The Experts below are selected from a list of 775206 Experts worldwide ranked by ideXlab platform
Julio Cesar Batista Ferreira - One of the best experts on this subject based on the ideXlab platform.
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Impact of exercise training on redox signaling in Cardiovascular Diseases.
Food and Chemical Toxicology, 2013Co-Authors: Juliane C. Campos, Kátia Maria Sampaio Gomes, Julio Cesar Batista FerreiraAbstract:Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs Cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of Cardiovascular Diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of Cardiovascular Diseases such as ischemia–reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in Cardiovascular Diseases.
Kai Huang - One of the best experts on this subject based on the ideXlab platform.
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NADPH oxidases and oxidase crosstalk in Cardiovascular Diseases: novel therapeutic targets
Nature Reviews Cardiology, 2020Co-Authors: Yixuan Zhang, Priya Murugesan, Kai HuangAbstract:In this Review, Cai and colleagues discuss the complex crosstalk between different oxidase systems and the consequences of this crosstalk in mediating Cardiovascular disease processes, focusing on the central role of particular NADPH oxidase isoforms activated in specific Cardiovascular Diseases. Reactive oxygen species (ROS)-dependent production of ROS underlies sustained oxidative stress, which has been implicated in the pathogenesis of Cardiovascular Diseases such as hypertension, aortic aneurysm, hypercholesterolaemia, atherosclerosis, diabetic vascular complications, cardiac ischaemia–reperfusion injury, myocardial infarction, heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase systems have been intensively investigated for their roles in inducing sustained oxidative stress. In this Review, we discuss the latest data on the pathobiology of each oxidase component, the complex crosstalk between different oxidase components and the consequences of this crosstalk in mediating Cardiovascular disease processes, focusing on the central role of particular NADPH oxidase (NOX) isoforms that are activated in specific Cardiovascular Diseases. An improved understanding of these mechanisms might facilitate the development of novel therapeutic agents targeting these oxidase systems and their interactions, which could be effective in the prevention and treatment of Cardiovascular disorders. Activation of NADPH oxidase (NOX) has a critical role in the pathogenesis of Cardiovascular Diseases. Activation of NOX induces activation of downstream secondary oxidase systems, including uncoupled endothelial nitric oxide synthase, dysfunctional mitochondria and xanthine oxidase. Crosstalk between oxidases or oxidase systems sustains oxidative stress to mediate the development of Cardiovascular Diseases. Targeting NOXs as well as interactions between NOXs and secondary oxidase systems might be a novel therapeutic strategy for the prevention and treatment of Cardiovascular Diseases.
Yang Zhang - One of the best experts on this subject based on the ideXlab platform.
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Ceramide in redox signaling and Cardiovascular Diseases.
Cellular Physiology and Biochemistry, 2010Co-Authors: Katrin Anne Becker, Yang ZhangAbstract:Lipid rafts are distinct cell membrane microdomains that consist of cholesterol, sphingolipids, and some associated proteins. Accumulating evidence suggests that activation of sphingomyelinase and generation of ceramide mediates clustering of lipid rafts to form large ceramide-enriched platforms, in which transmembrane signals are transmitted or amplified. Ceramide and reactive oxygen species (ROS) are involved in the modulation of the cell membrane and intracellular ion channels, cell proliferation and apoptotic cell death, neutrophil adhesion to the vessel wall, and vascular tone and in the development of Cardiovascular Diseases to name some important examples. Ceramide triggers the generation of ROS and increases oxidative stress in many mammalian cells and animal models. Moreover, inhibition of ROS generating enzymes or treatment of antioxidants impairs sphingomyelinase activation and ceramide production. Thus, a new concept has been proposed that ceramide-enriched raft platforms are important redox signaling platforms that amplify activation of ROS generating enzymes (e.g. NADPH oxidase family enzymes) and sphingomyelinases. The general function of ceramide to form redox signaling platforms amplifying oxdative stress might be critically involved in the dysfunction of vascular cells induced by death receptor ligands and stress stimuli contributing to the development of Cardiovascular Diseases.
Rienk Nieuwland - One of the best experts on this subject based on the ideXlab platform.
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microparticles in Cardiovascular Diseases
Cardiovascular Research, 2003Co-Authors: Marja J Vanwijk, Ed Vanbavel, A Sturk, Rienk NieuwlandAbstract:Microparticles are membrane vesicles released from many different cell types. There are two mechanisms that can result in their formation, cell activation and apoptosis. In these two mechanisms, different pathways are involved in microparticle generation. Microparticle generation seems to be a well regulated process. Microparticles vary in size, phospholipid and protein composition. They have a potent pro-inflammatory effect, promote coagulation and affect vascular function. Since these processes are all involved in the pathogenesis of Cardiovascular disease and circulating microparticle numbers are altered in many Cardiovascular Diseases, a role for microparticles in the pathogenesis of Cardiovascular Diseases is likely. Although hard evidence for a role of microparticles in Cardiovascular Diseases at present is still only limited, new evidence is accumulating rapidly to support this theory. Elucidation of the microparticle composition and the mechanisms involved in exertion of their effects will supply this evidence and enable us to develop additional intervention strategies for prevention and treatment of Cardiovascular Diseases.
Nicolantonio D'orazio - One of the best experts on this subject based on the ideXlab platform.
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Prevention of Cardiovascular Diseases with Carotenoids.
Frontiers in bioscience (Scholar edition), 2017Co-Authors: Maria Alessandra Gammone, Francesca Romana Pluchinotta, Sonia Bergante, Guido Tettamanti, Nicolantonio D'orazioAbstract:Oxidative stress is a key contributor to the development of Cardiovascular Diseases. Bioactive dietary elements including phytochemicals, and in particular, carotenoids display antioxidant effect and substantially reduce markers of oxidative stress. Carotenoids have been shown to prevent several chronic disorders including Cardiovascular Diseases by reducing the inflammatory responses. Here, we discuss the use of traditional and novel carotenoids in prevention of Cardiovascular disease.
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Antioxidant Vitamin Supplementation in Cardiovascular Diseases
Annals of clinical and laboratory science, 2007Co-Authors: Graziano Riccioni, Tonino Bucciarelli, Barbara Mancini, Francesco Corradi, Carmine Di Ilio, Peter A. Mattei, Nicolantonio D'orazioAbstract:Cardiovascular disease is the most important adult health problem in wealthy countries, where biological factors such as obesity, hypertension, dyslipidemia, diabetes, inappropriate diet, cigarette smoking, and sedentary life-style have contributed to its dissemination. Research concerning nutritional regimens has shown that persons who consume large amounts of fruit and vegetables have lower incidences of Cardiovascular Diseases, stroke, and tumors, although the precise mechanisms for this protective effect are elusive. Possible explanations include (a) increased consumption of dietary fiber, (b) reduced consumption of dietary cholesterol and other lipids, and (c) increased intake of the antioxidant vitamins (A, C, and E). Numerous studies have raised the question whether vitamin supplements help to prevent Cardiovascular Diseases. Results of randomized controlled trials of antioxidaht vitamin supplements in large numbers of participants has been ambiguous or contradictory. This minireview examines the relevant clinical reports on dietary supplements of vitamins A, C, and E to determine whether they support the premise that patients at risk of Cardiovascular disease may be candidates for this therapeutic option.
