The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform

Robert J. Genco - One of the best experts on this subject based on the ideXlab platform.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms
    The Journal of the American Dental Association, 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James D. Beck
    Abstract:

    ABSTRACT Background Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. Types of Studies Reviewed The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. Results The evidence suggests a moderate association—but not a causal relationship—between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. Conclusions The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms.
    Journal of the American Dental Association (1939), 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James Beck
    Abstract:

    Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. The evidence suggests a moderate association--but not a causal relationship--between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.

Elmer Jasper B. Llanes - One of the best experts on this subject based on the ideXlab platform.

  • Cardiac events occurred commonly among apparently healthy Filipinos with the Brugada ECG pattern in the LIFECARE cohort
    Heart Asia, 2018
    Co-Authors: Giselle G Gervacio, Elmer Jasper B. Llanes, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit, Olivia T. Sison, Jaime Alfonso M. Aherrera, Lauro L. Abrahan, Michael Joseph Agbayani, E. Shyong Tai
    Abstract:

    Background Brugada syndrome is the mechanism for sudden unexplained death. The Brugada ECG pattern is found in 2% of Filipinos. There is a knowledge gap on the clinical outcome of these individuals. The clinical profile and 5-year cardiac event rate of individuals with the Brugada ECG pattern were determined in this cohort. Methods This is a sub-study of LIFECARE (Life Course Study in Cardiovascular Disease Epidemiology), a community based cohort enrolling healthy individuals 20 to 50 years old conducted in 2009–2010. ECGs of all enrollees were screened independently by three cardiologists. The prevalence of the coved Brugada ECG pattern was ascertained, and the 5-year cardiac event rate was determined among those individuals with this pattern. The participants were contacted to determine the occurrence of cardiac events, which included syncope, presyncope, seizures, cardiac arrest and unexplained vehicular accidents. Results A total of 3072 ECGs were reviewed, and 14 subjects (0.4%) with the coved Brugada ECG pattern were identified. Four had a cardiac event on follow-up at 5 years, but all remained alive. Most of these 14 coved Brugada individuals were healthy and asymptomatic at baseline. Conclusion Cardiac events occurred commonly among initially asymptomatic Filipinos with the coved Brugada ECG pattern. Such patients need to be followed up closely.

  • Prevalence of and Associations for Complementary and Alternative Medicine Use among Apparently Healthy Individuals in the Philippine LIFECARE Cohort
    2018
    Co-Authors: Mary Ann J. Ladia, Elmer Jasper B. Llanes, Nina T. Castillo-carandang, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit, Wilbert Allan G. Gumatay, Olivia T. Sison, Felicidad V. Velandria
    Abstract:

    Objectives. The study determined the prevalence of complementary and alternative medicine (CAM) use and its association with socio-demographic and clinical characteristics among adult Filipinos aged 20-50 years. Methods. Data from the Philippine cohort of the Life Course Study in Cardiovascular Disease Epidemiology (LIFECARE) in Luzon were analyzed. Multiple logistic regression determined the factors associated with the use of CAM. Results. A total of 3,072 participants were included: average age of 36 years, more females, mostly married, living in the rural areas, and employed. The prevalence of CAM use in this population was 43%. The commonly sought traditional medicine practitioners were manghihilot (bone setter or partera) and albularyo (herbalist), and participants used herbal medicines and supplements. Use of CAM was more likely among older participants, females, living in rural areas, had medical consultation in the last six months, experienced moderate to extreme pain, and with poor perception of general health. Conclusion. The use of CAM is prevalent among apparently healthy individuals aged 20-50 years. Further studies should uncover reasons for CAM use.

  • Where We Are: Socio-Ecological and Health Profile of the Philippine LIFEcourse study in Cardiovascular Disease Epidemiology (LIFECARE) Study Sites
    Acta Medica Philippina, 2014
    Co-Authors: Elmer Jasper B. Llanes, Paulette D. Nacpil-dominguez, Nina T. Castillo-carandang, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit, Wilbert Allan G. Gumatay, Olivia T. Sison, Queenie G. Ngalob, Felicidad V. Velandria
    Abstract:

    ...

  • Prevalence of Cardiovascular Risk Factors in relation to Socio-demographic profile of the Life Course Study in Cardiovascular Disease Epidemiology Study (LIFECARE) Philippine Cohort
    Acta Medica Philippina, 2014
    Co-Authors: Felix Eduardo R. Punzalan, Paulette D. Nacpil-dominguez, Nina T. Castillo-carandang, Paul Ferdinand M. Reganit, Wilbert Allan G. Gumatay, Olivia T. Sison, Queenie G. Ngalob, Felicidad V. Velandria, Elmer Jasper B. Llanes
    Abstract:

    ...

  • Socio-demographic factors and the prevalence of metabolic syndrome among filipinos from the LIFECARE cohort
    Journal of atherosclerosis and thrombosis, 2014
    Co-Authors: Elmer Jasper B. Llanes, Richie Poulton, Nina T. Castillo-carandang, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit, Olivia T. Sison, Nang Ei Ei Khaing, Mark Woodward, E. Shyong Tai
    Abstract:

    Background Metabolic syndrome(MetS) is an aggregation of multiple metabolic risk factors shown to lead to the development of Cardiovascular Disease. The International Diabetes Federation(IDF) and the modified National Cholesterol Education Program Adult Treatment Panel Ⅲ(mNCEP) criteria are used in identifying MetS. This report will determine the prevalence of MetS and its component risk factors of the Philippine cohort of the LIFE course study in Cardiovascular Disease Epidemiology(LIFECARE). Methods Our study recruited 3,072 participants aged 20-50 years old from Metro Manila and four nearby provinces. Baseline anthropometric and clinical parameters were measured. Prevalence of MetS and its component factors were determined. Associations with socio-demographic factors were determined. Results The prevalence of MetS was 19.7% and 25.6% by IDF and mNCEP, respectively(kappa 0.83). Both were associated with increasing age, urban residence, and employed status. It was higher in females by IDF and in males by mNCEP. IDF missed 40% of males and 10% of females identified with MetS by mNCEP. More males were identified by the mNCEP as MetS despite relatively normal waist circumference. Conclusion MetS is common in the Philippines among older, educated, and urban residents. The mNCEP criteria identified more MetS than the IDF criteria.

James Beck - One of the best experts on this subject based on the ideXlab platform.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms.
    Journal of the American Dental Association (1939), 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James Beck
    Abstract:

    Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. The evidence suggests a moderate association--but not a causal relationship--between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.

James D. Beck - One of the best experts on this subject based on the ideXlab platform.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms
    The Journal of the American Dental Association, 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James D. Beck
    Abstract:

    ABSTRACT Background Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. Types of Studies Reviewed The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. Results The evidence suggests a moderate association—but not a causal relationship—between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. Conclusions The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.

Steven Offenbacher - One of the best experts on this subject based on the ideXlab platform.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms
    The Journal of the American Dental Association, 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James D. Beck
    Abstract:

    ABSTRACT Background Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. Types of Studies Reviewed The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. Results The evidence suggests a moderate association—but not a causal relationship—between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. Conclusions The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.

  • Periodontal Disease and Cardiovascular Disease: Epidemiology and possible mechanisms.
    Journal of the American Dental Association (1939), 2002
    Co-Authors: Robert J. Genco, Steven Offenbacher, James Beck
    Abstract:

    Many early epidemiologic studies reported an association between periodontal Disease and Cardiovascular Disease. However, other studies found no association or nonsignificant trends. This report summarizes the evidence from epidemiologic studies and studies that focused on potential contributing mechanisms to provide a more complete picture of the association between periodontal and heart Disease. The authors summarize the longitudinal studies reported to date, because they represent the highest level of evidence available regarding the connection between periodontal Disease and heart Disease. The authors also review many of the case-control and cross-sectional studies published, as well as findings from clinical, animal and basic laboratory studies. The evidence suggests a moderate association--but not a causal relationship--between periodontal Disease and heart Disease. Results of some case-control studies indicate that subgingival periodontal pathogenic infection may be associated with myocardial infarction. Basic laboratory studies point to the biological plausibility of this association, since oral bacteria have been found in carotid atheromas and some oral bacteria may be associated with platelet aggregation, an event important for thrombosis. Animal studies have shown that atheroma formation can be enhanced by exposure to periodontal pathogens. The accumulation of epidemiologic, in vitro, clinical and animal evidence suggests that periodontal infection may be a contributing risk factor for heart Disease. However, legitimate concerns have arisen about the nature of this relationship. These are early investigations. Since even a moderate risk contributed by periodontal Disease to heart Disease could contribute to significant morbidity and mortality, it is imperative that further studies be conducted to evaluate this relationship. One particularly important study to be carried out is the investigation of a possible clinically meaningful reduction in heart Disease resulting from the prevention or treatment of periodontal Disease.