The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform

Melissa J Suter - One of the best experts on this subject based on the ideXlab platform.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Proceedings of SPIE, 2013
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Lida P Hariri, Melissa J Suter
    Abstract:

    Lung cancer is the leading cause of cancer related death. Macroscopic imaging techniques such as computed tomography are highly sensitivity at detecting small, ≤ 2cm, peripheral pulmonary lesions (PPLs) in the lung but lack the specificity necessary for diagnosis. Bronchoscopy is a procedure routinely performed to diagnose PPLs but is hindered with a low diagnostic yield due to challenging lesion localization. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a ‘smart needle’ to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter that operates within a 21-gauge transbronchial needle aspiration (TBNA) needle. The OFDI Catheter can be easily removed from the needle to facilitate subsequent aspiration or biopsy acquisition. The OFDI imaging core consists of an angled-polished ball lens with a spot size of 25 μm at a working distance of 160 μm from the Catheter Sheath. The ball-lens was designed to have an ellipsoid shape in order to compensate for the astigmatism caused by encasing the optics within a protective Sheath. Transbronchial imaging of inflated excised swine lung parenchyma with the TB-OFDI smart needle yielded clear images of alveoli. In-vivo transbronchial imaging was also performed on three swine with artificial lesions injected transthoracially. Our results suggest that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield of PPLs.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Biomedical Optics Express, 2012
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Melissa J Suter
    Abstract:

    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the Catheter Sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.

K M Tan - One of the best experts on this subject based on the ideXlab platform.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Proceedings of SPIE, 2013
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Lida P Hariri, Melissa J Suter
    Abstract:

    Lung cancer is the leading cause of cancer related death. Macroscopic imaging techniques such as computed tomography are highly sensitivity at detecting small, ≤ 2cm, peripheral pulmonary lesions (PPLs) in the lung but lack the specificity necessary for diagnosis. Bronchoscopy is a procedure routinely performed to diagnose PPLs but is hindered with a low diagnostic yield due to challenging lesion localization. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a ‘smart needle’ to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter that operates within a 21-gauge transbronchial needle aspiration (TBNA) needle. The OFDI Catheter can be easily removed from the needle to facilitate subsequent aspiration or biopsy acquisition. The OFDI imaging core consists of an angled-polished ball lens with a spot size of 25 μm at a working distance of 160 μm from the Catheter Sheath. The ball-lens was designed to have an ellipsoid shape in order to compensate for the astigmatism caused by encasing the optics within a protective Sheath. Transbronchial imaging of inflated excised swine lung parenchyma with the TB-OFDI smart needle yielded clear images of alveoli. In-vivo transbronchial imaging was also performed on three swine with artificial lesions injected transthoracially. Our results suggest that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield of PPLs.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Biomedical Optics Express, 2012
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Melissa J Suter
    Abstract:

    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the Catheter Sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.

Matthew B Applegate - One of the best experts on this subject based on the ideXlab platform.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Proceedings of SPIE, 2013
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Lida P Hariri, Melissa J Suter
    Abstract:

    Lung cancer is the leading cause of cancer related death. Macroscopic imaging techniques such as computed tomography are highly sensitivity at detecting small, ≤ 2cm, peripheral pulmonary lesions (PPLs) in the lung but lack the specificity necessary for diagnosis. Bronchoscopy is a procedure routinely performed to diagnose PPLs but is hindered with a low diagnostic yield due to challenging lesion localization. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a ‘smart needle’ to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter that operates within a 21-gauge transbronchial needle aspiration (TBNA) needle. The OFDI Catheter can be easily removed from the needle to facilitate subsequent aspiration or biopsy acquisition. The OFDI imaging core consists of an angled-polished ball lens with a spot size of 25 μm at a working distance of 160 μm from the Catheter Sheath. The ball-lens was designed to have an ellipsoid shape in order to compensate for the astigmatism caused by encasing the optics within a protective Sheath. Transbronchial imaging of inflated excised swine lung parenchyma with the TB-OFDI smart needle yielded clear images of alveoli. In-vivo transbronchial imaging was also performed on three swine with artificial lesions injected transthoracially. Our results suggest that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield of PPLs.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Biomedical Optics Express, 2012
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Melissa J Suter
    Abstract:

    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the Catheter Sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.

Brett E Bouma - One of the best experts on this subject based on the ideXlab platform.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Proceedings of SPIE, 2013
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Lida P Hariri, Melissa J Suter
    Abstract:

    Lung cancer is the leading cause of cancer related death. Macroscopic imaging techniques such as computed tomography are highly sensitivity at detecting small, ≤ 2cm, peripheral pulmonary lesions (PPLs) in the lung but lack the specificity necessary for diagnosis. Bronchoscopy is a procedure routinely performed to diagnose PPLs but is hindered with a low diagnostic yield due to challenging lesion localization. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a ‘smart needle’ to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter that operates within a 21-gauge transbronchial needle aspiration (TBNA) needle. The OFDI Catheter can be easily removed from the needle to facilitate subsequent aspiration or biopsy acquisition. The OFDI imaging core consists of an angled-polished ball lens with a spot size of 25 μm at a working distance of 160 μm from the Catheter Sheath. The ball-lens was designed to have an ellipsoid shape in order to compensate for the astigmatism caused by encasing the optics within a protective Sheath. Transbronchial imaging of inflated excised swine lung parenchyma with the TB-OFDI smart needle yielded clear images of alveoli. In-vivo transbronchial imaging was also performed on three swine with artificial lesions injected transthoracially. Our results suggest that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield of PPLs.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Biomedical Optics Express, 2012
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Melissa J Suter
    Abstract:

    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the Catheter Sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.

Alex Chee - One of the best experts on this subject based on the ideXlab platform.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Proceedings of SPIE, 2013
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Lida P Hariri, Melissa J Suter
    Abstract:

    Lung cancer is the leading cause of cancer related death. Macroscopic imaging techniques such as computed tomography are highly sensitivity at detecting small, ≤ 2cm, peripheral pulmonary lesions (PPLs) in the lung but lack the specificity necessary for diagnosis. Bronchoscopy is a procedure routinely performed to diagnose PPLs but is hindered with a low diagnostic yield due to challenging lesion localization. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a ‘smart needle’ to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter that operates within a 21-gauge transbronchial needle aspiration (TBNA) needle. The OFDI Catheter can be easily removed from the needle to facilitate subsequent aspiration or biopsy acquisition. The OFDI imaging core consists of an angled-polished ball lens with a spot size of 25 μm at a working distance of 160 μm from the Catheter Sheath. The ball-lens was designed to have an ellipsoid shape in order to compensate for the astigmatism caused by encasing the optics within a protective Sheath. Transbronchial imaging of inflated excised swine lung parenchyma with the TB-OFDI smart needle yielded clear images of alveoli. In-vivo transbronchial imaging was also performed on three swine with artificial lesions injected transthoracially. Our results suggest that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield of PPLs.

  • flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
    Biomedical Optics Express, 2012
    Co-Authors: K M Tan, Milen Shishkov, Alex Chee, Matthew B Applegate, Brett E Bouma, Melissa J Suter
    Abstract:

    Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) Catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI Catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the Catheter Sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.