The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform
R. Maclennan - One of the best experts on this subject based on the ideXlab platform.
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Blood group, serum protein and red Cell Enzyme groups of Amerindian populations in Colombia.
American journal of physical anthropology, 2005Co-Authors: Robert Kirk, E. M. Mcdermid, N. M. Blake, D. C. Gajdusek, Webster C. Leyshon, R. MaclennanAbstract:Red Cell samples from persons belonging to four Amerindian linguistic groups in Colombia were investigated for genetic variants in eight blood group systems: for three of the groups investigations were extended to ten red Cell Enzyme and four serum protein systems. The groups studied are the Noanama (including six Empera) of the Rio Siquirisua and Rio Docampado on the Pacific lowlands and the Cofan, Ingano and Siona Indians of the Upper Rio Putumayo and its tributaries to the east of the Andes. Only blood group O was present among two of the groups and the same groups were 100% Kp(b +), k in the Kell system. Di(a +) frequencies were high in three groups and there was marked variation between groups for the MNS, Rh, P, Lewis and Duffy systems. Polymorphism in all the three linguistic groups studied for serum proteins and red Cell Enzymes was present only in the red Cell acid phosphatase, phosphoglucomutase (locus-1) and haptoglobin systems. 6-phosphogluconate dehydrogenase was polymorphic in the Noanama, and caeruloplasmin was polymorphic in the Ingano linguistic group. In addition two persons belonging to the Cofan linguistic group revealed the presence of an “atypical” component in the lactate dehydrogenase system. No variation was found in the other six red Cell Enzyme and two serum protein systems. Comparison with published data on red Cell Enzyme and serum protein groups for other South American Amerindian populations shows the Colombian populations studied here most closely resemble the Cayapo of Brazil.
Robert Kirk - One of the best experts on this subject based on the ideXlab platform.
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Blood group, serum protein and red Cell Enzyme groups of Amerindian populations in Colombia.
American journal of physical anthropology, 2005Co-Authors: Robert Kirk, E. M. Mcdermid, N. M. Blake, D. C. Gajdusek, Webster C. Leyshon, R. MaclennanAbstract:Red Cell samples from persons belonging to four Amerindian linguistic groups in Colombia were investigated for genetic variants in eight blood group systems: for three of the groups investigations were extended to ten red Cell Enzyme and four serum protein systems. The groups studied are the Noanama (including six Empera) of the Rio Siquirisua and Rio Docampado on the Pacific lowlands and the Cofan, Ingano and Siona Indians of the Upper Rio Putumayo and its tributaries to the east of the Andes. Only blood group O was present among two of the groups and the same groups were 100% Kp(b +), k in the Kell system. Di(a +) frequencies were high in three groups and there was marked variation between groups for the MNS, Rh, P, Lewis and Duffy systems. Polymorphism in all the three linguistic groups studied for serum proteins and red Cell Enzymes was present only in the red Cell acid phosphatase, phosphoglucomutase (locus-1) and haptoglobin systems. 6-phosphogluconate dehydrogenase was polymorphic in the Noanama, and caeruloplasmin was polymorphic in the Ingano linguistic group. In addition two persons belonging to the Cofan linguistic group revealed the presence of an “atypical” component in the lactate dehydrogenase system. No variation was found in the other six red Cell Enzyme and two serum protein systems. Comparison with published data on red Cell Enzyme and serum protein groups for other South American Amerindian populations shows the Colombian populations studied here most closely resemble the Cayapo of Brazil.
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Red Cell Enzyme and serum protein types in the Watut Anga of Papua New Guinea
Annals of human biology, 1992Co-Authors: K. Bhatia, N. M. Blake, G. G. Crane, Robert KirkAbstract:SummaryHistorically, the Angan populations of Papua New Guinea have maintained a strong isolation and absorbed limited genes from their neighbours. This lack of intermixing is reflected in their relatively homogeneous cultural, linguistic and genetic profiles. We have determined the electrophoretic variation at 26 red Cell Enzyme, serum protein and haemoglobin loci in the Watut Anga, a splinter group occupying the Upper Watut Valley of Morobe Province. Their genetic profile reveals the lack of a number of variants, such as PGM2*10 and MDH*3, known to exhibit high frequencies in other highland populations. The average heterozygosity in the Watut is also much lower when compared with other Papua New Guinean populations. Their present numerical strength notwithstanding, it appears that the Angan populations have experienced population bottlenecks in their evolutionary history which may have accentuated their genetic divergence from other Papua New Guinean populations.
Ernest Beutler - One of the best experts on this subject based on the ideXlab platform.
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The molecular biology of G6PD variants and other red Cell Enzyme defects.
Annual review of medicine, 1992Co-Authors: Ernest BeutlerAbstract:Modern techniques of molecular biology have made it possible to identify mutations in a number of different hereditary red Cell Enzyme defects. Most of the studies have been performed in glucose-6-phosphate dehydrogenase deficiency, where a large number of point mutations have been identified. The same mutations are encountered repeatedly, even in patients with defects that were thought, on the basis of biochemical properties of the residual Enzyme, to be distinct. A beginning has been made in identifying mutations in a few other red Cell Enzyme defects.
N. M. Blake - One of the best experts on this subject based on the ideXlab platform.
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Blood group, serum protein and red Cell Enzyme groups of Amerindian populations in Colombia.
American journal of physical anthropology, 2005Co-Authors: Robert Kirk, E. M. Mcdermid, N. M. Blake, D. C. Gajdusek, Webster C. Leyshon, R. MaclennanAbstract:Red Cell samples from persons belonging to four Amerindian linguistic groups in Colombia were investigated for genetic variants in eight blood group systems: for three of the groups investigations were extended to ten red Cell Enzyme and four serum protein systems. The groups studied are the Noanama (including six Empera) of the Rio Siquirisua and Rio Docampado on the Pacific lowlands and the Cofan, Ingano and Siona Indians of the Upper Rio Putumayo and its tributaries to the east of the Andes. Only blood group O was present among two of the groups and the same groups were 100% Kp(b +), k in the Kell system. Di(a +) frequencies were high in three groups and there was marked variation between groups for the MNS, Rh, P, Lewis and Duffy systems. Polymorphism in all the three linguistic groups studied for serum proteins and red Cell Enzymes was present only in the red Cell acid phosphatase, phosphoglucomutase (locus-1) and haptoglobin systems. 6-phosphogluconate dehydrogenase was polymorphic in the Noanama, and caeruloplasmin was polymorphic in the Ingano linguistic group. In addition two persons belonging to the Cofan linguistic group revealed the presence of an “atypical” component in the lactate dehydrogenase system. No variation was found in the other six red Cell Enzyme and two serum protein systems. Comparison with published data on red Cell Enzyme and serum protein groups for other South American Amerindian populations shows the Colombian populations studied here most closely resemble the Cayapo of Brazil.
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Red Cell Enzyme and serum protein types in the Watut Anga of Papua New Guinea
Annals of human biology, 1992Co-Authors: K. Bhatia, N. M. Blake, G. G. Crane, Robert KirkAbstract:SummaryHistorically, the Angan populations of Papua New Guinea have maintained a strong isolation and absorbed limited genes from their neighbours. This lack of intermixing is reflected in their relatively homogeneous cultural, linguistic and genetic profiles. We have determined the electrophoretic variation at 26 red Cell Enzyme, serum protein and haemoglobin loci in the Watut Anga, a splinter group occupying the Upper Watut Valley of Morobe Province. Their genetic profile reveals the lack of a number of variants, such as PGM2*10 and MDH*3, known to exhibit high frequencies in other highland populations. The average heterozygosity in the Watut is also much lower when compared with other Papua New Guinean populations. Their present numerical strength notwithstanding, it appears that the Angan populations have experienced population bottlenecks in their evolutionary history which may have accentuated their genetic divergence from other Papua New Guinean populations.
Shiro Miwa - One of the best experts on this subject based on the ideXlab platform.
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Red blood Cell Enzymes and their clinical application.
Advances in clinical chemistry, 1998Co-Authors: Hisaichi Fujii, Shiro MiwaAbstract:Publisher Summary The chapter discusses red blood Cell Enzymes and their clinical application. Structure and functions of major red blood Cell Enzymes are discussed in the chapter wherein hexokinase, glucose phosphate isomerase, phosphofructokinase, aldolase, triose phosphate isomerase, diphosphoglycerate mutase, phosphoglycerate kinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, adenylate kinase, pyrimidine 5'-nucleotidase, adenosine deaminase are described. The chapter also discusses hereditary hemolytic anemia associated with red blood Cell Enzyme deficiency in detail. The various defects in the Embden-Meyerhof pathway, hexose monophosphate pathway and glutathione metabolism and synthesis, and nucleotide metabolism are presented. Hereditary nonhemolytic blood disorders associated with red blood Cell Enzyme deficiency are discussed next in the chapter wherein diphosphoglycerate mutase deficiency, lactate dehydrogenase deficiency, and NADH cytochrome b5 reductase deficiency are described. The chapter discusses hereditary nonhematologic disorders that can be diagnosed by the determination of red blood Cell Enzyme activity. The various topics covered are Enzyme deficiencies associated with immunological disorders; Enzyme deficiencies in the metabolism of purine; prolidase deficiency; acatalasemia; galactosemia; porphyria; and carbonic anhydrase deficiency.