The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Yukio Imanishi - One of the best experts on this subject based on the ideXlab platform.
-
Enhancement of Cell Growth on a porous membrane co-immobilized with Cell-Growth and Cell adhesion factors
Biomaterials, 1997Co-Authors: Yoshihiro Ito, Ji Zheng, Yukio ImanishiAbstract:Abstract Insulin was co-immobilized with Cell adhesion factors such as fibronectin or polylysine on a porous poly(ethylene terephthalate) membrane. The surface of the polyfethylene terephthalate) membrane was partially hydrolysed under alkaline conditions and the proteins were immobilized on the membrane surface using a water-soluble carbodiimide. The adhesion of STO mouse fibroblast Cells onto the immobilized membrane was accelerated by the immobilization of fibronectin and polylysine. The Cell Growth was enhanced by immobilization of insulin. Co-immobilization of insulin with the adhesion factors markedly accelerated Cell Growth. No significant differences were found between the effects of fibronectin and polylysine. The absence of insulin release was confirmed by the fact that Growth was not accelerated under essentially the same culture conditions without direct contact with the protein-immobilized membrane.
-
Cell Growth on immobilized Cell Growth factor. 6. Enhancement of fibroblast Cell Growth by immobilized insulin and/or fibronectin
Journal of biomedical materials research, 1993Co-Authors: Yoshihiro Ito, Masatoshi Inoue, Shu Qin Liu, Yukio ImanishiAbstract:A Cell Growth factor protein (insulin) and/or a Cell-adhesion protein (fibronectin) were immobilized on surface-hydrolyzed poly(methyl methacrylate) membranes. The Growth of mouse fibroblast Cells STO was accelerated by the immobilized insulin. This acceleration was enhanced by introduction of spacer arms. Coimmobilization of insulin and fibronectin was very effective for the acceleration of Cell Growth. © 1993 John Wiley & Sons, Inc.
-
Cell Growth on immobilized Cell Growth factor: 5. Interaction of immobilized transferrin with fibroblast Cells
International journal of biological macromolecules, 1993Co-Authors: Shu Qin Liu, Yoshihiro Ito, Yukio ImanishiAbstract:Transferrin was immobilized on poly(methyl methacrylate) membrane and the interaction of the immobilized transferrin with mouse fibroblast Cells STO was investigated. The immobilized transferrin was stable without decomposition over 48 h and showed higher activities of Cell Growth acceleration than free transferrin and transported ferric ion as effectively as free transferrin. The specific interaction of the immobilized transferrin with fibroblast Cells was confirmed by experiment using the antibody. It was considered that Cell Growth acceleration and ferric ion transportation occur by different mechanisms.
Michael N Hall - One of the best experts on this subject based on the ideXlab platform.
-
TOR and paradigm change: Cell Growth is controlled
Molecular biology of the cell, 2016Co-Authors: Michael N HallAbstract:This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of Cell Growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its Cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls Cell Growth in response to nutrients.
-
Cell Growth : control of Cell size
2004Co-Authors: Michael N Hall, Martin Raff, George ThomasAbstract:Preface Foreword P. Nurse Chapter 1: How Metazoans Reach Their Full Size: The Natural History of Bigness P.H. O'Farrell Chapter 2: Growth and Cell Cycle Control in Drosophila B.A. Edgar and H.F. Nijhout Chapter 3: Coordination of Cell Growth and Cell-cycle Progression in Proliferating Mammalian Cells I. Conlon, A. Lloyd, and M. Raff Chapter 4: Coordination of Cell Growth and Cell Division E.V. Schmidt Chapter 5: TOR Signaling in Yeast: Temporal and Spatial Control of Cell Growth R. Loewith and M.N. Hall Chapter 6: Growth Regulation by Insulin and TOR Signaling in Drosophila S.J. Leevers and E. Hafen Chapter 7: Growth Control through the mTOR Network D.A. Guertin, D.-H. Kim, and D.M. Sabatini Chapter 8:IGF-I Receptor Signaling in Cell Growth and Proliferation R. Baserga Chapter 9: S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth J. Montagne and G. Thomas Chapter 10: Translation Initiation and Cell Growth Control E. Petroulakis and N. Sonenberg Chapter 11: Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast P. Jorgensen, M. Tyers, and J.R. Warner Chapter 12: Control of rRNA and tRNA Production Is Closely Tied to Cell Growth R.J. White Chapter 13: Autophagy: Reversing Cell Growth Y. Ohsumi Chapter 14: Synaptic Growth, Synaptic Maintenance, and the Persistence of Long-term Memory Storage C.H. Bailey, R.D. Hawkins, and E.R. Kandel Chapter 15: The Control of Synaptic Function by Local Protein Synthesis and Degradation W.B. Smith, B. Bingol, G.N. Patrick, and E.M. Schuman Chapter 16: Lymphocyte Growth D.E. Bauer and C.B. Thompson Chapter 17: Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets D.J. Glass and G.D. Yancopoulos Chapter 18: Mechanisms Controlling Heart Growth in Mammals J.R. McMullen and S. Izumo Chapter 19: Regulation of Cell Growth in the Endocrine Pancreas K. Roovers and M.J. Birnbaum Chapter 20: Plant Cell Growth B. Menand and C. Robaglia Index
-
TOR signaling in yeast : temporal and spatial control of Cell Growth
Cold Spring Harbor Monograph Archive, 2004Co-Authors: Robbie Loewith, Michael N HallAbstract:Cell Growth is highly regulated. Cells respond to nutrients or other appropriate Growth stimuli by up-regulating macromolecular synthesis, and thereby increasing in size. Conversely, Cells respond to nutrient limitation or other types of stress by down-regulating macromolecular synthesis and enhancing turnover of excess mass. Thus, the control of Cell Growth involves balancing positive regulation of anabolic processes with negative regulation of catabolic processes. Growth is also controlled relative to Cell division. In proliferating Cells, Growth is linked to the Cell cycle such that Cells generally double their mass before dividing. In other physiological contexts, such as load-induced muscle hypertrophy or Growth factor–induced neuronal Growth, Cell Growth can occur postmitotically. Furthermore, in addition to the temporal control of Cell Growth described above, Cell Growth can be subject to spatial constraints. For example, budding yeast and neurons grow in a polarized manner as a result of new mass being laid down only at one end of the Cell. Finally, in multiCellular organisms, Growth of individual Cells is controlled relative to overall body Growth such that the organs constituting the organism are properly proportioned. What are the mechanisms that mediate and integrate the many parameters of Cell Growth? In other words, what determines that a Cell grows only at the right time and at the right place? Remarkably, the study of these mechanisms has been largely neglected, despite their clinical relevance and despite Cell Growth being, along with Cell division and Cell death, one of the most fundamental aspects of Cell behavior.
-
TOR, a central controller of Cell Growth
Cell, 2000Co-Authors: Tobias Schmelzle, Michael N HallAbstract:Cell Growth (increase in Cell mass) and Cell proliferation (increase in Cell number) are distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. Cyclin-dependent kinase(s) is the central regulator of Cell proliferation. Is there an equivalent regulator for Cell Growth? Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for Cell Growth, suggesting that this conserved kinase is such a central regulator.
Yoshihiro Ito - One of the best experts on this subject based on the ideXlab platform.
-
Enhancement of Cell Growth on a porous membrane co-immobilized with Cell-Growth and Cell adhesion factors
Biomaterials, 1997Co-Authors: Yoshihiro Ito, Ji Zheng, Yukio ImanishiAbstract:Abstract Insulin was co-immobilized with Cell adhesion factors such as fibronectin or polylysine on a porous poly(ethylene terephthalate) membrane. The surface of the polyfethylene terephthalate) membrane was partially hydrolysed under alkaline conditions and the proteins were immobilized on the membrane surface using a water-soluble carbodiimide. The adhesion of STO mouse fibroblast Cells onto the immobilized membrane was accelerated by the immobilization of fibronectin and polylysine. The Cell Growth was enhanced by immobilization of insulin. Co-immobilization of insulin with the adhesion factors markedly accelerated Cell Growth. No significant differences were found between the effects of fibronectin and polylysine. The absence of insulin release was confirmed by the fact that Growth was not accelerated under essentially the same culture conditions without direct contact with the protein-immobilized membrane.
-
Cell Growth on immobilized Cell Growth factor. 6. Enhancement of fibroblast Cell Growth by immobilized insulin and/or fibronectin
Journal of biomedical materials research, 1993Co-Authors: Yoshihiro Ito, Masatoshi Inoue, Shu Qin Liu, Yukio ImanishiAbstract:A Cell Growth factor protein (insulin) and/or a Cell-adhesion protein (fibronectin) were immobilized on surface-hydrolyzed poly(methyl methacrylate) membranes. The Growth of mouse fibroblast Cells STO was accelerated by the immobilized insulin. This acceleration was enhanced by introduction of spacer arms. Coimmobilization of insulin and fibronectin was very effective for the acceleration of Cell Growth. © 1993 John Wiley & Sons, Inc.
-
Cell Growth on immobilized Cell Growth factor: 5. Interaction of immobilized transferrin with fibroblast Cells
International journal of biological macromolecules, 1993Co-Authors: Shu Qin Liu, Yoshihiro Ito, Yukio ImanishiAbstract:Transferrin was immobilized on poly(methyl methacrylate) membrane and the interaction of the immobilized transferrin with mouse fibroblast Cells STO was investigated. The immobilized transferrin was stable without decomposition over 48 h and showed higher activities of Cell Growth acceleration than free transferrin and transported ferric ion as effectively as free transferrin. The specific interaction of the immobilized transferrin with fibroblast Cells was confirmed by experiment using the antibody. It was considered that Cell Growth acceleration and ferric ion transportation occur by different mechanisms.
Shu Qin Liu - One of the best experts on this subject based on the ideXlab platform.
-
Cell Growth on immobilized Cell Growth factor. 6. Enhancement of fibroblast Cell Growth by immobilized insulin and/or fibronectin
Journal of biomedical materials research, 1993Co-Authors: Yoshihiro Ito, Masatoshi Inoue, Shu Qin Liu, Yukio ImanishiAbstract:A Cell Growth factor protein (insulin) and/or a Cell-adhesion protein (fibronectin) were immobilized on surface-hydrolyzed poly(methyl methacrylate) membranes. The Growth of mouse fibroblast Cells STO was accelerated by the immobilized insulin. This acceleration was enhanced by introduction of spacer arms. Coimmobilization of insulin and fibronectin was very effective for the acceleration of Cell Growth. © 1993 John Wiley & Sons, Inc.
-
Cell Growth on immobilized Cell Growth factor: 5. Interaction of immobilized transferrin with fibroblast Cells
International journal of biological macromolecules, 1993Co-Authors: Shu Qin Liu, Yoshihiro Ito, Yukio ImanishiAbstract:Transferrin was immobilized on poly(methyl methacrylate) membrane and the interaction of the immobilized transferrin with mouse fibroblast Cells STO was investigated. The immobilized transferrin was stable without decomposition over 48 h and showed higher activities of Cell Growth acceleration than free transferrin and transported ferric ion as effectively as free transferrin. The specific interaction of the immobilized transferrin with fibroblast Cells was confirmed by experiment using the antibody. It was considered that Cell Growth acceleration and ferric ion transportation occur by different mechanisms.
Alison C. Lloyd - One of the best experts on this subject based on the ideXlab platform.
-
Aspects of Cell Growth control illustrated by the Schwann Cell.
Current opinion in cell biology, 2012Co-Authors: Sinead A Roberts, Alison C. LloydAbstract:The control of Cell biogenesis remains poorly understood, despite being critical for the development and maintenance of all organisms. Studies in vitro and in vivo using the Schwann Cell, the glial Cell of the peripheral nervous system, have provided important insights into Cell Growth control. These studies have demonstrated how instructive Growth factor signals can control Cell Growth rates, Cell size and organelle biogenesis and how deregulated Cell Growth can contribute to diseases, such as cancer. Additional studies on Schwann Cells highlight the importance of Cell size control within a tissue--the size of myelinating Schwann Cells is coupled to the size of the axon they ensheath, which is necessary for efficient nerve conduction.