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Thierry Chinet - One of the best experts on this subject based on the ideXlab platform.
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Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction
International Journal of Chronic Obstructive Pulmonary Disease, 2018Co-Authors: Bertrand Herer, Thierry ChinetAbstract:This study was performed to examine acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR) and the usefulness of multidimensional indices (MIs) to predict AECOPD at enrolment in PR. A 4-week PR program (PRP) was implemented for 125 consecutive patients with COPD. At baseline and PRP completion, we recorded the FEV1, 6-minute walk test, peak work rate at Cardiopulmonary Testing, modified Medical Research Council score, and COPD Assessment Test (CAT) score. The risk of AECOPDs at baseline was assessed using the body mass index, airway obstruction, dyspnea, Exercise capacity (BODE), dyspnea, obstruction, smoking, exacerbation (DOSE), and score to predict short-term risk of COPD exacerbations (SCOPEX) MIs. Thirty-two episodes of AECOPD occurred. The COPD status was worse in patients with than without AECOPD at baseline (lower FEV1, 6-minute walk test, and peak work rate; higher modified Medical Research Council and CAT scores). The sensitivities of the BODE, DOSE, and SCOPEX MIs to predict the occurrence of AECOPD during PRP were 78.1%, 21.9%, and 84.4%, and the specificities were 73.6%, 87.1%, and 51.6%, respectively. The BODE and SCOPEX MIs help to predict the exacerbation risk during PR.
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Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction
International journal of chronic obstructive pulmonary disease, 2018Co-Authors: Bertrand Herer, Thierry ChinetAbstract:Purpose This study was performed to examine acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR) and the usefulness of multidimensional indices (MIs) to predict AECOPD at enrolment in PR. Patients and methods A 4-week PR program (PRP) was implemented for 125 consecutive patients with COPD. At baseline and PRP completion, we recorded the FEV1, 6-minute walk test, peak work rate at Cardiopulmonary Testing, modified Medical Research Council score, and COPD Assessment Test (CAT) score. The risk of AECOPDs at baseline was assessed using the body mass index, airway obstruction, dyspnea, Exercise capacity (BODE), dyspnea, obstruction, smoking, exacerbation (DOSE), and score to predict short-term risk of COPD exacerbations (SCOPEX) MIs. Results Thirty-two episodes of AECOPD occurred. The COPD status was worse in patients with than without AECOPD at baseline (lower FEV1, 6-minute walk test, and peak work rate; higher modified Medical Research Council and CAT scores). The sensitivities of the BODE, DOSE, and SCOPEX MIs to predict the occurrence of AECOPD during PRP were 78.1%, 21.9%, and 84.4%, and the specificities were 73.6%, 87.1%, and 51.6%, respectively. Conclusion The BODE and SCOPEX MIs help to predict the exacerbation risk during PR.
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Acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR): impact on outcomes and short-term prediction of risk
European Respiratory Journal, 2017Co-Authors: Bertrand Herer, Thierry ChinetAbstract:Methods: A 4-week PR program (PRP) was implemented in 125 patients (mean age 65±8 years, 54 females, 98% Gold B or D). We recorded at baseline and at PRP completion: FEV1 (% pred), 6-min walking test (m, 6MWT), peak work rate at Cardiopulmonary Testing (WR peak, W), mMRC, CAT scores and all episodes of AECOPD. The risk for AECOPD during PRP was assessed at baseline using the following scores: BODE, DOSE and SCOPEX. Results: Thirty two episodes of AECOPD occurred during PRP (25.6%). Patients with AECOPD (group EX) had a worse COPD status than patients without AECOPD (group NEX): lower FEV1 (40±20 % pred vs 49±20 % pred, p=0.03), 6MWT (309±101 m vs 376±88 m, p=10-3) and WR peak (41±18 W vs 64±24 W, p Conclusions: AECOPD during PRP is not a rare event especially in patients with more severe COPD and it should be promptly managed, as patients with exacerbations during PRP may still complete the PRP and exhibit improved outcomes. BODE and SCOPEX calculations at enrolment may help to predict patients at short-term risk of AECOPD.
Bertrand Herer - One of the best experts on this subject based on the ideXlab platform.
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Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction
International Journal of Chronic Obstructive Pulmonary Disease, 2018Co-Authors: Bertrand Herer, Thierry ChinetAbstract:This study was performed to examine acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR) and the usefulness of multidimensional indices (MIs) to predict AECOPD at enrolment in PR. A 4-week PR program (PRP) was implemented for 125 consecutive patients with COPD. At baseline and PRP completion, we recorded the FEV1, 6-minute walk test, peak work rate at Cardiopulmonary Testing, modified Medical Research Council score, and COPD Assessment Test (CAT) score. The risk of AECOPDs at baseline was assessed using the body mass index, airway obstruction, dyspnea, Exercise capacity (BODE), dyspnea, obstruction, smoking, exacerbation (DOSE), and score to predict short-term risk of COPD exacerbations (SCOPEX) MIs. Thirty-two episodes of AECOPD occurred. The COPD status was worse in patients with than without AECOPD at baseline (lower FEV1, 6-minute walk test, and peak work rate; higher modified Medical Research Council and CAT scores). The sensitivities of the BODE, DOSE, and SCOPEX MIs to predict the occurrence of AECOPD during PRP were 78.1%, 21.9%, and 84.4%, and the specificities were 73.6%, 87.1%, and 51.6%, respectively. The BODE and SCOPEX MIs help to predict the exacerbation risk during PR.
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Acute exacerbation of COPD during pulmonary rehabilitation: outcomes and risk prediction
International journal of chronic obstructive pulmonary disease, 2018Co-Authors: Bertrand Herer, Thierry ChinetAbstract:Purpose This study was performed to examine acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR) and the usefulness of multidimensional indices (MIs) to predict AECOPD at enrolment in PR. Patients and methods A 4-week PR program (PRP) was implemented for 125 consecutive patients with COPD. At baseline and PRP completion, we recorded the FEV1, 6-minute walk test, peak work rate at Cardiopulmonary Testing, modified Medical Research Council score, and COPD Assessment Test (CAT) score. The risk of AECOPDs at baseline was assessed using the body mass index, airway obstruction, dyspnea, Exercise capacity (BODE), dyspnea, obstruction, smoking, exacerbation (DOSE), and score to predict short-term risk of COPD exacerbations (SCOPEX) MIs. Results Thirty-two episodes of AECOPD occurred. The COPD status was worse in patients with than without AECOPD at baseline (lower FEV1, 6-minute walk test, and peak work rate; higher modified Medical Research Council and CAT scores). The sensitivities of the BODE, DOSE, and SCOPEX MIs to predict the occurrence of AECOPD during PRP were 78.1%, 21.9%, and 84.4%, and the specificities were 73.6%, 87.1%, and 51.6%, respectively. Conclusion The BODE and SCOPEX MIs help to predict the exacerbation risk during PR.
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Acute exacerbation of COPD (AECOPD) during pulmonary rehabilitation (PR): impact on outcomes and short-term prediction of risk
European Respiratory Journal, 2017Co-Authors: Bertrand Herer, Thierry ChinetAbstract:Methods: A 4-week PR program (PRP) was implemented in 125 patients (mean age 65±8 years, 54 females, 98% Gold B or D). We recorded at baseline and at PRP completion: FEV1 (% pred), 6-min walking test (m, 6MWT), peak work rate at Cardiopulmonary Testing (WR peak, W), mMRC, CAT scores and all episodes of AECOPD. The risk for AECOPD during PRP was assessed at baseline using the following scores: BODE, DOSE and SCOPEX. Results: Thirty two episodes of AECOPD occurred during PRP (25.6%). Patients with AECOPD (group EX) had a worse COPD status than patients without AECOPD (group NEX): lower FEV1 (40±20 % pred vs 49±20 % pred, p=0.03), 6MWT (309±101 m vs 376±88 m, p=10-3) and WR peak (41±18 W vs 64±24 W, p Conclusions: AECOPD during PRP is not a rare event especially in patients with more severe COPD and it should be promptly managed, as patients with exacerbations during PRP may still complete the PRP and exhibit improved outcomes. BODE and SCOPEX calculations at enrolment may help to predict patients at short-term risk of AECOPD.
Edimar Alcides Bocchi - One of the best experts on this subject based on the ideXlab platform.
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effects of reducing exposure to air pollution on submaximal Cardiopulmonary test in patients with heart failure analysis of the randomized double blind and controlled filter hf trial
International Journal of Cardiology, 2016Co-Authors: Jefferson Luis Vieira, Guilherme Veiga Guimaraes, Paulo Afonso De Andre, Paulo Hilario Nascimento Saldiva, Edimar Alcides BocchiAbstract:Abstract Background Air pollution exposure could mitigate the health benefits of exercise in patients with heart failure (HF). We tested the effects of a respiratory filter on HF patients exposed to air pollution during exercise. Methods and Results Ancillary analysis of the FILTER-HF trial, focused on the exercise outcomes. In a randomized, double-blind, 3-way crossover design, 26 HF patients and 15 control volunteers were exposed to clean air, unfiltered dilute diesel engine exhaust (DE), or filtered DE for 6 min during a submaximal Cardiopulmonary Testing in a controlled-exposure facility. Prospectively collected data included six-minute walking test [6mwt], VO2, VE/VCO2 Slope, O2Pulse, pulmonary ventilation [VE], tidal volume, VD/Vt, oxyhemoglobin saturation and CO2-rebreathing. Compared to clean air, DE adversely affected VO2 (11.0 ± 3.9 vs. 8.4 ± 2.8 ml/kg/min; p Conclusion DE adversely affects exercise capacity in patients with HF. A simple respiratory filter can reduce the adverse effects of pollution on VO2 and O2Pulse. Given the worldwide prevalence of exposure to traffic-related air pollution, these findings are relevant for public health especially in this highly susceptible population. The filter intervention holds great promise that needs to be tested in future studies.
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effects of reducing exposure to air pollution on submaximal Cardiopulmonary test in patients with heart failure analysis of the randomized double blind and controlled filter hf trial
International Journal of Cardiology, 2016Co-Authors: Jefferson Luis Vieira, Guilherme Veiga Guimaraes, Paulo Afonso De Andre, Paulo Hilario Nascimento Saldiva, Edimar Alcides BocchiAbstract:Abstract Background Air pollution exposure could mitigate the health benefits of exercise in patients with heart failure (HF). We tested the effects of a respiratory filter on HF patients exposed to air pollution during exercise. Methods and Results Ancillary analysis of the FILTER-HF trial, focused on the exercise outcomes. In a randomized, double-blind, 3-way crossover design, 26 HF patients and 15 control volunteers were exposed to clean air, unfiltered dilute diesel engine exhaust (DE), or filtered DE for 6min during a submaximal Cardiopulmonary Testing in a controlled-exposure facility. Prospectively collected data included six-minute walking test [6mwt], VO 2 , VE/VCO 2 Slope, O 2 Pulse, pulmonary ventilation [VE], tidal volume, VD/Vt, oxyhemoglobin saturation and CO2-rebreathing. Compared to clean air, DE adversely affected VO 2 (11.0±3.9 vs. 8.4±2.8ml/kg/min; p 2 Pulse (8.9±1.0 vs. 7.8±0.7ml/beat; p 3 , and was associated with an increase in VO 2 (10.4±3.8ml/kg/min; p 2 Pulse (9.7±1.1ml/beat; p 2 -rebreathing in both groups. VE/VCO 2 Slope was higher among patients with HF. Conclusion DE adversely affects exercise capacity in patients with HF. A simple respiratory filter can reduce the adverse effects of pollution on VO 2 and O 2 Pulse. Given the worldwide prevalence of exposure to traffic-related air pollution, these findings are relevant for public health especially in this highly susceptible population. The filter intervention holds great promise that needs to be tested in future studies.
Nenad Dikic - One of the best experts on this subject based on the ideXlab platform.
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O-35 Is there connection between food intolerance and sports performance in elite athletes?
British Journal of Sports Medicine, 2016Co-Authors: Marija Kostic-vucicevic, Danica Marinkovic, Nenad Dikic, Tamara Stojmenovic, Marija Andjelkovic, Ivan Nikolic, Milica Vukasinovic-vesic, Tatjana MalicAbstract:Objectives Food intolerance implies different health problems caused by certain foods. It is known that 2%−20% humans have this problem. Despite that, the food intolerance stays unrecognised in many cases. Generally, physical activity makes a lot of benefits for people health. On the other hand, very hard training, as in the case of the professional athletes, has bad influence on the immunity, such as increment of gastrointestinal barrier (GI) permeability. There are the studies that show presence of high sensitivity to food intolerance in elite athletes. It is apparently that extreme physical activity is one of the reasons. The aim of this study was to examine the influence of food intolerance on sports performance and health in elite athletes. Methods This was an experimental longitudinal study in the duration of 3 months. There were 12 men (mean ± SD; age 25 ± 7 years) and 10 women (age 25 ± 4 years) in the study. The participations were professional athletes, with training more than 10 hours per week. At the beginning of the study the athletes had to fill AQUA (Allergy Questionnaire for Athletes) and GSRS (Gastrointestinal Symptom Rating Scale) questionnaires. After that, they were underwent to food intolerance test from cubital vein blood, medical examination and maximal Cardiopulmonary Testing. This procedures, including AQUA and GSRS, were done again at the end of the study. The individual elimination diet based on food intolerance test was made for the athletes. All of them were on diet for 3 months. Results There wasn’t significant change in total GSRS score (p = 0.05) after diet, but syndrome indigestion score was significantly lowered (p = 0.01). The scores of AQUA were significant different at the beginning and at the end of the study (p = 0.0009). The blood analysis showed declining level of the food intolerance for each athlete. There was significant change in body composition of the athletes. Namely, the fat percent (FAT%) was significantly lowered (p = 0.0008) after the elimination diet. There wasn’t change in weight of the athletes (p = 0.06). Heart rate (HR) after Cardiopulmonary Testing was measured for the first 3 minutes. There was significant difference in HR at the second (p = 0.02) and the third (p = 0.006) minute. At the end of the study HR at the second and the third minute was lowered. The flexibility of the athletes, received by sit and reach test, was better after the diet (p = 0.001). Conclusions Our data shows that sports performances and health in elite athletes depend on food intolerance in many ways. The elimination diet for 3 months significantly improved health, body composition and faster lowering HR after Cardiopulmonary Testing. References Pasha I, Saeed F, Sultan, MT, Batool R, Aziz M, Ahmed, WWWW. WWWWheat allergy & intolerance; Recent updates and perspectives. Critical Reviews in Food Science and Nutrition 2016: 56 (1):13–24. Karsten K, Frank-Christoph M, Christian P. The immunomodulatory effects of physical activity. Current Pharmaceutical Design. 22. 2016: PMID: 27000826. LomerMC. Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance. Alimentary Pharmacology & Therapeutics 2015: 41 (3):262–275. Vandenplas Y. Debates in allergy medicine: food intolerance does exist. World Allergy Organ J 2015: 8 :36. doi: 10.1186/s40413-015-0087-7. Van Wijck K, Lenaerts K, Van Loon LJ, Peters, WH, Buurman WA, DejongCH. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS ONE 2011: 6 (7):e22366. Volpi N, Maccari F. Serum IgG responses to food antigens in the Italian population evaluated by highly sensitive and specific ELISA test. J Immunoassay Immunochem 2008: 30 (1):51–69.
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The combined exercise stress echocardiography and Cardiopulmonary exercise test for identification of masked heart failure with preserved ejection fraction in patients with hypertension
European journal of preventive cardiology, 2015Co-Authors: Ivana Nedeljkovic, Marko Banovic, Jelena Stepanovic, Vojislav Giga, Ana Djordjevic-dikic, Danijela Trifunovic, Milan Nedeljkovic, Milan Petrovic, Milan Dobric, Nenad DikicAbstract:BackgroundHeart failure with preserved ejection fraction (HFpEF) is commonly associated with hypertension (HTN). However, resting echocardiography (ECHO) can underestimate the severity of disease. Exercise stress echocardiography (ESE) and the Cardiopulmonary exercise Testing (CPX) appeared to be useful tests in dynamic assessment of HFpEF. The value of combined exercise stress echocardiography Cardiopulmonary Testing (ESE-CPX) in the identification of masked HFpEF is still undetermined.ObjectiveThe purpose of this study was to analyse the value of the combined ESE-CPX in the identification of masked HFpEF in patients with HTN, dyspnoea and normal resting left ventricular (LV) systolic and diastolic function.MethodologyWe studied 87 patients with HTN, exertional dyspnoea and normal resting LV function. They all underwent ESE-CPX Testing (supine bicycle, ramp protocol, 15 W/min). ECHO measurements were performed at rest, and at peak load. Achievement of peak E/e' ratio>15 was a marker for masked HFpEF.Resu...
Jefferson Luis Vieira - One of the best experts on this subject based on the ideXlab platform.
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effects of reducing exposure to air pollution on submaximal Cardiopulmonary test in patients with heart failure analysis of the randomized double blind and controlled filter hf trial
International Journal of Cardiology, 2016Co-Authors: Jefferson Luis Vieira, Guilherme Veiga Guimaraes, Paulo Afonso De Andre, Paulo Hilario Nascimento Saldiva, Edimar Alcides BocchiAbstract:Abstract Background Air pollution exposure could mitigate the health benefits of exercise in patients with heart failure (HF). We tested the effects of a respiratory filter on HF patients exposed to air pollution during exercise. Methods and Results Ancillary analysis of the FILTER-HF trial, focused on the exercise outcomes. In a randomized, double-blind, 3-way crossover design, 26 HF patients and 15 control volunteers were exposed to clean air, unfiltered dilute diesel engine exhaust (DE), or filtered DE for 6 min during a submaximal Cardiopulmonary Testing in a controlled-exposure facility. Prospectively collected data included six-minute walking test [6mwt], VO2, VE/VCO2 Slope, O2Pulse, pulmonary ventilation [VE], tidal volume, VD/Vt, oxyhemoglobin saturation and CO2-rebreathing. Compared to clean air, DE adversely affected VO2 (11.0 ± 3.9 vs. 8.4 ± 2.8 ml/kg/min; p Conclusion DE adversely affects exercise capacity in patients with HF. A simple respiratory filter can reduce the adverse effects of pollution on VO2 and O2Pulse. Given the worldwide prevalence of exposure to traffic-related air pollution, these findings are relevant for public health especially in this highly susceptible population. The filter intervention holds great promise that needs to be tested in future studies.
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effects of reducing exposure to air pollution on submaximal Cardiopulmonary test in patients with heart failure analysis of the randomized double blind and controlled filter hf trial
International Journal of Cardiology, 2016Co-Authors: Jefferson Luis Vieira, Guilherme Veiga Guimaraes, Paulo Afonso De Andre, Paulo Hilario Nascimento Saldiva, Edimar Alcides BocchiAbstract:Abstract Background Air pollution exposure could mitigate the health benefits of exercise in patients with heart failure (HF). We tested the effects of a respiratory filter on HF patients exposed to air pollution during exercise. Methods and Results Ancillary analysis of the FILTER-HF trial, focused on the exercise outcomes. In a randomized, double-blind, 3-way crossover design, 26 HF patients and 15 control volunteers were exposed to clean air, unfiltered dilute diesel engine exhaust (DE), or filtered DE for 6min during a submaximal Cardiopulmonary Testing in a controlled-exposure facility. Prospectively collected data included six-minute walking test [6mwt], VO 2 , VE/VCO 2 Slope, O 2 Pulse, pulmonary ventilation [VE], tidal volume, VD/Vt, oxyhemoglobin saturation and CO2-rebreathing. Compared to clean air, DE adversely affected VO 2 (11.0±3.9 vs. 8.4±2.8ml/kg/min; p 2 Pulse (8.9±1.0 vs. 7.8±0.7ml/beat; p 3 , and was associated with an increase in VO 2 (10.4±3.8ml/kg/min; p 2 Pulse (9.7±1.1ml/beat; p 2 -rebreathing in both groups. VE/VCO 2 Slope was higher among patients with HF. Conclusion DE adversely affects exercise capacity in patients with HF. A simple respiratory filter can reduce the adverse effects of pollution on VO 2 and O 2 Pulse. Given the worldwide prevalence of exposure to traffic-related air pollution, these findings are relevant for public health especially in this highly susceptible population. The filter intervention holds great promise that needs to be tested in future studies.