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C Caramella - One of the best experts on this subject based on the ideXlab platform.
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Cardiophrenic Angle lymph node is an indicator of metastatic spread but not specifically peritoneal carcinomatosis in colorectal cancer patients results of a prospective validation study in 91 patients
Ejso, 2016Co-Authors: F Jeune, C Caramella, Antoine Brouquet, M Gayet, Solafah Abdalla, A L Verin, Thirot A Bidault, Christophe Penna, Stephane BenoistAbstract:Abstract Background The presence of Cardiophrenic Angle lymph node (CPALN) has been associated with the risk of peritoneal carcinomatosis (PC) in high risk colon cancer patients. Its accuracy to predict PC and its prognostic value in non-selected CRC patients has not been validated prospectively. Methods From 2011 to 2013, all patients undergoing colectomy for colon cancer were included prospectively. Presence of CPALN was assessed on preoperative computed tomography scan by two radiologists. Surgical exploration was used as reference for the diagnosis of PC. Factors associated with presence of CPALN and progression-free survival were analyzed. Results Ninety one patients fulfilled inclusion criteria. CPALN was detected in 36 patients (39.5%) on CT scan. At surgical exploration, PC was found in 6 patients (6.5%). Sensitivity, specificity, negative predictive value, positive predictive value and overall accuracy of CPALN on CT scan for predicting PC were 67%, 62%, 96%, 11% and 63% respectively. In multivariate analysis, the presence of distant metastases whatever the site was associated with the presence of CPALN (p = 0.03; hazard ratio HR = 3.8; confidence interval CI 95% = 1.1–13.3). In the multivariate analysis, only vascular involvement (p = 0.034, HR = 3.574, CI 95% = 1.10–11.60) was associated with progression-free survival whereas CPALN was not found to predict outcome (p = 0.893). Conclusion CPALN is a common finding in non-selected colon cancer patients. Although in the absence of CPALN, PC can almost be excluded, its value for the diagnosis of PC is limited. Our findings support that CPALN is mainly an indicator of metastatic spread of the tumor.
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value of Cardiophrenic Angle lymph node for the diagnosis of colorectal peritoneal carcinomatosis
European Journal of Cancer, 2013Co-Authors: C Caramella, I Borget, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David Malka, E Pottier, Peggy Dartigues, Michel DucreuxAbstract:Abstract Background Cardiophrenic Angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
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value of Cardiophrenic Angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis
Journal of Clinical Oncology, 2013Co-Authors: C Caramella, I Borget, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, David Malka, E Pottier, D EliasAbstract:372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the Cardiophrenic Angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not...
Michel Ducreux - One of the best experts on this subject based on the ideXlab platform.
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value of Cardiophrenic Angle lymph node for the diagnosis of colorectal peritoneal carcinomatosis
European Journal of Cancer, 2013Co-Authors: C Caramella, I Borget, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David Malka, E Pottier, Peggy Dartigues, Michel DucreuxAbstract:Abstract Background Cardiophrenic Angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
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prognostic significance of visible Cardiophrenic Angle lymph nodes in the presence of peritoneal metastases from colorectal cancers
Ejso, 2013Co-Authors: D Elias, I Borget, M Farron, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David MalkaAbstract:Abstract Background Visible Cardiophrenic Angle lymph nodes (CPALN) (enlarged or not), detected on CT scan are correlated with the presence of peritoneal metastases (PM), and contribute to the diagnosis of PM in colorectal cancer patients. Objective To study whether visible CPALN exert a prognostic impact on survival after complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CCRS + HIPEC) treating PM. Patients and methods From 1999 to 2010, 114 patients with colorectal cancer and PM were treated with CCRS + HIPEC. CPALN were depicted in 64% of cases. The impact of visible CPALN on survival was investigated retrospectively. Results The mean peritoneal cancer index (PCI) score was 9.2, 21% of the patients had presented with associated liver metastases, and 71% of the women with ovarian metastases. Median follow-up was 3.9 years. Visible CPALN had no impact on OS nor on DFS, unlike the PCI score which was unequivocably the most potent prognostic factor in the multivariate analysis. Conclusion Although some arguments might suggest that CPALN are malignant, paradoxically, we found that visible CPALN did not exert a positive nor a negative impact on survival after CCRS + HIPEC. Synopsis Visible Cardiophrenic Angle lymph nodes (CPALN) on CT-scan are strongly associated with the presence of peritoneal metastases. But this study demonstrates that the presence of CPALN has no prognostic impact after optimal cytoreductive surgery plus HIPEC.
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value of Cardiophrenic Angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis
Journal of Clinical Oncology, 2013Co-Authors: C Caramella, I Borget, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, David Malka, E Pottier, D EliasAbstract:372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the Cardiophrenic Angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not...
David Malka - One of the best experts on this subject based on the ideXlab platform.
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value of Cardiophrenic Angle lymph node for the diagnosis of colorectal peritoneal carcinomatosis
European Journal of Cancer, 2013Co-Authors: C Caramella, I Borget, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David Malka, E Pottier, Peggy Dartigues, Michel DucreuxAbstract:Abstract Background Cardiophrenic Angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
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prognostic significance of visible Cardiophrenic Angle lymph nodes in the presence of peritoneal metastases from colorectal cancers
Ejso, 2013Co-Authors: D Elias, I Borget, M Farron, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David MalkaAbstract:Abstract Background Visible Cardiophrenic Angle lymph nodes (CPALN) (enlarged or not), detected on CT scan are correlated with the presence of peritoneal metastases (PM), and contribute to the diagnosis of PM in colorectal cancer patients. Objective To study whether visible CPALN exert a prognostic impact on survival after complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CCRS + HIPEC) treating PM. Patients and methods From 1999 to 2010, 114 patients with colorectal cancer and PM were treated with CCRS + HIPEC. CPALN were depicted in 64% of cases. The impact of visible CPALN on survival was investigated retrospectively. Results The mean peritoneal cancer index (PCI) score was 9.2, 21% of the patients had presented with associated liver metastases, and 71% of the women with ovarian metastases. Median follow-up was 3.9 years. Visible CPALN had no impact on OS nor on DFS, unlike the PCI score which was unequivocably the most potent prognostic factor in the multivariate analysis. Conclusion Although some arguments might suggest that CPALN are malignant, paradoxically, we found that visible CPALN did not exert a positive nor a negative impact on survival after CCRS + HIPEC. Synopsis Visible Cardiophrenic Angle lymph nodes (CPALN) on CT-scan are strongly associated with the presence of peritoneal metastases. But this study demonstrates that the presence of CPALN has no prognostic impact after optimal cytoreductive surgery plus HIPEC.
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value of Cardiophrenic Angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis
Journal of Clinical Oncology, 2013Co-Authors: C Caramella, I Borget, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, David Malka, E Pottier, D EliasAbstract:372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the Cardiophrenic Angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not...
D Elias - One of the best experts on this subject based on the ideXlab platform.
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prognostic significance of visible Cardiophrenic Angle lymph nodes in the presence of peritoneal metastases from colorectal cancers
Ejso, 2013Co-Authors: D Elias, I Borget, M Farron, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David MalkaAbstract:Abstract Background Visible Cardiophrenic Angle lymph nodes (CPALN) (enlarged or not), detected on CT scan are correlated with the presence of peritoneal metastases (PM), and contribute to the diagnosis of PM in colorectal cancer patients. Objective To study whether visible CPALN exert a prognostic impact on survival after complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CCRS + HIPEC) treating PM. Patients and methods From 1999 to 2010, 114 patients with colorectal cancer and PM were treated with CCRS + HIPEC. CPALN were depicted in 64% of cases. The impact of visible CPALN on survival was investigated retrospectively. Results The mean peritoneal cancer index (PCI) score was 9.2, 21% of the patients had presented with associated liver metastases, and 71% of the women with ovarian metastases. Median follow-up was 3.9 years. Visible CPALN had no impact on OS nor on DFS, unlike the PCI score which was unequivocably the most potent prognostic factor in the multivariate analysis. Conclusion Although some arguments might suggest that CPALN are malignant, paradoxically, we found that visible CPALN did not exert a positive nor a negative impact on survival after CCRS + HIPEC. Synopsis Visible Cardiophrenic Angle lymph nodes (CPALN) on CT-scan are strongly associated with the presence of peritoneal metastases. But this study demonstrates that the presence of CPALN has no prognostic impact after optimal cytoreductive surgery plus HIPEC.
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value of Cardiophrenic Angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis
Journal of Clinical Oncology, 2013Co-Authors: C Caramella, I Borget, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, David Malka, E Pottier, D EliasAbstract:372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the Cardiophrenic Angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not...
Charles Honore - One of the best experts on this subject based on the ideXlab platform.
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value of Cardiophrenic Angle lymph node for the diagnosis of colorectal peritoneal carcinomatosis
European Journal of Cancer, 2013Co-Authors: C Caramella, I Borget, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David Malka, E Pottier, Peggy Dartigues, Michel DucreuxAbstract:Abstract Background Cardiophrenic Angle lymph nodes (CPALN) have been reported in patients with abdominopelvic malignancies. We aimed to assess whether the presence of CPALN is associated with peritoneal carcinomatosis (PC) in colorectal cancer. Patients and methods Between 2007 and 2011, 550 patients with colorectal cancer, including 165 (30%) with PC, had undergone surgery with complete peritoneal exploration. We retrospectively reviewed preoperative CT scans for the presence of CPALN and assessed its association with confirmed PC by univariate and multivariate analyses. Results CPALN were present in 123 (75%) patients with PC, but absent in 263 (68%) patients without PC (Se: 0.72; Sp: 0.68; PPV: 0.49; NPV: 0.85; [OR], 3.3; p Conclusion The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.
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prognostic significance of visible Cardiophrenic Angle lymph nodes in the presence of peritoneal metastases from colorectal cancers
Ejso, 2013Co-Authors: D Elias, I Borget, M Farron, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, F Dumont, David MalkaAbstract:Abstract Background Visible Cardiophrenic Angle lymph nodes (CPALN) (enlarged or not), detected on CT scan are correlated with the presence of peritoneal metastases (PM), and contribute to the diagnosis of PM in colorectal cancer patients. Objective To study whether visible CPALN exert a prognostic impact on survival after complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CCRS + HIPEC) treating PM. Patients and methods From 1999 to 2010, 114 patients with colorectal cancer and PM were treated with CCRS + HIPEC. CPALN were depicted in 64% of cases. The impact of visible CPALN on survival was investigated retrospectively. Results The mean peritoneal cancer index (PCI) score was 9.2, 21% of the patients had presented with associated liver metastases, and 71% of the women with ovarian metastases. Median follow-up was 3.9 years. Visible CPALN had no impact on OS nor on DFS, unlike the PCI score which was unequivocably the most potent prognostic factor in the multivariate analysis. Conclusion Although some arguments might suggest that CPALN are malignant, paradoxically, we found that visible CPALN did not exert a positive nor a negative impact on survival after CCRS + HIPEC. Synopsis Visible Cardiophrenic Angle lymph nodes (CPALN) on CT-scan are strongly associated with the presence of peritoneal metastases. But this study demonstrates that the presence of CPALN has no prognostic impact after optimal cytoreductive surgery plus HIPEC.
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value of Cardiophrenic Angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis
Journal of Clinical Oncology, 2013Co-Authors: C Caramella, I Borget, Clarisse Dromain, Michel Ducreux, Diane Goere, Charles Honore, Valerie Boige, David Malka, E Pottier, D EliasAbstract:372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the Cardiophrenic Angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not...