The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

Rafi Ahmed - One of the best experts on this subject based on the ideXlab platform.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2008
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4(+) T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2007
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4+ T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets. See accompanying articles: http://dx.doi.org/10.1002/eji200737611 and http://dx.doi.org/10.1002/eji200737852

Vandana Kalia - One of the best experts on this subject based on the ideXlab platform.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2008
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4(+) T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2007
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4+ T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets. See accompanying articles: http://dx.doi.org/10.1002/eji200737611 and http://dx.doi.org/10.1002/eji200737852

Mckenzie L Shaw - One of the best experts on this subject based on the ideXlab platform.

  • dissecting hematopoietic and renal Cell Heterogeneity in adult zebrafish at single Cell resolution using rna sequencing
    Journal of Experimental Medicine, 2017
    Co-Authors: Qin Tang, John C. Moore, Sowmya Iyer, Riadh Lobbardi, Huidong Chen, Caleb A Lareau, Christine Hebert, Mckenzie L Shaw
    Abstract:

    : Recent advances in single-Cell, transcriptomic profiling have provided unprecedented access to investigate Cell Heterogeneity during tissue and organ development. In this study, we used massively parallel, single-Cell RNA sequencing to define Cell Heterogeneity within the zebrafish kidney marrow, constructing a comprehensive molecular atlas of definitive hematopoiesis and functionally distinct renal Cells found in adult zebrafish. Because our method analyzed blood and kidney Cells in an unbiased manner, our approach was useful in characterizing immune-Cell deficiencies within DNA-protein kinase catalytic subunit (prkdc), interleukin-2 receptor γ a (il2rga), and double-homozygous-mutant fish, identifying blood Cell losses in T, B, and natural killer Cells within specific genetic mutants. Our analysis also uncovered novel Cell types, including two classes of natural killer immune Cells, classically defined and erythroid-primed hematopoietic stem and progenitor Cells, mucin-secreting kidney Cells, and kidney stem/progenitor Cells. In total, our work provides the first, comprehensive, single-Cell, transcriptomic analysis of kidney and marrow Cells in the adult zebrafish.

Surojit Sarkar - One of the best experts on this subject based on the ideXlab platform.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2008
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4(+) T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets.

  • Fine-tuning CD4+ central memory T Cell Heterogeneity by strength of stimulation
    European Journal of Immunology, 2007
    Co-Authors: Vandana Kalia, Surojit Sarkar, Rafi Ahmed
    Abstract:

    The memory T Cell pool serves as a relatively long-lived heterogeneous repository of antigen-experienced T Cells that "remember" previous encounters with antigen. While Heterogeneity in the memory T Cell pool is now well established, signals regulating the generation of this memory T Cell Heterogeneity are not fully understood. Two articles in this issue of the European Journal of Immunology highlight the importance of the strength of antigenic stimulation in regulating the generation of phenotypically and functionally distinct CD4+ T Cell memory subsets. New insights are also provided into key molecular players that likely mediate differences in homeostatic and secondary expansion between the memory subsets. See accompanying articles: http://dx.doi.org/10.1002/eji200737611 and http://dx.doi.org/10.1002/eji200737852

Alessandra Sacco - One of the best experts on this subject based on the ideXlab platform.

  • satellite Cell Heterogeneity in skeletal muscle homeostasis
    Trends in Cell Biology, 2016
    Co-Authors: Matthew Tierney, Alessandra Sacco
    Abstract:

    The Cellular turnover required for skeletal muscle maintenance and repair is mediated by resident stem Cells, also termed satellite Cells. Satellite Cells normally reside in a quiescent state, intermittently entering the Cell cycle to fuse with neighboring myofibers and replenish the stem Cell pool. However, the mechanisms by which satellite Cells maintain the precise balance between self-renewal and differentiation necessary for long-term homeostasis remain unclear. Recent work has supported a previously unappreciated Heterogeneity in the satellite Cell compartment that may underlie the observed variability in Cell fate and function. In this review, we examine the work supporting this notion as well as the potential governing principles, developmental origins, and principal determinants of satellite Cell Heterogeneity.