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Vincent W. V. Jaddoe - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat mass in infancy and abdominal pericardial and liver Fat assessed by magnetic resonance imaging at the age of 10 years
International Journal of Obesity, 2019Co-Authors: Bernadeta Patro Golab, Susana Santos, Ellis Voerman, Aad Van Der Lugt, Vincent W. V. JaddoeAbstract:Fat mass development in infancy contributes to later adiposity, but its relation to ectopic Fat depots is unknown. We examined the associations of infant Subcutaneous Fat with childhood general and organ-specific Fat. Among 593 children from a population-based prospective cohort study, we obtained total Subcutaneous Fat mass (as sum of biceps, triceps, suprailiacal, and subscapular skinfolds thickness), central-to-total Subcutaneous Fat ratio (sum of suprailiacal and subscapular skinfold thickness/total Subcutaneous Fat) at 1.5, 6 and 24 months of age. At 10 years, we assessed BMI, Fat mass index (FMI) based on total body Fat by dual-energy X-ray absorptiometry, and abdominal Subcutaneous, visceral and pericardial Fat mass indices, and liver Fat fraction by Magnetic Resonance Imaging. A higher central-to-total Subcutaneous Fat ratio at 1.5 months only and higher total Subcutaneous Fat at 6 and 24 months were associated with higher BMI, FMI and Subcutaneous Fat mass index at 10 years. The observed associations were the strongest between total Subcutaneous Fat at 24 months and these childhood outcomes (difference per 1-SDS increase in total Subcutaneous Fat: 0.15 SDS (95% Confidence Interval (CI) 0.08, 0.23), 0.17 SDS (95% CI 0.10, 0.24), 0.16 SDS (95% CI 0.08, 0.23) for BMI, FMI and childhood Subcutaneous Fat mass index, respectively). Infant Subcutaneous Fat measures at any time point were not associated with visceral and pericardial Fat mass indices, and liver Fat fraction at 10 years. Our results suggest that infant Subcutaneous Fat is associated with later childhood abdominal Subcutaneous Fat and general adiposity, but not with other organ-specific Fat depots.
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associations of infant Subcutaneous Fat mass with total and abdominal Fat mass at school age the generation r study
Paediatric and Perinatal Epidemiology, 2016Co-Authors: Susana Santos, Albert Hofman, Romy Gaillard, Andreia Oliveira, Henrique Barros, Marieke Abrahamseberkeveld, Eline M Van Der Beek, Vincent W. V. JaddoeAbstract:Background Skinfold thickness enables the measurement of overall and regional Subcutaneous Fatness in infancy and may be associated with total and abdominal body Fat in later childhood. We examined the associations of Subcutaneous Fat in infancy with total and abdominal Fat at school-age. Methods In a population-based prospective cohort study among 821 children, we calculated total Subcutaneous Fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total Subcutaneous Fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total Subcutaneous Fat) at 1.5 and 24 months. At 6 years, we measured Fat mass index (total Fat/height3), central-to-total Fat ratio (trunk Fat/total Fat), and android-to-gynoid Fat ratio (android Fat/gynoid Fat) by dual-energy X-ray absorptiometry and preperitoneal Fat mass area by abdominal ultrasound. Results Central-to-total Subcutaneous Fat ratio at 1.5 months was positively associated with Fat mass index and central-to-total Fat ratio at 6 years, whereas both total and central-to-total Subcutaneous Fat ratio at 24 months were positively associated with all childhood adiposity measures. A 1-standard-deviation scores higher total Subcutaneous Fat at 24 months was associated with an increased risk of childhood overweight (odds ratio 1.70, 95% confidence interval 1.36, 2.12). These associations were weaker than those for body mass index and stronger among girls than boys. Conclusions Subcutaneous Fat in infancy is positively associated with total and abdominal Fat at school-age. Our results also suggest that skinfold thicknesses add little value to estimate later body Fat, as compared with body mass index.
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maternal plasma n 3 and n 6 polyunsaturated Fatty acid concentrations during pregnancy and Subcutaneous Fat mass in infancy
Obesity, 2016Co-Authors: Aleksandra Jelena Vidakovic, Hans Demmelmair, Berthold Koletzko, Susana Santos, Michelle A Williams, Liesbeth Duijts, Albert Hofman, Vincent W. V. JaddoeAbstract:Objective The associations of maternal plasma n-3 and n-6 polyunsaturated Fatty acid (PUFA) concentrations during pregnancy with infant Subcutaneous Fat were examined. Methods In a population-based prospective cohort study among 904 mothers and their infants, maternal plasma n-3 and n-6 PUFA concentrations were measured at midpregnancy. Body mass index, total Subcutaneous Fat, and central-to-total Subcutaneous Fat ratio were calculated at 1.5, 6, and 24 months. Results Maternal n-3 PUFA levels were not consistently associated with infant body mass index or total Subcutaneous Fat. Higher maternal total n-3 PUFA levels, and specifically eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid, were associated with higher central-to-total Subcutaneous Fat ratio at 1.5 months, whereas higher maternal total n-3 PUFA levels were associated with lower central-to-total Subcutaneous Fat ratio at 6 months (all P values < 0.05). These associations were not present at 24 months. Maternal n-6 PUFA levels were not consistently associated with infant Subcutaneous Fat. A higher n-6/n-3 ratio was associated with lower central-to-total Subcutaneous Fat ratio at 1.5 months only (P value < 0.05). Conclusions Maternal n-3 PUFA levels during pregnancy may have transient effects on infant Subcutaneous Fat. Further studies are needed to assess the effects of maternal PUFA concentrations on Fat mass development during early infancy.
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Maternal smoking during pregnancy and Subcutaneous Fat mass in early childhood. The Generation R Study
European Journal of Epidemiology, 2011Co-Authors: Büşra Durmuş, Albert Hofman, Anita C. S. Hokken-koelega, Hein Raat, Eric A. P. Steegers, Vincent W. V. JaddoeAbstract:Maternal smoking during pregnancy increases the risk of obesity in the offspring. Not much is known about the associations with other measures of body composition. We assessed the associations of maternal smoking during pregnancy with the development of Subcutaneous Fat mass measured as peripheral and central skinfold thickness measurements in early childhood, in a population-based prospective cohort study from early fetal life onward in the city of Rotterdam, The Netherlands. The study was performed in 907 mothers and their children at the ages of 1.5, 6 and 24 months. As compared to non-smoking mothers, mothers who continued smoking during pregnancy were more likely to have a younger age and a lower educational level. Their children had a lower birth weight, higher risk of small size for gestational age and were breastfed for a shorter duration (-values 0.05). Also, the reported number of cigarettes smoked by mothers in both first and third trimester of pregnancy were not associated with peripheral, central and total Subcutaneous Fat mass in the offspring at the ages of 1.5, 6 and 24 months. Our findings suggest that fetal exposure to cigarette smoke during pregnancy does not influence Subcutaneous Fat mass in early childhood. Follow-up studies are needed in children at older ages and to identify associations of maternal smoking during pregnancy with other measures of body composition.
C C Chang - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat necrosis of the newborn complicating hypothermic cardiac surgery
British Journal of Dermatology, 2006Co-Authors: S D Chuang, Hsienching Chiu, C C ChangAbstract:Summary A newborn male infant developed Subcutaneous Fat necrosis (SCFN) with extensive calcification, 1 week after hypothermic cardiac surgery. The lesions resolved spontaneously, without sequelae, within 10 weeks. Five cases of SCFN occurring after induced hypothermia, used as an adjuvant in cardiac surgery, have been reported to date in the English literature. Our description of a sixth case re-emphasizes hypothermia as one possible cause of SCFN of the newborn.
Susana Santos - One of the best experts on this subject based on the ideXlab platform.
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Subcutaneous Fat mass in infancy and abdominal pericardial and liver Fat assessed by magnetic resonance imaging at the age of 10 years
International Journal of Obesity, 2019Co-Authors: Bernadeta Patro Golab, Susana Santos, Ellis Voerman, Aad Van Der Lugt, Vincent W. V. JaddoeAbstract:Fat mass development in infancy contributes to later adiposity, but its relation to ectopic Fat depots is unknown. We examined the associations of infant Subcutaneous Fat with childhood general and organ-specific Fat. Among 593 children from a population-based prospective cohort study, we obtained total Subcutaneous Fat mass (as sum of biceps, triceps, suprailiacal, and subscapular skinfolds thickness), central-to-total Subcutaneous Fat ratio (sum of suprailiacal and subscapular skinfold thickness/total Subcutaneous Fat) at 1.5, 6 and 24 months of age. At 10 years, we assessed BMI, Fat mass index (FMI) based on total body Fat by dual-energy X-ray absorptiometry, and abdominal Subcutaneous, visceral and pericardial Fat mass indices, and liver Fat fraction by Magnetic Resonance Imaging. A higher central-to-total Subcutaneous Fat ratio at 1.5 months only and higher total Subcutaneous Fat at 6 and 24 months were associated with higher BMI, FMI and Subcutaneous Fat mass index at 10 years. The observed associations were the strongest between total Subcutaneous Fat at 24 months and these childhood outcomes (difference per 1-SDS increase in total Subcutaneous Fat: 0.15 SDS (95% Confidence Interval (CI) 0.08, 0.23), 0.17 SDS (95% CI 0.10, 0.24), 0.16 SDS (95% CI 0.08, 0.23) for BMI, FMI and childhood Subcutaneous Fat mass index, respectively). Infant Subcutaneous Fat measures at any time point were not associated with visceral and pericardial Fat mass indices, and liver Fat fraction at 10 years. Our results suggest that infant Subcutaneous Fat is associated with later childhood abdominal Subcutaneous Fat and general adiposity, but not with other organ-specific Fat depots.
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associations of infant Subcutaneous Fat mass with total and abdominal Fat mass at school age the generation r study
Paediatric and Perinatal Epidemiology, 2016Co-Authors: Susana Santos, Albert Hofman, Romy Gaillard, Andreia Oliveira, Henrique Barros, Marieke Abrahamseberkeveld, Eline M Van Der Beek, Vincent W. V. JaddoeAbstract:Background Skinfold thickness enables the measurement of overall and regional Subcutaneous Fatness in infancy and may be associated with total and abdominal body Fat in later childhood. We examined the associations of Subcutaneous Fat in infancy with total and abdominal Fat at school-age. Methods In a population-based prospective cohort study among 821 children, we calculated total Subcutaneous Fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total Subcutaneous Fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total Subcutaneous Fat) at 1.5 and 24 months. At 6 years, we measured Fat mass index (total Fat/height3), central-to-total Fat ratio (trunk Fat/total Fat), and android-to-gynoid Fat ratio (android Fat/gynoid Fat) by dual-energy X-ray absorptiometry and preperitoneal Fat mass area by abdominal ultrasound. Results Central-to-total Subcutaneous Fat ratio at 1.5 months was positively associated with Fat mass index and central-to-total Fat ratio at 6 years, whereas both total and central-to-total Subcutaneous Fat ratio at 24 months were positively associated with all childhood adiposity measures. A 1-standard-deviation scores higher total Subcutaneous Fat at 24 months was associated with an increased risk of childhood overweight (odds ratio 1.70, 95% confidence interval 1.36, 2.12). These associations were weaker than those for body mass index and stronger among girls than boys. Conclusions Subcutaneous Fat in infancy is positively associated with total and abdominal Fat at school-age. Our results also suggest that skinfold thicknesses add little value to estimate later body Fat, as compared with body mass index.
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maternal plasma n 3 and n 6 polyunsaturated Fatty acid concentrations during pregnancy and Subcutaneous Fat mass in infancy
Obesity, 2016Co-Authors: Aleksandra Jelena Vidakovic, Hans Demmelmair, Berthold Koletzko, Susana Santos, Michelle A Williams, Liesbeth Duijts, Albert Hofman, Vincent W. V. JaddoeAbstract:Objective The associations of maternal plasma n-3 and n-6 polyunsaturated Fatty acid (PUFA) concentrations during pregnancy with infant Subcutaneous Fat were examined. Methods In a population-based prospective cohort study among 904 mothers and their infants, maternal plasma n-3 and n-6 PUFA concentrations were measured at midpregnancy. Body mass index, total Subcutaneous Fat, and central-to-total Subcutaneous Fat ratio were calculated at 1.5, 6, and 24 months. Results Maternal n-3 PUFA levels were not consistently associated with infant body mass index or total Subcutaneous Fat. Higher maternal total n-3 PUFA levels, and specifically eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid, were associated with higher central-to-total Subcutaneous Fat ratio at 1.5 months, whereas higher maternal total n-3 PUFA levels were associated with lower central-to-total Subcutaneous Fat ratio at 6 months (all P values < 0.05). These associations were not present at 24 months. Maternal n-6 PUFA levels were not consistently associated with infant Subcutaneous Fat. A higher n-6/n-3 ratio was associated with lower central-to-total Subcutaneous Fat ratio at 1.5 months only (P value < 0.05). Conclusions Maternal n-3 PUFA levels during pregnancy may have transient effects on infant Subcutaneous Fat. Further studies are needed to assess the effects of maternal PUFA concentrations on Fat mass development during early infancy.
R E Selby - One of the best experts on this subject based on the ideXlab platform.
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fine needle aspiration cytodiagnosis of Subcutaneous Fat necrosis of newborn a case report
Acta Cytologica, 1995Co-Authors: Raj K Gupta, S Naran, R E SelbyAbstract:We recently diagnosed Subcutaneous Fat necrosis in a newborn female infant using fine needle aspiration cytology. The neonate had perinatal asphyxia and her mother a difficult labor, but otherwise the neonate was well developed and healthy and within a few days developed well-defined areas of Subcutaneous induration all over. On cytologic examination of the aspirated material, many necrotizing Fat cells were found with refractile, needle-shaped crystals arranged in a sheaflike or starburst pattern. Subcutaneous Fat necrosis of the newborn is uncommon today, and although the histologic findings from excised tissue are known, this appears to be the first case in which the diagnosis was possible from a sample of fine needle aspirate.
Ping Zhou - One of the best experts on this subject based on the ideXlab platform.
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the effect of Subcutaneous Fat on electrical impedance myography electrode configuration and multi frequency analyses
PLOS ONE, 2016Co-Authors: Henry Shin, Ping ZhouAbstract:This study investigates the impact of the Subcutaneous Fat layer (SFL) thickness on localized electrical impedance myography (EIM), as well as the effects of different current electrodes, varying in distance and direction, on EIM output. Twenty-three healthy subjects underwent localized multi-frequency EIM on their biceps brachii muscles with a hand-held electrode array. The EIM measurements were recorded under three different configurations: wide (or outer) longitudinal configuration 6.8 cm, narrow (or inner) longitudinal configuration 4.5 cm, and narrow transverse configuration 4.5 cm. Ultrasound was applied to measure the SFL thickness. Coefficients of determination (R2) of three EIM variables (resistance, reactance, and phase) and SFL thickness were calculated. For the longitudinal configuration, the wide distance could reduce the effects of the Subcutaneous Fat when compared with the narrow distance, but a significant correlation still remained for all three EIM parameters. However, there was no significant correlation between SFL thickness and reactance in the transverse configuration (R2 = 0.0294, p = 0.434). Utilizing a ratio of 50kHz/100kHz phase was found to be able to help reduce the correlation with SFL thickness for all the three configurations. The findings indicate that the appropriate selection of the current electrode distance, direction and the multi-frequency phase ratio can reduce the impact of Subcutaneous Fat on EIM. These settings should be evaluated for future clinical studies using hand-held localized arrays to perform EIM.
