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Xianxiang Xu - One of the best experts on this subject based on the ideXlab platform.
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Plant polysaccharides and their effects on Cell Adhesion
Polysaccharides, 2021Co-Authors: Xianxiang XuAbstract:Cell Adhesion mediated by Cell Adhesion molecules (CAMs) constitutes essential life phenomenon. In inflammation, immunity, infection, tumor, cardiovascular injury, and wound healing, Cell Adhesion comes into being the basic physiological and pathological process. Intervening with Cell Adhesion has been the important therapeutic and prophylactic strategies for diseases. Accumulated evidence has indicated that plant polysaccharides especially those exacted from Chinese traditional and herbal medicine (most of plant medicine) displayed various pharmacological effects such as anti-inflammation, antitumor, anti-infection, immunomodulation, cardiovascular protective effects, and so on. Focusing on Cell Adhesion, further research is expected to reveal the therapeutic mechanism of plant polysaccharides in disease processes.
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Research progresses of plant polysaccharides on Cell Adhesion
Acta pharmaceutica Sinica, 2012Co-Authors: Xianxiang Xu, Yong Diao, Ruian XuAbstract:: Cell Adhesion mediated by Cell Adhesion molecules (CAMs) constitutes essential life phenomenon. In inflammation, immunity, infection, thrombosis, tumor metastasis and wound healing, Cell Adhesion comes into being the basic physiological and pathological process. Intervening with Cell Adhesion has been the important therapeutic and prophylactic strategies for diseases. Accumulated evidence has indicated that plant polysaccharides especially those exacted from Chinese traditional and herbal drugs displayed various pharmacological effects such as anti-inflammation, anti-cancer, anti-infection, immunomodulation, cardiovascular protective effects and so on. In this paper, the research progress of plant polysaccharides on Cell Adhesion is reviewed.
Urs Rutishauser - One of the best experts on this subject based on the ideXlab platform.
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Spatio-temporal diversity in the microenvironments for neural Cell Adhesion molecule, neural Cell Adhesion molecule-polysialic acid, and L1-Cell Adhesion molecule expression by sensory neurons and their targets during cochleo-vestibular innervation
Neuroscience, 1998Co-Authors: S.h Hrynkow, D.k. Morest, Craig Brumwell, Urs RutishauserAbstract:Abstract Sixteen phases in the microenvironments were defined for the structural development and innervation of the cochleo-vestibular ganglion and its targets. In each phase the Cell Adhesion molecules, neural Cell Adhesion molecule, neural Cell Adhesion molecule-polysialic acid, and L1-Cell Adhesion molecule, were expressed differentially by cochleo-vestibular ganglion Cells, their precursors, and the target Cells on which they synapse. Detected by immunocytochemistry in staged chicken embryos, in the otocyst, neural Cell Adhesion molecule, but not L1-Cell Adhesion molecule, was localized to the ganglion and hair Cell precursors. Ganglionic precursors, migrating from the otocyst, only weakly expressed neural Cell Adhesion molecule. Epithelial hair Cell precursors, remaining in the otocyst, expressed neural Cell Adhesion molecule, but not L1-Cell Adhesion molecule. Post-migratory ganglion Cell processes expressed both molecules in all stages. The Cell Adhesion molecules were most heavily expressed by axons penetrating the otic epithelium and accumulated in large amounts in the basal lamina. In the basilar papilla (cochlea), Cell Adhesion molecule expression followed the innervation gradient. Neural Cell Adhesion molecule and L1 were heavily concentrated on axonal endings peripherally and centrally. In the rhombencephalon, primitive epithelial Cells expressed neural Cell Adhesion molecule, but not L1-Cell Adhesion molecule, except in the floorplate. The neuroblasts and their axons expressed L1-Cell Adhesion molecule, but not neural Cell Adhesion molecule, when they began to migrate and form the dorsal commissure. There was a stage-dependent, differential distribution of the Cell Adhesion molecules in the floorplate. Commissural axons expressed both Cell Adhesion molecules, but their polysialic acid disappeared within the floorplate at later stages. In conclusion, the Cell Adhesion molecules are expressed by the same Cells at different times and places during their development. They are positioned to play different roles in migration, target penetration, and synapse formation by sensory neurons. A multiphasic model provides a morphological basis for experimental analyses of the molecules critical for the changing roles of the microenvironment in neuronal specification.
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Neural Cell Adhesion molecule in aged mouse muscle
Neuroscience, 1992Co-Authors: H. Kobayashi, N. Robbins, Urs RutishauserAbstract:Abstract Expression of the neural Cell Adhesion molecule was compared in endplate and non-endplate regions of skeletal muscles of mature and old CBF-1 mice, in order to determine whether age-related changes in neuromuscular morphology were correlated with age changes in neural Cell Adhesion molecule expression. Three muscles were examined: two (soleus and sternomastoid) showed age-related regionalization of nerve terminals as one manifestation of increased synaptic remodelling, while the third (diaphragm) did not. Relative neural Cell Adhesion molecule content in these muscles was measured by densitometry of immunoblots after concentration by affinity chromatography. Expression of the major 140,000 mol. wt form of neural Cell Adhesion molecule, which was most abundant in the endplate region, was increased in sternomastoid and soleus of old compared to adult mouse, but was unchanged with age in diaphragm. A 70,000–80,000 mol. wt presumably proteolytic polypeptide fragment of neural Cell Adhesion molecule was increased in immunoblots of all old muscles. Immunocytochemical studies of skeletal muscles showed no difference in neural Cell Adhesion molecule Cellular distribution in mature vs old mice, but in motor nerve of sternomastoid, the number of neural Cell Adhesion molecule-positive nerve fibers was increased in old mice. Several lines of evidence indicated that partial denervation was rare in old CBF-1 mice, and therefore could not account for the findings above. Selective increase of 140,000 mol. wt neural Cell Adhesion molecule expression in the junctional regions of those muscles of old mice which show neuromuscular remodelling indicates that this Adhesion molecule may play a role in the age-related instability of motor nerve terminals.
R L Juliano - One of the best experts on this subject based on the ideXlab platform.
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signal transduction and signal modulation by Cell Adhesion receptors the role of integrins cadherins immunoglobulin Cell Adhesion molecules and selectins
Pharmacological Reviews, 1998Co-Authors: Andrew E Aplin, Alan K Howe, Suresh K Alahari, R L JulianoAbstract:Cell Adhesion is critical for the genesis and maintenance of both three-dimensional structure and normal function in tissues. The biochemical entities mediating Cell Adhesion are multiprotein complexes comprising three broad classes of macromolecules: the Adhesion receptors, the extraCellular matrix
Mats W. Johansson - One of the best experts on this subject based on the ideXlab platform.
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Cell Adhesion molecules in invertebrate immunity.
Developmental and comparative immunology, 1999Co-Authors: Mats W. JohanssonAbstract:Cell Adhesion is essential in immunity in invertebrates, e.g., in the Cellular immune responses of encapsulation and nodule formation. Here Cell Adhesion molecules shown or suggested to be involved in invertebrate immunity are reviewed. Blood Cells of the crayfish, Pacifastacus leniusculus, can release a Cell-adhesive and opsonic peroxidase, peroxinectin. A site containing the motif, KGD, appears to be adhesive by binding to a transmembrane receptor of the integrin family on the blood Cells. Peroxinectin also binds a peripheral blood Cell surface CuZn-superoxide dismutase. The peroxidase-integrin interaction appears to have evolved early and seems conserved; human myeloperoxidase supports Cell Adhesion via the alphaMbeta2 integrin. There is evidence for peroxinectin-like proteins in other arthropods. Effects by RGD peptides indicate that integrins mediate blood Cell Adhesion and Cellular immunity in diverse invertebrate species. Other invertebrate blood Cell molecules proposed to be involved in Adhesion include the insect plasmatocyte-spreading peptide, as well as soluble and transmembrane proteins which show some similarity to vertebrate adhesive or extraCellular matrix molecules. Proteins such as the Ig family member hemolin, or proteins found in insects that are hosts for parasitic wasps, inhibit Cell Adhesion and may regulate or block Cellular immunity.
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Cell Adhesion molecules in invertebrate immunity.
Developmental and Comparative Immunology, 1999Co-Authors: Mats W. JohanssonAbstract:Cell Adhesion is essential in immunity in invertebrates, e.g., in the Cellular immune responses of encapsulation and nodule formation. Here Cell Adhesion molecules shown or suggested to be involved in invertebrate immunity are reviewed. Blood Cells of the crayfish, Pacifastacus leniusculus, can release a Cell-adhesive and opsonic peroxidase, peroxinectin. A site containing the motif, KGD, appears to be adhesive by binding to a transmembrane receptor of the integrin family on the blood Cells. Peroxinectin also binds a peripheral blood Cell surface CuZn-superoxide dismutase. The peroxidase–integrin interaction appears to have evolved early and seems conserved; human myeloperoxidase supports Cell Adhesion via the αMβ2 integrin. There is evidence for peroxinectin-like proteins in other arthropods. Effects by RGD peptides indicate that integrins mediate blood Cell Adhesion and Cellular immunity in diverse invertebrate species. Other invertebrate blood Cell molecules proposed to be involved in Adhesion include the insect plasmatocyte-spreading peptide, as well as soluble and transmembrane proteins which show some similarity to vertebrate adhesive or extraCellular matrix molecules. Proteins such as the Ig family member hemolin, or proteins found in insects that are hosts for parasitic wasps, inhibit Cell Adhesion and may regulate or block Cellular immunity.
Ruian Xu - One of the best experts on this subject based on the ideXlab platform.
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Research progresses of plant polysaccharides on Cell Adhesion
Acta pharmaceutica Sinica, 2012Co-Authors: Xianxiang Xu, Yong Diao, Ruian XuAbstract:: Cell Adhesion mediated by Cell Adhesion molecules (CAMs) constitutes essential life phenomenon. In inflammation, immunity, infection, thrombosis, tumor metastasis and wound healing, Cell Adhesion comes into being the basic physiological and pathological process. Intervening with Cell Adhesion has been the important therapeutic and prophylactic strategies for diseases. Accumulated evidence has indicated that plant polysaccharides especially those exacted from Chinese traditional and herbal drugs displayed various pharmacological effects such as anti-inflammation, anti-cancer, anti-infection, immunomodulation, cardiovascular protective effects and so on. In this paper, the research progress of plant polysaccharides on Cell Adhesion is reviewed.