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David Zeltser - One of the best experts on this subject based on the ideXlab platform.
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lack of an increased expression of the cd11b CD18 Antigen on the surface of peripheral blood circulating pool of leukocytes in patients with an acute neurological ischemic event
Stroke, 2001Co-Authors: David Zeltser, Vadim G Karepov, Natan M BornsteinAbstract:37 OBJECTIVE: To reveal the intensity of the surface expression of the adhesion molecules (CD11b/CD18) on monocytes and neutrophils in the peripheral blood of patients with an acute brain ischemia compared to healthy individuals who served as controls. BACKGROUND: The Leukocyte Integrin CD11b/CD18 is an important receptor that is involved in the modulation of leukocyte to endothelial interactions and is expressed in increased amounts during cell activation. It has been previously suggested that activated white blood cells, mainly polymorphonuclear leukocytes and monocytes, participate in the development of ischemic vascular disorders by virtue of their capability to obstruct the microvasculature and enhance tissue damage. DESIGN/METHODS: Cellular surface expression of the adhesion molecules CD11b/CD18 on the neutrophils and monocytes in the peripheral blood was measured by a direct immunotechnique of flow cytometry in two groups: patients who had transient ischemic attacks (TIA) or ischemic stroke (confirmed by CT scans, within 24 hours from onset of symptoms), and healthy individuals who served as controls. Analysis was done by ANOVA test. RESULT: Seventy-one patients and 150 controls were included in the study. The respective mean fluorescence intensity for CD11b/CD18 being 161±76, 155±87 for polymorphonuclear leukocytes and 231±99, 203±79 for monocytes. No statistically significant difference was noted between the groups. CONCLUSIONS: The results of the present study show that patients with acute cerebral ischemic event do not present increased amount of the CD11b/CD18 Antigen on the surface of the peripheral blood polymorphonuclear or monocytes compared to control. Our data do not support the hypothesis that the white blood cells participate in the development of acute cerebral ischemia by the mechanism of activation of the adhesion molecule CD11b/CD18.
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Lack of an Increased Expression of the CD11b/CD18 Antigen on the Surface of Peripheral Blood Circulating Pool of Leukocytes in Patients with an Acute Neurological Ischemic Event
Stroke, 2001Co-Authors: David Zeltser, Vadim G Karepov, Natan M BornsteinAbstract:37 OBJECTIVE: To reveal the intensity of the surface expression of the adhesion molecules (CD11b/CD18) on monocytes and neutrophils in the peripheral blood of patients with an acute brain ischemia compared to healthy individuals who served as controls. BACKGROUND: The Leukocyte Integrin CD11b/CD18 is an important receptor that is involved in the modulation of leukocyte to endothelial interactions and is expressed in increased amounts during cell activation. It has been previously suggested that activated white blood cells, mainly polymorphonuclear leukocytes and monocytes, participate in the development of ischemic vascular disorders by virtue of their capability to obstruct the microvasculature and enhance tissue damage. DESIGN/METHODS: Cellular surface expression of the adhesion molecules CD11b/CD18 on the neutrophils and monocytes in the peripheral blood was measured by a direct immunotechnique of flow cytometry in two groups: patients who had transient ischemic attacks (TIA) or ischemic stroke (confirmed by CT scans, within 24 hours from onset of symptoms), and healthy individuals who served as controls. Analysis was done by ANOVA test. RESULT: Seventy-one patients and 150 controls were included in the study. The respective mean fluorescence intensity for CD11b/CD18 being 161±76, 155±87 for polymorphonuclear leukocytes and 231±99, 203±79 for monocytes. No statistically significant difference was noted between the groups. CONCLUSIONS: The results of the present study show that patients with acute cerebral ischemic event do not present increased amount of the CD11b/CD18 Antigen on the surface of the peripheral blood polymorphonuclear or monocytes compared to control. Our data do not support the hypothesis that the white blood cells participate in the development of acute cerebral ischemia by the mechanism of activation of the adhesion molecule CD11b/CD18.
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increased expression of the cd11b CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease further evidence for smoldering inflammation in patients with atherosclerosis
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Neutrophilia of infection/inflammation: are we really dealing with "inflamed" leukocytes?
Journal of medicine, 1998Co-Authors: Y. Sasson, M Kassirer, David Zeltser, O. Rogowski, N. Maharshak, Nissenkorn A, Eugene Leibovitz, P. Halperin, Sharvit D, Sorkine PAbstract:We adopted whole blood flow cytometry and direct labeling of the CD11b/CD18 and CD62L Antigens to study the relationship between their expression and leukocytosis in patients with infection/inflammation, acute stress and healthy volunteers. Mean +/- S.D. channel fluorescence intensity of CD11b/CD18 Antigen on peripheral blood polymorphonuclears did not differ between patients with infection/ inflammation (173+/-78) and controls (167+/-72), but was significantly (p = 0.04) reduced in stress (135+/-60). No correlation was found between CD11b/CD18 Antigen level and either polymorphonuclears absolute number or serum C-reactive protein. A significant negative correlation was noted between CD62L Antigen expression on polymorphonuclears and their absolute number. We assume that cells with increased CD11b/CD18 surface concentrations are retained in the capillaries and that part of the leukocytes in the peripheral blood are stressed leukocytes with reduced CD11b/CD18. Thus, leukocytes detected in peripheral blood are not necessarily the most "inflamed" ones.
M Kassirer - One of the best experts on this subject based on the ideXlab platform.
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increased expression of the cd11b CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease further evidence for smoldering inflammation in patients with atherosclerosis
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American heart journal, 1999Co-Authors: M Kassirer, D Zeltser, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, H Miller, A Roth, N ArberAbstract:This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly (P <.002) higher concentrations of CD11b/CD18 Antigen on the surface of their polymorphonuclear leukocytes and monocytes (mean fluorescence intensity of 203 +/- 81 and 261 +/- 75, respectively) compared with the control group (mean fluorescence intensity 158 +/- 68 and 211 +/- 74, respectively) and to the group of patients with acute stress (mean fluorescence intensity of 146 +/- 70 and 200 +/- 22, respectively). The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress.
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Neutrophilia of infection/inflammation: are we really dealing with "inflamed" leukocytes?
Journal of medicine, 1998Co-Authors: Y. Sasson, M Kassirer, David Zeltser, O. Rogowski, N. Maharshak, Nissenkorn A, Eugene Leibovitz, P. Halperin, Sharvit D, Sorkine PAbstract:We adopted whole blood flow cytometry and direct labeling of the CD11b/CD18 and CD62L Antigens to study the relationship between their expression and leukocytosis in patients with infection/inflammation, acute stress and healthy volunteers. Mean +/- S.D. channel fluorescence intensity of CD11b/CD18 Antigen on peripheral blood polymorphonuclears did not differ between patients with infection/ inflammation (173+/-78) and controls (167+/-72), but was significantly (p = 0.04) reduced in stress (135+/-60). No correlation was found between CD11b/CD18 Antigen level and either polymorphonuclears absolute number or serum C-reactive protein. A significant negative correlation was noted between CD62L Antigen expression on polymorphonuclears and their absolute number. We assume that cells with increased CD11b/CD18 surface concentrations are retained in the capillaries and that part of the leukocytes in the peripheral blood are stressed leukocytes with reduced CD11b/CD18. Thus, leukocytes detected in peripheral blood are not necessarily the most "inflamed" ones.
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Dissociation between the state of leukocyte adhesiveness/aggregation in the peripheral blood and the availability of the CD11B/CD18 and CD62L Antigens on the surface of the cells in patients with stress.
Journal of medicine, 1998Co-Authors: Y. Sasson, M Kassirer, I Shapira, David Zeltser, O. Rogowski, R. Rotstein, V. Rudick, Dmitry Pevni, Nadir ArberAbstract:We adopted whole blood flow cytometry and direct labeling of the CD11b/CD18 and the CD62L Antigens to study the relationship between their expression on the surface of peripheral leukocytes and the state of leukocyte adhesiveness/aggregation (LAA) as revealed by the leukergy test. We examined patients with infection/inflammation, acute stress and controls. The mean +/- S.D. channel fluorescence intensity of CD11b/CD18 Antigen did not differ between patients with infection/inflammation (173 +/- 78) and controls (167 +/- 72). However, a significant (p < 0.0001) difference between these groups was noted regarding LAA state. There was a significant (p = 0.04) reduction in CD11b/CD18 in stress (135 +/- 60) and a significant (p < 0.001) increment in LAA. In both study groups, there was a significant reduction in CD62L. Patients were divided into those with CD11b/CD18 above and below the control's average. No correlation was found between the Antigens and LAA. We assume that LAA in patients with stress state is CD11b/CD18 and CD62L independent.
Nadir Arber - One of the best experts on this subject based on the ideXlab platform.
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increased expression of the cd11b CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease further evidence for smoldering inflammation in patients with atherosclerosis
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Dissociation between the state of leukocyte adhesiveness/aggregation in the peripheral blood and the availability of the CD11B/CD18 and CD62L Antigens on the surface of the cells in patients with stress.
Journal of medicine, 1998Co-Authors: Y. Sasson, M Kassirer, I Shapira, David Zeltser, O. Rogowski, R. Rotstein, V. Rudick, Dmitry Pevni, Nadir ArberAbstract:We adopted whole blood flow cytometry and direct labeling of the CD11b/CD18 and the CD62L Antigens to study the relationship between their expression on the surface of peripheral leukocytes and the state of leukocyte adhesiveness/aggregation (LAA) as revealed by the leukergy test. We examined patients with infection/inflammation, acute stress and controls. The mean +/- S.D. channel fluorescence intensity of CD11b/CD18 Antigen did not differ between patients with infection/inflammation (173 +/- 78) and controls (167 +/- 72). However, a significant (p < 0.0001) difference between these groups was noted regarding LAA state. There was a significant (p = 0.04) reduction in CD11b/CD18 in stress (135 +/- 60) and a significant (p < 0.001) increment in LAA. In both study groups, there was a significant reduction in CD62L. Patients were divided into those with CD11b/CD18 above and below the control's average. No correlation was found between the Antigens and LAA. We assume that LAA in patients with stress state is CD11b/CD18 and CD62L independent.
Natan M Bornstein - One of the best experts on this subject based on the ideXlab platform.
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lack of an increased expression of the cd11b CD18 Antigen on the surface of peripheral blood circulating pool of leukocytes in patients with an acute neurological ischemic event
Stroke, 2001Co-Authors: David Zeltser, Vadim G Karepov, Natan M BornsteinAbstract:37 OBJECTIVE: To reveal the intensity of the surface expression of the adhesion molecules (CD11b/CD18) on monocytes and neutrophils in the peripheral blood of patients with an acute brain ischemia compared to healthy individuals who served as controls. BACKGROUND: The Leukocyte Integrin CD11b/CD18 is an important receptor that is involved in the modulation of leukocyte to endothelial interactions and is expressed in increased amounts during cell activation. It has been previously suggested that activated white blood cells, mainly polymorphonuclear leukocytes and monocytes, participate in the development of ischemic vascular disorders by virtue of their capability to obstruct the microvasculature and enhance tissue damage. DESIGN/METHODS: Cellular surface expression of the adhesion molecules CD11b/CD18 on the neutrophils and monocytes in the peripheral blood was measured by a direct immunotechnique of flow cytometry in two groups: patients who had transient ischemic attacks (TIA) or ischemic stroke (confirmed by CT scans, within 24 hours from onset of symptoms), and healthy individuals who served as controls. Analysis was done by ANOVA test. RESULT: Seventy-one patients and 150 controls were included in the study. The respective mean fluorescence intensity for CD11b/CD18 being 161±76, 155±87 for polymorphonuclear leukocytes and 231±99, 203±79 for monocytes. No statistically significant difference was noted between the groups. CONCLUSIONS: The results of the present study show that patients with acute cerebral ischemic event do not present increased amount of the CD11b/CD18 Antigen on the surface of the peripheral blood polymorphonuclear or monocytes compared to control. Our data do not support the hypothesis that the white blood cells participate in the development of acute cerebral ischemia by the mechanism of activation of the adhesion molecule CD11b/CD18.
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Lack of an Increased Expression of the CD11b/CD18 Antigen on the Surface of Peripheral Blood Circulating Pool of Leukocytes in Patients with an Acute Neurological Ischemic Event
Stroke, 2001Co-Authors: David Zeltser, Vadim G Karepov, Natan M BornsteinAbstract:37 OBJECTIVE: To reveal the intensity of the surface expression of the adhesion molecules (CD11b/CD18) on monocytes and neutrophils in the peripheral blood of patients with an acute brain ischemia compared to healthy individuals who served as controls. BACKGROUND: The Leukocyte Integrin CD11b/CD18 is an important receptor that is involved in the modulation of leukocyte to endothelial interactions and is expressed in increased amounts during cell activation. It has been previously suggested that activated white blood cells, mainly polymorphonuclear leukocytes and monocytes, participate in the development of ischemic vascular disorders by virtue of their capability to obstruct the microvasculature and enhance tissue damage. DESIGN/METHODS: Cellular surface expression of the adhesion molecules CD11b/CD18 on the neutrophils and monocytes in the peripheral blood was measured by a direct immunotechnique of flow cytometry in two groups: patients who had transient ischemic attacks (TIA) or ischemic stroke (confirmed by CT scans, within 24 hours from onset of symptoms), and healthy individuals who served as controls. Analysis was done by ANOVA test. RESULT: Seventy-one patients and 150 controls were included in the study. The respective mean fluorescence intensity for CD11b/CD18 being 161±76, 155±87 for polymorphonuclear leukocytes and 231±99, 203±79 for monocytes. No statistically significant difference was noted between the groups. CONCLUSIONS: The results of the present study show that patients with acute cerebral ischemic event do not present increased amount of the CD11b/CD18 Antigen on the surface of the peripheral blood polymorphonuclear or monocytes compared to control. Our data do not support the hypothesis that the white blood cells participate in the development of acute cerebral ischemia by the mechanism of activation of the adhesion molecule CD11b/CD18.
I Shapira - One of the best experts on this subject based on the ideXlab platform.
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increased expression of the cd11b CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease further evidence for smoldering inflammation in patients with atherosclerosis
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American heart journal, 1999Co-Authors: M Kassirer, D Zeltser, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, H Miller, A Roth, N ArberAbstract:This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly (P <.002) higher concentrations of CD11b/CD18 Antigen on the surface of their polymorphonuclear leukocytes and monocytes (mean fluorescence intensity of 203 +/- 81 and 261 +/- 75, respectively) compared with the control group (mean fluorescence intensity 158 +/- 68 and 211 +/- 74, respectively) and to the group of patients with acute stress (mean fluorescence intensity of 146 +/- 70 and 200 +/- 22, respectively). The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress.
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Increased expression of the CD11b/CD18 Antigen on the surface of peripheral white blood cells in patients with ischemic heart disease: further evidence for smoldering inflammation in patients with atherosclerosis.
American Heart Journal, 1999Co-Authors: M Kassirer, V Prochorov, G Schoenman, A Frimerman, G Keren, I Shapira, A Roth, David Zeltser, Hylton I Miller, Nadir ArberAbstract:Abstract Background This study examined the availability of the CD11b/CD18 and CD62L Antigens on the surface of peripheral blood leukocytes in patients with ischemic heart disease. Methods and Results The study population included 45 patients with angiographically documented ischemic heart disease admitted to our department of internal medicine and the cardiology department during 1 month (December 1997). Sixty-six healthy members of the hospital medical staff served as control subjects. Another 39 post-trauma patients who were admitted to the emergency room were also evaluated. Patients with ischemic heart disease had significantly ( P Conclusions The presence of increased concentration of CD11b/CD18 suggests that circulating leukocytes are activated in patients with ischemic heart disease. This activation probably reflects the presence of an inflammatory response involving the atherosclerotic lesion and is not merely a result of acute stress. (Am Heart J 1999;138:555-9.)
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Dissociation between the state of leukocyte adhesiveness/aggregation in the peripheral blood and the availability of the CD11B/CD18 and CD62L Antigens on the surface of the cells in patients with stress.
Journal of medicine, 1998Co-Authors: Y. Sasson, M Kassirer, I Shapira, David Zeltser, O. Rogowski, R. Rotstein, V. Rudick, Dmitry Pevni, Nadir ArberAbstract:We adopted whole blood flow cytometry and direct labeling of the CD11b/CD18 and the CD62L Antigens to study the relationship between their expression on the surface of peripheral leukocytes and the state of leukocyte adhesiveness/aggregation (LAA) as revealed by the leukergy test. We examined patients with infection/inflammation, acute stress and controls. The mean +/- S.D. channel fluorescence intensity of CD11b/CD18 Antigen did not differ between patients with infection/inflammation (173 +/- 78) and controls (167 +/- 72). However, a significant (p < 0.0001) difference between these groups was noted regarding LAA state. There was a significant (p = 0.04) reduction in CD11b/CD18 in stress (135 +/- 60) and a significant (p < 0.001) increment in LAA. In both study groups, there was a significant reduction in CD62L. Patients were divided into those with CD11b/CD18 above and below the control's average. No correlation was found between the Antigens and LAA. We assume that LAA in patients with stress state is CD11b/CD18 and CD62L independent.