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T.k. Hevor - One of the best experts on this subject based on the ideXlab platform.

  • Some aspects of Carbohydrate Metabolism in the brain.
    Biochimie, 1994
    Co-Authors: T.k. Hevor
    Abstract:

    A convenient physiology of the nervous system closely depends on the availability of glucose, the lack of which quickly results in syncope and death. Carbohydrate Metabolism in the brain was long thought of as being specific and different from liver Carbohydrate Metabolism. The present report tries to summarize current data and advances in our knowledge about Carbohydrate Metabolism. Glucose is brought to the brain by blood flowing through a special network of arteries and is quickly catabolized by the glycolytic and tricarboxylic acid cycle pathways to synthesize energy. It is also used in the synthesis of numerous amino acids, nucleotides and NADPH. Glucose can be polymerized into glycogen in the brain. The nerve tissue is capable of synthesizing glucose-6-phosphate in the gluconeogenic pathway since the fructose-1,6-bisphosphatase, the key enzyme believed to be absent, is actually active and has been purified up to electrophoretic homogeneity. Moreover, the possibility of free glucose synthesis by astrocytes exists. Although the exact role of glycogen in the brain is not totally clear, it is known that the polysaccharide content generally decreases when the functioning of the brain is stimulated and increases in sedative state. This Carbohydrate can therefore serve as an indicator for the level of brain activity. Through the administration of methionine sulfoximine, it is possible to increase the amount of glycogen in the brain massively and obtain particles similar to those found in the liver. These in vivo findings have been confirmed by studies based on cultured astrocytes. It has been shown with cultured astrocytes that glutamate increases glycogen synthesis in a pathway which still remains to be elucidated. Brain Carbohydrate Metabolism is thus in many ways similar to liver Carbohydrate Metabolism. The astrocyte constitutes the main cell implicated in this Metabolism. Improvement in our knowledge about brain Carbohydrate Metabolism should spread the use of brain glucose Metabolism in the diagnosis of certain diseases.

M.i. Bobryk - One of the best experts on this subject based on the ideXlab platform.

Mathias Montenarh - One of the best experts on this subject based on the ideXlab platform.

  • CK2 and the regulation of the Carbohydrate Metabolism
    Metabolism: clinical and experimental, 2012
    Co-Authors: Faizeh Al Quobaili, Mathias Montenarh
    Abstract:

    Protein kinase CK2 was originally identified by analyzing Carbohydrate Metabolism. Now it is clear that life without CK2 is impossible. Moreover, CK2 activity was found elevated in rapidly proliferating cells when compared to slowly proliferating or resting cells. Proliferating cells have an elevated need for energy which is generated from an elevated Carbohydrate Metabolism. From early observations and the emerging role of CK2 in cellular regulation, it is not surprising that CK2 plays a role in hormonal regulation of Carbohydrate Metabolism as well as modulating activities of enzymes directly involved in Carbohydrate storage and Metabolism. The aim of the present review is to summarize the knowledge about the role of CK2 in the regulation of the Carbohydrate Metabolism.

Donna Shoupe - One of the best experts on this subject based on the ideXlab platform.

  • Effects of desogestrel on Carbohydrate Metabolism
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: Donna Shoupe
    Abstract:

    Associated with progesterone and the synthetic progestins used in oral contraceptives is a dose-dependent impairment of Carbohydrate Metabolism. It is well known that in the general population hyperinsulinemia and alterations in glucose Metabolism are significant risk factors for the development of cardiovascular disease. Studies that use curve analysis of glucose tolerance tests have demonstrated insulin resistance, rises in plasma insulin, and relative glucose intolerance in women using oral contraceptives. Desogestrel, a new progestin, has been demonstrated to have generally less pronounced effects on these parameters of Carbohydrate Metabolism.

Yavuz Demir - One of the best experts on this subject based on the ideXlab platform.

  • Acrochordon and impaired Carbohydrate Metabolism
    Acta diabetologica, 2002
    Co-Authors: Serap Demir, Yavuz Demir
    Abstract:

    Acrochordons were reported to have a probable association with diabetes mellitus but detailed data about this relation has not been introduced yet. We evaluated 120 patients with acrochordon for the presence of impaired Carbohydrate Metabolism. Overt diabetes mellitus (DM) was found in 88 patients and glucose intolerance was detected in 6 patients; 4 patients had reactive hypoglycemia. We concluded that acrochordons may be skin markers of underlying impaired Carbohydrate Metabolism and the patients with acrochordon should be evaluated for the presence of diabetes mellitus.