The Experts below are selected from a list of 765348 Experts worldwide ranked by ideXlab platform

Ajay Nehra - One of the best experts on this subject based on the ideXlab platform.

  • Erectile dysfunction and Cardiovascular Disease.
    Mayo Clinic proceedings, 2004
    Co-Authors: Shane T. Russell, Bijoy K. Khandheria, Ajay Nehra
    Abstract:

    Cardiovascular Disease and erectile dysfunction (ED) are closely interrelated Disease processes. Erectile dysfunction reportedly affects 10 million to 20 million men in the United States and more than 100 million men worldwide. Each year, about 500,000 persons in the United States survive a myocardial infarction, and an estimated 11 million have existing Cardiovascular Disease, making the issue of sexual function and cardiac Disease relevant to many patients. We explore the relationship between ED and the presence of Cardiovascular Disease in the general population. We also review the prevalence and pathophysiological associations of ED and Cardiovascular Disease. The risks of sexual activity for patients with Cardiovascular Disease are discussed, as are prevention and treatment strategies for ED in this patient population.

Jonathan A. Zlabek - One of the best experts on this subject based on the ideXlab platform.

  • Nicotine replacement therapy and Cardiovascular Disease.
    Mayo Clinic proceedings, 2005
    Co-Authors: Catherine L. Ford, Jonathan A. Zlabek
    Abstract:

    Smoking is a well-established and important risk factor for Cardiovascular Disease. Cessation of smoking clearly decreases the chances of a first or subsequent Cardiovascular event. Nicotine replacement therapy (NRT) is a proven adjunctive therapy to increase the probability of quitting smoking. Anecdotal reports of adverse events in patients using NRT have led some to question its safety. Is nicotine, whether in tobacco products or in NRT, the cause of the Cardiovascular consequences associated with tobacco use? Is using NRT to assist with smoking cessation safer than smoking? Should health care professionals avoid recommending NRT for patients with established Cardiovascular Disease? This article summarizes the mechanisms of harm associated with smoking and reviews the safety of NRT in both the general population and the population with Cardiovascular Disease. Recommendations for NRT use are offered.

Deborah Wool - One of the best experts on this subject based on the ideXlab platform.

  • Functional foods and Cardiovascular Disease
    Current Atherosclerosis Reports, 2000
    Co-Authors: Clare M. Hasler, Susan Kundrat, Deborah Wool
    Abstract:

    Functional foods are foods that, by virtue of physiologically active food components, provide health benefits beyond basic nutrition. Many functional foods have been found to be potentially beneficial in the prevention and treatment of Cardiovascular Disease, the leading cause of mortality in the United States. These foods include soybeans, oats, psyllium, flaxseed, garlic, tea, fish, grapes, nuts, and stanol- and sterol ester enhanced margarine. When eaten in adequate amounts on a consistent basis, these foods may aid in decreasing the risk of Cardiovascular Disease by several potential mechanisms: lowering blood lipid levels, improving arterial compliance, reducing low-density lipoprotein oxidation, decreasing plaque formation, scavenging free radicals, and inhibiting platelet aggregation.

Anushka Patel - One of the best experts on this subject based on the ideXlab platform.

  • Managing the global burden of Cardiovascular Disease
    European Heart Journal Supplements, 2002
    Co-Authors: Bruce Neal, Neil Chapman, Anushka Patel
    Abstract:

    There is a large and increasing global burden of Cardiovascular Disease. Approximately 14 million individuals died of Cardiovascular Disease in 1990, and this is projected to rise to about 25 million by 2020. In large part, this increase can be explained on the basis of major ongoing sociodemographic changes in developing countries, and associated effects on the numbers of individuals at risk and the levels of Cardiovascular risk factors. Developing countries now experience a much greater burden of Cardiovascular Disease than do developed countries. In addition, developing countries are expected to experience the greatest rise in Cardiovascular Disease burden over the next few years. Cardiovascular Disease prevention programmes designed and implemented primarily in developed countries have most likely averted much premature Cardiovascular Disease in those countries over the past few decades. However, Cardiovascular Disease prevention programmes designed for developed countries are unlikely to be directly transferable to developing countries. Reliable information to inform the design and implementation of Cardiovascular Disease prevention programmes, tailored to the socioeconomic circumstances of developing countries, is now required. Such programmes have great potential to impact on the current and projected global epidemic of Cardiovascular Disease.

Donald M Lloydjones - One of the best experts on this subject based on the ideXlab platform.

  • lifetime risks of Cardiovascular Disease
    The New England Journal of Medicine, 2012
    Co-Authors: Jarett D Berry, Alan R Dyer, Xuan Cai, Daniel B Garside, Hongyan Ning, Avis J Thomas, Philip Greenland, Linda Van Horn, Russell P Tracy, Donald M Lloydjones
    Abstract:

    Background The lifetime risks of Cardiovascular Disease have not been reported across the age spectrum in black adults and white adults. Methods We conducted a meta-analysis at the individual level using data from 18 cohort studies involving a total of 257,384 black men and women and white men and women whose risk factors for Cardiovascular Disease were measured at the ages of 45, 55, 65, and 75 years. Blood pressure, cholesterol level, smoking status, and diabetes status were used to stratify participants according to risk factors into five mutually exclusive categories. The remaining lifetime risks of Cardiovascular events were estimated for participants in each category at each age, with death free of Cardiovascular Disease treated as a competing event. Results We observed marked differences in the lifetime risks of Cardiovascular Disease across risk-factor strata. Among participants who were 55 years of age, those with an optimal risk-factor profile (total cholesterol level, <180 mg per deciliter [4.7...

  • parental Cardiovascular Disease as a risk factor for Cardiovascular Disease in middle aged adults a prospective study of parents and offspring
    JAMA, 2004
    Co-Authors: Donald M Lloydjones, Ralph B Dagostino, Daniel Levy, Joanne M Murabito, Thomas J Wang
    Abstract:

    ContextWhether parental Cardiovascular Disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events.ObjectiveTo determine whether parental Cardiovascular Disease predicts offspring events independent of traditional risk factors, using a prospective design for both parents and offspring, and uniform criteria to validate events.DesignInception cohort study.SettingFramingham Heart Study, a US population-based epidemiologic cohort begun in 1948 with the offspring cohort established in 1971.ParticipantsAll Framingham Offspring Study participants (aged ≥30 years) who were free of Cardiovascular Disease and both parents in the original Framingham cohort.Main Outcome MeasuresWe examined the association of parental Cardiovascular Disease with 8-year risk of offspring Cardiovascular Disease, using pooled logistic regression.ResultsAmong 2302 men and women (mean age, 44 years), 164 men and 79 women had Cardiovascular events during follow-up. Compared with participants with no parental Cardiovascular Disease, those with at least 1 parent with premature Cardiovascular Disease (onset age <55 years in father, <65 years in mother) had greater risk for events, with age-adjusted odds ratios of 2.6 (95% confidence interval [CI], 1.7-4.1) for men and 2.3 (95% CI, 1.3-4.3) for women. Multivariable adjustment resulted in odds ratios of 2.0 (95% CI, 1.2-3.1) for men and 1.7 (95% CI, 0.9-3.1) for women. Nonpremature parental Cardiovascular Disease and parental coronary Disease were weaker predictors. Addition of parental information aided in discriminating event rates, notably among offspring with intermediate levels of cholesterol and blood pressure, as well as intermediate predicted multivariable risk.ConclusionsUsing validated events, we found that parental Cardiovascular Disease independently predicted future offspring events in middle-aged adults. Addition of parental information may help clinicians and patients with primary prevention of Cardiovascular Disease, when treatment decisions may be difficult in patients at intermediate risk based on levels of single or multiple risk factors. These data also support further research into genetic determinants of Cardiovascular risk.