romero, María Celia García-alvarez-coqueAbstract:A reversed-phase liquid chromatographic procedure with a micellar mobile phase of sodium dodecyl sulfate (SDS), containing a small amount of pentanol, was developed for the control of 7 antihistamines of diverse action in pharmaceutical preparations (tablets, capsules, powders, solutions, and syrups): azatadine, Carbinoxamine, cyclizine, cyproheptadine, diphenhydramine, doxylamine, and tripelennamine. The retention times of the drugs were
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Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures.
The Analyst, 2001Co-Authors: Mayte Gil-agustí, Li Monferrer-pons, María Celia García-alvarez-coque, Ma. Elisa Capella-peiró, Josep Esteve-romeroAbstract:The chromatographic behaviour of binary and ternary mixtures of several phenethylamines (phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, Carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, tripolidine, azatadine and phenyltoloxamine), found in cough–cold pharmaceutical preparations, was studied using C8, C18 and cyano columns, micellar mobile phases of sodium dodecyl sulfate (SDS) and pentanol and UV detection. Using a C8 column and mobile phases of 0.05 mol l−1 SDS–6% v/v pentanol or 0.15 mol l−1 SDS–2% v/v pentanol at pH 7, more than 30 different phenethylamine–antihistamine combinations can be resolved in
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Spectrophotometric Determination of the Antihistamines, Carbinoxamine Maleate and Doxylamine Succinate, in an N-Cetylpyridinium Chloride Micellar Medium
Analytical Letters, 1996Co-Authors: Li Monferrer-pons, Josep Esteve-romero, Guillermo Ramis-ramos, M.c. García-alvarez-coqueAbstract:Abstract The pyridine antihistamines Carbinoxamine maleate and doxylamine succinate were derivatized by hydrolysis with cyanogen bromide and coupling with aniline to form a polymethine dye, and determined by colorimetry. In a micellar cationic medium of N-cetylpyridinium chloride (NCPC), the reaction times were reduced and the sensitivities improved. In 0.1 M NCPC the apparent molar absorptivities of the derivatives were 5,900 and 3,500 M−1 cm−1, and the limits of detection (as 3s) were 8.6x10−7 M and 1.7x106 M, for Carbinoxamine and doxylamine, respectively. The sensitivity was enhanced in a three- to six-fold factor with respect to a non-micellar medium. The reproducibility was 0.8% for 1.6x10−4 M Carbinoxamine, and 1.8% for 1.3x10−4 M doxylamine. The procedure was applied to the evaluation of the drugs in pharmaceutical preparations.