The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

Stefano Cascinu - One of the best experts on this subject based on the ideXlab platform.

  • allele polymorphisms of tumor integrins correlate with peritoneal Carcinosis capability of gastric cancer cells in radically resected patients
    Annals of Oncology, 2011
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, A Onofri, M Pistelli, A Bittoni, Rossana Berardi, Stefano Cascinu
    Abstract:

    Background: Preclinical studies suggested that integrins are relevant for gastric cancer diffusion. We investigated integrins polymorphisms role in determining peritoneal Carcinosis or hematogenous metastases in radically resected gastric cancer. Patients and methods: Integrins genotyping was carried out on pT3 radically resected gastric tumors recurring with either peritoneal-only Carcinosis or hematogenous metastases. Results: The following factors resulted independently associated with peritoneal Carcinosis or hematogenous metastases: the A genotype of rs2269772 (ITGA3) [odds ratio (OR) for peritoneal Carcinosis: 22.2, 95% confidence interval 1.2-40, P = 0.03], the G genotype of rs2269772 (ITGA3) (OR for hematogenous metastases: 5.5, 95% confidence interval 2.2-14.15, P = 0.0003), the C genotype of rs11902171 (ITGV) (OR for peritoneal Carcinosis: 6.8, 95% confidence interval 1.3-33.4, P = 0.01), the G genotype of rs11902171 (ITGV) (OR for hematogenous metastases: 2.5, 95% confidence interval 1.1-5.7, P = 0.02), diffuse histology (OR for peritoneal Carcinosis: 4.7, 95% confidence interval 1.9-11.3, P = 0.0005) and intestinal histology (OR for hematogenous metastases: 4.2, 95% confidence interval 1.9-9.9, P = 0.0008). Conclusions: Tumor histology represents a crucial issue conditioning tumoral behavior; genotyping of rs2269772 (ITGA3) and rs11902171 (ITGV) may be a further asset in the definition of high-risk patients for peritoneal Carcinosis among those relapsing after curative resection. The selection tool deriving from this analysis may allow an optimal use of innovative treatment strategies.

  • correlation of tumor integrins and peritoneal Carcinosis capability of gastric cancer
    Journal of Clinical Oncology, 2010
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, M Pistelli, A Bittoni, Rossana Berardi, Francesca Giorgi, Stefano Cascinu
    Abstract:

    e14539 Background: The availability of multiple treatment options for peritoneal Carcinosis from gastric cancer has re-opened the question of patients selection. Unfortunately to date no factors pr...

Ana Maria Waagagasser - One of the best experts on this subject based on the ideXlab platform.

Mario Scartozzi - One of the best experts on this subject based on the ideXlab platform.

  • allele polymorphisms of tumor integrins correlate with peritoneal Carcinosis capability of gastric cancer cells in radically resected patients
    Annals of Oncology, 2011
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, A Onofri, M Pistelli, A Bittoni, Rossana Berardi, Stefano Cascinu
    Abstract:

    Background: Preclinical studies suggested that integrins are relevant for gastric cancer diffusion. We investigated integrins polymorphisms role in determining peritoneal Carcinosis or hematogenous metastases in radically resected gastric cancer. Patients and methods: Integrins genotyping was carried out on pT3 radically resected gastric tumors recurring with either peritoneal-only Carcinosis or hematogenous metastases. Results: The following factors resulted independently associated with peritoneal Carcinosis or hematogenous metastases: the A genotype of rs2269772 (ITGA3) [odds ratio (OR) for peritoneal Carcinosis: 22.2, 95% confidence interval 1.2-40, P = 0.03], the G genotype of rs2269772 (ITGA3) (OR for hematogenous metastases: 5.5, 95% confidence interval 2.2-14.15, P = 0.0003), the C genotype of rs11902171 (ITGV) (OR for peritoneal Carcinosis: 6.8, 95% confidence interval 1.3-33.4, P = 0.01), the G genotype of rs11902171 (ITGV) (OR for hematogenous metastases: 2.5, 95% confidence interval 1.1-5.7, P = 0.02), diffuse histology (OR for peritoneal Carcinosis: 4.7, 95% confidence interval 1.9-11.3, P = 0.0005) and intestinal histology (OR for hematogenous metastases: 4.2, 95% confidence interval 1.9-9.9, P = 0.0008). Conclusions: Tumor histology represents a crucial issue conditioning tumoral behavior; genotyping of rs2269772 (ITGA3) and rs11902171 (ITGV) may be a further asset in the definition of high-risk patients for peritoneal Carcinosis among those relapsing after curative resection. The selection tool deriving from this analysis may allow an optimal use of innovative treatment strategies.

  • correlation of tumor integrins and peritoneal Carcinosis capability of gastric cancer
    Journal of Clinical Oncology, 2010
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, M Pistelli, A Bittoni, Rossana Berardi, Francesca Giorgi, Stefano Cascinu
    Abstract:

    e14539 Background: The availability of multiple treatment options for peritoneal Carcinosis from gastric cancer has re-opened the question of patients selection. Unfortunately to date no factors pr...

Martin Gasser - One of the best experts on this subject based on the ideXlab platform.

A Bittoni - One of the best experts on this subject based on the ideXlab platform.

  • allele polymorphisms of tumor integrins correlate with peritoneal Carcinosis capability of gastric cancer cells in radically resected patients
    Annals of Oncology, 2011
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, A Onofri, M Pistelli, A Bittoni, Rossana Berardi, Stefano Cascinu
    Abstract:

    Background: Preclinical studies suggested that integrins are relevant for gastric cancer diffusion. We investigated integrins polymorphisms role in determining peritoneal Carcinosis or hematogenous metastases in radically resected gastric cancer. Patients and methods: Integrins genotyping was carried out on pT3 radically resected gastric tumors recurring with either peritoneal-only Carcinosis or hematogenous metastases. Results: The following factors resulted independently associated with peritoneal Carcinosis or hematogenous metastases: the A genotype of rs2269772 (ITGA3) [odds ratio (OR) for peritoneal Carcinosis: 22.2, 95% confidence interval 1.2-40, P = 0.03], the G genotype of rs2269772 (ITGA3) (OR for hematogenous metastases: 5.5, 95% confidence interval 2.2-14.15, P = 0.0003), the C genotype of rs11902171 (ITGV) (OR for peritoneal Carcinosis: 6.8, 95% confidence interval 1.3-33.4, P = 0.01), the G genotype of rs11902171 (ITGV) (OR for hematogenous metastases: 2.5, 95% confidence interval 1.1-5.7, P = 0.02), diffuse histology (OR for peritoneal Carcinosis: 4.7, 95% confidence interval 1.9-11.3, P = 0.0005) and intestinal histology (OR for hematogenous metastases: 4.2, 95% confidence interval 1.9-9.9, P = 0.0008). Conclusions: Tumor histology represents a crucial issue conditioning tumoral behavior; genotyping of rs2269772 (ITGA3) and rs11902171 (ITGV) may be a further asset in the definition of high-risk patients for peritoneal Carcinosis among those relapsing after curative resection. The selection tool deriving from this analysis may allow an optimal use of innovative treatment strategies.

  • correlation of tumor integrins and peritoneal Carcinosis capability of gastric cancer
    Journal of Clinical Oncology, 2010
    Co-Authors: Mario Scartozzi, Cristian Loretelli, I Bearzi, Alessandra Mandolesi, E Galizia, M Pistelli, A Bittoni, Rossana Berardi, Francesca Giorgi, Stefano Cascinu
    Abstract:

    e14539 Background: The availability of multiple treatment options for peritoneal Carcinosis from gastric cancer has re-opened the question of patients selection. Unfortunately to date no factors pr...