The Experts below are selected from a list of 23079 Experts worldwide ranked by ideXlab platform
Alexei V. Demchenko - One of the best experts on this subject based on the ideXlab platform.
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Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study
The Journal of organic chemistry, 2013Co-Authors: N. Vijaya Ganesh, Keith J. Stine, Kohki Fujikawa, Yih Horng Tan, Swati S. Nigudkar, Alexei V. DemchenkoAbstract:Comparative study of Surface-Tethered Iterative Carbohydrate Synthesis (STICS) using HPLC-assisted experimental setup clearly demonstrates benefits of using longer spacer-anchoring systems. The use of mixed self-assembled monolayers helps provide the required space for glycosylation reaction around the immobilized glycosyl acceptor. Both extension of the spacer length and using mixed self-assembled monolayers help promote the reaction, and the beneficial effects may include moving the glycosyl acceptor further out into solution and providing additional conformational flexibility. It is possible that surface-immobilized glycosyl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-phase reaction environment than acceptors with shorter spacers.
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STICS: surface-tethered iterative Carbohydrate Synthesis.
Chemical communications (Cambridge England), 2009Co-Authors: Papapida Pornsuriyasak, Sneha C. Ranade, M. Cristina Parlato, Charles R. Sims, Olga V. Shulga, Keith J. Stine, Alexei V. DemchenkoAbstract:A new surface-tethered iterative Carbohydrate Synthesis (STICS) technology is presented in which a surface functionalized ‘stick’ made of chemically stable high surface area porous gold allows one to perform cost efficient and simple Synthesis of oligosaccharide chains; at the end of the Synthesis, the oligosaccharide can be cleaved off and the stick reused for subsequent syntheses.
Peter H. Seeberger - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of photolabile protecting group ppg protected uronic acid building blocks applications in Carbohydrate Synthesis with the assistance of a continuous flow photoreactor
Organic chemistry frontiers, 2019Co-Authors: Varsha Tiwari, Peter H. Seeberger, Adesh Kumar Singh, Priyanka Chaudhary, Jeyakumar KandasamyAbstract:Photolabile protecting group (PPG) protected uronic acid building blocks were prepared and used for Carbohydrate Synthesis. Deprotection of the photolabile protecting group was achieved very efficiently by employing a continuous flow photoreactor under neutral conditions. Many conventional protecting groups were found to be stable during the photo-cleavage of the 2-nitrobenzyl group at 355 nm in methanol.
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Chemical glycobiology: why now?
Nature chemical biology, 2009Co-Authors: Peter H. SeebergerAbstract:Understanding the structure and function of Carbohydrates remains a key challenge for chemical biologists. Developments in Carbohydrate Synthesis and analysis together with the advent of high-throughput methods such as Carbohydrate microarrays have helped shed light on the function of glycoconjugates. Similarly, consortia have provided technology platforms and focus to a burgeoning field. Now, recruitment of scientists from related fields and further integration of chemistry and biology to achieve technical goals are needed for rapid advancements.
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Automated Carbohydrate Synthesis as platform to address fundamental aspects of glycobiology--current status and future challenges.
Carbohydrate research, 2008Co-Authors: Peter H. SeebergerAbstract:This award account attempts to define the status of automated Carbohydrate Synthesis and its applications while trying to identify areas critical for further development. In this context the work of the Seeberger laboratory over the past 10 years is reviewed. Advances and shortcomings of the first automated oligosaccharide synthesizer platform will be discussed. Using this method, access to a multitude of complex oligosaccharides has been accelerated more than 100-fold. The Synthesis of usable quantities of oligosaccharides has given rise to tools that had been common-place in nucleic acid and protein biochemistry. Carbohydrate microarrays are a versatile screening platform, and affinity columns and labeled Carbohydrates are beginning to aid glycobiologists. While much has been achieved, many questions remain before a generally applicable set of tools will be available to facilitate Carbohydrate research much in the same way oligonucleotide and peptide biology is explored today. Application of this technology to synthetic Carbohydrate antigens in synthetic vaccine candidates against parasites and bacteria is attractive and has already yielded important insights.
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Automated Carbohydrate Synthesis to drive chemical glycomics
Chemical communications (Cambridge England), 2003Co-Authors: Peter H. SeebergerAbstract:This feature article describes the development of the first automated solid-phase oligosaccharide synthesizer. A series of chemical challenges had to be addressed to accomplish this breakthrough and provide rapid access to oligosaccharides of biological significance. Accelerated Synthesis of glycoconjugates promises to greatly impact the emerging field of glycobiology. Chemical glycomics uses synthetic Carbohydrates and analogs to study their role in recognition, signal transduction pathways and other events of fundamental biomedical significance and shapes up to become the next major wave in biomedical research. The automated Synthesis of a novel malaria vaccine candidate is discussed to illustrate the medical potential of chemical glycomics.
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Recent advances in automated solid-phase Carbohydrate Synthesis: from screening to vaccines.
Current opinion in drug discovery & development, 2003Co-Authors: Obadiah J. Plante, Peter H. SeebergerAbstract:The past year has witnessed significant advances in a new technology for the Synthesis of complex Carbohydrates. Solid-phase methods have been applied to the construction of previously inaccessible Carbohydrates. Furthermore, the application of automated solid-phase Carbohydrate Synthesis is promising. New methods for the Synthesis of Carbohydrates and potential applications are described in this review.
Keith J. Stine - One of the best experts on this subject based on the ideXlab platform.
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Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study
The Journal of organic chemistry, 2013Co-Authors: N. Vijaya Ganesh, Keith J. Stine, Kohki Fujikawa, Yih Horng Tan, Swati S. Nigudkar, Alexei V. DemchenkoAbstract:Comparative study of Surface-Tethered Iterative Carbohydrate Synthesis (STICS) using HPLC-assisted experimental setup clearly demonstrates benefits of using longer spacer-anchoring systems. The use of mixed self-assembled monolayers helps provide the required space for glycosylation reaction around the immobilized glycosyl acceptor. Both extension of the spacer length and using mixed self-assembled monolayers help promote the reaction, and the beneficial effects may include moving the glycosyl acceptor further out into solution and providing additional conformational flexibility. It is possible that surface-immobilized glycosyl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-phase reaction environment than acceptors with shorter spacers.
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STICS: surface-tethered iterative Carbohydrate Synthesis.
Chemical communications (Cambridge England), 2009Co-Authors: Papapida Pornsuriyasak, Sneha C. Ranade, M. Cristina Parlato, Charles R. Sims, Olga V. Shulga, Keith J. Stine, Alexei V. DemchenkoAbstract:A new surface-tethered iterative Carbohydrate Synthesis (STICS) technology is presented in which a surface functionalized ‘stick’ made of chemically stable high surface area porous gold allows one to perform cost efficient and simple Synthesis of oligosaccharide chains; at the end of the Synthesis, the oligosaccharide can be cleaved off and the stick reused for subsequent syntheses.
N. Vijaya Ganesh - One of the best experts on this subject based on the ideXlab platform.
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Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study
The Journal of organic chemistry, 2013Co-Authors: N. Vijaya Ganesh, Keith J. Stine, Kohki Fujikawa, Yih Horng Tan, Swati S. Nigudkar, Alexei V. DemchenkoAbstract:Comparative study of Surface-Tethered Iterative Carbohydrate Synthesis (STICS) using HPLC-assisted experimental setup clearly demonstrates benefits of using longer spacer-anchoring systems. The use of mixed self-assembled monolayers helps provide the required space for glycosylation reaction around the immobilized glycosyl acceptor. Both extension of the spacer length and using mixed self-assembled monolayers help promote the reaction, and the beneficial effects may include moving the glycosyl acceptor further out into solution and providing additional conformational flexibility. It is possible that surface-immobilized glycosyl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-phase reaction environment than acceptors with shorter spacers.
Yih Horng Tan - One of the best experts on this subject based on the ideXlab platform.
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Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study
The Journal of organic chemistry, 2013Co-Authors: N. Vijaya Ganesh, Keith J. Stine, Kohki Fujikawa, Yih Horng Tan, Swati S. Nigudkar, Alexei V. DemchenkoAbstract:Comparative study of Surface-Tethered Iterative Carbohydrate Synthesis (STICS) using HPLC-assisted experimental setup clearly demonstrates benefits of using longer spacer-anchoring systems. The use of mixed self-assembled monolayers helps provide the required space for glycosylation reaction around the immobilized glycosyl acceptor. Both extension of the spacer length and using mixed self-assembled monolayers help promote the reaction, and the beneficial effects may include moving the glycosyl acceptor further out into solution and providing additional conformational flexibility. It is possible that surface-immobilized glycosyl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-phase reaction environment than acceptors with shorter spacers.