The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Nobuoki Kohno - One of the best experts on this subject based on the ideXlab platform.

  • pulse wave velocity predicts Cardiovascular Mortality findings from the hawaii los angeles hiroshima study
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

  • pulse wave velocity predicts Cardiovascular Mortality
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

Tomoki Shokawa - One of the best experts on this subject based on the ideXlab platform.

  • aortic pulse wave velocity predicts Cardiovascular Mortality in middle aged and elderly japanese men
    Circulation, 2009
    Co-Authors: Noriko Inoue, Tomoki Shokawa, Hideya Yamamoto, Ryo Maeda, Hideshi Kawakami, Hideo Sasaki
    Abstract:

    Background: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and Cardiovascular Mortality in the middle-aged and elderly Japanese population using a longitudinal study design. Methods and Results: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from Cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and Cardiovascular disease Mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). Conclusions: An increased PWV can predict Cardiovascular Mortality in middle-aged and elderly Japanese men. (Circ J 2009; 73: 549 - 553)

  • pulse wave velocity predicts Cardiovascular Mortality findings from the hawaii los angeles hiroshima study
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

  • pulse wave velocity predicts Cardiovascular Mortality
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

Hideya Yamamoto - One of the best experts on this subject based on the ideXlab platform.

  • aortic pulse wave velocity predicts Cardiovascular Mortality in middle aged and elderly japanese men
    Circulation, 2009
    Co-Authors: Noriko Inoue, Tomoki Shokawa, Hideya Yamamoto, Ryo Maeda, Hideshi Kawakami, Hideo Sasaki
    Abstract:

    Background: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and Cardiovascular Mortality in the middle-aged and elderly Japanese population using a longitudinal study design. Methods and Results: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from Cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and Cardiovascular disease Mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). Conclusions: An increased PWV can predict Cardiovascular Mortality in middle-aged and elderly Japanese men. (Circ J 2009; 73: 549 - 553)

  • pulse wave velocity predicts Cardiovascular Mortality findings from the hawaii los angeles hiroshima study
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

  • pulse wave velocity predicts Cardiovascular Mortality
    Circulation, 2005
    Co-Authors: Tomoki Shokawa, Naohito Tasaki, Tomokazu Okimoto, Kiminori Yamane, Mamoru Toyofuku, Michinori Imazu, Hideya Yamamoto, Nobuoki Kohno
    Abstract:

    Background Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term Cardiovascular Mortality in general populations. Methods and Results We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 ±8.8 years) to assess the relationship between PWV and Cardiovascular disease Mortality and all-cause Mortality. During the 10-year follow-up, 43 patients died (14 from Cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause Mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for Cardiovascular Mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively. Conclusions The present study demonstrated that an increased PWV value is associated with future Cardiovascular disease death in Japanese-Americans living in Hawaii. (Circ J 2005; 69: 259 - 264)

Athanase Benetos - One of the best experts on this subject based on the ideXlab platform.

  • aortic pulse wave velocity predicts Cardiovascular Mortality in subjects 70 years of age
    Arteriosclerosis Thrombosis and Vascular Biology, 2001
    Co-Authors: S Meaume, Annie Rudnichi, Athanase Benetos, O Henry, M E Safar
    Abstract:

    Aortic pulse wave velocity (PWV) is a significant and independent predictor of Cardiovascular Mortality in subjects with essential hypertension and in patients with end-stage renal disease. Its contribution to Cardiovascular risk in subjects 70 to 100 years old has never been tested. A cohort of 141 subjects (mean±SD age, 87.1±6.6 years) was studied in 3 geriatrics departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured with a validated automatic device. During the 30-month follow-up, 56 patients died (27 from Cardiovascular events). Logistic regressions indicated that age ( P =0.005) and a loss of autonomy ( P =0.01) were the best predictors of overall Mortality. For Cardiovascular Mortality, aortic PWV was the major risk predictor ( P =0.016). The odds ratio was 1.19 (95% confidence interval, 1.03 to 1.37). Antihypertensive drug treatment and blood pressure, including systolic and pulse pressure, had no additive role. In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of Cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial.

  • aortic stiffness is an independent predictor of all cause and Cardiovascular Mortality in hypertensive patients
    Hypertension, 2001
    Co-Authors: Stephane Laurent, Louis Guize, Pierre Boutouyrie, Roland Asmar, Isabelle Gautier, Brigitte Laloux, Pierre Ducimetiere, Athanase Benetos
    Abstract:

    Although various studies reported that pulse pressure, an indirect index of arterial stiffening, was an independent risk factor for Mortality, a direct relationship between arterial stiffness and all-cause and Cardiovascular Mortality remained to be established in patients with essential hypertension. A cohort of 1980 essential hypertensive patients who attended the outpatient hypertension clinic of Broussais Hospital between 1980 and 1996 and who had a measurement of arterial stiffness was studied. At entry, aortic stiffness was assessed from the measurement of carotid-femoral pulse-wave velocity (PWV). A logistic regression model was used to estimate the relative risk of all-cause and Cardiovascular deaths. Selection of classic risk factors for adjustment of PWV was based on their influence on Mortality in this cohort in univariate analysis. Mean age at entry was 50+/-13 years (mean+/-SD). During an average follow-up of 112+/-53 months, 107 fatal events occurred. Among them, 46 were of Cardiovascular origin. PWV was significantly associated with all-cause and Cardiovascular Mortality in a univariate model of logistic regression analysis (odds ratio for 5 m/s PWV was 2.14 [95% confidence interval, 1.71 to 2.67, P<0.0001] and 2.35 [95% confidence interval, 1.76 to 3.14, P<0.0001], respectively). In multivariate models of logistic regression analysis, PWV was significantly associated with all-cause and Cardiovascular Mortality, independent of previous Cardiovascular diseases, age, and diabetes. By contrast, pulse pressure was not significantly and independently associated to Mortality. This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and Cardiovascular Mortality in patients with essential hypertension.

  • pulse pressure and Cardiovascular Mortality in normotensive and hypertensive subjects
    Hypertension, 1998
    Co-Authors: Athanase Benetos, Annie Rudnichi, Michel E. Safar, Louis Guize
    Abstract:

    Abstract —There is now increasing evidence that high pulse pressure, which is an indicator of large artery stiffness, is an independent risk factor for Cardiovascular Mortality, especially coronary Mortality, in different populations. We have recently shown in a large French population that in male subjects aged 40 to 69 years, increased pulse pressure was a strong predictor of Cardiovascular Mortality, especially coronary Mortality. In the present report, we analyzed the effect of pulse pressure in men and women of the same cohort after classifying them as normotensive (systolic blood pressure [SBP] 50 mm Hg and in the group of hypertensive men with a pulse pressure

Matthew R Smith - One of the best experts on this subject based on the ideXlab platform.

  • Cardiovascular Mortality after androgen deprivation therapy for locally advanced prostate cancer rtog 85 31
    Journal of Clinical Oncology, 2009
    Co-Authors: Jason A Efstathiou, William U Shipley, Gerald E Hanks, M V Pilepich, Howard M Sandler, Matthew R Smith
    Abstract:

    Purpose Gonadotropin-releasing hormone (GnRH) agonists are associated with greater risk of coronary heart disease and myocardial infarction in men with prostate cancer, but little is known about potential impact on Cardiovascular Mortality. We assessed the relationship between GnRH agonists and Cardiovascular Mortality in a large randomized phase III trial of men treated with or without adjuvant goserelin after radiation therapy (RT) for locally advanced prostate cancer. Patients and Methods Between 1987 and 1992, 945 men with locally advanced prostate cancer were randomly assigned to RT and adjuvant goserelin or RT alone. Fine and Gray's regression was used to evaluate treatment effect on Cardiovascular Mortality. Covariates included age, prevalent Cardiovascular disease (CVD), hypertension, diabetes mellitus (DM), body mass index, race, Gleason score, stage, acid phosphatase level, prostatectomy history, and nodal involvement. Results After a median follow-up of 8.1 years, there were 117 Cardiovascular-...

  • Cardiovascular Mortality and duration of androgen deprivation for locally advanced prostate cancer analysis of rtog 92 02
    European Urology, 2008
    Co-Authors: Jason A Efstathiou, Kyounghwa Bae, William U Shipley, Gerald E Hanks, M V Pilepich, Howard M Sandler, Matthew R Smith
    Abstract:

    Abstract Objectives Gonadotropin-releasing hormone agonists (GnRHa) are associated with greater risk of coronary heart disease and myocardial infarction in men with prostate cancer, but little is known about their potential effects on Cardiovascular Mortality. We assessed the relationship between duration of GnRHa therapy and Cardiovascular Mortality in a large randomized trial of men treated with short-term versus longer-term adjuvant goserelin and radiation therapy (RT) for locally advanced prostate cancer. Methods From 1992 to 1995, 1554 men with locally advanced prostate cancer (T2c–4, prostate-specific antigen [PSA] Results After median follow-up of 8.1 yr, 185 Cardiovascular-related deaths had occurred. No increase in Cardiovascular Mortality occurred for men receiving a longer duration of goserelin. At 5 yr, Cardiovascular Mortality for men receiving longer-term adjuvant goserelin was 5.9% versus 4.8% with short-term goserelin (Gray's p =0.16). In multivariate analyses, treatment arm was not significantly associated with increased risk of Cardiovascular Mortality (adjusted hazard ratio [HR]=1.09; 95% confidence interval [CI], 0.81–1.47; p =0.58; when censoring at time of salvage goserelin, HR=1.02, 95%CI, 0.73–1.43; p =0.9). Traditional cardiac risk factors, including age, prevalent CVD, and DM, were significantly associated with greater Cardiovascular Mortality. Conclusions Longer duration of adjuvant GnRHa therapy does not appear to increase Cardiovascular Mortality in men with locally advanced prostate cancer.