The Experts below are selected from a list of 72279 Experts worldwide ranked by ideXlab platform
Helen Morrison - One of the best experts on this subject based on the ideXlab platform.
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the Peripheral Nervous System in hematopoietic stem cell aging
Mechanisms of Ageing and Development, 2020Co-Authors: Leopold Bohm, Dariolucas Helbing, Nova Oraha, Helen MorrisonAbstract:Abstract Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming System, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cells – which in turn are influenced by Systemic factors distributed by the bone marrow extracellular fluid. Although hematopoietic cell-intrinsic aging contributes to the aging phenotype of the hematopoietic System, the architecture and cellular composition of the bone marrow microenvironment have emerged to be highly dynamic during aging and suggested as a major driver for the functional limitations of the blood System observable in old individuals. Recent attention has been paid to the interface between the Peripheral Nervous System and blood-forming cells in the bone marrow in several clinical contexts and in aging – the latter is reviewed here.
Zhong Lin Wang - One of the best experts on this subject based on the ideXlab platform.
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artificial tactile Peripheral Nervous System supported by self powered transducers
Nano Energy, 2021Co-Authors: Libo Chen, Chenyu Wen, Shili Zhang, Zhong Lin Wang, Zhibin ZhangAbstract:Abstract The tactile Peripheral Nervous System innervating human hands, which is essential for sensitive haptic exploration and dexterous object manipulation, features overlapped receptive fields in the skin, arborization of Peripheral neurons and many-to-many synaptic connections. Inspired by the structural features of the natural System, we report a supersensitive artificial slowly adapting tactile afferent Nervous System based on the triboelectric nanogenerator technology. Using tribotronic transistors in the design of mechanoreceptors, the artificial afferent Nervous System exhibits the typical adapting behaviours of the biological counterpart in response to mechanical stimulations. The artificial afferent Nervous System is self-powered in the transduction and event-driven in the operation. Moreover, it has inherent proficiency of neuromorphic signal processing, delivering a minimum resolvable dimension two times smaller than the inter-receptor distance which is the lower limit of the dimension that existing electronic skins can resolve. These results open up a route to scalable neuromorphic skins aiming at the level of human’s exceptional perception for neurorobotic and neuroprosthetic applications.
Zhibin Zhang - One of the best experts on this subject based on the ideXlab platform.
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artificial tactile Peripheral Nervous System supported by self powered transducers
Nano Energy, 2021Co-Authors: Libo Chen, Chenyu Wen, Shili Zhang, Zhong Lin Wang, Zhibin ZhangAbstract:Abstract The tactile Peripheral Nervous System innervating human hands, which is essential for sensitive haptic exploration and dexterous object manipulation, features overlapped receptive fields in the skin, arborization of Peripheral neurons and many-to-many synaptic connections. Inspired by the structural features of the natural System, we report a supersensitive artificial slowly adapting tactile afferent Nervous System based on the triboelectric nanogenerator technology. Using tribotronic transistors in the design of mechanoreceptors, the artificial afferent Nervous System exhibits the typical adapting behaviours of the biological counterpart in response to mechanical stimulations. The artificial afferent Nervous System is self-powered in the transduction and event-driven in the operation. Moreover, it has inherent proficiency of neuromorphic signal processing, delivering a minimum resolvable dimension two times smaller than the inter-receptor distance which is the lower limit of the dimension that existing electronic skins can resolve. These results open up a route to scalable neuromorphic skins aiming at the level of human’s exceptional perception for neurorobotic and neuroprosthetic applications.
Leopold Bohm - One of the best experts on this subject based on the ideXlab platform.
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the Peripheral Nervous System in hematopoietic stem cell aging
Mechanisms of Ageing and Development, 2020Co-Authors: Leopold Bohm, Dariolucas Helbing, Nova Oraha, Helen MorrisonAbstract:Abstract Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming System, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cells – which in turn are influenced by Systemic factors distributed by the bone marrow extracellular fluid. Although hematopoietic cell-intrinsic aging contributes to the aging phenotype of the hematopoietic System, the architecture and cellular composition of the bone marrow microenvironment have emerged to be highly dynamic during aging and suggested as a major driver for the functional limitations of the blood System observable in old individuals. Recent attention has been paid to the interface between the Peripheral Nervous System and blood-forming cells in the bone marrow in several clinical contexts and in aging – the latter is reviewed here.
Brad Bolon - One of the best experts on this subject based on the ideXlab platform.
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international regulatory guiding documents and best practice recommendations on Peripheral Nervous System pns histopathologic evaluation in good laboratory practice glp compliant animal toxicity studies
Toxicologic Pathology, 2020Co-Authors: Brad Bolon, Mark T Butt, Alys Bradley, Karl F JensenAbstract:Assessment of the Peripheral Nervous System (PNS) tissues during animal toxicity studies generally is included within guiding documents issued by regulatory agencies of individual nations (eg, US E...
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atlas of normal microanatomy procedural and processing artifacts common background findings and neurotoxic lesions in the Peripheral Nervous System of laboratory animals
Toxicologic Pathology, 2020Co-Authors: Ingrid D. Pardo, Alok K. Sharma, Mark T Butt, Klaus Weber, Sarah D Cramer, G Krinke, Brad BolonAbstract:The ability to differentiate among normal structures, procedural and processing artifacts, spontaneous background changes, and test article–related effects in the Peripheral Nervous System (PNS) is...
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toxicologic pathology of the Peripheral Nervous System pns overview challenges and current practices
Toxicologic Pathology, 2018Co-Authors: Ingrid D. Pardo, Alok K. Sharma, Deepa B. Rao, Mark T Butt, Bernard S Jortner, William M Valentine, Joseph C Arezzo, Brad BolonAbstract:Peripheral Nervous System (PNS) toxicity is a frequent adverse effect encountered in patients treated with certain therapeutics (e.g., antiretroviral drugs, cancer chemotherapeutics), in occupational workers exposed to industrial chemicals (e.g., solvents), or during accidental exposures to household chemicals and/or environmental agents (e.g., pesticides). However, the literature and expertise needed for the effective design, conduct, analysis, and reporting of safety studies to identify and define PNS toxicity are hard to find. This half-day course familiarized participants with basic PNS biology; causes and mechanisms of PNS pathology; classic methods and current best practice recommendations for PNS sampling, preparation, and evaluation; and examples of commonly observed lesions and artifacts. Three concluding case presentations synthesized information from the prior technical lectures by presenting real-world examples of lesions caused by drugs and chemicals to demonstrate how PNS toxicity may be addressed in evaluating product safety during nonclinical studies. Topics emphasized comparative and correlative data among animal species used in toxicity studies and clinical evaluation in humans in order to facilitate the translation of animal data into human risk assessment with respect to PNS toxicologic pathology.