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Akiko Takasuga - One of the best experts on this subject based on the ideXlab platform.

  • non synonymous fgd3 variant as positional candidate for disproportional tall stature accounting for a Carcass Weight qtl cw 3 and skeletal dysplasia in japanese black cattle
    PLOS Genetics, 2015
    Co-Authors: Akiko Takasuga, Kunio Sato, Ryouichi Nakamura, Yosuke Saito, Shinji Sasaki, Takehito Tsuji, Akio Suzuki, Hiroshi Kobayashi, Tamako Matsuhashi, Koji Setoguchi
    Abstract:

    Recessive skeletal dysplasia, characterized by joint- and/or hip bone-enlargement, was mapped within the critical region for a major quantitative trait locus (QTL) influencing Carcass Weight; previously named CW-3 in Japanese Black cattle. The risk allele was on the same chromosome as the Q allele that increases Carcass Weight. Phenotypic characterization revealed that the risk allele causes disproportional tall stature and bone size that increases Carcass Weight in heterozygous individuals but causes disproportionately narrow chest width in homozygotes. A non-synonymous variant of FGD3 was identified as a positional candidate quantitative trait nucleotide (QTN) and the corresponding mutant protein showed reduced activity as a guanine nucleotide exchange factor for Cdc42. FGD3 is expressed in the growth plate cartilage of femurs from bovine and mouse. Thus, loss of FDG3 activity may lead to subsequent loss of Cdc42 function. This would be consistent with the columnar disorganization of proliferating chondrocytes in chondrocyte-specific inactivated Cdc42 mutant mice. This is the first report showing association of FGD3 with skeletal dysplasia.

  • comparison of the effects explained by variations in the bovine plag1 and ncapg genes on daily body Weight gain linear skeletal measurements and Carcass traits in japanese black steers from a progeny testing program
    Animal Science Journal, 2013
    Co-Authors: Hiroshi Hoshiba, Kouji Setoguchi, Toshio Watanabe, Akihiro Kinoshita, Kazunori Mizoshita, Yoshikazu Sugimoto, Akiko Takasuga
    Abstract:

    The c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG gene, which leads to an amino acid change of Ile442 to Met442, was previously identified as a candidate causative variation for a bovine Carcass Weight quantitative trait loci (QTL) on chromosome 6, which was associated with linear skeletal measurement gains and daily body Weight gain at puberty. Recently, we identified the stature quantitative trait nucleotides (QTNs) in the PLAG1-CHCHD7 intergenic region as the causative variations for another Carcass Weight QTL on chromosome 14. This study aimed to compare the effects of the two QTL on growth and Carcass traits using 768 Japanese Black steers from a progeny testing program and to determine whether a genetic interaction was present between them. The FJX_250879 SNP representing the stature QTL was associated with linear skeletal measurements and average daily body Weight gain at early and late periods during adolescence. A genetic interaction between FJX_250879 and NCAPG c.1326T>G was detected only for body and rump lengths. Both were associated with increased Carcass Weight and Longissimus muscle area, and NCAPG c.1326T>G was also associated with reduced subcutaneous fat thickness and increased Carcass yield estimate. These results will provide useful information to improve Carcass Weight in Japanese Black cattle.

  • genome wide association study identified three major qtl for Carcass Weight including the plag1 chchd7 qtn for stature in japanese black cattle
    BMC Genetics, 2012
    Co-Authors: Shota Nishimura, Toshio Watanabe, Kazunori Mizoshita, Yoshikazu Sugimoto, Ken Tatsuda, Tatsuo Fujita, Naoto Watanabe, Akiko Takasuga
    Abstract:

    Significant quantitative trait loci (QTL) for Carcass Weight were previously mapped on several chromosomes in Japanese Black half-sib families. Two QTL, CW-1 and CW-2, were narrowed down to 1.1-Mb and 591-kb regions, respectively. Recent advances in genomic tools allowed us to perform a genome-wide association study (GWAS) in cattle to detect associations in a general population and estimate their effect size. Here, we performed a GWAS for Carcass Weight using 1156 Japanese Black steers. Bonferroni-corrected genome-wide significant associations were detected in three chromosomal regions on bovine chromosomes (BTA) 6, 8, and 14. The associated single nucleotide polymorphisms (SNP) on BTA 6 were in linkage disequilibrium with the SNP encoding NCAPG Ile442Met, which was previously identified as a candidate quantitative trait nucleotide for CW-2. In contrast, the most highly associated SNP on BTA 14 was located 2.3-Mb centromeric from the previously identified CW-1 region. Linkage disequilibrium mapping led to a revision of the CW-1 region within a 0.9-Mb interval around the associated SNP, and targeted resequencing followed by association analysis highlighted the quantitative trait nucleotides for bovine stature in the PLAG1-CHCHD7 intergenic region. The association on BTA 8 was accounted for by two SNP on the BovineSNP50 BeadChip and corresponded to CW-3, which was simultaneously detected by linkage analyses using half-sib families. The allele substitution effects of CW-1, CW-2, and CW-3 were 28.4, 35.3, and 35.0 kg per allele, respectively. The GWAS revealed the genetic architecture underlying Carcass Weight variation in Japanese Black cattle in which three major QTL accounted for approximately one-third of the genetic variance.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine. We used 38 microsatellite markers to search for a shared Q (increasing Carcass and/or body Weight) haplotype within the 17-cM CW-2 region among five sires. Linkage disequilibrium mapping using maternal alleles of the offspring showed that an 815-kb shared Q haplotype was associated with body or Carcass Weight in both breeds. The addition of 43 single nucleotide polymorphism (SNP) markers narrowed the region to 591 kb containing 4 genes. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) was significantly associated with Carcass Weight (p < 1.2 × 10-11) in a large Japanese Black population as well as in the five families. The Q allele of the SNP was also associated with a larger longissimus muscle area and thinner subcutaneous fat thickness in steers of all five families, indicating that the CW-2 locus is pleiotropic and favorable for marker-assisted selection of beef cattle. A 591-kb critical region for CW-2 was identified. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) can be used as a positional candidate of CW-2 for marker-assisted selection.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Background Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine.

Yoshikazu Sugimoto - One of the best experts on this subject based on the ideXlab platform.

  • effects of single nucleotide polymorphism marker density on degree of genetic variance explained and genomic evaluation for Carcass traits in japanese black beef cattle
    BMC Genetics, 2014
    Co-Authors: Shinichiro Ogawa, Toshio Watanabe, Yoshikazu Sugimoto, Shota Nishimura, Hirokazu Matsuda, Yukio Taniguchi, Hiroaki Iwaisaki
    Abstract:

    Japanese Black cattle are a beef breed whose meat is well known to excel in meat quality, especially in marbling, and whose effective population size is relatively low in Japan. Unlike dairy cattle, the accuracy of genomic evaluation (GE) for Carcass traits in beef cattle, including this breed, has been poorly studied. For Carcass Weight and marbling score in the breed, as well as the extent of whole genome linkage disequilibrium (LD), the effects of equally-spaced single nucleotide polymorphisms (SNPs) density on genomic relationship matrix (G matrix), genetic variance explained and GE were investigated using the genotype data of about 40,000 SNPs and two statistical models. Using all pairs of two adjacent SNPs in the whole SNP set, the means of LD (r 2 ) at ranges 0–0.1, 0.1–0.2, 0.2–0.5 and 0.5–1 Mb were 0.22, 0.13, 0.10 and 0.08, respectively, and 25.7, 13.9, 10.4 and 6.4% of the r 2 values exceeded 0.3, respectively. While about 90% of the genetic variance for Carcass Weight estimated using all available SNPs was explained using 4,000–6,000 SNPs, the corresponding percentage for marbling score was consistently lower. With the conventional linear model incorporating the G matrix, correlation between the genomic estimated breeding values (GEBVs) obtained using 4,000 SNPs and all available SNPs was 0.99 for Carcass Weight and 0.98 for marbling score, with an underestimation of the former GEBVs, especially for marbling score. The Japanese Black is likely to be in a breed group with a relatively high extent of whole genome LD. The results indicated that the degree of marbling is controlled by only QTLs with relatively small effects, compared with Carcass Weight, and that using at least 4,000 equally-spaced SNPs, there is a possibility of ranking animals genetically for these Carcass traits in this breed.

  • comparison of the effects explained by variations in the bovine plag1 and ncapg genes on daily body Weight gain linear skeletal measurements and Carcass traits in japanese black steers from a progeny testing program
    Animal Science Journal, 2013
    Co-Authors: Hiroshi Hoshiba, Kouji Setoguchi, Toshio Watanabe, Akihiro Kinoshita, Kazunori Mizoshita, Yoshikazu Sugimoto, Akiko Takasuga
    Abstract:

    The c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG gene, which leads to an amino acid change of Ile442 to Met442, was previously identified as a candidate causative variation for a bovine Carcass Weight quantitative trait loci (QTL) on chromosome 6, which was associated with linear skeletal measurement gains and daily body Weight gain at puberty. Recently, we identified the stature quantitative trait nucleotides (QTNs) in the PLAG1-CHCHD7 intergenic region as the causative variations for another Carcass Weight QTL on chromosome 14. This study aimed to compare the effects of the two QTL on growth and Carcass traits using 768 Japanese Black steers from a progeny testing program and to determine whether a genetic interaction was present between them. The FJX_250879 SNP representing the stature QTL was associated with linear skeletal measurements and average daily body Weight gain at early and late periods during adolescence. A genetic interaction between FJX_250879 and NCAPG c.1326T>G was detected only for body and rump lengths. Both were associated with increased Carcass Weight and Longissimus muscle area, and NCAPG c.1326T>G was also associated with reduced subcutaneous fat thickness and increased Carcass yield estimate. These results will provide useful information to improve Carcass Weight in Japanese Black cattle.

  • genome wide association study identified three major qtl for Carcass Weight including the plag1 chchd7 qtn for stature in japanese black cattle
    BMC Genetics, 2012
    Co-Authors: Shota Nishimura, Toshio Watanabe, Kazunori Mizoshita, Yoshikazu Sugimoto, Ken Tatsuda, Tatsuo Fujita, Naoto Watanabe, Akiko Takasuga
    Abstract:

    Significant quantitative trait loci (QTL) for Carcass Weight were previously mapped on several chromosomes in Japanese Black half-sib families. Two QTL, CW-1 and CW-2, were narrowed down to 1.1-Mb and 591-kb regions, respectively. Recent advances in genomic tools allowed us to perform a genome-wide association study (GWAS) in cattle to detect associations in a general population and estimate their effect size. Here, we performed a GWAS for Carcass Weight using 1156 Japanese Black steers. Bonferroni-corrected genome-wide significant associations were detected in three chromosomal regions on bovine chromosomes (BTA) 6, 8, and 14. The associated single nucleotide polymorphisms (SNP) on BTA 6 were in linkage disequilibrium with the SNP encoding NCAPG Ile442Met, which was previously identified as a candidate quantitative trait nucleotide for CW-2. In contrast, the most highly associated SNP on BTA 14 was located 2.3-Mb centromeric from the previously identified CW-1 region. Linkage disequilibrium mapping led to a revision of the CW-1 region within a 0.9-Mb interval around the associated SNP, and targeted resequencing followed by association analysis highlighted the quantitative trait nucleotides for bovine stature in the PLAG1-CHCHD7 intergenic region. The association on BTA 8 was accounted for by two SNP on the BovineSNP50 BeadChip and corresponded to CW-3, which was simultaneously detected by linkage analyses using half-sib families. The allele substitution effects of CW-1, CW-2, and CW-3 were 28.4, 35.3, and 35.0 kg per allele, respectively. The GWAS revealed the genetic architecture underlying Carcass Weight variation in Japanese Black cattle in which three major QTL accounted for approximately one-third of the genetic variance.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine. We used 38 microsatellite markers to search for a shared Q (increasing Carcass and/or body Weight) haplotype within the 17-cM CW-2 region among five sires. Linkage disequilibrium mapping using maternal alleles of the offspring showed that an 815-kb shared Q haplotype was associated with body or Carcass Weight in both breeds. The addition of 43 single nucleotide polymorphism (SNP) markers narrowed the region to 591 kb containing 4 genes. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) was significantly associated with Carcass Weight (p < 1.2 × 10-11) in a large Japanese Black population as well as in the five families. The Q allele of the SNP was also associated with a larger longissimus muscle area and thinner subcutaneous fat thickness in steers of all five families, indicating that the CW-2 locus is pleiotropic and favorable for marker-assisted selection of beef cattle. A 591-kb critical region for CW-2 was identified. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) can be used as a positional candidate of CW-2 for marker-assisted selection.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Background Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine.

Toshio Watanabe - One of the best experts on this subject based on the ideXlab platform.

  • effects of single nucleotide polymorphism marker density on degree of genetic variance explained and genomic evaluation for Carcass traits in japanese black beef cattle
    BMC Genetics, 2014
    Co-Authors: Shinichiro Ogawa, Toshio Watanabe, Yoshikazu Sugimoto, Shota Nishimura, Hirokazu Matsuda, Yukio Taniguchi, Hiroaki Iwaisaki
    Abstract:

    Japanese Black cattle are a beef breed whose meat is well known to excel in meat quality, especially in marbling, and whose effective population size is relatively low in Japan. Unlike dairy cattle, the accuracy of genomic evaluation (GE) for Carcass traits in beef cattle, including this breed, has been poorly studied. For Carcass Weight and marbling score in the breed, as well as the extent of whole genome linkage disequilibrium (LD), the effects of equally-spaced single nucleotide polymorphisms (SNPs) density on genomic relationship matrix (G matrix), genetic variance explained and GE were investigated using the genotype data of about 40,000 SNPs and two statistical models. Using all pairs of two adjacent SNPs in the whole SNP set, the means of LD (r 2 ) at ranges 0–0.1, 0.1–0.2, 0.2–0.5 and 0.5–1 Mb were 0.22, 0.13, 0.10 and 0.08, respectively, and 25.7, 13.9, 10.4 and 6.4% of the r 2 values exceeded 0.3, respectively. While about 90% of the genetic variance for Carcass Weight estimated using all available SNPs was explained using 4,000–6,000 SNPs, the corresponding percentage for marbling score was consistently lower. With the conventional linear model incorporating the G matrix, correlation between the genomic estimated breeding values (GEBVs) obtained using 4,000 SNPs and all available SNPs was 0.99 for Carcass Weight and 0.98 for marbling score, with an underestimation of the former GEBVs, especially for marbling score. The Japanese Black is likely to be in a breed group with a relatively high extent of whole genome LD. The results indicated that the degree of marbling is controlled by only QTLs with relatively small effects, compared with Carcass Weight, and that using at least 4,000 equally-spaced SNPs, there is a possibility of ranking animals genetically for these Carcass traits in this breed.

  • comparison of the effects explained by variations in the bovine plag1 and ncapg genes on daily body Weight gain linear skeletal measurements and Carcass traits in japanese black steers from a progeny testing program
    Animal Science Journal, 2013
    Co-Authors: Hiroshi Hoshiba, Kouji Setoguchi, Toshio Watanabe, Akihiro Kinoshita, Kazunori Mizoshita, Yoshikazu Sugimoto, Akiko Takasuga
    Abstract:

    The c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG gene, which leads to an amino acid change of Ile442 to Met442, was previously identified as a candidate causative variation for a bovine Carcass Weight quantitative trait loci (QTL) on chromosome 6, which was associated with linear skeletal measurement gains and daily body Weight gain at puberty. Recently, we identified the stature quantitative trait nucleotides (QTNs) in the PLAG1-CHCHD7 intergenic region as the causative variations for another Carcass Weight QTL on chromosome 14. This study aimed to compare the effects of the two QTL on growth and Carcass traits using 768 Japanese Black steers from a progeny testing program and to determine whether a genetic interaction was present between them. The FJX_250879 SNP representing the stature QTL was associated with linear skeletal measurements and average daily body Weight gain at early and late periods during adolescence. A genetic interaction between FJX_250879 and NCAPG c.1326T>G was detected only for body and rump lengths. Both were associated with increased Carcass Weight and Longissimus muscle area, and NCAPG c.1326T>G was also associated with reduced subcutaneous fat thickness and increased Carcass yield estimate. These results will provide useful information to improve Carcass Weight in Japanese Black cattle.

  • genome wide association study identified three major qtl for Carcass Weight including the plag1 chchd7 qtn for stature in japanese black cattle
    BMC Genetics, 2012
    Co-Authors: Shota Nishimura, Toshio Watanabe, Kazunori Mizoshita, Yoshikazu Sugimoto, Ken Tatsuda, Tatsuo Fujita, Naoto Watanabe, Akiko Takasuga
    Abstract:

    Significant quantitative trait loci (QTL) for Carcass Weight were previously mapped on several chromosomes in Japanese Black half-sib families. Two QTL, CW-1 and CW-2, were narrowed down to 1.1-Mb and 591-kb regions, respectively. Recent advances in genomic tools allowed us to perform a genome-wide association study (GWAS) in cattle to detect associations in a general population and estimate their effect size. Here, we performed a GWAS for Carcass Weight using 1156 Japanese Black steers. Bonferroni-corrected genome-wide significant associations were detected in three chromosomal regions on bovine chromosomes (BTA) 6, 8, and 14. The associated single nucleotide polymorphisms (SNP) on BTA 6 were in linkage disequilibrium with the SNP encoding NCAPG Ile442Met, which was previously identified as a candidate quantitative trait nucleotide for CW-2. In contrast, the most highly associated SNP on BTA 14 was located 2.3-Mb centromeric from the previously identified CW-1 region. Linkage disequilibrium mapping led to a revision of the CW-1 region within a 0.9-Mb interval around the associated SNP, and targeted resequencing followed by association analysis highlighted the quantitative trait nucleotides for bovine stature in the PLAG1-CHCHD7 intergenic region. The association on BTA 8 was accounted for by two SNP on the BovineSNP50 BeadChip and corresponded to CW-3, which was simultaneously detected by linkage analyses using half-sib families. The allele substitution effects of CW-1, CW-2, and CW-3 were 28.4, 35.3, and 35.0 kg per allele, respectively. The GWAS revealed the genetic architecture underlying Carcass Weight variation in Japanese Black cattle in which three major QTL accounted for approximately one-third of the genetic variance.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine. We used 38 microsatellite markers to search for a shared Q (increasing Carcass and/or body Weight) haplotype within the 17-cM CW-2 region among five sires. Linkage disequilibrium mapping using maternal alleles of the offspring showed that an 815-kb shared Q haplotype was associated with body or Carcass Weight in both breeds. The addition of 43 single nucleotide polymorphism (SNP) markers narrowed the region to 591 kb containing 4 genes. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) was significantly associated with Carcass Weight (p < 1.2 × 10-11) in a large Japanese Black population as well as in the five families. The Q allele of the SNP was also associated with a larger longissimus muscle area and thinner subcutaneous fat thickness in steers of all five families, indicating that the CW-2 locus is pleiotropic and favorable for marker-assisted selection of beef cattle. A 591-kb critical region for CW-2 was identified. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) can be used as a positional candidate of CW-2 for marker-assisted selection.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Background Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine.

Kouji Setoguchi - One of the best experts on this subject based on the ideXlab platform.

  • comparison of the effects explained by variations in the bovine plag1 and ncapg genes on daily body Weight gain linear skeletal measurements and Carcass traits in japanese black steers from a progeny testing program
    Animal Science Journal, 2013
    Co-Authors: Hiroshi Hoshiba, Kouji Setoguchi, Toshio Watanabe, Akihiro Kinoshita, Kazunori Mizoshita, Yoshikazu Sugimoto, Akiko Takasuga
    Abstract:

    The c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG gene, which leads to an amino acid change of Ile442 to Met442, was previously identified as a candidate causative variation for a bovine Carcass Weight quantitative trait loci (QTL) on chromosome 6, which was associated with linear skeletal measurement gains and daily body Weight gain at puberty. Recently, we identified the stature quantitative trait nucleotides (QTNs) in the PLAG1-CHCHD7 intergenic region as the causative variations for another Carcass Weight QTL on chromosome 14. This study aimed to compare the effects of the two QTL on growth and Carcass traits using 768 Japanese Black steers from a progeny testing program and to determine whether a genetic interaction was present between them. The FJX_250879 SNP representing the stature QTL was associated with linear skeletal measurements and average daily body Weight gain at early and late periods during adolescence. A genetic interaction between FJX_250879 and NCAPG c.1326T>G was detected only for body and rump lengths. Both were associated with increased Carcass Weight and Longissimus muscle area, and NCAPG c.1326T>G was also associated with reduced subcutaneous fat thickness and increased Carcass yield estimate. These results will provide useful information to improve Carcass Weight in Japanese Black cattle.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine. We used 38 microsatellite markers to search for a shared Q (increasing Carcass and/or body Weight) haplotype within the 17-cM CW-2 region among five sires. Linkage disequilibrium mapping using maternal alleles of the offspring showed that an 815-kb shared Q haplotype was associated with body or Carcass Weight in both breeds. The addition of 43 single nucleotide polymorphism (SNP) markers narrowed the region to 591 kb containing 4 genes. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) was significantly associated with Carcass Weight (p < 1.2 × 10-11) in a large Japanese Black population as well as in the five families. The Q allele of the SNP was also associated with a larger longissimus muscle area and thinner subcutaneous fat thickness in steers of all five families, indicating that the CW-2 locus is pleiotropic and favorable for marker-assisted selection of beef cattle. A 591-kb critical region for CW-2 was identified. The SNP changing Ile-442 to Met in NCAPG (chromosome condensation protein G) can be used as a positional candidate of CW-2 for marker-assisted selection.

  • cross breed comparisons identified a critical 591 kb region for bovine Carcass Weight qtl cw 2 on chromosome 6 and the ile 442 met substitution in ncapg as a positional candidate
    BMC Genetics, 2009
    Co-Authors: Kouji Setoguchi, Toshio Watanabe, Yoshikazu Sugimoto, Masako Furuta, Takashi Hirano, Tomoko Nagao, Akiko Takasuga
    Abstract:

    Background Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for Carcass and body Weight (CW-2) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or Carcass Weight that overlapped with CW-2 in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine.

Peter B Mather - One of the best experts on this subject based on the ideXlab platform.

  • genetic response to combined family selection for improved mean harvest Weight in giant freshwater prawn macrobrachium rosenbergii in vietnam
    Aquaculture, 2013
    Co-Authors: Dinh Hung, Nguyen Hong Nguyen, David A Hurwood, Raul W Ponzoni, Peter B Mather
    Abstract:

    We estimated genetic changes in body and Carcass Weight traits in a giant freshwater prawn (GFP) (Macrobrachium rosenbergii) population selected for increased body Weight at harvest in Vietnam. The data set consisted of 18,387 individual body and 1730 Carcass Weight records, as well as full pedigree information collected over four generations. Average selection response (per generation) in body Weight at harvest (transformed to square root) estimated as the difference between the Selection line and the Control group was 7.4% calculated from least squares mean (LSMs), 7.0% from estimated breeding values (EBVs) and 4.4% calculated from EBVs between two consecutive generations. Favorable correlated selection responses (estimated from LSMs) were found for other body traits including: total length, cephalothorax length, abdominal length, cephalothorax width, and abdominal width (12.1%, 14.5%, 10.4%, 15.5% and 13.3% over three selection generations, respectively). Data in the second generation of selection showed positive correlated responses for Carcass Weight traits including: abdominal Weight, exoskeleton-off Weight, and telson-off Weight of 8.8%, 8.6% and 8.8%, respectively. We conclude that body Weight at harvest responded well to the application of combined (between and within) family selection and correlated responses in Carcass Weight traits were favorable.

  • quantitative genetic parameter estimates for body and Carcass traits in a cultured stock of giant freshwater prawn macrobrachium rosenbergii selected for harvest Weight in vietnam
    Aquaculture, 2013
    Co-Authors: Dinh Hung, Nguyen Hong Nguyen, David A Hurwood, Raul W Ponzoni, Peter B Mather
    Abstract:

    Abstract We estimated the heritability and correlations between body and Carcass Weight traits in a cultured stock of giant freshwater prawn (GFP) ( Macrobrachium rosenbergii) selected for harvest body Weight in Vietnam. The data set consisted of 18,387 body and 1,730 Carcass records, as well as full pedigree information collected over four generations. Variance and covariance components were estimated by restricted maximum likelihood fitting a multi-trait animal model. Across generations, estimates of heritability for body and Carcass Weight traits were moderate and ranged from 0.14 to 0.19 and 0.17 to 0.21, respectively. Body trait heritabilities estimated for females were significantly higher than for males whereas Carcass Weight trait heritabilities estimated for females and males were not significantly different ( P  > 0.05). Maternal effects for body traits accounted for 4 to 5% of the total variance and were greater in females than in males. Genetic correlations among body traits were generally high in the mixed sexes. Genetic correlations between body and Carcass Weight traits were also high. Although some issues remain regarding the best statistical model to be fitted to GFP data, our results suggest that selection for high harvest body Weight based on breeding values estimated by fitting an animal model to the data can significantly improve mean body and Carcass Weight in GFP.