The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Liv Kroona - One of the best experts on this subject based on the ideXlab platform.
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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study.
Acta dermato-venereologica, 2018Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Camilla Ahlgren, Jakob Dahlin, Gunnar WarfvingeAbstract:Carvone (l-Carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to Carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmo clinic, for the period 1996 to 2016, were studied. Carvone-positive and Carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested Carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to Carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison Carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.
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FC?17: Use test with l?Carvone in toothpaste on sensitized individuals
Contact Dermatitis, 2018Co-Authors: Liv KroonaAbstract:INTRODUCTION Carvone (l‐Carvone), a mint‐tasting flavour often found in toothpaste, is considered a weak contact allergen and the prevalence of positive patch tests to Carvone among dermatitis pat ...
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Quantification of l-Carvone in toothpastes available on the Swedish market
Contact dermatitis, 2017Co-Authors: Liv Kroona, Marléne Isaksson, Gunnar Warfvinge, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus BruzeAbstract:SummaryBackground Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-Carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives To qualitatively and quantitatively investigate the presence of l-Carvone in commercially available toothpastes on the Swedish market. Methods l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-Carvone were found if limonene was listed on the label. Conclusion The majority of toothpastes on the Swedish market contain l-Carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.
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Abstract 411: Carvone contact allergy in southern Sweden : a 15-year retrospective study
Contact Dermatitis, 2014Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Gunnar Warfvinge, Camilla AhlgrenAbstract:Background: Carvone (L-Carvone) is naturally found in spearmint oil and is considered a mild skin sensitizer. It commonly serves as a flavoring agent in toothpaste and other mint tasting products. T ...
Eiichi Kumamoto - One of the best experts on this subject based on the ideXlab platform.
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spontaneous l glutamate release enhancement in rat substantia gelatinosa neurons by Carvone and Carvone which activate different types of trp channel
Biochemical and Biophysical Research Communications, 2015Co-Authors: Qin Kang, Changyu Jiang, Tsugumi Fujita, Eiichi KumamotoAbstract:Abstract Transient receptor potential (TRP) channels in the spinal dorsal horn lamina II (substantia gelatinosa; SG), which are involved in the modulation of nociceptive transmission, have not yet been fully examined in property. Activation of the TRP channels by various plant-derived chemicals results in an increase in the spontaneous release of l -glutamate onto the SG neurons. We examined the effects of a monoterpene ketone (−)-Carvone (contained in spearmint) and its stereoisomer (+)-Carvone (in caraway) on glutamatergic spontaneous excitatory transmission in SG neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. (−)-Carvone and (+)-Carvone increased the frequency of spontaneous excitatory postsynaptic current (sEPSC) in a reversible and concentration-dependent manner with a small increase in its amplitude. Half-maximal effective concentrations of (−)-Carvone and (+)-Carvone in increasing sEPSC frequency were 0.70 mM and 0.72 mM, respectively. The (−)-Carvone but not (+)-Carvone activity was inhibited by a TRPV1 antagonist capsazepine. On the other hand, the (+)-Carvone but not (−)-Carvone activity was inhibited by a TRPA1 antagonist HC-030031. These results indicate that (−)-Carvone and (+)-Carvone activate TRPV1 and TRPA1 channels, respectively, resulting in an increase in spontaneous l -glutamate release onto SG neurons, with almost the same efficacy. Such a difference in TRP activation between the stereoisomers may serve to know the properties of TRP channels in the SG.
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Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-Carvone and (+)-Carvone which activate different types of TRP channel.
Biochemical and biophysical research communications, 2015Co-Authors: Qin Kang, Changyu Jiang, Tsugumi Fujita, Eiichi KumamotoAbstract:Abstract Transient receptor potential (TRP) channels in the spinal dorsal horn lamina II (substantia gelatinosa; SG), which are involved in the modulation of nociceptive transmission, have not yet been fully examined in property. Activation of the TRP channels by various plant-derived chemicals results in an increase in the spontaneous release of l -glutamate onto the SG neurons. We examined the effects of a monoterpene ketone (−)-Carvone (contained in spearmint) and its stereoisomer (+)-Carvone (in caraway) on glutamatergic spontaneous excitatory transmission in SG neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. (−)-Carvone and (+)-Carvone increased the frequency of spontaneous excitatory postsynaptic current (sEPSC) in a reversible and concentration-dependent manner with a small increase in its amplitude. Half-maximal effective concentrations of (−)-Carvone and (+)-Carvone in increasing sEPSC frequency were 0.70 mM and 0.72 mM, respectively. The (−)-Carvone but not (+)-Carvone activity was inhibited by a TRPV1 antagonist capsazepine. On the other hand, the (+)-Carvone but not (−)-Carvone activity was inhibited by a TRPA1 antagonist HC-030031. These results indicate that (−)-Carvone and (+)-Carvone activate TRPV1 and TRPA1 channels, respectively, resulting in an increase in spontaneous l -glutamate release onto SG neurons, with almost the same efficacy. Such a difference in TRP activation between the stereoisomers may serve to know the properties of TRP channels in the SG.
Camilla Ahlgren - One of the best experts on this subject based on the ideXlab platform.
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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study.
Acta dermato-venereologica, 2018Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Camilla Ahlgren, Jakob Dahlin, Gunnar WarfvingeAbstract:Carvone (l-Carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to Carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmo clinic, for the period 1996 to 2016, were studied. Carvone-positive and Carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested Carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to Carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison Carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.
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Quantification of l-Carvone in toothpastes available on the Swedish market
Contact dermatitis, 2017Co-Authors: Liv Kroona, Marléne Isaksson, Gunnar Warfvinge, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus BruzeAbstract:SummaryBackground Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-Carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives To qualitatively and quantitatively investigate the presence of l-Carvone in commercially available toothpastes on the Swedish market. Methods l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-Carvone were found if limonene was listed on the label. Conclusion The majority of toothpastes on the Swedish market contain l-Carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.
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Abstract 411: Carvone contact allergy in southern Sweden : a 15-year retrospective study
Contact Dermatitis, 2014Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Gunnar Warfvinge, Camilla AhlgrenAbstract:Background: Carvone (L-Carvone) is naturally found in spearmint oil and is considered a mild skin sensitizer. It commonly serves as a flavoring agent in toothpaste and other mint tasting products. T ...
Gunnar Warfvinge - One of the best experts on this subject based on the ideXlab platform.
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Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study.
Acta dermato-venereologica, 2018Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Camilla Ahlgren, Jakob Dahlin, Gunnar WarfvingeAbstract:Carvone (l-Carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to Carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmo clinic, for the period 1996 to 2016, were studied. Carvone-positive and Carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested Carvone-positive patients were also compared with a matched group. A total of 147 out of 4,221 referred patients had a positive patch test to Carvone. Sensitized patients had higher mean age and were primarily women; 73% had oral signs and 57% had oral lichen. Concomitant patch test reactions to gold, nickel and mercury were common. In the matched group-comparison Carvone-positive patients had a higher frequency of oral lichen, but no difference was found in sensitization to gold and mercury.
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Quantification of l-Carvone in toothpastes available on the Swedish market
Contact dermatitis, 2017Co-Authors: Liv Kroona, Marléne Isaksson, Gunnar Warfvinge, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus BruzeAbstract:SummaryBackground Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-Carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives To qualitatively and quantitatively investigate the presence of l-Carvone in commercially available toothpastes on the Swedish market. Methods l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-Carvone were found if limonene was listed on the label. Conclusion The majority of toothpastes on the Swedish market contain l-Carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.
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Abstract 411: Carvone contact allergy in southern Sweden : a 15-year retrospective study
Contact Dermatitis, 2014Co-Authors: Liv Kroona, Marléne Isaksson, Magnus Bruze, Gunnar Warfvinge, Camilla AhlgrenAbstract:Background: Carvone (L-Carvone) is naturally found in spearmint oil and is considered a mild skin sensitizer. It commonly serves as a flavoring agent in toothpaste and other mint tasting products. T ...
Qin Kang - One of the best experts on this subject based on the ideXlab platform.
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spontaneous l glutamate release enhancement in rat substantia gelatinosa neurons by Carvone and Carvone which activate different types of trp channel
Biochemical and Biophysical Research Communications, 2015Co-Authors: Qin Kang, Changyu Jiang, Tsugumi Fujita, Eiichi KumamotoAbstract:Abstract Transient receptor potential (TRP) channels in the spinal dorsal horn lamina II (substantia gelatinosa; SG), which are involved in the modulation of nociceptive transmission, have not yet been fully examined in property. Activation of the TRP channels by various plant-derived chemicals results in an increase in the spontaneous release of l -glutamate onto the SG neurons. We examined the effects of a monoterpene ketone (−)-Carvone (contained in spearmint) and its stereoisomer (+)-Carvone (in caraway) on glutamatergic spontaneous excitatory transmission in SG neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. (−)-Carvone and (+)-Carvone increased the frequency of spontaneous excitatory postsynaptic current (sEPSC) in a reversible and concentration-dependent manner with a small increase in its amplitude. Half-maximal effective concentrations of (−)-Carvone and (+)-Carvone in increasing sEPSC frequency were 0.70 mM and 0.72 mM, respectively. The (−)-Carvone but not (+)-Carvone activity was inhibited by a TRPV1 antagonist capsazepine. On the other hand, the (+)-Carvone but not (−)-Carvone activity was inhibited by a TRPA1 antagonist HC-030031. These results indicate that (−)-Carvone and (+)-Carvone activate TRPV1 and TRPA1 channels, respectively, resulting in an increase in spontaneous l -glutamate release onto SG neurons, with almost the same efficacy. Such a difference in TRP activation between the stereoisomers may serve to know the properties of TRP channels in the SG.
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Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-Carvone and (+)-Carvone which activate different types of TRP channel.
Biochemical and biophysical research communications, 2015Co-Authors: Qin Kang, Changyu Jiang, Tsugumi Fujita, Eiichi KumamotoAbstract:Abstract Transient receptor potential (TRP) channels in the spinal dorsal horn lamina II (substantia gelatinosa; SG), which are involved in the modulation of nociceptive transmission, have not yet been fully examined in property. Activation of the TRP channels by various plant-derived chemicals results in an increase in the spontaneous release of l -glutamate onto the SG neurons. We examined the effects of a monoterpene ketone (−)-Carvone (contained in spearmint) and its stereoisomer (+)-Carvone (in caraway) on glutamatergic spontaneous excitatory transmission in SG neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. (−)-Carvone and (+)-Carvone increased the frequency of spontaneous excitatory postsynaptic current (sEPSC) in a reversible and concentration-dependent manner with a small increase in its amplitude. Half-maximal effective concentrations of (−)-Carvone and (+)-Carvone in increasing sEPSC frequency were 0.70 mM and 0.72 mM, respectively. The (−)-Carvone but not (+)-Carvone activity was inhibited by a TRPV1 antagonist capsazepine. On the other hand, the (+)-Carvone but not (−)-Carvone activity was inhibited by a TRPA1 antagonist HC-030031. These results indicate that (−)-Carvone and (+)-Carvone activate TRPV1 and TRPA1 channels, respectively, resulting in an increase in spontaneous l -glutamate release onto SG neurons, with almost the same efficacy. Such a difference in TRP activation between the stereoisomers may serve to know the properties of TRP channels in the SG.